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SG10202110500TA - Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use - Google Patents

Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Info

Publication number
SG10202110500TA
SG10202110500TA SG10202110500TA SG10202110500TA SG10202110500TA SG 10202110500T A SG10202110500T A SG 10202110500TA SG 10202110500T A SG10202110500T A SG 10202110500TA SG 10202110500T A SG10202110500T A SG 10202110500TA SG 10202110500T A SG10202110500T A SG 10202110500TA
Authority
SG
Singapore
Prior art keywords
mtsp
polypeptides
methods
serine protease
membrane type
Prior art date
Application number
SG10202110500TA
Inventor
Edwin Madison
Vanessa Soros
Mikhail Popkov
Original Assignee
Catalyst Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalyst Biosciences Inc filed Critical Catalyst Biosciences Inc
Publication of SG10202110500TA publication Critical patent/SG10202110500TA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21109Matriptase (3.4.21.109)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Photolithography (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Medicinal Preparation (AREA)
SG10202110500TA 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use SG10202110500TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762523735P 2017-06-22 2017-06-22
US201862664051P 2018-04-27 2018-04-27

Publications (1)

Publication Number Publication Date
SG10202110500TA true SG10202110500TA (en) 2021-11-29

Family

ID=63015005

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10202110492YA SG10202110492YA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
SG11201912071QA SG11201912071QA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
SG10202110500TA SG10202110500TA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10202110492YA SG10202110492YA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
SG11201912071QA SG11201912071QA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Country Status (19)

Country Link
US (5) US10781435B2 (en)
EP (1) EP3641801A1 (en)
JP (3) JP7091373B2 (en)
KR (1) KR102675270B1 (en)
CN (1) CN111107870A (en)
AU (2) AU2018290281B2 (en)
BR (1) BR112019027583A2 (en)
CA (2) CA3177086A1 (en)
CL (3) CL2019003813A1 (en)
CO (1) CO2020000584A2 (en)
IL (2) IL271587B2 (en)
JO (1) JOP20190288A1 (en)
MX (1) MX2019015402A (en)
MY (1) MY202652A (en)
PE (1) PE20200697A1 (en)
PH (1) PH12019502838A1 (en)
SG (3) SG10202110492YA (en)
WO (1) WO2018237201A1 (en)
ZA (1) ZA202000332B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
SG10202110492YA (en) * 2017-06-22 2021-11-29 Catalyst Biosciences Inc Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
US10785574B2 (en) 2017-12-14 2020-09-22 Flodesign Sonics, Inc. Acoustic transducer driver and controller
AU2020300680A1 (en) * 2019-07-03 2022-02-03 Palleon Pharmaceuticals Inc. Recombinant sialidases and methods of using the same
US11396529B2 (en) * 2020-11-12 2022-07-26 National Sun Yat-Sen University Isolated peptide, anti-cancer medicinal composition including the same and method of specifically reducing or inhibiting activities of cancer cells using the same
CA3204445A1 (en) * 2021-01-08 2022-07-14 Mikhail Popkov Factor b proteases
CN113456527B (en) * 2021-07-30 2023-04-07 北京清大赛尔生物科技有限公司 NADH microcapsule preparation and preparation method and application thereof
WO2024205149A1 (en) * 2023-03-24 2024-10-03 카오티에스 주식회사 Novel granzyme fusion protein and use thereof
CN119570766B (en) * 2025-02-08 2025-05-16 上海锴泰生物科技有限公司 Collagenase mutant, gene fragment, recombinant plasmid, recombinant expression system, collagen peptide, and preparation method and use thereof

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US237A (en) 1837-06-15 Egbert beale
US569A (en) 1838-01-09 Caruiag-e-spiiln g
US5795A (en) 1848-09-19 Saddletree for carts
US844A (en) 1838-07-17 Boiler for
US5324A (en) 1847-10-09 Cooking-stove
US5990A (en) 1848-12-26 of baltimore
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
DE3921528A1 (en) 1989-06-30 1991-01-10 Draegerwerk Ag MEASURING CELL FOR ELECTROCHEMICAL GAS DETECTION
US5256643A (en) 1990-05-29 1993-10-26 The Government Of The United States Human cripto protein
US5262522A (en) 1991-11-22 1993-11-16 Immunex Corporation Receptor for oncostatin M and leukemia inhibitory factor
WO1994028024A1 (en) 1993-06-01 1994-12-08 Enzon, Inc. Carbohydrate-modified polymer conjugates with erythropoietic activity
US5457035A (en) 1993-07-23 1995-10-10 Immunex Corporation Cytokine which is a ligand for OX40
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5795569A (en) 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
JP2996415B2 (en) 1994-03-31 1999-12-27 アムジエン・インコーポレーテツド MonoPEGylated MGDF polypeptide stimulates megakaryocyte growth and differentiation
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
ATE268609T1 (en) 1998-03-12 2004-06-15 Nektar Therapeutics Al Corp POLYETHYLENE GLYCOL DERIVATIVES WITH ADJACENT REACTIVE GROUPS
JP2002519686A (en) 1998-07-03 2002-07-02 ネレス・フィールド・コントロールズ・オイ Liquid substance measuring method and apparatus
US6153394A (en) 1998-09-18 2000-11-28 Board Of Trustees Operating Michigan State University Immunoassay for equine protozoal myeloencephalitis in horses
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
EP1157275A4 (en) 1999-02-28 2003-01-15 Univ Washington Novel transduction molecules and methods for using same
CA2362670A1 (en) 1999-03-12 2000-09-14 Georgetown University Matriptase, a serine protease and its applications
JO2291B1 (en) 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythopintin derivatives
CZ299516B6 (en) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof
US6461802B1 (en) 1999-08-02 2002-10-08 Agfa-Gevaert Adhesive layer for polyester film
US7030231B1 (en) 1999-09-30 2006-04-18 Catalyst Biosciences, Inc. Membrane type serine protease 1 (MT-SP1) and uses thereof
WO2001032711A2 (en) 1999-10-21 2001-05-10 Board Of Trustees Of The University Of Arkansas Adeno-associated virus aav rep78 major regulatory protein, mutants thereof and uses thereof
CA2394980C (en) 1999-12-22 2008-05-13 Shearwater Corporation Sterically hindered derivatives of water soluble polymers
US6413507B1 (en) 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
AU2001238595A1 (en) 2000-02-22 2001-09-03 Shearwater Corporation N-maleimidyl polymer derivatives
JP4873818B2 (en) 2000-05-16 2012-02-08 ボルダー バイオテクノロジー, インコーポレイテッド Methods for refolding proteins containing free cysteine residues
GB0103110D0 (en) 2000-08-25 2001-03-28 Aventis Pharma Inc A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1
US7157596B2 (en) 2000-09-08 2007-01-02 Dendreon Corporation Inhibitors of serine protease activity of matriptase or MTSP1
WO2002049673A2 (en) 2000-12-20 2002-06-27 F. Hoffmann-La Roche Ag Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
WO2002072786A2 (en) 2001-03-13 2002-09-19 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US7105333B2 (en) 2001-03-27 2006-09-12 Deadreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
KR20040080940A (en) 2001-05-14 2004-09-20 덴드레온 코포레이션 Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
WO2002095007A2 (en) 2001-05-23 2002-11-28 Dendreon San Diego Llc Conjugates activated by cell surface proteases and therapeutic uses thereof
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
WO2003035892A2 (en) 2001-10-19 2003-05-01 The Scripps Research Institute Novel methods for introducing molecules into cells and vectors and compositions for use in such methods
JP4758608B2 (en) 2001-11-07 2011-08-31 ネクター セラピューティックス Branched polymers and their conjugates
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US7192468B2 (en) 2002-04-15 2007-03-20 Fluor Technologies Corporation Configurations and method for improved gas removal
WO2003104394A2 (en) 2002-05-21 2003-12-18 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon
US7939304B2 (en) 2002-10-02 2011-05-10 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
US20060024289A1 (en) 2002-10-02 2006-02-02 Ruggles Sandra W Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases
JP5376747B2 (en) 2002-10-02 2013-12-25 カタリスト バイオサイエンシーズ, インコーポレイテッド Methods for producing and screening proteases with altered specificity
KR20040040782A (en) 2002-11-08 2004-05-13 선바이오(주) Novel hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof
US7482117B2 (en) 2002-12-20 2009-01-27 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
US7019019B2 (en) 2002-12-23 2006-03-28 Dendreon Corporation Matriptase inhibitors and methods of use
US20060178297A1 (en) 2003-01-28 2006-08-10 Troy Carol M Systems and methods for silencing expression of a gene in a cell and uses thereof
US20040147027A1 (en) 2003-01-28 2004-07-29 Troy Carol M. Complex for facilitating delivery of dsRNA into a cell and uses thereof
EP2572733A1 (en) 2003-02-26 2013-03-27 Nektar Therapeutics Polymer-factor VIII moiety conjugates
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
KR100512483B1 (en) 2003-05-07 2005-09-05 선바이오(주) Novel Preparation method of PEG-maleimide PEG derivatives
NZ541374A (en) 2003-05-23 2008-09-26 Nektar Therapeutics Al Corp PEG derivatives having an amidocarbonate linkage
US7595306B2 (en) 2003-06-09 2009-09-29 Alnylam Pharmaceuticals Inc Method of treating neurodegenerative disease
EP1732581A4 (en) 2003-06-20 2008-06-04 Univ California San Diego POLYPEPTIDE TRANSDUCTION AND FUSOGENIC PEPTIDES
US7439226B2 (en) 2003-09-30 2008-10-21 The United States Of America As Represented By The Department Of Health And Human Services Serine protease inhibitors
CN1922210A (en) 2003-12-19 2007-02-28 健泰科生物技术公司 Monovalent antibody fragments useful as therapeutics
WO2005110453A2 (en) 2004-04-12 2005-11-24 Catalyst Biosciences, Inc. Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1
US8173144B2 (en) 2004-11-04 2012-05-08 L'oreal Administration of urea compounds for combating signs of cutaneous aging
WO2006090389A2 (en) 2005-02-24 2006-08-31 Compugen Ltd. Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
AU2011218753B2 (en) * 2005-10-21 2013-10-24 Vertex Pharmaceuticals Incorporated Modified proteases that inhibit complement activation
ES2611608T3 (en) 2005-10-21 2017-05-09 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
CA2626868A1 (en) 2005-11-01 2007-05-10 The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizo Na State University Novel protein transduction domains and uses therefor
US7579318B2 (en) 2005-12-06 2009-08-25 Centre De La Recherche De La Scientifique Cell penetrating peptides for intracellular delivery of molecules
KR100859972B1 (en) 2006-02-20 2008-09-25 이화여자대학교 산학협력단 Cell membrane-penetrating peptide
EP1867661A1 (en) 2006-06-12 2007-12-19 Diatos Compositions and methods for delivering anti-activated ras antibodies into cells
CA2791144C (en) * 2006-07-05 2019-04-09 Catalyst Biosciences, Inc. Protease screening methods and proteases identified thereby
TWI369402B (en) 2006-07-05 2012-08-01 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
CA2761310C (en) 2009-05-07 2017-02-28 Charles S. Craik Antibodies and methods of use thereof
CA2843684A1 (en) 2010-08-13 2012-02-16 Tufts University Compositions, kits and methods for treatment of macular degeneration using soluble membrane-independent cd59 protein
CA2843631A1 (en) 2011-10-14 2013-04-18 Alain Moreau Methods and kits for diagnosing and/or prognosing osteoarthritis
HK1208875A1 (en) 2012-01-12 2016-03-18 耶鲁大学 Compounds & methods for the enhanced degradation of targeted proteins & other polypeptides by an e3 ubiquitin ligase
AU2013243952A1 (en) 2012-04-02 2014-10-30 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10029415B2 (en) 2012-08-16 2018-07-24 Stratasys, Inc. Print head nozzle for use with additive manufacturing system
WO2014028861A1 (en) * 2012-08-17 2014-02-20 Apellis Pharmaceuticals, Inc. Detection of high risk drusen
CA2836167A1 (en) 2013-12-10 2015-06-10 Christina Xiaolin Dai Thickness increase spring
DK3536776T5 (en) 2014-04-29 2024-09-02 Novartis Ag PREVIOUSLY UNKNOWN VERTEBRATE CELLS AND METHODS FOR RECOMBINANT EXPRESSION OF A POLYPEPTIDE OF INTEREST
TWI702228B (en) 2014-08-08 2020-08-21 美商Alx腫瘤技術股份有限公司 Sirp-alpha variant constructs and uses thereof
EP3244907B1 (en) 2015-01-13 2020-02-19 City of Hope Ctla4-binding protein peptide-linker masks
CA2974367A1 (en) 2015-01-20 2016-07-28 Arvinas, Inc. Compounds and methods for the targeted degradation of the androgen receptor
CA2987641A1 (en) 2015-07-06 2017-01-12 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules and uses thereof
US11903996B2 (en) * 2015-10-07 2024-02-20 David C. Fritzinger Modulators of complement function
WO2017079267A1 (en) 2015-11-02 2017-05-11 Yale University Proteolysis targeting chimera compounds and methods of preparing and using same
SG10202110492YA (en) * 2017-06-22 2021-11-29 Catalyst Biosciences Inc Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
EP3902913A1 (en) 2018-12-28 2021-11-03 Catalyst Biosciences, Inc. Modified urokinase-type plasminogen activator polypeptides and methods of use

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CN111107870A (en) 2020-05-05
US20200291376A1 (en) 2020-09-17
JP2020528742A (en) 2020-10-01
CA3067851A1 (en) 2018-12-27
EP3641801A1 (en) 2020-04-29
BR112019027583A2 (en) 2020-10-06
CO2020000584A2 (en) 2020-05-05
CL2021003080A1 (en) 2022-08-12
PH12019502838A1 (en) 2020-09-21
CL2019003813A1 (en) 2020-05-29
NZ760116A (en) 2024-03-22
JOP20190288A1 (en) 2019-12-16
SG10202110492YA (en) 2021-11-29
IL271587B1 (en) 2024-01-01
AU2022201445B2 (en) 2023-11-23
IL308949B1 (en) 2025-11-01
JP2024095662A (en) 2024-07-10
US10781435B2 (en) 2020-09-22
US20240018502A1 (en) 2024-01-18
US11807882B2 (en) 2023-11-07
CA3067851C (en) 2023-01-31
AU2018290281B2 (en) 2021-12-16
US12173337B2 (en) 2024-12-24
KR102675270B1 (en) 2024-06-17
US11401513B2 (en) 2022-08-02
MY202652A (en) 2024-05-13
IL308949A (en) 2024-01-01
ZA202000332B (en) 2024-12-18
AU2018290281A1 (en) 2020-01-30
PE20200697A1 (en) 2020-06-16
US10954501B2 (en) 2021-03-23
JP7773579B2 (en) 2025-11-19
JP2022120155A (en) 2022-08-17
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