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SG10201911665UA - Heterocyclic compounds as ret kinase inhibitors - Google Patents

Heterocyclic compounds as ret kinase inhibitors

Info

Publication number
SG10201911665UA
SG10201911665UA SG10201911665UA SG10201911665UA SG10201911665UA SG 10201911665U A SG10201911665U A SG 10201911665UA SG 10201911665U A SG10201911665U A SG 10201911665UA SG 10201911665U A SG10201911665U A SG 10201911665UA SG 10201911665U A SG10201911665U A SG 10201911665UA
Authority
SG
Singapore
Prior art keywords
kinase inhibitors
heterocyclic compounds
ret kinase
ret
heterocyclic
Prior art date
Application number
SG10201911665UA
Inventor
Allan Jordan
Rebecca Newton
Bohdan Waszkowycz
Jonathan Mark Sutton
George Hynd
Silvia Paoletta
Euan Alexander Fraser Fordyce
Original Assignee
Cancer Research Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Tech Ltd filed Critical Cancer Research Tech Ltd
Publication of SG10201911665UA publication Critical patent/SG10201911665UA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201911665UA 2016-04-15 2017-04-18 Heterocyclic compounds as ret kinase inhibitors SG10201911665UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201606631 2016-04-15
GB201619277 2016-11-14

Publications (1)

Publication Number Publication Date
SG10201911665UA true SG10201911665UA (en) 2020-01-30

Family

ID=58633035

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201808878UA SG11201808878UA (en) 2016-04-15 2017-04-18 Heterocyclic compounds as ret kinase inhibitors
SG10201911665UA SG10201911665UA (en) 2016-04-15 2017-04-18 Heterocyclic compounds as ret kinase inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201808878UA SG11201808878UA (en) 2016-04-15 2017-04-18 Heterocyclic compounds as ret kinase inhibitors

Country Status (24)

Country Link
US (4) US10954241B2 (en)
EP (2) EP3960180A1 (en)
JP (3) JP6943876B2 (en)
KR (3) KR20240142568A (en)
CN (2) CN109195972B (en)
AU (3) AU2017250448C1 (en)
BR (2) BR112018071097B1 (en)
CA (1) CA3020778A1 (en)
CY (1) CY1124478T1 (en)
DK (1) DK3442980T3 (en)
ES (1) ES2886587T3 (en)
HR (1) HRP20211362T1 (en)
HU (1) HUE056135T2 (en)
IL (3) IL297192A (en)
LT (1) LT3442980T (en)
MX (2) MX387394B (en)
PL (1) PL3442980T3 (en)
PT (1) PT3442980T (en)
RS (1) RS62322B1 (en)
RU (1) RU2742115C2 (en)
SG (2) SG11201808878UA (en)
SI (1) SI3442980T1 (en)
SM (1) SMT202100538T1 (en)
WO (1) WO2017178844A1 (en)

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LT3442980T (en) 2021-09-27
EP3442980A1 (en) 2019-02-20
US20190106425A1 (en) 2019-04-11
AU2020220079B2 (en) 2022-04-21
IL289793B (en) 2022-11-01
CN115650985B (en) 2024-08-02
JP2023159230A (en) 2023-10-31
KR102706837B1 (en) 2024-09-19
BR112018071097B1 (en) 2024-02-20
CN115650985A (en) 2023-01-31
AU2022203916A1 (en) 2022-06-23
BR122023026297A2 (en) 2024-01-16
JP6943876B2 (en) 2021-10-06
EP3960180A1 (en) 2022-03-02
JP2019515903A (en) 2019-06-13
US20230339954A1 (en) 2023-10-26
MX387394B (en) 2025-03-18
AU2017250448C1 (en) 2021-01-07
RU2742115C2 (en) 2021-02-02
CA3020778A1 (en) 2017-10-19
RU2018138471A (en) 2020-05-15
HUE056135T2 (en) 2022-01-28
IL262185B (en) 2022-02-01
CN109195972A (en) 2019-01-11
KR20180134983A (en) 2018-12-19
NZ747678A (en) 2024-05-31
IL262185A (en) 2018-11-29
MX2021013110A (en) 2021-11-17
SI3442980T1 (en) 2021-11-30
PL3442980T3 (en) 2021-12-06
US20210155628A1 (en) 2021-05-27
AU2017250448B2 (en) 2020-05-21
US11548896B2 (en) 2023-01-10
IL289793A (en) 2022-03-01
HRP20211362T1 (en) 2021-11-26
PT3442980T (en) 2021-09-13
RS62322B1 (en) 2021-10-29
US10954241B2 (en) 2021-03-23
WO2017178844A1 (en) 2017-10-19
JP2021193108A (en) 2021-12-23
BR112018071097A2 (en) 2019-01-29
SMT202100538T1 (en) 2021-11-12
CY1124478T1 (en) 2022-07-22
IL297192A (en) 2022-12-01
US20250236624A1 (en) 2025-07-24
ES2886587T3 (en) 2021-12-20
AU2020220079A1 (en) 2020-09-03
IL289793B2 (en) 2023-03-01
CN109195972B (en) 2022-10-28
DK3442980T3 (en) 2021-08-30
KR102390578B1 (en) 2022-04-26
MX2018012609A (en) 2019-08-01
KR20220054894A (en) 2022-05-03
SG11201808878UA (en) 2018-11-29
KR20240142568A (en) 2024-09-30
RU2018138471A3 (en) 2020-05-15
AU2017250448A1 (en) 2018-11-01
EP3442980B1 (en) 2021-06-09

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