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SG11201505918TA - Immobilized transaminases and process for making and using immobilized transaminase - Google Patents

Immobilized transaminases and process for making and using immobilized transaminase

Info

Publication number
SG11201505918TA
SG11201505918TA SG11201505918TA SG11201505918TA SG11201505918TA SG 11201505918T A SG11201505918T A SG 11201505918TA SG 11201505918T A SG11201505918T A SG 11201505918TA SG 11201505918T A SG11201505918T A SG 11201505918TA SG 11201505918T A SG11201505918T A SG 11201505918TA
Authority
SG
Singapore
Prior art keywords
immobilized
making
transaminases
transaminase
immobilized transaminase
Prior art date
Application number
SG11201505918TA
Inventor
Matthew D Truppo
Michel Journet
Hallena Strotman
Jonathan P Mcmullen
Shane T Grosser
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SG11201505918TA publication Critical patent/SG11201505918TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087Acrylic polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1096Transferases (2.) transferring nitrogenous groups (2.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/001Amines; Imines
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
SG11201505918TA 2013-02-28 2014-02-24 Immobilized transaminases and process for making and using immobilized transaminase SG11201505918TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361770366P 2013-02-28 2013-02-28
PCT/US2014/017898 WO2014133928A1 (en) 2013-02-28 2014-02-24 Immobilized transaminases and process for making and using immobilized transaminase

Publications (1)

Publication Number Publication Date
SG11201505918TA true SG11201505918TA (en) 2015-09-29

Family

ID=51428712

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505918TA SG11201505918TA (en) 2013-02-28 2014-02-24 Immobilized transaminases and process for making and using immobilized transaminase

Country Status (5)

Country Link
US (1) US9523107B2 (en)
EP (1) EP2961838B1 (en)
CN (1) CN105073983B (en)
SG (1) SG11201505918TA (en)
WO (1) WO2014133928A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109251925A (en) * 2017-07-14 2019-01-22 上海蓝木化工有限公司 A kind of preparation and its application of fixed on ion exchange resin transaminase
CN110129306A (en) * 2018-02-08 2019-08-16 广东东阳光药业有限公司 Immobilized transaminase and its application
CN108689984B (en) * 2018-05-02 2019-09-20 淮阴工学院 A kind of biosynthesis method and intermediate of ticagrelor intermediate
WO2021108957A1 (en) * 2019-12-02 2021-06-10 吉林凯莱英医药化学有限公司 Co-immobilized enzyme, preparation method therefor and application thereof
CN112430632B (en) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 Preparation method of 2- ((trans) -4-aminocyclohexyl) isopropanol
CN113481254B (en) * 2021-06-29 2023-05-26 台州酶易生物技术有限公司 Preparation method of sitagliptin intermediate
CN113430184B (en) * 2021-06-29 2022-04-01 台州酶易生物技术有限公司 Transaminase and application thereof in preparation of sitagliptin
CN115232807A (en) * 2022-09-01 2022-10-25 沈阳农业大学 A thermogel-assisted mesoporous silica cross-linking enzyme aggregation carrier and its embedded DFA synthase
CN117467733B (en) * 2023-12-27 2024-03-12 北京元延医药科技股份有限公司 High chiral purity sitagliptin and method for preparing same by using immobilized transaminase
CN118063351B (en) * 2024-04-18 2024-06-28 北京元延医药科技股份有限公司 Green synthesis of chiral beta amino acids using biological enzymes and immobilized aminotransferase used

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020132295A1 (en) 1996-02-09 2002-09-19 Short Jay M. Enzymes having transaminase and aminotransferase activity and methods of use thereof
AR043515A1 (en) 2003-03-19 2005-08-03 Merck & Co Inc PROCEDURE TO PREPARE CHIRAL DERIVATIVES BETA AMINO ACIDS BY ASYMMETRIC HYDROGENATION
WO2004085624A2 (en) 2003-03-24 2004-10-07 Diversa Corporation Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification
JO2625B1 (en) 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
ES2587572T3 (en) 2005-04-26 2016-10-25 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin stereoisomers and their precursors
PL2238242T3 (en) 2008-01-03 2015-06-30 Basf Enzymes Llc Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
CN102405281B (en) 2009-02-26 2015-05-13 科德克希思公司 Transaminase biocatalysts
ES2644992T3 (en) * 2009-06-22 2017-12-01 Codexis, Inc. Transaminase reactions
JP5927178B2 (en) * 2011-03-11 2016-06-01 株式会社カネカ Modified aminotransferase, gene thereof, and method for producing optically active amino compound using them
US9587229B2 (en) * 2011-06-24 2017-03-07 Merck Sharp & Dohme Corp. Immobilized transaminases and process for making and using immobilized transaminase
JP6436541B2 (en) * 2013-02-28 2018-12-12 コデクシス, インコーポレイテッド Engineered transaminase polypeptides for industrial biocatalysis

Also Published As

Publication number Publication date
CN105073983B (en) 2018-09-18
US9523107B2 (en) 2016-12-20
US20150368682A1 (en) 2015-12-24
CN105073983A (en) 2015-11-18
EP2961838B1 (en) 2018-04-18
WO2014133928A1 (en) 2014-09-04
EP2961838A1 (en) 2016-01-06
EP2961838A4 (en) 2016-07-13

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