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SG10201913623PA - Diagnostic methods for t cell therapy - Google Patents

Diagnostic methods for t cell therapy

Info

Publication number
SG10201913623PA
SG10201913623PA SG10201913623PA SG10201913623PA SG10201913623PA SG 10201913623P A SG10201913623P A SG 10201913623PA SG 10201913623P A SG10201913623P A SG 10201913623PA SG 10201913623P A SG10201913623P A SG 10201913623PA SG 10201913623P A SG10201913623P A SG 10201913623PA
Authority
SG
Singapore
Prior art keywords
cell therapy
diagnostic methods
diagnostic
methods
therapy
Prior art date
Application number
SG10201913623PA
Inventor
Adrian Bot
Jeffrey S Wiezorek
William GO
Rajul JAIN
James N Kochenderfer
Steven A Rosenberg
Original Assignee
Kite Pharma Inc
The United States Of America As Represented By The Secretary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57393492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201913623P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kite Pharma Inc, The United States Of America As Represented By The Secretary filed Critical Kite Pharma Inc
Publication of SG10201913623PA publication Critical patent/SG10201913623PA/en

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    • A61K40/42—Cancer antigens
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    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5418—IL-7
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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SG10201913623PA 2015-05-28 2016-05-27 Diagnostic methods for t cell therapy SG10201913623PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562167738P 2015-05-28 2015-05-28
US201562262111P 2015-12-02 2015-12-02

Publications (1)

Publication Number Publication Date
SG10201913623PA true SG10201913623PA (en) 2020-03-30

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SG10201913620QA SG10201913620QA (en) 2015-05-28 2016-05-27 Diagnostic methods for t cell therapy
SG10201913623PA SG10201913623PA (en) 2015-05-28 2016-05-27 Diagnostic methods for t cell therapy

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Country Status (23)

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US (2) US11779601B2 (en)
EP (2) EP4218778A3 (en)
JP (4) JP6917903B2 (en)
KR (3) KR102481922B1 (en)
CN (2) CN107921064A (en)
AU (2) AU2016268863B2 (en)
BR (1) BR122023022076A2 (en)
CA (1) CA2986793A1 (en)
CL (1) CL2017003005A1 (en)
DO (1) DOP2017000272A (en)
EA (1) EA201792642A1 (en)
ES (1) ES2944962T3 (en)
HK (1) HK1251960A1 (en)
IL (2) IL284172B2 (en)
MA (1) MA45281A (en)
MX (2) MX388325B (en)
NZ (2) NZ776402A (en)
PH (1) PH12017502153A1 (en)
PL (1) PL3302507T3 (en)
PT (1) PT3302507T (en)
SG (2) SG10201913620QA (en)
SI (1) SI3302507T1 (en)
WO (1) WO2016191755A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014117121A1 (en) 2013-01-28 2014-07-31 St. Jude Children's Research Hospital, Inc. A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
SG11201609118RA (en) 2014-05-15 2016-11-29 Univ Singapore Modified natural killer cells and uses thereof
US9855298B2 (en) 2015-05-28 2018-01-02 Kite Pharma, Inc. Methods of conditioning patients for T cell therapy
KR102481922B1 (en) 2015-05-28 2022-12-28 카이트 파마 인코포레이티드 Diagnostic Methods for T Cell Therapy
KR20200010179A (en) 2017-02-27 2020-01-30 주노 쎄러퓨티크스 인코퍼레이티드 Compositions, Articles of Manufacture, and Methods Associated with Dosing in Cell Therapy
CA3056439A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
SG11201908980PA (en) 2017-04-03 2019-10-30 Kite Pharma Inc Treatment using chimeric receptor t cells incorporating optimized polyfunctional t cells
WO2018223101A1 (en) 2017-06-02 2018-12-06 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
BR112020008340A2 (en) 2017-11-01 2020-11-17 Juno Therapeutics Inc process for generating therapeutic compositions of modified cells
US12031975B2 (en) 2017-11-01 2024-07-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
US12161670B2 (en) 2017-12-08 2024-12-10 Juno Therapeutics, Inc. Phenotypic markers for cell therapy and related methods
JP7360174B2 (en) 2018-02-09 2023-10-12 ナショナル ユニヴァーシティー オブ シンガポール Activated chimeric receptors and their use in natural killer cell immunotherapy
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
JP6630026B1 (en) * 2018-04-27 2020-01-15 隆代 大田 Biomarkers to assess the efficacy of cancer treatment with immune checkpoint inhibitors
KR102734592B1 (en) * 2018-06-01 2024-11-27 카이트 파마 인코포레이티드 Chimeric antigen receptor t cell therapy
EP3810780A1 (en) 2018-06-22 2021-04-28 Kite Pharma Eu B.V. Compositions and methods for making engineered t cells
CN109207430A (en) * 2018-09-25 2019-01-15 华东师范大学 A kind of Chimeric antigen receptor NK cell and its preparation method and application
CN118546960A (en) 2019-03-05 2024-08-27 恩卡尔塔公司 CD 19-directed chimeric antigen receptor and use thereof in immunotherapy
US20220168394A1 (en) * 2019-04-23 2022-06-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of inducing or restoring immune tolerance
GB201911066D0 (en) 2019-08-02 2019-09-18 Achilles Therapeutics Ltd T cell therapy
IL292665B1 (en) * 2019-11-06 2025-10-01 Kite Pharma Inc Chimeric antigen receptor t cell therapy
US20230071910A1 (en) * 2020-01-24 2023-03-09 Juno Therapeutics, Inc. Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy
KR20230002554A (en) 2020-04-28 2023-01-05 아킬레스 테라퓨틱스 유케이 리미티드 T cell therapy
US20240016936A1 (en) * 2020-12-04 2024-01-18 Celgene Corporation Uses of chimeric antigen receptor (car) t-cell therapies in combination with inhibitors of inflammation-related soluble factors
EP4320435A1 (en) 2021-04-09 2024-02-14 Achilles Therapeutics UK Limited Batch release assay for pharmaceutical products relating to t cell therapies
GB202109886D0 (en) 2021-07-08 2021-08-25 Achilles Therapeutics Uk Ltd Assay
KR20230173179A (en) * 2021-05-14 2023-12-26 카이트 파마 인코포레이티드 Chimeric antigen receptor T cell therapy
JP2024524185A (en) 2021-06-22 2024-07-05 アキレス セラピューティクス ユーケー リミテッド Methods for generating antigen-specific T cells
US20230392119A1 (en) 2022-05-27 2023-12-07 Kite Pharma, Inc. Compositions and methods for preparing engineered lymphocytes for cell therapy
EP4608416A1 (en) 2022-10-28 2025-09-03 Kite Pharma, Inc. Expedited administration of engineered lymphocytes
EP4608987A1 (en) 2022-10-28 2025-09-03 Kite Pharma, Inc. Factors for optimizing immunotherapy
AU2024241240A1 (en) 2023-03-17 2025-10-16 Kite Pharma, Inc. Impact of tumor microenvironment on efficacy of immunotherapy
WO2025096517A1 (en) 2023-11-01 2025-05-08 Kite Pharma, Inc. Factors for optimizing immunotherapy efficacy
US20250297219A1 (en) 2024-02-08 2025-09-25 Kite Pharma, Inc. Methods for generating engineered lymphocytes with enriched t memory stem cells
US20250262300A1 (en) 2024-02-16 2025-08-21 Kite Pharma, Inc. Systems, methods, and kits for generating and administering engineered t cells and cd38 targeting compounds as a combination therapy
US20250290154A1 (en) 2024-03-04 2025-09-18 Kite Pharma, Inc. Predictive markers for immunotherapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US20030031652A1 (en) 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism
US7718196B2 (en) 2001-07-02 2010-05-18 The United States Of America, As Represented By The Department Of Health And Human Services Rapamycin-resistant T cells and therapeutic uses thereof
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
CN107519499A (en) * 2010-03-23 2017-12-29 英特瑞克斯顿股份有限公司 The carrier of condition expression treatment albumen, include the host cell of the carrier, and its application
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
SG192010A1 (en) 2011-01-18 2013-08-30 Univ Pennsylvania Compositions and methods for treating cancer
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
CN103946952A (en) 2011-09-16 2014-07-23 宾夕法尼亚大学董事会 RNA-engineered T cells for cancer treatment
CA3132353A1 (en) 2012-05-08 2013-11-14 The Johns Hopkins University Methods and compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes to treat cancer
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
EP3010528B1 (en) * 2013-06-19 2019-09-11 Massachusetts Institute of Technology In vivo targeting of cells with ligand-conjugated particles
BR112016010224A2 (en) 2013-11-05 2018-05-02 Cognate Bioservices, Inc. checkpoint inhibitor combinations and therapeutic products to treat cancer.
KR102481922B1 (en) 2015-05-28 2022-12-28 카이트 파마 인코포레이티드 Diagnostic Methods for T Cell Therapy
US9855298B2 (en) 2015-05-28 2018-01-02 Kite Pharma, Inc. Methods of conditioning patients for T cell therapy
PE20190173A1 (en) 2016-04-01 2019-02-01 Kite Pharma Inc CHEMERIC ANTIGEN RECEPTORS AND T-CELLS AND METHODS OF USE

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