[go: up one dir, main page]

SG10201911680SA - Systems and methods for generating, visualizing and classifying molecular functional profiles - Google Patents

Systems and methods for generating, visualizing and classifying molecular functional profiles

Info

Publication number
SG10201911680SA
SG10201911680SA SG10201911680SA SG10201911680SA SG10201911680SA SG 10201911680S A SG10201911680S A SG 10201911680SA SG 10201911680S A SG10201911680S A SG 10201911680SA SG 10201911680S A SG10201911680S A SG 10201911680SA SG 10201911680S A SG10201911680S A SG 10201911680SA
Authority
SG
Singapore
Prior art keywords
visualizing
generating
systems
methods
molecular functional
Prior art date
Application number
SG10201911680SA
Inventor
Alexander Bagaev
Feliks Frenkel
Nikita Kotlov
Ravshan Ataullakhanov
Original Assignee
Bostongene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bostongene Corp filed Critical Bostongene Corp
Publication of SG10201911680SA publication Critical patent/SG10201911680SA/en

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/28Databases characterised by their database models, e.g. relational or object models
    • G06F16/284Relational databases
    • G06F16/285Clustering or classification
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10Complex mathematical operations
    • G06F17/18Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30Unsupervised data analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20Probabilistic models
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30Data warehousing; Computing architectures
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/20ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00ICT specially adapted for the handling or processing of medical references
    • G16H70/20ICT specially adapted for the handling or processing of medical references relating to practices or guidelines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Public Health (AREA)
  • Databases & Information Systems (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioethics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Software Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Probability & Statistics with Applications (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mathematical Physics (AREA)
  • Computational Mathematics (AREA)
SG10201911680SA 2017-06-13 2018-06-12 Systems and methods for generating, visualizing and classifying molecular functional profiles SG10201911680SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762518787P 2017-06-13 2017-06-13
US201762598440P 2017-12-13 2017-12-13

Publications (1)

Publication Number Publication Date
SG10201911680SA true SG10201911680SA (en) 2020-02-27

Family

ID=62779138

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201911541YA SG10201911541YA (en) 2017-06-13 2018-06-12 Systems and methods for identifying cancer treatments from normalized biomarker scores
SG10201911680SA SG10201911680SA (en) 2017-06-13 2018-06-12 Systems and methods for generating, visualizing and classifying molecular functional profiles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201911541YA SG10201911541YA (en) 2017-06-13 2018-06-12 Systems and methods for identifying cancer treatments from normalized biomarker scores

Country Status (12)

Country Link
US (28) US10311967B2 (en)
EP (5) EP4012713B1 (en)
JP (8) JP6776464B2 (en)
KR (1) KR102396784B1 (en)
CN (2) CN111052247B (en)
AU (4) AU2018282759A1 (en)
CA (1) CA3066004A1 (en)
DE (1) DE112018002990T5 (en)
GB (5) GB2601923B8 (en)
IL (3) IL270887B2 (en)
SG (2) SG10201911541YA (en)
WO (3) WO2018231771A1 (en)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105190656B (en) 2013-01-17 2018-01-16 佩索纳里斯公司 Method and system for genetic analysis
CA2990281A1 (en) * 2015-06-22 2016-12-29 Sunnybrook Research Institute Systems and methods for prediction of tumor response to chemotherapy using pre-treatment quantitative ultrasound parameters
US11497476B2 (en) * 2015-06-22 2022-11-15 Sunnybrook Research Institute Systems and methods for prediction of tumor treatment response to using texture derivatives computed from quantitative ultrasound parameters
CA3043038A1 (en) 2016-11-22 2018-05-31 Hyperfine Research, Inc. Systems and methods for automated detection in magnetic resonance images
US10627464B2 (en) 2016-11-22 2020-04-21 Hyperfine Research, Inc. Low-field magnetic resonance imaging methods and apparatus
EP4012713B1 (en) 2017-06-13 2025-10-29 BostonGene Corporation Systems and methods for generating, visualizing and classifying molecular functional profiles
US11505831B2 (en) 2017-12-20 2022-11-22 Dana-Farber Cancer Institute, Inc. Compositions and methods comprising digital signatures to predict response and resistance to targeted therapy and immunotherapy
US11335464B2 (en) * 2018-01-12 2022-05-17 Siemens Medical Solutions Usa, Inc. Integrated precision medicine by combining quantitative imaging techniques with quantitative genomics for improved decision making
CN112513297B (en) 2018-03-28 2024-10-22 得克萨斯州大学系统董事会 Identification of epigenetic changes in DNA isolated from exosomes
SG11202009881WA (en) * 2018-04-12 2020-11-27 Kite Pharma Inc Chimeric receptor t cell treatment using characteristics of the tumor microenvironment
SG11202009696WA (en) 2018-04-13 2020-10-29 Freenome Holdings Inc Machine learning implementation for multi-analyte assay of biological samples
US11475995B2 (en) 2018-05-07 2022-10-18 Perthera, Inc. Integration of multi-omic data into a single scoring model for input into a treatment recommendation ranking
US10957041B2 (en) 2018-05-14 2021-03-23 Tempus Labs, Inc. Determining biomarkers from histopathology slide images
US11348661B2 (en) 2018-05-14 2022-05-31 Tempus Labs, Inc. Predicting total nucleic acid yield and dissection boundaries for histology slides
US11348239B2 (en) 2018-05-14 2022-05-31 Tempus Labs, Inc. Predicting total nucleic acid yield and dissection boundaries for histology slides
US11741365B2 (en) 2018-05-14 2023-08-29 Tempus Labs, Inc. Generalizable and interpretable deep learning framework for predicting MSI from histopathology slide images
US11348240B2 (en) 2018-05-14 2022-05-31 Tempus Labs, Inc. Predicting total nucleic acid yield and dissection boundaries for histology slides
US11574718B2 (en) * 2018-05-31 2023-02-07 Perthera, Inc. Outcome driven persona-typing for precision oncology
USD887431S1 (en) * 2018-06-18 2020-06-16 Genomic Prediction, Inc. Display screen with graphical user interface
USD896241S1 (en) * 2018-12-03 2020-09-15 Illumina, Inc. Display screen or portion thereof with graphical user interface
CN109712716B (en) * 2018-12-25 2021-08-31 广州医科大学附属第一医院 Method, system and computer equipment for determining disease influencing factors
US20200210852A1 (en) * 2018-12-31 2020-07-02 Tempus Labs, Inc. Transcriptome deconvolution of metastatic tissue samples
USD910706S1 (en) 2019-01-31 2021-02-16 Driv Ip, Llc Display screen with graphical user interface
WO2020172591A1 (en) * 2019-02-22 2020-08-27 Mitra Rxdx, Inc. A method to predict a patient's response to an anti-cancer drug from an expression level of a set of genes
WO2020176620A1 (en) * 2019-02-26 2020-09-03 Tempus Systems and methods for using sequencing data for pathogen detection
CN111621564B (en) * 2019-02-28 2022-03-25 武汉大学 A method for identifying potent tumor neoantigens
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. Data compression and communication using machine learning
WO2020231937A1 (en) * 2019-05-10 2020-11-19 University Of Massachusetts Irf2 as a prognostic biomarker and target for augmenting immunotherapy
US11527323B2 (en) 2019-05-14 2022-12-13 Tempus Labs, Inc. Systems and methods for multi-label cancer classification
USD892825S1 (en) 2019-06-10 2020-08-11 Bostongene Corporation Display screen or portion thereof with graphical user interface
USD891445S1 (en) 2019-06-10 2020-07-28 Bostongene Corporation Display screen or portion thereof with graphical user interface
US20220310208A1 (en) * 2019-06-13 2022-09-29 Roche Sequencing Solutions, Inc. Systems and methods with improved user interface for interpreting and visualizing longitudinal
CN110309382B (en) * 2019-06-17 2021-05-28 暨南大学 Multidimensional feature-based homology edge clustering method for mobile applications
US20220357329A1 (en) * 2019-07-01 2022-11-10 Accure Health Inc. Predictive liquid markers for cancer immunotherapy
EP3994696B1 (en) 2019-07-03 2025-05-14 BostonGene Corporation Systems and methods for sample preparation, sample sequencing, and sequencing data bias correction and quality control
CA3147100A1 (en) * 2019-07-12 2021-01-21 Tempus Labs Adaptive order fulfillment and tracking methods and systems
US10581851B1 (en) 2019-07-17 2020-03-03 Capital One Services, Llc Change monitoring and detection for a cloud computing environment
US11379757B2 (en) * 2019-07-31 2022-07-05 BioSymetrics, Inc. Methods, systems, and frameworks for data analytics using machine learning
CN110277135B (en) * 2019-08-10 2021-06-01 杭州新范式生物医药科技有限公司 Method and system for selecting individualized tumor neoantigen based on expected curative effect
WO2021030193A1 (en) * 2019-08-13 2021-02-18 Nantomics, Llc System and method for classifying genomic data
AU2020334901A1 (en) 2019-08-16 2022-03-24 Tempus Ai, Inc. Systems and methods for detecting cellular pathway dysregulation in cancer specimens
CN110716171A (en) * 2019-08-28 2020-01-21 上海无线电设备研究所 Polarization DOA joint estimation method based on genetic algorithm
EP3799057A1 (en) * 2019-09-25 2021-03-31 Koninklijke Philips N.V. Prediction tool for patient immune response to a therapy
EP4034098A4 (en) * 2019-09-27 2024-02-28 The Regents of the University of Colorado, a body corporate IMPROVEMENT OF CANCER THERAPY WITH BH3 MIMETICS
US20240369538A1 (en) * 2019-10-16 2024-11-07 Rene Anand Live Virus Vaccine Injury Risk
CN114945987A (en) 2019-11-05 2022-08-26 佩索纳里斯公司 Estimation of tumor purity from a single sample
TWI895295B (en) * 2019-11-12 2025-09-01 美商方得生醫療公司 Methods of detecting a fusion gene encoding a neoantigen
CN110938627B (en) * 2019-11-25 2021-07-06 西安交通大学第二附属医院 Use of ESCO2 inhibitor in the preparation of a medicament for the treatment of hypopharyngeal carcinoma
TWI709904B (en) * 2019-11-26 2020-11-11 國立中央大學 Methods for training an artificial neural network to predict whether a subject will exhibit a characteristic gene expression and systems for executing the same
JP7684303B2 (en) 2019-12-05 2025-05-27 ボストンジーン コーポレイション Machine learning techniques for gene expression analysis
CN112574309B (en) * 2019-12-05 2023-06-16 启愈生物技术(上海)有限公司 anti-PD-L1 nano antibody and application thereof
EP4073807A4 (en) 2019-12-12 2024-05-01 Tempus AI, Inc. REAL-WORLD EVIDENCE ON DIAGNOSTIC TESTING AND TREATMENT PATTERNS IN BREAST CANCER PATIENTS IN THE USA
EP4116436A4 (en) * 2020-01-07 2024-01-31 Korea Advanced Institute of Science and Technology Method and system for screening for neoantigens, and uses thereof
WO2021158966A1 (en) * 2020-02-05 2021-08-12 Board Of Regents, The University Of Texas System Diagnostic and prognostic utility of exosomes in immunotherapy
CN111292542B (en) * 2020-02-24 2021-08-31 深圳市综合交通设计研究院有限公司 Signal lamp system and control method thereof
CN111354420B (en) * 2020-03-08 2020-12-22 吉林大学 A siRNA development method for COVID-19 viral drug therapy
US20210363592A1 (en) * 2020-03-11 2021-11-25 Vanderbilt University Detection of Signatures in a Breast Cancer Subject
KR20220156855A (en) 2020-03-19 2022-11-28 추가이 세이야쿠 가부시키가이샤 Biomarkers for predicting response to checkpoint inhibitors
WO2021205274A1 (en) * 2020-04-08 2021-10-14 Immunitybio, Inc. Methods for assessing chemokine activity
EP4143310A4 (en) * 2020-04-29 2024-06-19 Personalis, Inc. COMPOSITE BIOMARKERS FOR CANCER IMMUNOTHERAPY
US20230178245A1 (en) * 2020-04-30 2023-06-08 Caris Mpi, Inc. Immunotherapy Response Signature
TWI894280B (en) * 2020-05-26 2025-08-21 南韓商愛思阿爾法數字醫療科技有限公司 System for treating cancer cachexia, computing system for treating cancer cachexia and operating method thereof, and non-transitory readable medium
CN111863137B (en) * 2020-05-28 2024-01-02 上海朴岱生物科技合伙企业(有限合伙) Complex disease state evaluation method based on high-throughput sequencing data and clinical phenotype construction and application
CN111755073B (en) * 2020-05-31 2022-11-15 复旦大学 Transcriptome-Based PD-1 Therapy Effect Prediction System
JP7570088B2 (en) * 2020-06-18 2024-10-21 国立研究開発法人産業技術総合研究所 Information processing system, information processing method, identification method and program
CN115803085A (en) 2020-06-27 2023-03-14 新月生物科学 Novel cell metabolism regulating compounds and uses
CN111863120B (en) * 2020-06-28 2022-05-13 深圳晶泰科技有限公司 Medicine virtual screening system and method for crystal compound
US11568959B2 (en) 2020-07-06 2023-01-31 Bostongene Corporation Tumor microenvironment-based methods for assessing CAR-T and other immunotherapies
WO2022016447A1 (en) * 2020-07-23 2022-01-27 碳逻辑生物科技(香港)有限公司 Marker for assessing responsiveness of colorectal cancer patients to immunotherapeutic drug
AU2021314061A1 (en) * 2020-07-23 2023-03-16 The DNA Company Inc. Systems and methods for determining a physiological profile using genetic information
WO2022031620A2 (en) * 2020-08-01 2022-02-10 Aigene Methods for the rapid assessment of the efficacy of cancer therapy and related applications
CN112147326B (en) * 2020-09-04 2022-04-08 北京大学 An accurate detection kit for tumor immune cell subset typing
CN112086199B (en) * 2020-09-14 2023-06-09 中科院计算所西部高等技术研究院 Liver cancer data processing system based on multiple groups of study data
US12482566B2 (en) * 2020-09-21 2025-11-25 Mestastop Solutions Private Limited Systems and methods for predicting cancer metastasis and screening of drugs
WO2022089426A1 (en) * 2020-10-27 2022-05-05 细胞图谱有限公司 Method for analyzing peripheral blood sample and kit
EP4247980A4 (en) * 2020-11-19 2024-10-02 Tempus AI, Inc. DETERMINATION OF THE CYTOTOXIC GENE SIGNATURE AND RELATED SYSTEMS AND METHODS FOR RESPONSE PREDICTION AND TREATMENT
CN112637134A (en) * 2020-12-02 2021-04-09 电子科技大学 Signal sorting method for time hopping signals of data link communication system
CN112530581B (en) * 2020-12-03 2023-11-21 安徽医科大学第一附属医院 An immune molecular classification system for prostate cancer patients and its application
TWD216917S (en) 2020-12-11 2022-02-01 股感媒體科技股份有限公司 Graphical User Interface for Display Panel
EP4394048A3 (en) 2020-12-11 2024-09-25 BostonGene Corporation Techniques for identifying follicular lymphoma types
US12161635B2 (en) 2020-12-22 2024-12-10 Case Western Reserve University Compositions and methods of treating PIK3CA helical domain mutant cancers
CN112635063B (en) * 2020-12-30 2022-05-24 华南理工大学 Comprehensive lung cancer prognosis prediction model, construction method and device
US20240085417A1 (en) * 2021-01-20 2024-03-14 Memorial Sloan Kettering Cancer Center Peripheral blood phenotype linked to outcomes after immunotherapy treatment
JP7697790B2 (en) * 2021-01-21 2025-06-24 キヤノンメディカルシステムズ株式会社 Medical information processing device
CN112735520B (en) * 2021-02-03 2021-07-20 深圳裕康医学检验实验室 Interpretation method, system and storage medium for tumor individualized immunotherapy gene detection result
CN112863595A (en) * 2021-03-08 2021-05-28 中国农业科学院兰州畜牧与兽药研究所 Method for excavating Tibetan sheep high-altitude hypoxia adaptability related gene based on MeRIP-Seq technology
WO2022192857A1 (en) * 2021-03-08 2022-09-15 Venn Biosciences Corporation Biomarkers for determining an immuno-onocology response
WO2022192457A1 (en) 2021-03-09 2022-09-15 Bostongene Corporation Predicting response to treatments in patients with clear cell renal cell carcinoma
US20220290254A1 (en) * 2021-03-09 2022-09-15 Bostongene Corporation B cell-enriched tumor microenvironments
US20220307088A1 (en) 2021-03-09 2022-09-29 Bostongene Corporation B cell-enriched tumor microenvironments
EP4305191A4 (en) * 2021-03-12 2025-02-26 Pragma Biosciences Inc. SYSTEMS AND METHODS FOR IDENTIFYING GENETIC CLUSTERS FOR MICROBIAL BIOSYNTHESIS
CN112698044B (en) * 2021-03-23 2021-06-22 信纳克(北京)生化标志物检测医学研究有限责任公司 Device and method for evaluating immune state after targeted therapy
ES1277194Y (en) * 2021-03-25 2021-11-26 Keyzell Holding Sl Artificial intelligence-based system to analyze biomarkers and personalize cancer treatments
US11931127B1 (en) 2021-04-08 2024-03-19 T-Mobile Usa, Inc. Monitoring users biological indicators using a 5G telecommunication network
EP4323541A1 (en) 2021-04-13 2024-02-21 Elegen Corporation Methods and compositions for cell-free cloning
EP4341939A1 (en) * 2021-05-18 2024-03-27 BostonGene Corporation Techniques for single sample expression projection to an expression cohort sequenced with another protocol
WO2022246462A1 (en) * 2021-05-21 2022-11-24 University Of Virginia Patent Foundation An adventitial painting modality of local drug delivery to abate intimal hyperplasia
USD1027977S1 (en) 2021-06-28 2024-05-21 Gestalt Diagnostics, LLC Display screen or portion thereof having a graphical user interface
EP4385024A4 (en) * 2021-08-11 2025-06-25 Oncohost Ltd PREDICTING A PATIENT'S RESPONSE
WO2023055657A1 (en) * 2021-09-30 2023-04-06 Selonterra, Inc. Use of c9orf72 -mediated genes for diagnosis and treatment of neuronal diseases
WO2023059654A1 (en) 2021-10-05 2023-04-13 Personalis, Inc. Customized assays for personalized cancer monitoring
AU2022376433A1 (en) 2021-10-29 2024-05-09 Bostongene Corporation Tumor microenvironment types in breast cancer
EP4436671A2 (en) * 2021-11-22 2024-10-02 Venn Biosciences Corporation Predicting sarcoma treatment response using targeted quantification of site-specific protein glycosylation
WO2023097300A1 (en) * 2021-11-23 2023-06-01 Curematch Inc. Clinical trial optimization
USD1005310S1 (en) * 2021-12-02 2023-11-21 Inspire Medical Systems, Inc. Display screen or portion thereof with a graphical user interface
US12051490B2 (en) 2021-12-03 2024-07-30 Digital Diagnostics Inc. Direct medical treatment predictions using artificial intelligence
JP2023091970A (en) * 2021-12-21 2023-07-03 行正 塩津 Presentation device and program
US12138243B2 (en) 2021-12-31 2024-11-12 Crescenta Biosciences Antiviral use of FABP4 modulating compounds
JP2023103039A (en) * 2022-01-13 2023-07-26 キヤノンメディカルシステムズ株式会社 Medical information processing device, method and program
US20250075276A1 (en) * 2022-01-13 2025-03-06 Synthorx, Inc. Methods for selecting subjects and treating cancer with il-2 therapy
WO2023154549A1 (en) 2022-02-14 2023-08-17 Bostongene Corporation Urothelial tumor microenvironment (tme) types
WO2023194090A1 (en) 2022-04-08 2023-10-12 Bayer Aktiengesellschaft Multiple instance learning considering neighborhood aggregations
EP4515457A1 (en) 2022-04-26 2025-03-05 Bayer Aktiengesellschaft Multiple-instance learning based on regional embeddings
WO2023213623A1 (en) 2022-05-03 2023-11-09 Bayer Aktiengesellschaft Dynamic sampling strategy for multiple-instance learning
USD1027999S1 (en) * 2022-05-13 2024-05-21 Inspire Medical Systems, Inc. Display screen or portion thereof with an animated graphical user interface
WO2024025923A1 (en) * 2022-07-26 2024-02-01 Washington University Methods for selection of cancer patients for anti-angiogenic and immune checkpoint blockade therapies and combinations thereof
CA3264003A1 (en) * 2022-08-11 2024-02-15 OncoHost Ltd. Predicting patient response
WO2024054951A1 (en) * 2022-09-08 2024-03-14 Cardiff Oncology, Inc. Methods of monitoring mutations in treatment of colorectal cancer
CN115312153B (en) * 2022-09-15 2025-09-26 重庆邮电大学 Intelligent monitoring and optimized drug delivery system for cancer chemotherapy based on multi-stage Gaussian pseudospectral method
WO2024081737A1 (en) * 2022-10-12 2024-04-18 Exagen Inc. Biomarker selection for machine learning enabled prediction of treatment response
USD1042503S1 (en) * 2022-12-05 2024-09-17 Igt Display screen or a portion thereof with a graphical user interface
USD1050174S1 (en) 2022-12-05 2024-11-05 Igt Display screen or a portion thereof with a graphical user interface
WO2024151840A1 (en) 2023-01-13 2024-07-18 Bostongene Corporation Tumor microenvironment types in lung adenocarcinoma
US12462941B2 (en) * 2023-04-13 2025-11-04 Bostongene Corporation Pan-cancer tumor microenvironment classification based on immune escape mechanisms and immune infiltration
WO2024220680A2 (en) * 2023-04-20 2024-10-24 Foundation Medicine, Inc. Methods and systems for predicting treatment response to mono-immunotherapy and chemo-immunotherapy
CN116721699B (en) * 2023-04-27 2024-10-18 百洋智能科技集团股份有限公司 An intelligent recommendation method based on tumor gene detection results
CN116248680B (en) * 2023-05-11 2023-08-01 湖南工商大学 A de novo peptide sequencing method, device and related equipment
WO2024242714A1 (en) * 2023-05-22 2024-11-28 Venn Biosciences Corporation Methods and systems for analyzing site-specific monomer composition
CN117095743B (en) * 2023-10-17 2024-01-05 山东鲁润阿胶药业有限公司 Polypeptide spectrum matching data analysis method and system for small molecular peptide donkey-hide gelatin
WO2025094183A1 (en) * 2023-10-31 2025-05-08 OncoHost Ltd. Predicting anti-cancer therapy related adverse event
WO2025096811A1 (en) 2023-10-31 2025-05-08 Bostongene Corporation Machine learning technique for identifying ici responders and non-responders
CN117542529B (en) * 2024-01-10 2024-04-02 北京博富瑞基因诊断技术有限公司 Method, system, device and storage medium for predicting non-recurrent death risk of HLA-incompatible allogeneic hematopoietic stem cell transplantation
CN117877721B (en) * 2024-03-12 2025-03-07 天津市肿瘤医院(天津医科大学肿瘤医院) Endocrine treatment management system after personalized thyroid cancer radiotherapy

Family Cites Families (177)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US280468A (en) * 1883-07-03 Carrier for store-service apparatus
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5422120A (en) 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
WO1990007936A1 (en) 1989-01-23 1990-07-26 Chiron Corporation Recombinant therapies for infection and hyperproliferative disorders
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
DE69034078T2 (en) 1989-03-21 2004-04-01 Vical, Inc., San Diego Expression of exogenous polynucleotide sequences in vertebrates
EP1645635A3 (en) 1989-08-18 2010-07-07 Oxford Biomedica (UK) Limited Replication defective recombinant retroviruses expressing a palliative
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
ZA911974B (en) 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
DK0648271T3 (en) 1991-08-20 2003-07-21 Us Gov Health & Human Serv Adenovirus-mediated transmission of gastrointestinal tract genes
WO1993010218A1 (en) 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
GB9125623D0 (en) 1991-12-02 1992-01-29 Dynal As Cell modification
FR2688514A1 (en) 1992-03-16 1993-09-17 Centre Nat Rech Scient Defective recombinant adenoviruses expressing cytokines and antitumour drugs containing them
EP0650370A4 (en) 1992-06-08 1995-11-22 Univ California METHODS AND COMPOSITIONS FOR TARGETING SPECIFIC TISSUES.
WO1993025698A1 (en) 1992-06-10 1993-12-23 The United States Government As Represented By The Vector particles resistant to inactivation by human serum
GB2269175A (en) 1992-07-31 1994-02-02 Imperial College Retroviral vectors
EP1024198A3 (en) 1992-12-03 2002-05-29 Genzyme Corporation Pseudo-adenoviral vectors for the gene therapy of haemophiliae
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ES2188612T3 (en) 1993-04-22 2003-07-01 Skyepharma Inc MULTIVESICULAR CYCLODEXTRINE LIPOSOMES TO ENCAPSULATE PHARMACOLOGICAL COMPOUNDS AND METHODS FOR USE.
JP3532566B2 (en) 1993-06-24 2004-05-31 エル. グラハム,フランク Adenovirus vectors for gene therapy
CA2158937C (en) 1993-09-15 2006-01-03 Thomas W. Dubensky, Jr. Recombinant alphavirus vectors
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
DE69435223D1 (en) 1993-10-25 2009-09-03 Canji Inc Recombinant adenovirus vector and method of use
CN1099868C (en) 1993-11-16 2003-01-29 斯卡法玛公司 Vesicles with controlled release of actives
EP0772689B1 (en) 1994-05-09 2007-12-19 Oxford Biomedica (UK) Limited Retroviral vectors having a reduced recombination rate
AU4594996A (en) 1994-11-30 1996-06-19 Chiron Viagene, Inc. Recombinant alphavirus vectors
WO1997042338A1 (en) 1996-05-06 1997-11-13 Chiron Corporation Crossless retroviral vectors
EP1158997A2 (en) 1999-03-09 2001-12-05 University Of Southern California Method of promoting myocyte proliferation and myocardial tissue repair
US7905134B2 (en) 2002-08-06 2011-03-15 The Regents Of The University Of California Biomarker normalization
CA2516182A1 (en) 2003-02-28 2004-09-16 Bayer Pharmaceuticals Corporation Expression profiles for breast cancer and methods of use
USD496297S1 (en) * 2003-11-13 2004-09-21 Susan M. Kahil Face for a timepiece
US7858323B2 (en) 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
WO2006133460A2 (en) 2005-06-09 2006-12-14 Yale University Methods for diagnosing and treating breast cancer based on a her/er ratio
CA2624086A1 (en) 2005-09-28 2007-04-05 H. Lee Moffitt Cancer Center Individualized cancer treatments
US9347945B2 (en) * 2005-12-22 2016-05-24 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
NZ544432A (en) * 2005-12-23 2009-07-31 Pacific Edge Biotechnology Ltd Prognosis prediction for colorectal cancer using a prognositc signature comprising markers ME2 and FAS
US8068994B2 (en) 2007-07-27 2011-11-29 Wayne State University Method for analyzing biological networks
NZ562237A (en) 2007-10-05 2011-02-25 Pacific Edge Biotechnology Ltd Proliferation signature and prognosis for gastrointestinal cancer
US20090105167A1 (en) 2007-10-19 2009-04-23 Duke University Predicting responsiveness to cancer therapeutics
CA2726531A1 (en) 2008-06-05 2009-12-10 University Health Network Compositions and methods for classifying lung cancer and prognosing lung cancer survival
CN102040569B (en) 2009-10-20 2012-11-07 北京绿色金可生物技术股份有限公司 Carotinoid derivatives and preparation method and application thereof
CA2782620A1 (en) * 2009-12-01 2011-06-09 Compendia Bioscience, Inc. Classification of cancers
US20120237488A1 (en) * 2009-12-04 2012-09-20 University Health Network Lsc and hsc signatures for predicting survival of patients having hematological cancer
WO2011085276A2 (en) * 2010-01-09 2011-07-14 The Translational Genomics Research Institute Methods and kits to predict prognostic and therapeutic outcome in small cell lung cancer
USD697080S1 (en) * 2010-02-26 2014-01-07 Draeger Medical Systems, Inc. Display screen with an icon
US9400958B2 (en) * 2010-06-30 2016-07-26 Oracle International Corporation Techniques for display of information related to policies
HUE051674T2 (en) * 2010-09-24 2021-03-29 Niels Grabe Means and methods for the prediction of treatment response of a cancer patient
PL3141617T3 (en) 2011-01-11 2019-04-30 Assist Publique Hopitaux De Paris Methods for predicting the outcome of a cancer in a patient by analysing gene expression
JP2014511159A (en) * 2011-03-10 2014-05-12 テヴァ ファーマスーティカル インダストリーズ エルティーディー. Methods, systems, and programs for improved health care
US10260097B2 (en) * 2011-06-02 2019-04-16 Almac Diagnostics Limited Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
EP2717901A4 (en) 2011-06-06 2015-01-21 Women And Infants Hospital Of Rhode Island HE4-BASED THERAPY FOR MALIGNANT DISEASE
EP2718485A4 (en) * 2011-06-07 2015-05-06 Caris Mpi Inc MOLECULAR PROFILING FOR CANCER
WO2012170710A1 (en) * 2011-06-08 2012-12-13 Altheadx Incorporated Disease classification modules
EP2721179A4 (en) * 2011-06-16 2014-10-01 Caris Life Sciences Luxembourg Holdings S A R L Biomarker compositions and methods
WO2013030841A1 (en) * 2011-09-04 2013-03-07 Yissum Research Development Company Of The Hebrew Universitiy Of Jerusalem Ltd. Prognostic methods and compositions for predicting interferon treatment eficacy in a subject
US20140363816A1 (en) * 2011-12-22 2014-12-11 The Regents Of The University Of Colorado, A Body Corporate Methods for prediction of clinical response to radiation therapy in cancer patients
JP2015503330A (en) * 2011-12-22 2015-02-02 アベオ ファーマシューティカルズ, インコーポレイテッド Identification of multigene biomarkers
EP2885640B1 (en) * 2012-08-16 2018-07-18 Genomedx Biosciences, Inc. Prostate cancer prognostics using biomarkers
USD743413S1 (en) * 2012-09-19 2015-11-17 ABBYY InfoPiosk LLC Display screen or portion thereof with graphical user interface
AU2013353839A1 (en) * 2012-12-03 2015-06-18 Almac Diagnostics Limited Molecular diagnostic test for cancer
USD719177S1 (en) * 2012-12-27 2014-12-09 Jason M. Cohen Display screen or portion thereof with graphical user interface
CN105144179B (en) * 2013-01-29 2019-05-17 分子健康股份有限公司 Systems and methods for clinical decision support
US9809857B2 (en) * 2013-02-28 2017-11-07 Washington University Methods and signatures for oropharyngeal cancer prognosis
USD735732S1 (en) * 2013-03-12 2015-08-04 Hewlett-Packard Development Company, L.P. Display screen with graphical user interface
KR20220053691A (en) * 2013-03-15 2022-04-29 제넨테크, 인크. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
EP2787670A1 (en) 2013-04-05 2014-10-08 Panasonic Intellectual Property Corporation of America MCS table adaptation for 256-QAM
USD725148S1 (en) * 2013-04-30 2015-03-24 Microsoft Corporation Display screen with animated icon
US10679730B2 (en) * 2013-05-28 2020-06-09 The University Of Chicago Prognostic and predictive breast cancer signature
USD741912S1 (en) * 2013-05-29 2015-10-27 Microsoft Corporation Display screen with animated graphical user interface
USD805535S1 (en) * 2013-06-04 2017-12-19 Abbyy Production Llc Display screen or portion thereof with a transitional graphical user interface
USD743423S1 (en) * 2013-06-04 2015-11-17 Abbyy Infopoisk Llc Display screen or portion thereof with graphical user interface
USD743424S1 (en) * 2013-06-04 2015-11-17 Abbyy Infopoisk Llc Display screen or portion thereof with graphical user interface
USD819649S1 (en) * 2013-06-09 2018-06-05 Apple Inc. Display screen or portion thereof with graphical user interface
USD755240S1 (en) * 2013-06-09 2016-05-03 Apple Inc. Display screen or portion thereof with graphical user interface
DK3011059T3 (en) 2013-06-20 2019-05-13 Immunexpress Pty Ltd IDENTIFICATION biomarker
USD744500S1 (en) * 2013-07-05 2015-12-01 Lg Electronics Inc. Display screen with transitional graphical user interface
US20160154928A1 (en) * 2013-07-12 2016-06-02 Immuneering Corporation Systems, methods, and environment for automated review of genomic data to identify downregulated and/or upregulated gene expression indicative of a disease or condition
USD708193S1 (en) * 2013-08-30 2014-07-01 Nike, Inc. Display screen with graphical user interface
USD746831S1 (en) * 2013-09-10 2016-01-05 Apple Inc. Display screen or portion thereof with graphical user interface
USD759068S1 (en) * 2013-09-23 2016-06-14 Bally Gaming, Inc. Display screen or portion thereof with a baccarat game graphical user interface
WO2015073896A2 (en) 2013-11-15 2015-05-21 Psma Development Company, Llc Biomarkers for psma targeted therapy for prostate cancer
US20150205509A1 (en) * 2013-12-02 2015-07-23 Daydials, Inc. User interface using graphical dials to represent user activity
SG10201805674YA (en) * 2014-01-02 2018-08-30 Memorial Sloan Kettering Cancer Center Determinants of cancer response to immunotherapy
US20150218640A1 (en) * 2014-02-06 2015-08-06 Immunexpress Pty Ltd Biomarker signature method, and apparatus and kits therefor
GB201409479D0 (en) * 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
USD771063S1 (en) * 2014-02-21 2016-11-08 Huawei Device Co., Ltd. Display screen or portion thereof with animated graphical user interface
US20150254433A1 (en) * 2014-03-05 2015-09-10 Bruce MACHER Methods and Models for Determining Likelihood of Cancer Drug Treatment Success Utilizing Predictor Biomarkers, and Methods of Diagnosing and Treating Cancer Using the Biomarkers
EP3119908A4 (en) * 2014-03-11 2018-02-21 The Council Of The Queensland Institute Of Medical Research Determining cancer aggressiveness, prognosis and responsiveness to treatment
USD711420S1 (en) * 2014-03-14 2014-08-19 Nike, Inc. Display screen with graphical user interface for athletic achievements
USD772241S1 (en) * 2014-03-19 2016-11-22 Symantec Corporation Display screen or portion thereof with transitional graphical user interface
USD759076S1 (en) * 2014-04-18 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
US20150317430A1 (en) 2014-05-05 2015-11-05 Advaita Corporation Systems and methods for analyzing biological pathways for the purpose of modeling drug effects, side effects, and interactions
WO2015175305A1 (en) * 2014-05-12 2015-11-19 Janssen Pharmaceutica Nv Biological markers for identifying patients for treatment with abiraterone acetate
FR3021776A1 (en) * 2014-05-28 2015-12-04 Vaiomer METHOD FOR IDENTIFYING A RELATION BETWEEN PHYSICAL ELEMENTS
EP3936145A1 (en) 2014-07-31 2022-01-12 The University Of Western Australia A method for the identification of immunotherapy-drug combinations using a network approach
USD762691S1 (en) * 2014-09-01 2016-08-02 Apple Inc. Display screen or portion thereof with graphical user interface
USD753696S1 (en) * 2014-09-01 2016-04-12 Apple Inc. Display screen or portion thereof with graphical user interface
USD766950S1 (en) * 2014-09-02 2016-09-20 Apple Inc. Display screen or portion thereof with graphical user interface
USD757079S1 (en) * 2014-09-02 2016-05-24 Apple Inc. Display screen or portion thereof with graphical user interface
USD765114S1 (en) * 2014-09-02 2016-08-30 Apple Inc. Display screen or portion thereof with graphical user interface
USD765693S1 (en) * 2014-09-02 2016-09-06 Apple Inc. Display screen or portion thereof with graphical user interface
US11275080B2 (en) 2014-11-05 2022-03-15 The Regents Of The University Of California Methods for stratifying non-responders to therapies that block PD1/PDL1 axis
WO2016109546A2 (en) 2014-12-30 2016-07-07 Genentech, Inc. Methods and compositions for prognosis and treatment of cancers
USD765673S1 (en) * 2014-12-30 2016-09-06 Energous Corporation Display screen with graphical user interface
USD784402S1 (en) * 2015-02-04 2017-04-18 Sengled Optoelectronics Co., Ltd Display screen with animated graphical user interface
USD775185S1 (en) * 2015-03-06 2016-12-27 Apple Inc. Display screen or portion thereof with graphical user interface
USD765098S1 (en) * 2015-03-06 2016-08-30 Apple Inc. Display screen or portion thereof with graphical user interface
US20190057182A1 (en) * 2015-05-22 2019-02-21 Csts Health Care Inc. Biomarker-driven molecularly targeted combination therapies based on knowledge representation pathway analysis
AU2016267392B2 (en) * 2015-05-28 2021-12-09 Immunexpress Pty Ltd Validating biomarker measurement
WO2017004153A1 (en) 2015-06-29 2017-01-05 The Broad Institute Inc. Tumor and microenvironment gene expression, compositions of matter and methods of use thereof
GB201512869D0 (en) 2015-07-21 2015-09-02 Almac Diagnostics Ltd Gene signature for minute therapies
CA2995372C (en) * 2015-08-13 2023-10-24 Northeastern University Biomaterials for combined radiotherapy and immunotherapy of cancer
JP6830105B2 (en) * 2015-09-29 2021-02-17 クレッシェンド バイオサイエンス インコーポレイテッド Biomarkers and methods for assessing disease activity in psoriatic arthritis
WO2017058999A2 (en) * 2015-09-29 2017-04-06 Crescendo Bioscience Biomarkers and methods for assessing response to inflammatory disease therapy withdrawal
USD809535S1 (en) * 2015-10-06 2018-02-06 Lg Electronics Inc. Vehicle dashboard display screen with an animated graphical user interface
USD855629S1 (en) * 2015-10-23 2019-08-06 Sony Corporation Display panel or screen or portion thereof with an animated graphical user interface
USD783656S1 (en) * 2015-10-28 2017-04-11 SynerScope B.V. Display screen with graphical user interface
USD795922S1 (en) * 2015-11-05 2017-08-29 Samsung Electronics Co., Ltd. Display screen or portion thereof with animated graphical user interface
USD797124S1 (en) * 2015-11-18 2017-09-12 Samsung Electronics Co., Ltd. Display screen or portion thereof with graphical user interface
GB201521481D0 (en) 2015-12-04 2016-01-20 Healx Ltd Prognostic system
USD799516S1 (en) * 2015-12-23 2017-10-10 Samsung Electronics Co., Ltd. Display screen or portion thereof with graphical user interface
USD806730S1 (en) * 2016-01-05 2018-01-02 Kneevoice, Inc. Display screen or portion thereof with graphical user interface
USD782516S1 (en) * 2016-01-19 2017-03-28 Apple Inc. Display screen or portion thereof with graphical user interface
CA169252S (en) * 2016-02-04 2018-07-24 Coway Co Ltd Display screen with animated graphical user interface
USD810757S1 (en) * 2016-02-19 2018-02-20 Samsung Electronics Co., Ltd. Display screen or portion thereof with transitional graphical user interface
JP1572940S (en) * 2016-03-16 2018-06-18
USD807913S1 (en) * 2016-03-17 2018-01-16 Lg Electronics Inc. Display panel with transitional graphical user interface
USD802611S1 (en) * 2016-04-14 2017-11-14 Alpha Dominche Holdings, Inc. Beverage brewer display screen with graphical user interface
MX393482B (en) * 2016-05-09 2025-03-24 Inst Nat Sante Rech Med Methods for classifying patients with a solid cancer
USD804502S1 (en) * 2016-06-11 2017-12-05 Apple Inc. Display screen or portion thereof with graphical user interface
USD835121S1 (en) * 2016-06-15 2018-12-04 Sony Interactive Entertainment Europe Limited Display screen or portion thereof with graphical user interface
USD882583S1 (en) * 2016-07-12 2020-04-28 Google Llc Display screen with graphical user interface
USD840413S1 (en) * 2016-08-15 2019-02-12 Facebook, Inc. Display screen or portion thereof with digital visual codes graphical user interface
USD852209S1 (en) * 2016-08-24 2019-06-25 Beijing Kingsoft Internet Security Software Co., Ltd. Mobile communication terminal with animated graphical user interface
USD813250S1 (en) * 2016-08-30 2018-03-20 Ponsse Oyj Display screen with graphical user interface
CA3039402A1 (en) * 2016-10-07 2018-04-12 Omniseq, Inc. Methods and systems for determining personalized therapies
USD806120S1 (en) * 2016-10-31 2017-12-26 Agile Transformation, Inc. Display screen or portion thereof with icon
USD847857S1 (en) * 2016-10-31 2019-05-07 Agile Transformation, Inc. Display screen or portion thereof with icon
USD829730S1 (en) * 2016-11-10 2018-10-02 Karma Automotive Llc Display screen with an infotainment graphical user interface
USD865776S1 (en) * 2016-11-18 2019-11-05 Luis Miguel Porturas Display screen with graphical user interface
USD813249S1 (en) * 2017-02-22 2018-03-20 Banuba Limited Display screen with an animated graphical user interface
USD832283S1 (en) * 2017-03-28 2018-10-30 Akamai Technologies, Inc. Display screen with animated graphical user interface
USD822705S1 (en) * 2017-04-20 2018-07-10 Palantir Technologies, Inc. Display screen or portion thereof with graphical user interface
USD880489S1 (en) * 2017-05-18 2020-04-07 The Coca-Cola Company Beverage dispenser display screen or portion thereof with animated graphical user interface
USD818494S1 (en) * 2017-06-04 2018-05-22 Apple Inc. Display screen or portion thereof with animated graphical user interface
USD822059S1 (en) * 2017-06-05 2018-07-03 Apple Inc. Display screen or portion thereof with graphical user interface
EP4012713B1 (en) 2017-06-13 2025-10-29 BostonGene Corporation Systems and methods for generating, visualizing and classifying molecular functional profiles
USD879808S1 (en) * 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
IL319255A (en) 2017-08-07 2025-04-01 Univ Johns Hopkins Methods and materials for assessing and treating cancer
USD833471S1 (en) * 2017-08-18 2018-11-13 Salesforce.Com, Inc. Display screen or portion thereof with animated graphical user interface
USD846585S1 (en) * 2017-08-22 2019-04-23 Samsung Electronics Co., Ltd. Display screen or portion thereof with graphical user interface
USD840415S1 (en) * 2017-08-25 2019-02-12 Samsung Electronics Co., Ltd. Display screen or portion thereof with transitional graphical user interface
USD860228S1 (en) * 2017-09-05 2019-09-17 Byton Limited Display screen with a graphical user interface
USD868103S1 (en) * 2017-09-27 2019-11-26 Toyota Research Institute, Inc. Display screen or portion thereof with an animated graphical user interface
EP3695408A4 (en) 2017-10-02 2021-12-15 The Broad Institute, Inc. PROCEDURES AND COMPOSITIONS FOR DETECTION AND MODULATION OF IMMUNOTHERAPY RESISTANT GENE SIGNATURE IN CANCER
USD861022S1 (en) * 2017-10-13 2019-09-24 Honeywell International Inc. Display screen or portion thereof with a graphical user interface
USD879112S1 (en) * 2017-11-14 2020-03-24 Geographic Services, Inc. Display screen or portion thereof with graphical user interface
USD873854S1 (en) * 2017-11-24 2020-01-28 Fujifilm Corporation Display screen or portion thereof with transitional icon
USD870763S1 (en) * 2018-01-05 2019-12-24 Samsung Electronics Co., Ltd. Display screen or portion thereof with graphical user interface
USD852820S1 (en) * 2018-01-19 2019-07-02 Mouth Player Inc. Display screen or portion thereof with animated graphical user interface
USD878393S1 (en) * 2018-01-30 2020-03-17 Magic Leap, Inc. Display panel or portion thereof with a transitional mixed reality graphical user interface
USD868812S1 (en) * 2018-02-16 2019-12-03 Early Warning Services, Llc Display screen portion with animated graphical user interface for transmittal notification
USD868811S1 (en) * 2018-02-22 2019-12-03 Samsung Electronics Co., Ltd. Display screen or portion thereof with transitional graphical user interface
USD874482S1 (en) * 2018-02-28 2020-02-04 Fujifilm Corporation Display screen or portion thereof with icon
USD865807S1 (en) * 2018-07-24 2019-11-05 Magic Leap, Inc. Display panel or portion thereof with a graphical user interface
USD877176S1 (en) * 2018-07-24 2020-03-03 Magic Leap, Inc. Display panel or portion thereof with a transitional graphical user interface
USD879147S1 (en) * 2018-07-31 2020-03-24 Google Llc Display screen with animated icon
USD868094S1 (en) * 2018-08-30 2019-11-26 Apple Inc. Electronic device with graphical user interface
USD882615S1 (en) * 2018-09-06 2020-04-28 Apple Inc. Electronic device with animated graphical user interface
USD855073S1 (en) * 2019-04-05 2019-07-30 Le-Vel Brands, Llc Display screen with icon
CA3151629A1 (en) 2019-11-07 2021-05-14 Laura E. BENJAMIN Classification of tumor microenvironments
EP4394048A3 (en) 2020-12-11 2024-09-25 BostonGene Corporation Techniques for identifying follicular lymphoma types
WO2023154549A1 (en) 2022-02-14 2023-08-17 Bostongene Corporation Urothelial tumor microenvironment (tme) types

Also Published As

Publication number Publication date
EP4012713A1 (en) 2022-06-15
EP3639169B1 (en) 2022-03-23
AU2018102201A4 (en) 2021-01-21
US10580517B2 (en) 2020-03-03
US11322226B2 (en) 2022-05-03
US10340030B2 (en) 2019-07-02
KR102396784B1 (en) 2022-05-13
US11705220B2 (en) 2023-07-18
EP4012713B1 (en) 2025-10-29
US11004542B2 (en) 2021-05-11
US20200335180A1 (en) 2020-10-22
GB202209539D0 (en) 2022-08-10
US10720230B2 (en) 2020-07-21
US11373733B2 (en) 2022-06-28
US11984200B2 (en) 2024-05-14
IL270887A (en) 2020-01-30
CN111052247B (en) 2024-06-14
US10340031B2 (en) 2019-07-02
US20200175134A9 (en) 2020-06-04
JP7401710B2 (en) 2023-12-19
US20210257058A1 (en) 2021-08-19
US11430545B2 (en) 2022-08-30
WO2018231771A1 (en) 2018-12-20
JP2022050445A (en) 2022-03-30
IL270888A (en) 2020-01-30
IL270888B1 (en) 2024-08-01
CA3065568A1 (en) 2018-12-20
KR20200028388A (en) 2020-03-16
GB2601923A8 (en) 2023-03-08
US10636513B2 (en) 2020-04-28
US10636514B2 (en) 2020-04-28
IL270886A (en) 2020-01-30
CA3066004A1 (en) 2018-12-20
JP6812580B2 (en) 2021-01-13
US20190179998A9 (en) 2019-06-13
SG10201911541YA (en) 2020-02-27
US20180357361A1 (en) 2018-12-13
US20220389512A1 (en) 2022-12-08
US20180357378A1 (en) 2018-12-13
GB2601923B8 (en) 2023-03-08
US10504615B2 (en) 2019-12-10
US11367509B2 (en) 2022-06-21
USD891446S1 (en) 2020-07-28
JP7408534B2 (en) 2024-01-05
AU2018282865B2 (en) 2024-10-10
USD890779S1 (en) 2020-07-21
GB201918035D0 (en) 2020-01-22
US20240290434A1 (en) 2024-08-29
JP7034183B2 (en) 2022-03-11
US20180357377A1 (en) 2018-12-13
JP2020523705A (en) 2020-08-06
US20180358125A1 (en) 2018-12-13
GB2576680A (en) 2020-02-26
US20180358118A1 (en) 2018-12-13
IL270887B2 (en) 2025-01-01
EP3639170A1 (en) 2020-04-22
GB201918335D0 (en) 2020-01-29
AU2018282865A1 (en) 2019-12-19
US20190325993A1 (en) 2019-10-24
GB201918389D0 (en) 2020-01-29
GB2576680B (en) 2022-03-23
US20180357373A1 (en) 2018-12-13
US20180358132A1 (en) 2018-12-13
US20200135302A1 (en) 2020-04-30
US20200058377A1 (en) 2020-02-20
US11302420B2 (en) 2022-04-12
DE112018002990T5 (en) 2020-04-02
US20180357376A1 (en) 2018-12-13
GB2601923B (en) 2023-01-04
EP3639172A1 (en) 2020-04-22
US20200273543A1 (en) 2020-08-27
US10311967B2 (en) 2019-06-04
JP6776464B2 (en) 2020-10-28
US10706954B2 (en) 2020-07-07
EP3879535B1 (en) 2024-12-11
US20210249107A9 (en) 2021-08-12
JP2020523028A (en) 2020-08-06
JP2020528268A (en) 2020-09-24
JP2023169202A (en) 2023-11-29
US20200175133A9 (en) 2020-06-04
GB2576857A (en) 2020-03-04
JP7343565B2 (en) 2023-09-12
US20180357362A1 (en) 2018-12-13
US20190252046A1 (en) 2019-08-15
US20200075131A1 (en) 2020-03-05
CN111033631A (en) 2020-04-17
JP2021036868A (en) 2021-03-11
CA3065193A1 (en) 2018-12-20
US10395761B1 (en) 2019-08-27
US20190332744A9 (en) 2019-10-31
JP2021072778A (en) 2021-05-13
US20180358128A1 (en) 2018-12-13
US20200265924A1 (en) 2020-08-20
GB2576857B (en) 2022-12-07
US11842797B2 (en) 2023-12-12
US10650911B2 (en) 2020-05-12
US20240006029A1 (en) 2024-01-04
IL270887B1 (en) 2024-09-01
AU2018282759A2 (en) 2021-01-07
WO2018231762A1 (en) 2018-12-20
EP3639172B1 (en) 2021-03-31
US20180357374A1 (en) 2018-12-13
GB202201288D0 (en) 2022-03-16
JP6999771B2 (en) 2022-02-04
AU2018284077B2 (en) 2021-09-23
US20200098443A1 (en) 2020-03-26
US20180357372A1 (en) 2018-12-13
CN111052247A (en) 2020-04-21
US20190243943A9 (en) 2019-08-08
WO2018231762A8 (en) 2019-12-19
AU2018282759A1 (en) 2020-01-02
US20200175135A9 (en) 2020-06-04
JP2024029038A (en) 2024-03-05
CN111033631B (en) 2024-03-12
GB2577828A (en) 2020-04-08
GB2601923A (en) 2022-06-15
EP3879535A1 (en) 2021-09-15
US20200005903A1 (en) 2020-01-02
WO2018231772A1 (en) 2018-12-20
EP3639170B1 (en) 2021-03-24
AU2018284077A1 (en) 2020-01-02
EP3639169A1 (en) 2020-04-22
IL270888B2 (en) 2024-12-01

Similar Documents

Publication Publication Date Title
GB2576680B (en) Systems and methods for generating, visualizing and classifying molecular functional profiles
GB2571458B (en) Methods, systems and apparatus for segmenting objects
IL265469B1 (en) Sample tracking via sample tracking chains, systems and methods
GB2567590B (en) Methods, systems and apparatus for segmenting and dimensioning objects
IL261434B (en) Planar-beam, light detection and ranging system
GB2547155B (en) Formation characteristics determination apparatus, methods, and systems
BR112017007052A2 (en) network analysis methods, apparatus and systems.
ZA201608164B (en) Systems, apparatus, and methods for generating and analyzing resistome profiles
SG11202000871WA (en) Systems, devices, and methods for isotachophoresis
GB2587284B (en) Well ranging apparatus. methods, and systems
GB201714329D0 (en) In-store audio systems, devices, and methods
GB2545947B (en) Dual-energy detection apparatus, system and method
GB2549200B (en) Well ranging apparatus, methods and systems
GB2557623B (en) Railway monitoring systems, apparatus and methods
EP3268857A4 (en) Systems, methods, and apparatus for reverse geocoding
GB2556198B (en) Imaging apparatuses, systems, and moving imaging objects
PL3596443T3 (en) Dissolved gas analysis devices, systems, and methods
GB201718907D0 (en) Downhole annulus evaluation apparatus, systems, and methods
GB201714215D0 (en) Formation property measurement apparatus, methods, and systems
GB201513132D0 (en) Support systems, apparatus and methods
ZA201901084B (en) Classifying apparatus, systems and methods
GB201516337D0 (en) Entity location systems, methods and devices
GB201514108D0 (en) Distillation systems, apparatus and methods
GB2601940B (en) Methods, systems and apparatus for segmenting and dimensioning objects
GB2597875B (en) Methods, systems and apparatus for segmenting and dimensioning objects