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SG11201403540RA - Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor - Google Patents

Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor

Info

Publication number
SG11201403540RA
SG11201403540RA SG11201403540RA SG11201403540RA SG11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA
Authority
SG
Singapore
Prior art keywords
agonists
stimulating hormone
hormone receptor
follicle stimulating
analogues
Prior art date
Application number
SG11201403540RA
Inventor
Henry Yu
Marianne Donnelly
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201403540RA publication Critical patent/SG11201403540RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/42Gynaecological or obstetrical instruments or methods
    • A61B17/425Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SG11201403540RA 2012-02-08 2013-01-24 Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor SG11201403540RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261596417P 2012-02-08 2012-02-08
PCT/EP2013/000215 WO2013117299A1 (en) 2012-02-08 2013-01-24 Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor

Publications (1)

Publication Number Publication Date
SG11201403540RA true SG11201403540RA (en) 2014-07-30

Family

ID=47666083

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201403540RA SG11201403540RA (en) 2012-02-08 2013-01-24 Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor

Country Status (15)

Country Link
US (1) US20150111933A1 (en)
EP (1) EP2812320B1 (en)
JP (1) JP6386382B2 (en)
KR (1) KR20140120903A (en)
CN (1) CN104114544A (en)
AU (1) AU2013218368B2 (en)
BR (1) BR112014019351A8 (en)
CA (1) CA2860489C (en)
ES (1) ES2672326T3 (en)
HK (1) HK1201837A1 (en)
IL (1) IL233983B (en)
MX (1) MX2014009416A (en)
RU (1) RU2014136334A (en)
SG (1) SG11201403540RA (en)
WO (1) WO2013117299A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015196335A1 (en) 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CA2339018A1 (en) 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US6426357B1 (en) 1999-07-27 2002-07-30 Affymax, Inc. Antagonists of follicle stimulating hormone activity
PT1104760E (en) * 1999-12-03 2003-06-30 Pfizer Prod Inc SULFAMOYL-HETEROARILPIRAZOLE COMPOUNDS AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS
JP2004505051A (en) * 2000-07-27 2004-02-19 スミスクライン ビーチャム コーポレーション Agonists of follicle stimulating hormone activity
TW200413273A (en) * 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
CN101309917B (en) * 2005-10-06 2013-09-11 奥斯拜客斯制药有限公司 Deuterated inhibitor of gastric H+, K+-ATPase with enhanced therapeutic properties
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
EP2209774A1 (en) * 2007-10-02 2010-07-28 Concert Pharmaceuticals Inc. Pyrimidinedione derivatives
JP2012502038A (en) * 2008-09-03 2012-01-26 テバ ファーマシューティカル インダストリーズ リミティド 2-oxo-1,2-dihydro-quinoline modulator of immune function
TWI461426B (en) 2009-05-27 2014-11-21 Merck Sharp & Dohme (dihydro)imidazoiso[5,1-a]quinolines

Also Published As

Publication number Publication date
IL233983B (en) 2019-12-31
WO2013117299A1 (en) 2013-08-15
KR20140120903A (en) 2014-10-14
JP6386382B2 (en) 2018-09-05
AU2013218368A1 (en) 2014-07-17
CA2860489A1 (en) 2013-08-15
ES2672326T3 (en) 2018-06-13
US20150111933A1 (en) 2015-04-23
BR112014019351A8 (en) 2017-07-11
BR112014019351A2 (en) 2017-06-20
IL233983A0 (en) 2014-09-30
HK1201837A1 (en) 2015-09-11
CN104114544A (en) 2014-10-22
EP2812320A1 (en) 2014-12-17
CA2860489C (en) 2019-11-12
AU2013218368B2 (en) 2017-09-07
MX2014009416A (en) 2014-11-10
RU2014136334A (en) 2016-04-10
EP2812320B1 (en) 2018-03-07
JP2015511943A (en) 2015-04-23

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