[go: up one dir, main page]

SG11201510181YA - Compositions and methods using capsids resistant to hydrolases - Google Patents

Compositions and methods using capsids resistant to hydrolases

Info

Publication number
SG11201510181YA
SG11201510181YA SG11201510181YA SG11201510181YA SG11201510181YA SG 11201510181Y A SG11201510181Y A SG 11201510181YA SG 11201510181Y A SG11201510181Y A SG 11201510181YA SG 11201510181Y A SG11201510181Y A SG 11201510181YA SG 11201510181Y A SG11201510181Y A SG 11201510181YA
Authority
SG
Singapore
Prior art keywords
hydrolases
compositions
methods
capsids
resistant
Prior art date
Application number
SG11201510181YA
Inventor
Juan Pedro Humberto Arhancet
Juan P Arhancet
Kimberly Delaney
Kathleen B Hall
Neena Summers
Edward Oates
Original Assignee
Apse Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apse Llc filed Critical Apse Llc
Publication of SG11201510181YA publication Critical patent/SG11201510181YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • C12N15/8616—Special methods for targeting systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184—Virus capsids or envelopes enclosing drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2795/00042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/18142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
SG11201510181YA 2013-06-19 2014-06-05 Compositions and methods using capsids resistant to hydrolases SG11201510181YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361836833P 2013-06-19 2013-06-19
US201361838736P 2013-06-24 2013-06-24
US201361857965P 2013-07-24 2013-07-24
PCT/US2014/041111 WO2014204667A1 (en) 2013-06-19 2014-06-05 Compositions and methods using capsids resistant to hydrolases

Publications (1)

Publication Number Publication Date
SG11201510181YA true SG11201510181YA (en) 2016-01-28

Family

ID=52105110

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201805197VA SG10201805197VA (en) 2013-06-19 2014-06-05 Compositions and methods using capsids resistant to hydrolases
SG11201510181YA SG11201510181YA (en) 2013-06-19 2014-06-05 Compositions and methods using capsids resistant to hydrolases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201805197VA SG10201805197VA (en) 2013-06-19 2014-06-05 Compositions and methods using capsids resistant to hydrolases

Country Status (15)

Country Link
US (2) US9822361B2 (en)
EP (3) EP3010494B1 (en)
JP (1) JP6636418B2 (en)
AU (1) AU2014281061B2 (en)
BR (1) BR112015029559A2 (en)
CA (1) CA2912131C (en)
CY (1) CY1124583T1 (en)
DK (1) DK3222274T3 (en)
ES (1) ES2847151T3 (en)
HU (1) HUE053033T2 (en)
IL (1) IL242487B (en)
MX (2) MX364809B (en)
PL (1) PL3222274T3 (en)
SG (2) SG10201805197VA (en)
WO (1) WO2014204667A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201402657WA (en) * 2011-12-21 2014-09-26 Apse Llc Processes using vlps with capsids resistant to hydrolases
DK3222274T3 (en) 2013-06-19 2020-11-02 Apse Llc Compositions and methods using capsules that are resistant to hydrolases
WO2015038746A1 (en) * 2013-09-11 2015-03-19 Georgia Tech Research Corporation Compositions and methods for inhibiting gene expression
US20180291066A1 (en) * 2015-05-12 2018-10-11 Apse, Llc In vivo production of long double stranded rna utilizing vlps
WO2017059277A1 (en) * 2015-10-01 2017-04-06 Apse, Llc Methods and compositions comprising apse knots
MX381136B (en) * 2016-03-15 2025-03-12 Rnaissance Ag Llc METHODS AND COMPOSITIONS FOR INCREASING DOUBLE-STRANDED RNA PRODUCTION.
JP7094949B2 (en) 2016-11-07 2022-07-04 ナノスール エルエルシー Post-transcriptional chemically modified double-stranded RNA
CN114269374A (en) * 2019-05-21 2022-04-01 艾斯佩罗疫苗公司 Yeast-based oral vaccination
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
JP2023553341A (en) * 2020-11-25 2023-12-21 エスペロバックス インコーポレイティド Yeast-based expression of therapeutic proteins in vivo
CN118302524A (en) 2021-08-31 2024-07-05 纳诺索尔公司 High molecular weight modified dsRNA compositions
WO2023077145A1 (en) * 2021-11-01 2023-05-04 Arizona Board Of Regents On Behalf Of Arizona State University A method for production of self-replicating, nucleic acid-loaded, virus-like particles (vlp-na) and the uses thereof
US20250207132A1 (en) * 2023-12-22 2025-06-26 Commonwealth Scientific And Industrial Research Organisation Asymmetric rna molecules

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443969A (en) 1992-10-29 1995-08-22 Rutgers University RNA packaging system
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6232287B1 (en) * 1998-03-13 2001-05-15 The Burnham Institute Molecules that home to various selected organs or tissues
GB9925459D0 (en) * 1999-10-27 1999-12-29 Plant Bioscience Ltd Gene silencing
GB9927444D0 (en) * 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
KR20080023768A (en) * 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 RNA sequence specific mediator of RNA interference
CH695778A5 (en) * 2000-11-29 2006-08-31 Hoffmann La Roche Inhibition of transcription of a target gene in a cell or in tissues.
US7264810B2 (en) * 2001-01-19 2007-09-04 Cytos Biotechnology Ag Molecular antigen array
EP1432791B2 (en) 2001-09-06 2013-10-23 Alphavax, Inc. Alphavirus replicon vector systems
CA2492826C (en) 2001-09-14 2016-12-13 Cytos Biotechnology Ag Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use
KR101228376B1 (en) 2002-07-18 2013-01-31 사이토스 바이오테크놀로지 아게 Hapten-carrier conjugates and uses thereof
WO2005001039A2 (en) * 2003-05-29 2005-01-06 Creighton University Ribozyme-regulated small inhibitory rna (sirna) production and methods of use thereof
EP3388521A1 (en) 2004-02-27 2018-10-17 Dow AgroSciences LLC High efficiency peptide production in plant cells
GR20060100496A (en) * 2006-09-01 2008-04-15 Παρθενιος Μπουλικας LIPOSOMALLY ENCAPSULATED HYBRID ADENOVIRUS-SEMLIKI FOREST VIRUS (SFV) VECTORS CARRYING RNAi CONSTRUCTS AND THERAPEUTIC GENES FOR USE AGAINST CANCER TARGETS AND OTHER DISEASES.
US20080171361A1 (en) * 2007-01-11 2008-07-17 The Board Of Regents For Oklahoma State University CAP-Independent Translational Enhancer for Protein Synthesis in Wheat Germ Extract and Transgenic Cereals
WO2009014782A2 (en) 2007-04-27 2009-01-29 Dow Global Technologies Inc. Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles
CN107129957A (en) * 2007-06-29 2017-09-05 北京强新生物科技有限公司 Facilitating the use of long dsRNA for gene targeting in mammalian and other selected animal cells
EP2085479A1 (en) 2008-01-31 2009-08-05 Institut Pasteur Reverse genetics of negative-strand rna viruses in yeast
WO2009120883A2 (en) 2008-03-26 2009-10-01 Life Technologies Corporation Virus-like particle mediated cellular delivery
US8324149B2 (en) * 2008-11-18 2012-12-04 The Board Of Trustees Of The Leland Stanford Junior University Encapsidation of heterologous entities into virus-like particles
US8906862B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Multiple antigen delivery system using hepatitis E virus-like particle
US8906863B2 (en) * 2009-02-27 2014-12-09 The Regents Of The University Of California Proteolysis-resistant capsid of chimeric hepatitis E virus as an oral delivery vector
IN2012DN00324A (en) * 2009-06-15 2015-05-08 Plant Bioscience Ltd
CN102822350B (en) 2010-03-08 2015-05-06 孟山都技术公司 Polynucleotide molecules for gene regulation in plants
US20130017210A1 (en) 2010-03-17 2013-01-17 Stc.Unm Display of antibody fragments on virus-like particles of rna bacteriophages
WO2012051152A2 (en) * 2010-10-12 2012-04-19 Kevin Ryan Novel dna templates for small rna production in mammalian cells
US20130224828A1 (en) * 2010-11-01 2013-08-29 Qapsule Technologies, Inc. RNA-Directed Packaging of Enzymes Within Protein Particles
JP2013018754A (en) * 2011-07-13 2013-01-31 Univ Of Tokushima Therapeutic agent for treating malignant pleural mesothelioma
JP6137484B2 (en) * 2011-11-02 2017-05-31 公立大学法人大阪市立大学 Double-stranded nucleic acid molecule for gene expression suppression
SG11201402657WA (en) * 2011-12-21 2014-09-26 Apse Llc Processes using vlps with capsids resistant to hydrolases
DK3222274T3 (en) 2013-06-19 2020-11-02 Apse Llc Compositions and methods using capsules that are resistant to hydrolases
WO2015038746A1 (en) * 2013-09-11 2015-03-19 Georgia Tech Research Corporation Compositions and methods for inhibiting gene expression

Also Published As

Publication number Publication date
SG10201805197VA (en) 2018-07-30
BR112015029559A2 (en) 2017-12-12
US20160177299A1 (en) 2016-06-23
EP3010494A4 (en) 2017-06-07
PL3222274T3 (en) 2021-07-19
US10428329B2 (en) 2019-10-01
JP2016521992A (en) 2016-07-28
CY1124583T1 (en) 2022-03-24
WO2014204667A1 (en) 2014-12-24
US20180030445A1 (en) 2018-02-01
AU2014281061B2 (en) 2019-07-18
EP3789017A1 (en) 2021-03-10
MX2015017593A (en) 2016-04-15
EP3010494B1 (en) 2018-08-15
MX364809B (en) 2019-05-07
US9822361B2 (en) 2017-11-21
AU2014281061A1 (en) 2015-11-26
JP6636418B2 (en) 2020-01-29
EP3010494A1 (en) 2016-04-27
IL242487B (en) 2020-05-31
CA2912131A1 (en) 2014-12-24
ES2847151T3 (en) 2021-08-02
MX394708B (en) 2025-03-24
HUE053033T2 (en) 2021-06-28
EP3222274B1 (en) 2020-10-21
CA2912131C (en) 2020-07-07
DK3222274T3 (en) 2020-11-02
EP3222274A1 (en) 2017-09-27
MX2019005298A (en) 2019-08-12

Similar Documents

Publication Publication Date Title
IL273205A (en) Compositions and methods
IL277196A (en) Methods and compositions for genome engineering
IL269461B (en) Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
IL242487B (en) Compositions and methods using capsids resistant to hydrolases
GB2527241B (en) Compositions and methods
IL286759A (en) Therapeutic methods and compositions
AP2016009060A0 (en) Compositions and methods related to isolated endophytes
IL245550A0 (en) Compositions and methods of using transposons
ZA201601250B (en) Density enhancement methods and compositions
GB201308072D0 (en) Compositions and methods
SMT201900635T1 (en) Compositions and methods for activating
SMT202100154T1 (en) COMPOSITIONS AND METHODS TO PRECISELY IDENTIFY MUTATIONS
PL3260558T3 (en) NEW COMPOSITIONS AND WAYS TO IMPROVE PCR SPECIFICATIONS
GB201322094D0 (en) Methods and compositions relating to alzheimers disease
ZA201408594B (en) Xylitol-based anti-mucosal compositions and related methods and compositions
SG10201708595YA (en) Cenicriviroc compositions and methods of making and using the same
GB201305813D0 (en) Compositions and methods
SG11201505891VA (en) Catalyst compositions and methods of making and using same
GB201322456D0 (en) Radiotracer compositions and methods
EP2964610A4 (en) Vinylsulfone-based 18f-labeling compositions and methods and uses thereof
GB201315350D0 (en) Methods and compositions
GB201315347D0 (en) Methods and compositions
IL244537A0 (en) Novel delivery compositions and methods of using same
GB201322617D0 (en) Methods and compositions
GB201312393D0 (en) Compositions and Methods