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SG10202106935UA - Analysis of fragmentation patterns of cell-free dna - Google Patents

Analysis of fragmentation patterns of cell-free dna

Info

Publication number
SG10202106935UA
SG10202106935UA SG10202106935UA SG10202106935UA SG10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA
Authority
SG
Singapore
Prior art keywords
analysis
cell
free dna
fragmentation patterns
fragmentation
Prior art date
Application number
SG10202106935UA
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Peiyong Jiang
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/073753 external-priority patent/WO2016127944A1/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of SG10202106935UA publication Critical patent/SG10202106935UA/en

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    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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SG10202106935UA 2015-07-23 2016-07-25 Analysis of fragmentation patterns of cell-free dna SG10202106935UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562196250P 2015-07-23 2015-07-23
US201662294948P 2016-02-12 2016-02-12
PCT/CN2016/073753 WO2016127944A1 (en) 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis

Publications (1)

Publication Number Publication Date
SG10202106935UA true SG10202106935UA (en) 2021-08-30

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SG10202106935UA SG10202106935UA (en) 2015-07-23 2016-07-25 Analysis of fragmentation patterns of cell-free dna

Country Status (16)

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US (5) US10453556B2 (en)
EP (3) EP3325664B1 (en)
JP (3) JP6931236B2 (en)
KR (1) KR20180031742A (en)
CN (2) CN108026572B (en)
AU (2) AU2016295616B2 (en)
CA (1) CA2993362A1 (en)
DK (2) DK3967775T3 (en)
ES (2) ES2907697T3 (en)
FI (1) FI3967775T3 (en)
HU (2) HUE057821T2 (en)
IL (3) IL305462A (en)
PT (2) PT3325664T (en)
SG (1) SG10202106935UA (en)
TW (3) TW202332776A (en)
WO (1) WO2017012592A1 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014093330A1 (en) 2012-12-10 2014-06-19 Clearfork Bioscience, Inc. Methods for targeted genomic analysis
TWI895765B (en) 2014-07-18 2025-09-01 香港中文大學 Methylation pattern analysis of tissues in a dna mixture
KR102696857B1 (en) 2014-07-25 2024-08-19 유니버시티 오브 워싱톤 Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
HUE057821T2 (en) 2015-07-23 2022-06-28 Univ Hong Kong Chinese Analysis of the fragmentation pattern of cell-free DNA
CN108431233B (en) 2015-11-11 2022-04-01 分析生物科学有限公司 Efficient construction of DNA libraries
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
AU2017315769B2 (en) 2016-08-25 2024-02-01 Resolution Bioscience, Inc. Methods for the detection of genomic copy changes in DNA samples
WO2018064629A1 (en) 2016-09-30 2018-04-05 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3535415A4 (en) 2016-10-24 2020-07-01 The Chinese University of Hong Kong METHODS AND SYSTEMS FOR TUMOR DETECTION
IL315032A (en) 2016-11-30 2024-10-01 Univ Hong Kong Chinese Analysis of cell-free DNA in urine and other samples
CA3051509A1 (en) * 2017-01-25 2018-08-02 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
EP3635133A4 (en) * 2017-06-09 2021-03-03 Bellwether Bio, Inc. Determination of cancer type in a subject by probabilistic modeling of circulating nucleic acid fragment endpoints
WO2018227211A1 (en) * 2017-06-09 2018-12-13 Bellwether Bio, Inc. Diagnosis of cancer or other physiological condition using circulating nucleic acid fragment sentinel endpoints
JP7776099B2 (en) * 2017-07-26 2025-11-26 ザ チャイニーズ ユニバーシティー オブ ホンコン Enhanced cancer screening using cell-free viral nucleic acid
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
EP4269583A3 (en) 2017-09-28 2024-01-17 Grail, LLC Enrichment of short nucleic acid fragments in sequencing library preparation
DE202019005627U1 (en) 2018-04-02 2021-05-31 Grail, Inc. Methylation markers and targeted methylation probe panels
TW202012639A (en) * 2018-04-24 2020-04-01 美商格瑞爾公司 System and method for determining whether an individual has a cancer condition using pathogen nucleic acid load
CN112292458A (en) * 2018-05-03 2021-01-29 香港中文大学 Analysis of preferred ends and recognition orientations of size markers for measuring properties of cell-free mixtures
US20210198747A1 (en) 2018-05-18 2021-07-01 The Johns Hopkins University Cell-free dna for assessing and/or treating cancer
SG11202100564PA (en) * 2018-07-23 2021-02-25 Univ Hong Kong Chinese Cell-free dna damage analysis and its clinical applications
US20210207229A1 (en) * 2018-07-27 2021-07-08 Seekln, Inc. Hepatocellular carcinoma screening
AU2019351130B2 (en) 2018-09-27 2025-10-23 GRAIL, Inc Methylation markers and targeted methylation probe panel
TW202536188A (en) * 2018-12-19 2025-09-16 香港中文大學 Cell-free dna end characteristics
CN109584959B (en) * 2018-12-27 2020-10-27 北京优迅医学检验实验室有限公司 Method and device for correcting sequencing depth
CN109767813B (en) * 2018-12-27 2021-06-22 北京优迅医学检验实验室有限公司 Method and device for correcting sequencing depth
US20210310067A1 (en) * 2019-01-24 2021-10-07 Illumina, Inc. Methods and systems for monitoring organ health and disease
ES3013495T3 (en) 2019-01-31 2025-04-14 Guardant Health Inc Method for isolating and sequencing cell-free dna
EP3696279A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Methods for noninvasive prenatal testing of fetal abnormalities
EP3696278A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Method of determining the origin of nucleic acids in a mixed sample
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
KR102452413B1 (en) * 2019-08-19 2022-10-11 주식회사 지씨지놈 Method for detecting chromosomal abnormality using distance information between nucleic acid fragments
EP4020484A4 (en) * 2019-08-19 2023-08-30 Green Cross Genome Corporation Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
AU2020409879A1 (en) * 2019-12-18 2022-06-23 Grail, Inc. Cell-free DNA fragmentation and nucleases
US20230042332A1 (en) 2019-12-24 2023-02-09 Vib Vzw Disease Detection in Liquid Biopsies
AU2021205853A1 (en) * 2020-01-08 2023-11-23 Grail, Inc. Biterminal dna fragment types in cell-free samples and uses thereof
WO2021141220A1 (en) * 2020-01-09 2021-07-15 서울대학교 산학협력단 Atac-seq data normalization and method for utilizing same
KR102746245B1 (en) * 2020-02-05 2024-12-23 더 차이니즈 유니버시티 오브 홍콩 Molecular analyses using long cell-free fragments in pregnancy
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
CN111383757B (en) * 2020-03-04 2023-08-25 南京亿科人群健康研究院有限公司 A method for computer-aided development of echinococcosis diagnostic kit
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
CN111575347A (en) * 2020-05-19 2020-08-25 清华大学 Method for constructing library for simultaneously obtaining free DNA methylation and fragmentation pattern information in plasma
US20250266125A1 (en) * 2020-06-22 2025-08-21 Children's Hospital Medical Center De novo characterization of cell-free dna fragmentation hotspots in healthy and early-stage cancers
CN115997035A (en) 2020-06-30 2023-04-21 通用诊断股份公司 Systems and methods for detecting multiple cancer types
TW202242130A (en) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 Circulating transcription factor analysis
TW202242145A (en) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 Transcription factor binding site analysis of nucleosome depleted circulating cell free chromatin fragments
EP4359562A1 (en) 2021-06-21 2024-05-01 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
WO2023056065A1 (en) 2021-09-30 2023-04-06 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
JP2025518492A (en) * 2022-05-12 2025-06-17 デルフィ ダイアグノスティックス インコーポレイテッド Use of the cell-free DNA fragmentome in the diagnostic evaluation of patients with signs and symptoms suggestive of cancer
US20240011105A1 (en) * 2022-07-08 2024-01-11 The Chinese University Of Hong Kong Analysis of microbial fragments in plasma
CN118028462B (en) * 2022-11-02 2025-04-15 深圳湾实验室 A pan-cancer blood diagnostic marker and its application
KR20250114032A (en) * 2022-11-29 2025-07-28 센터 포 노보스틱스 Fragmentation in urine and plasma
IL307784A (en) * 2023-10-16 2025-05-01 Identifai Genetics Ltd Noninvasive fetal variant identification using fragmentomics-based classification
CN117106857B (en) * 2023-10-24 2024-02-09 北京大学 Detection method and kit for plasma free chromatin and application of detection method and kit
US20250171858A1 (en) * 2023-11-29 2025-05-29 Centre For Novostics Enrichment of clinically-relevant nucleic acids
WO2025137389A2 (en) 2023-12-22 2025-06-26 Guardant Health, Inc. Methods for targeted single-molecule genetic and epigenetic sequencing

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2369578A1 (en) 1999-04-02 2000-10-19 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer
US20030219765A1 (en) 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
US20030211522A1 (en) 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
PL201608B1 (en) 2003-06-13 2009-04-30 Cezary Cybulski Method and set designed for detection of high genetic predisposition for prostate gland cancer as well as use of germinal change within the NBS1 gene
WO2005108621A1 (en) 2004-04-30 2005-11-17 Yale University Methods and compositions for cancer diagnosis
WO2008024009A1 (en) 2006-08-15 2008-02-28 Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) Transcriptional level of a timp3 gene in the form of a diagnosis marker of a non-small cell carcinoma of lung
EP2535425A1 (en) 2007-05-25 2012-12-19 Decode Genetics EHF. Variantes génétiques sur les chr 10q26 utilisées comme marqueurs dans l'évaluation, le diagnostic, le pronostic et le traitement d'un risque de cancer du sein
KR102222378B1 (en) 2007-07-23 2021-03-04 더 차이니즈 유니버시티 오브 홍콩 Determining a nucleic acid sequence imbalance
CA2778926C (en) 2009-10-26 2018-03-27 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
HUE061110T2 (en) 2009-11-05 2023-05-28 Univ Hong Kong Chinese Fetal genome analysis from maternal biological sample
WO2011054936A1 (en) 2009-11-06 2011-05-12 The Chinese University Of Hong Kong Size-based genomic analysis
KR101891847B1 (en) 2010-11-30 2018-08-24 더 차이니즈 유니버시티 오브 홍콩 Detection of genetic or molecular aberrations associated with cancer
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013060762A1 (en) 2011-10-25 2013-05-02 Roche Diagnostics Gmbh Method for diagnosing a disease based on plasma-dna distribution
US9892230B2 (en) * 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013177581A2 (en) 2012-05-24 2013-11-28 University Of Washington Through Its Center For Commercialization Whole genome sequencing of a human fetus
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
EP4036247B1 (en) 2012-09-04 2024-04-10 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US9732390B2 (en) * 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
LT3354747T (en) 2012-09-20 2021-04-12 The Chinese University Of Hong Kong NON - INVASIVE DETERMINATION OF TUMOR METHYLOMA IN PLASMA
EP2959016A4 (en) 2013-02-21 2016-10-12 Toma Biosciences Inc Methods, compositions, and kits for nucleic acid analysis
AU2014233373B2 (en) 2013-03-15 2019-10-24 Verinata Health, Inc. Generating cell-free DNA libraries directly from blood
CN103215350B (en) * 2013-03-26 2016-11-02 苏州贝康医疗器械有限公司 A kind of assay method of the fetal DNA in maternal plasma DNA content based on mononucleotide polymorphism site
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
CN111863131A (en) 2013-10-07 2020-10-30 塞昆纳姆股份有限公司 Methods and procedures for non-invasive assessment of chromosomal alterations
US20160002717A1 (en) 2014-07-02 2016-01-07 Boreal Genomics, Inc. Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease
TWI895765B (en) 2014-07-18 2025-09-01 香港中文大學 Methylation pattern analysis of tissues in a dna mixture
KR102696857B1 (en) 2014-07-25 2024-08-19 유니버시티 오브 워싱톤 Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
EP3224380A1 (en) 2014-11-25 2017-10-04 The Broad Institute Inc. Clonal haematopoiesis
AU2015357573B2 (en) 2014-12-05 2022-04-07 Foundation Medicine, Inc. Multigene analysis of tumor samples
GB2552267B (en) 2014-12-31 2020-06-10 Guardant Health Inc Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
CA2976303A1 (en) 2015-02-10 2016-08-18 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
CA2980078C (en) 2015-03-16 2024-03-12 Personal Genome Diagnostics Inc. Systems and methods for analyzing nucleic acid
HUE057821T2 (en) 2015-07-23 2022-06-28 Univ Hong Kong Chinese Analysis of the fragmentation pattern of cell-free DNA
US12234454B2 (en) 2015-10-22 2025-02-25 The Broad Institute, Inc. Crispr enzymes and systems
KR102610098B1 (en) 2016-07-06 2023-12-04 가던트 헬쓰, 인크. Methods for fragmentome profiling of cell-free nucleic acids
ES2983411T3 (en) 2016-12-13 2024-10-23 Bellwether Bio Inc Determination of a physiological state in an individual by analyzing the endpoints of cell-free DNA fragments in a biological sample
US20220259647A1 (en) 2019-07-09 2022-08-18 The Translational Genomics Research Institute METHODS OF DETECTING DISEASE AND TREATMENT RESPONSE IN cfDNA

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