SG11201404677TA - Process of expanding t cells - Google Patents
Process of expanding t cellsInfo
- Publication number
- SG11201404677TA SG11201404677TA SG11201404677TA SG11201404677TA SG11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA
- Authority
- SG
- Singapore
- Prior art keywords
- expanding
- cells
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1121—Dendritic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569577P | 2011-12-12 | 2011-12-12 | |
| PCT/GB2012/050896 WO2013088114A1 (en) | 2011-12-12 | 2012-04-23 | Process of expanding t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201404677TA true SG11201404677TA (en) | 2014-11-27 |
Family
ID=46146968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201404677TA SG11201404677TA (en) | 2011-12-12 | 2012-04-23 | Process of expanding t cells |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10351824B2 (en) |
| EP (1) | EP2791322A1 (en) |
| JP (3) | JP6081483B2 (en) |
| KR (1) | KR101749195B1 (en) |
| CN (3) | CN109182266A (en) |
| AU (1) | AU2012351347B2 (en) |
| BR (1) | BR112014014591A8 (en) |
| SG (1) | SG11201404677TA (en) |
| WO (1) | WO2013088114A1 (en) |
Families Citing this family (61)
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|---|---|---|---|---|
| WO2011028531A1 (en) | 2009-08-24 | 2011-03-10 | Baylor College Of Medicine | Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| BR112014014591A8 (en) * | 2011-12-12 | 2017-07-04 | Baylor College Medicine | process for the in vitro expansion of antigen-specific t cells, expanded autologous or allogeneic t-cell product, pharmaceutical composition, and method of treatment of a patient, and uses of an engineered cell line, mixed pulsed dendritic cells antigen-peptide, t-apcs pulsed with antigen-peptide / peptide mixtures, and antigen-peptide mixtures with pbmcs |
| PT2812431T (en) | 2012-02-09 | 2019-10-18 | Baylor College Medicine | PEPMIXES TO GENERATE MULTIVIRAL CTLS WITH WIDE SPECIFICITY |
| JP2015519080A (en) * | 2012-06-11 | 2015-07-09 | ウィルソン ウォルフ マニュファクチャリング コーポレイションWilson Wolf Manufacturing Corporation | Improved cell culture method for adoptive cell therapy |
| JP6599450B2 (en) * | 2014-10-02 | 2019-10-30 | アメリカ合衆国 | Method for isolating T cells having antigen specificity for a cancer specific mutation |
| US10046047B2 (en) * | 2015-02-06 | 2018-08-14 | Heat Biologics, Inc. | Vector co-expressing vaccine and costimulatory molecules |
| US12478670B2 (en) | 2015-03-20 | 2025-11-25 | Children's National Medical Center | Generating HPV antigen-specific T cells from a naïve T cell population |
| IL294055A (en) * | 2015-03-20 | 2022-08-01 | Childrens Nat Medical Ct | Production of t-cells specific for a virus antigen or other antigen from a population of naïve t-cells |
| WO2017075571A1 (en) | 2015-10-30 | 2017-05-04 | Children's National Medical Center | Generating hpv antigen-specific cells from a naive t cell population |
| CN104830793A (en) * | 2015-05-05 | 2015-08-12 | 杨光华 | DC cell based on LMP-1 antigen, targeting immune cell population, preparation method and applications thereof |
| WO2017023803A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
| SG10202112047TA (en) | 2015-09-18 | 2021-12-30 | Baylor College Medicine | Immunogenic antigen identification from a pathogen and correlation to clinical efficacy |
| CN108138171B (en) * | 2015-10-08 | 2022-05-13 | 国立大学法人名古屋大学 | Method for preparing gene modified T cell for expressing chimeric antigen receptor |
| ITUB20154769A1 (en) * | 2015-11-04 | 2017-05-04 | Centro Di Riferimento Oncologico Cro Irccs Aviano | Anti-BARF1 monoclonal antibody |
| EP3430131B1 (en) * | 2016-03-17 | 2022-06-08 | Berkeley Lights, Inc. | Selection and cloning of t lymphocytes in a microfluidic device |
| WO2017197347A1 (en) * | 2016-05-12 | 2017-11-16 | Adicet Bio, Inc. | METHODS FOR SELECTIVE EXPANSION OF γδ T-CELL POPULATIONS AND COMPOSITIONS THEREOF |
| US10052372B2 (en) * | 2016-05-24 | 2018-08-21 | Tessa Therapeutics Pte Ltd | T cell expansion |
| KR20190028662A (en) | 2016-05-25 | 2019-03-19 | 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 | Methods of immunotherapy |
| KR20190028664A (en) * | 2016-05-25 | 2019-03-19 | 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 | Immune checkpoint inhibitors and cytotoxic T cells for the treatment of cancer |
| SG11201809534UA (en) * | 2016-05-25 | 2018-12-28 | Council Queensland Inst Medical Res | Methods of treating autoimmune disease using allogeneic t cells |
| US11472856B2 (en) | 2016-06-13 | 2022-10-18 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| US11549090B2 (en) * | 2016-08-21 | 2023-01-10 | Adva Biotechnology Ltd. | Bioreactor and methods of use thereof |
| US9642906B2 (en) * | 2016-09-16 | 2017-05-09 | Baylor College Of Medicine | Generation of HPV-specific T-cells |
| AU2017326173B2 (en) * | 2016-09-16 | 2022-08-18 | Baylor College Of Medicine | Platform for activation and expansion of virus-specific T-cells |
| BR112019014406A2 (en) | 2017-01-20 | 2020-04-28 | Atara Biotherapeutics Inc | methods of treating multiple sclerosis using autologous t cells |
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| WO2019031939A2 (en) * | 2017-08-10 | 2019-02-14 | 주식회사 굳티셀 | Method for activating t cells for cancer treatment |
| JP7285828B2 (en) | 2017-09-05 | 2023-06-02 | トルク セラピューティクス, インコーポレイテッド | Therapeutic protein compositions and methods of making and using them |
| US20200338125A1 (en) * | 2017-11-06 | 2020-10-29 | Ludwig Institute For Cancer Research Ltd | Method for expansion of lymphocytes |
| EP3784696A1 (en) | 2018-04-23 | 2021-03-03 | Baylor College Of Medicine | Chimeric hla accessory receptor |
| WO2019222763A1 (en) * | 2018-05-18 | 2019-11-21 | Children's National Medical Center | System of cell expansion and methods of using the same |
| WO2019239216A2 (en) * | 2018-06-13 | 2019-12-19 | The Council Of The Queensland Institute Of Medical Research | Viral detection assay |
| ES3000183T3 (en) | 2018-09-10 | 2025-02-27 | Atara Biotherapeutics Inc | Methods for expanding antigen-specific car-t cells, compositions and uses related thereto |
| WO2020069377A1 (en) * | 2018-09-27 | 2020-04-02 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods of using lysine deacetylase (kdac) inhibition to generate antigen specific memory t cell responses for durable immunotherapy |
| WO2020077200A1 (en) * | 2018-10-12 | 2020-04-16 | Georgia Tech Research Corporation | Methods and systems for dynamic predictive modeling and control of inflammation |
| CA3118757A1 (en) | 2018-11-08 | 2020-05-14 | Neximmune, Inc. | T cell compositions with improved phenotypic properties |
| US20200199567A1 (en) * | 2018-12-20 | 2020-06-25 | Medimmune, Llc | Methods for selection and expansion of t cells expressing pd-1 |
| CN113597430A (en) * | 2019-02-08 | 2021-11-02 | 古德T细胞有限公司 | Methods of activating T cells for cancer treatment |
| BR112021019669A2 (en) | 2019-04-12 | 2021-12-07 | C4 Therapeutics Inc | Compound, pharmaceutical composition, method of treating a disorder, compound for use in the production of a medicine, and, use of a compound in treating a disorder |
| GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
| CN110646619A (en) * | 2019-09-25 | 2020-01-03 | 格源致善(上海)生物科技有限公司 | Method for detecting cell factor secreted by specific T cell in lung cancer or intestinal cancer |
| JP7340144B2 (en) * | 2019-10-02 | 2023-09-07 | アメリカ合衆国 | Method for isolating T cells with antigenic specificity for cancer-specific mutations |
| JP6878544B2 (en) * | 2019-10-02 | 2021-05-26 | アメリカ合衆国 | A method for isolating T cells that have antigen specificity for cancer-specific mutations |
| CN110964698B (en) * | 2019-12-25 | 2022-05-10 | 杭州中赢生物医疗科技有限公司 | Artificial antigen presenting cell and preparation method and application thereof |
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| JP2020143057A (en) * | 2020-04-01 | 2020-09-10 | アメリカ合衆国 | Methods for isolating t cell receptors having antigen specificity to cancer specific mutations |
| WO2021221927A1 (en) | 2020-04-27 | 2021-11-04 | Parsons Corporation | Narrowband iq signal obfuscation |
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| CN111856020B (en) * | 2020-06-19 | 2022-09-27 | 南方医科大学南方医院 | Hepatitis B Virus (HBV) specific T cell detection method and application thereof |
| GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
| WO2022214835A1 (en) | 2021-04-09 | 2022-10-13 | Achilles Therapeutics Uk Limited | Batch release assay for pharmaceutical products relating to t cell therapies |
| CN117529551A (en) | 2021-04-27 | 2024-02-06 | 贝勒医学院 | Virus-specific immune cells expressing chimeric antigen receptors |
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| TW202340455A (en) * | 2021-11-23 | 2023-10-16 | 美國貝勒醫學院 | Improved virus-specific t cell |
| CA3251962A1 (en) * | 2022-02-15 | 2023-08-24 | Marker Therapeutics, Inc. | Compositions and methods for antigen-specific t cell expansion |
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- 2012-04-23 WO PCT/GB2012/050896 patent/WO2013088114A1/en not_active Ceased
- 2012-04-23 US US14/364,592 patent/US10351824B2/en active Active
- 2012-04-23 CN CN201811136709.9A patent/CN109182266A/en active Pending
- 2012-04-23 KR KR1020147019227A patent/KR101749195B1/en not_active Ceased
- 2012-04-23 JP JP2014546625A patent/JP6081483B2/en not_active Ceased
- 2012-04-23 SG SG11201404677TA patent/SG11201404677TA/en unknown
- 2012-04-23 AU AU2012351347A patent/AU2012351347B2/en active Active
- 2012-04-23 CN CN201280069568.8A patent/CN104769104A/en active Pending
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| CN104769104A (en) | 2015-07-08 |
| JP2017038621A (en) | 2017-02-23 |
| KR20140123489A (en) | 2014-10-22 |
| US20150017723A1 (en) | 2015-01-15 |
| BR112014014591A8 (en) | 2017-07-04 |
| CN110241080A (en) | 2019-09-17 |
| US11155784B2 (en) | 2021-10-26 |
| BR112014014591A2 (en) | 2017-06-13 |
| KR101749195B1 (en) | 2017-06-20 |
| US10351824B2 (en) | 2019-07-16 |
| EP2791322A1 (en) | 2014-10-22 |
| AU2012351347B2 (en) | 2016-05-19 |
| JP2015501651A (en) | 2015-01-19 |
| WO2013088114A1 (en) | 2013-06-20 |
| JP2020054348A (en) | 2020-04-09 |
| JP6081483B2 (en) | 2017-02-15 |
| CN109182266A (en) | 2019-01-11 |
| US20190270966A1 (en) | 2019-09-05 |
| AU2012351347A1 (en) | 2014-08-07 |
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