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SG10201811190SA - Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon - Google Patents

Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon

Info

Publication number
SG10201811190SA
SG10201811190SA SG10201811190SA SG10201811190SA SG10201811190SA SG 10201811190S A SG10201811190S A SG 10201811190SA SG 10201811190S A SG10201811190S A SG 10201811190SA SG 10201811190S A SG10201811190S A SG 10201811190SA SG 10201811190S A SG10201811190S A SG 10201811190SA
Authority
SG
Singapore
Prior art keywords
vlp
replicon
cancer immunotherapy
mhc antigens
class
Prior art date
Application number
SG10201811190SA
Inventor
Deb Chatterjee
Stanislaw Kaczmarczyk
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of SG10201811190SA publication Critical patent/SG10201811190SA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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Abstract

Described herein is a method of preventing or treating a disease in a mammalian subject, comprising administering to the subject who is in need thereof an effective dosage of a pharmaceutical composition comprising a virus like particle (VLP) comprising: an alphavirus replicon comprising a recombinant polynucleotide, wherein the polynucleotide comprises a sequence encoding both subunits of a human class II major histocompatibility antigen, a retroviral gag protein, and a fusogenic envelope protein, wherein the VLP does not contain an alphavirus structural protein gene.
SG10201811190SA 2013-12-16 2014-12-16 Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon SG10201811190SA (en)

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US201361916394P 2013-12-16 2013-12-16

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SG10201811190SA true SG10201811190SA (en) 2019-01-30

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SG11201604868YA SG11201604868YA (en) 2013-12-16 2014-12-16 Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon

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US (3) US20160312242A1 (en)
EP (3) EP3659620B1 (en)
JP (2) JP6861516B2 (en)
KR (1) KR102467982B1 (en)
CN (2) CN113648406A (en)
AU (1) AU2014365777B2 (en)
BR (1) BR112016013804A2 (en)
CA (1) CA2934075C (en)
ES (1) ES2899078T3 (en)
MX (1) MX387755B (en)
SG (2) SG10201811190SA (en)
WO (1) WO2015095167A2 (en)

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CA2934075C (en) 2013-12-16 2023-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon
KR20230076812A (en) * 2020-07-31 2023-05-31 레플리케이트 바이오사이언스, 인크. Modified Chikungunya Virus and Sindbis Virus and Uses Thereof
WO2022261343A1 (en) 2021-06-09 2022-12-15 Chimeron Bio Corporation Peptide vlp-based vaccines
WO2022261355A1 (en) 2021-06-09 2022-12-15 Chimeron Bio Corporation Self-amplifying rna-based vlp vaccines
CN118987278A (en) * 2023-05-19 2024-11-22 粤港澳大湾区精准医学研究院(广州) Cell for delivering gene or therapeutic drug and application thereof
CN117778432B (en) * 2024-02-26 2024-05-28 苏州左旋星生物科技有限公司 Self-replicating RNA vector, preparation method and application thereof

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