SG11201500005SA - Pyrimidine pyrazolyl derivatives - Google Patents
Pyrimidine pyrazolyl derivativesInfo
- Publication number
- SG11201500005SA SG11201500005SA SG11201500005SA SG11201500005SA SG11201500005SA SG 11201500005S A SG11201500005S A SG 11201500005SA SG 11201500005S A SG11201500005S A SG 11201500005SA SG 11201500005S A SG11201500005S A SG 11201500005SA SG 11201500005S A SG11201500005S A SG 11201500005SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- july
- chemin
- pct
- unless
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- -1 PYRIMIDINE PYRAZOLYL Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261669843P | 2012-07-10 | 2012-07-10 | |
| EP12175660 | 2012-07-10 | ||
| PCT/EP2013/001950 WO2014008992A1 (fr) | 2012-07-10 | 2013-07-03 | Dérivés de pyrazolyl-pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
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| SG11201500005SA SG11201500005SA (en) | 2012-07-10 | 2013-07-03 | Pyrimidine pyrazolyl derivatives |
Country Status (18)
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| US (1) | US9216991B2 (fr) |
| EP (1) | EP2872501B1 (fr) |
| JP (1) | JP6189434B2 (fr) |
| KR (1) | KR20150033716A (fr) |
| CN (1) | CN104662014B (fr) |
| AU (1) | AU2013289615B2 (fr) |
| BR (1) | BR112015000399A2 (fr) |
| CA (1) | CA2878621C (fr) |
| DK (1) | DK2872501T3 (fr) |
| ES (1) | ES2589558T3 (fr) |
| HU (1) | HUE029559T2 (fr) |
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| MX (1) | MX2015000129A (fr) |
| PT (1) | PT2872501T (fr) |
| RU (1) | RU2015104123A (fr) |
| SG (1) | SG11201500005SA (fr) |
| WO (1) | WO2014008992A1 (fr) |
| ZA (1) | ZA201500917B (fr) |
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| CN106068264B (zh) * | 2014-01-09 | 2019-06-21 | 默克专利有限公司 | 嘧啶吡唑基衍生物及其作为irak抑制剂的用途 |
| CN112898196B (zh) | 2014-03-27 | 2024-12-27 | 艾科西斯有限责任公司 | 有效的可溶性环氧化物水解酶抑制剂 |
| HUE047586T2 (hu) * | 2014-11-20 | 2020-04-28 | Merck Patent Gmbh | Heteroaril vegyületek mint IRAK inhibitorok és alkalmazásaik |
| CN105153211B (zh) * | 2015-09-22 | 2017-02-01 | 上海晋鲁医药科技有限公司 | 一种合成1‑(N‑Boc‑4‑哌啶)‑4‑吡唑硼酸频哪醇酯的方法 |
| US10435396B2 (en) | 2016-03-03 | 2019-10-08 | Bayer Pharma Aktiegesellschaft | 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| MX387359B (es) | 2017-03-16 | 2025-03-18 | Bristol Myers Squibb Co | Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos. |
| CN106967073A (zh) * | 2017-04-24 | 2017-07-21 | 刘双伟 | 一种治疗类风湿性关节炎的药物 |
| CN106946891B (zh) * | 2017-05-08 | 2018-07-13 | 宿州市徽腾知识产权咨询有限公司 | 一种用于治疗类风湿性关节炎的药物 |
| WO2019060693A1 (fr) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Ligands crbn et utilisations de ces derniers |
| CA3076613A1 (fr) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Agents de degradation des proteines et utilisations de ces derniers |
| WO2019111218A1 (fr) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs d'irak4 |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| EP3737675A4 (fr) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | Ligands crbn et leurs utilisations |
| WO2020010227A1 (fr) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Agents de dégradation de protéines et leurs utilisations |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| EP3870177A1 (fr) * | 2018-10-26 | 2021-09-01 | Arrien Pharmaceuticals LLC | Composés de pyrazolyle et leurs procédés d'utilisation |
| JP7623943B2 (ja) | 2018-11-30 | 2025-01-29 | カイメラ セラピューティクス, インコーポレイテッド | Irak分解剤およびそれらの使用 |
| WO2021099406A1 (fr) * | 2019-11-20 | 2021-05-27 | F. Hoffmann-La Roche Ag | Composés de spiro(isobenzofurane azétidine) pour le traitement d'une maladie auto-immune |
| CN110950839B (zh) * | 2019-12-17 | 2023-04-14 | 蚌埠中实化学技术有限公司 | 4-(4-卤代-1h-吡唑-1-基)哌啶-1-羧酸叔丁酯的制备方法 |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| AR124547A1 (es) | 2020-12-30 | 2023-04-05 | Kymera Therapeutics Inc | Degradadores de irak y sus usos |
| TW202246282A (zh) * | 2021-02-01 | 2022-12-01 | 美商西建公司 | Mk2抑制劑、其合成及其中間體 |
| MX2023009527A (es) | 2021-02-15 | 2023-08-24 | Kymera Therapeutics Inc | Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos. |
| AR125798A1 (es) | 2021-05-07 | 2023-08-16 | Kymera Therapeutics Inc | Degradadores cdk2 y usos de los mismos |
| EP4422635A4 (fr) | 2021-10-29 | 2025-11-26 | Kymera Therapeutics Inc | Agents de dégradation d'irak4 et leur synthèse |
| CA3243560A1 (fr) | 2022-01-31 | 2023-08-03 | Kymera Therapeutics, Inc. | Agents de dégradation d'irak et leurs utilisations |
| EP4551218A2 (fr) * | 2022-07-07 | 2025-05-14 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs irréversibles puissants et sélectifs d'irak1 |
| CN115490621B (zh) * | 2022-10-14 | 2024-06-21 | 浙江工业大学 | 一种碘代双环[1.1.1]戊烷衍生物的制备方法 |
Family Cites Families (10)
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|---|---|---|---|---|
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| ATE354573T1 (de) * | 2000-12-21 | 2007-03-15 | Vertex Pharma | ßPYRAZOLVERBINDUNGEN, DIE SICH ALS PROTEINKINASEINHIBITOREN EIGNENß |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| DE102008025750A1 (de) * | 2008-05-29 | 2009-12-03 | Merck Patent Gmbh | Dihydropyrazolderivate |
| DE102008062825A1 (de) * | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate |
| WO2010100144A1 (fr) | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Composés bicycliques fusionnés utilisés comme inhibiteurs de la pi3 kinase |
| WO2010112210A1 (fr) * | 2009-04-03 | 2010-10-07 | Cellzome Ag | Procédés pour l'identification de molécules interagissant avec une kinase et pour la purification de protéines kinases |
| DE102009033208A1 (de) * | 2009-07-15 | 2011-01-20 | Merck Patent Gmbh | Aminopyridinderivate |
| AU2010340087A1 (en) * | 2009-12-21 | 2012-07-26 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| MX358682B (es) | 2010-07-13 | 2018-08-31 | Hoffmann La Roche | Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4). |
-
2013
- 2013-07-03 CA CA2878621A patent/CA2878621C/fr active Active
- 2013-07-03 HU HUE13737134A patent/HUE029559T2/en unknown
- 2013-07-03 PT PT137371340T patent/PT2872501T/pt unknown
- 2013-07-03 CN CN201380047170.9A patent/CN104662014B/zh active Active
- 2013-07-03 EP EP13737134.0A patent/EP2872501B1/fr active Active
- 2013-07-03 SG SG11201500005SA patent/SG11201500005SA/en unknown
- 2013-07-03 DK DK13737134.0T patent/DK2872501T3/en active
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- 2013-07-03 MX MX2015000129A patent/MX2015000129A/es unknown
- 2013-07-03 KR KR20157003049A patent/KR20150033716A/ko not_active Withdrawn
- 2013-07-03 RU RU2015104123A patent/RU2015104123A/ru not_active Application Discontinuation
- 2013-07-03 WO PCT/EP2013/001950 patent/WO2014008992A1/fr not_active Ceased
- 2013-07-03 JP JP2015520844A patent/JP6189434B2/ja active Active
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2014
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- 2015-02-09 ZA ZA2015/00917A patent/ZA201500917B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2589558T3 (es) | 2016-11-15 |
| JP6189434B2 (ja) | 2017-08-30 |
| ZA201500917B (en) | 2017-08-30 |
| WO2014008992A1 (fr) | 2014-01-16 |
| US20150141396A1 (en) | 2015-05-21 |
| PT2872501T (pt) | 2016-09-06 |
| IL236542B (en) | 2018-05-31 |
| AU2013289615B2 (en) | 2017-06-08 |
| HK1210778A1 (en) | 2016-05-06 |
| RU2015104123A (ru) | 2016-08-27 |
| EP2872501A1 (fr) | 2015-05-20 |
| CN104662014A (zh) | 2015-05-27 |
| CA2878621C (fr) | 2020-09-15 |
| EP2872501B1 (fr) | 2016-06-01 |
| DK2872501T3 (en) | 2016-08-29 |
| CA2878621A1 (fr) | 2014-01-16 |
| AU2013289615A1 (en) | 2015-02-26 |
| HUE029559T2 (en) | 2017-03-28 |
| KR20150033716A (ko) | 2015-04-01 |
| IL236542A0 (en) | 2015-02-26 |
| US9216991B2 (en) | 2015-12-22 |
| MX2015000129A (es) | 2015-04-14 |
| JP2015522045A (ja) | 2015-08-03 |
| CN104662014B (zh) | 2017-02-22 |
| BR112015000399A2 (pt) | 2017-06-27 |
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