[go: up one dir, main page]

SG10201811186XA - Purification of proteins - Google Patents

Purification of proteins

Info

Publication number
SG10201811186XA
SG10201811186XA SG10201811186XA SG10201811186XA SG10201811186XA SG 10201811186X A SG10201811186X A SG 10201811186XA SG 10201811186X A SG10201811186X A SG 10201811186XA SG 10201811186X A SG10201811186X A SG 10201811186XA SG 10201811186X A SG10201811186X A SG 10201811186XA
Authority
SG
Singapore
Prior art keywords
proteins
purification
peg
antibodies
methods
Prior art date
Application number
SG10201811186XA
Inventor
Alois Jungbauer
Ralf Sommer
Original Assignee
Novasep Process
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novasep Process filed Critical Novasep Process
Publication of SG10201811186XA publication Critical patent/SG10201811186XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURIFICATION OF PROTEINS This application relates to methods for purification of proteins such as antibodies using a hydrophilic polymer (e.g., PEG), a fatty acid (e.g., caprylic acid), and / or another agent (e.g., calcium chloride). FIGURE 1
SG10201811186XA 2013-10-18 2014-10-17 Purification of proteins SG10201811186XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361892975P 2013-10-18 2013-10-18

Publications (1)

Publication Number Publication Date
SG10201811186XA true SG10201811186XA (en) 2019-01-30

Family

ID=51945951

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201603028SA SG11201603028SA (en) 2013-10-18 2014-10-17 Purification of proteins
SG10201811186XA SG10201811186XA (en) 2013-10-18 2014-10-17 Purification of proteins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201603028SA SG11201603028SA (en) 2013-10-18 2014-10-17 Purification of proteins

Country Status (6)

Country Link
US (1) US10508133B2 (en)
EP (1) EP3057987B1 (en)
KR (1) KR102356757B1 (en)
CN (1) CN106029690B (en)
SG (2) SG11201603028SA (en)
WO (1) WO2015056237A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014123485A1 (en) * 2013-02-06 2014-08-14 Agency For Science, Technology And Research Protein purification methods
SG11201603028SA (en) 2013-10-18 2016-05-30 Universität Für Bodenkultur Wien Purification of proteins
US10246485B2 (en) * 2013-11-08 2019-04-02 Csl Limited Method to concentrate von willebrand factor or complexes thereof
WO2015130222A1 (en) * 2014-02-27 2015-09-03 Agency For Science, Technology And Research Antibody purification process
WO2016073401A1 (en) * 2014-11-03 2016-05-12 Bristol-Myers Squibb Company Use of caprylic acid precipitation for protein purification
AU2016282916B2 (en) 2015-06-26 2022-01-20 Ferring B.V. Methods of purification and/or viral inactivation
US20190002495A1 (en) * 2015-08-14 2019-01-03 Kbi Biopharma, Inc. Non-chromatographic separation of polypeptides using the combination of a steric exclusion agent and a charge neutralization agent
HUE042984T2 (en) * 2015-08-31 2019-07-29 Inst Grifols S A Method for the preparation of immunoglobulins
MX2018009331A (en) 2016-02-03 2018-11-09 Plasma Tech Llc Methods for extracting proteins from a blood-based material.
US20220402969A1 (en) * 2016-02-03 2022-12-22 Plasma Technologies, Llc Methods for Extracting Proteins from a Blood-Based Material
TWI712612B (en) * 2016-09-26 2020-12-11 西班牙商格里佛機構有限公司 Method for the preparation of immunoglobulins solution
CN107880116B (en) * 2016-09-30 2023-02-03 盖立复集团公司 Method for producing immunoglobulins
FR3076294B1 (en) * 2017-12-29 2022-01-28 Lab Francais Du Fractionnement METHOD FOR PURIFYING ANTIBODIES FROM RAW MILK
WO2020125757A1 (en) * 2018-12-21 2020-06-25 Wuxi Biologics (Shanghai) Co., Ltd. A method for improving aggregate removal by protein a chromatography
WO2021064079A1 (en) * 2019-10-04 2021-04-08 Merck Patent Gmbh Purification of proteins and viral inactivation
IT202100004496A1 (en) 2021-02-25 2022-08-25 Univ Della Calabria RECOVERY OF BIOLOGICAL DRUGS OR THEIR FRAGMENTS FROM IMPURE SOLUTIONS BY CRYSTALLIZATION OR PRECIPITATION WITH MEMBRANE
PL448410A1 (en) * 2024-04-25 2025-10-27 Politechnika Rzeszowska im. Ignacego Łukasiewicza Method for isolating monoclonal antibodies from a post-culture mixture of proteins

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286954A (en) 1962-01-03
US4164495A (en) 1976-04-06 1979-08-14 Nordisk Insulinlaboratorium Method of recovering immunoglobulin using a polyol and an alkanoic acid
DK25877A (en) 1977-01-21 1978-08-15 Nordisk Insulinlab PROCEDURE FOR EXTRACTING PURE ALBUMIN FROM BLOOD PLASMA
FR2578425B1 (en) 1985-03-07 1988-06-10 Nal Transfusion Sanguine Centr IMMUNOGLOBULIN PREPARATIONS HAVING HIGH TITLES OF ANTI-ALLERGENIC BLOCKING ANTIBODIES, THEIR PREPARATION AND THEIR APPLICATIONS FOR THE TREATMENT OF ALLERGIES
AU6487286A (en) 1985-11-08 1987-05-14 Baxter Travenol Laboratories Inc. Antihemophilic factor by cold precipitation
US4939176A (en) 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
DK0447585T4 (en) 1990-03-22 2003-09-01 Biotest Pharma Gmbh Process for the preparation of an intravenously tolerant immunoglobulin G preparation
US5525519A (en) * 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
US5747031A (en) 1995-10-05 1998-05-05 Immucell Corporation Process for isolating immunoglobulins in whey
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
KR20010043323A (en) * 1998-05-06 2001-05-25 제넨테크, 인크. Protein Purification by Ion Exchange Chromatography
CN1180080C (en) * 2002-01-18 2004-12-15 中国科学院上海细胞生物学研究所 An improved preparation method of liver cancer mouse monoclonal antibody
AU2003250684A1 (en) * 2002-07-31 2004-02-16 Affinium Pharmaceuticals, Inc. Deoxyuridine 5' triphosphate nucleotidohydrolase polypeptides and structures
KR20070009995A (en) 2004-01-30 2007-01-19 수오멘 푸나이넨 리스티 베리팔베루 How to prepare viral safety immunoglobulins
US7855280B2 (en) 2005-09-15 2010-12-21 Wyeth Llc Separation methods
JP5732196B2 (en) * 2006-11-01 2015-06-10 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． Method for isolating biopolymers using low pH and divalent cations
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008100578A2 (en) 2007-02-14 2008-08-21 Amgen Inc. Method of isolating antibodies by precipitation
DE602008004747D1 (en) 2007-02-22 2011-03-10 Baxter Int PROCESS FOR PURIFYING HYDROPHOUS PROTEINS
JP2010534719A (en) 2007-07-27 2010-11-11 ファイザー・リミテッド Antibody purification by precipitation
MY150984A (en) * 2008-12-12 2014-03-31 Boehringer Ingelheim Int Anti-agf antibodies
EP2445925A1 (en) 2009-06-25 2012-05-02 Bristol-Myers Squibb Company Protein purification by caprylic acid (octanoic acid) precipitation
ES2596407T3 (en) 2011-04-08 2017-01-09 Universidad De Costa Rica Method for the production of injectable formulations of blood products and products obtained using said method
SG11201603028SA (en) 2013-10-18 2016-05-30 Universität Für Bodenkultur Wien Purification of proteins

Also Published As

Publication number Publication date
CN106029690A (en) 2016-10-12
KR102356757B1 (en) 2022-02-03
WO2015056237A3 (en) 2015-07-16
US10508133B2 (en) 2019-12-17
WO2015056237A2 (en) 2015-04-23
EP3057987B1 (en) 2020-12-23
CN106029690B (en) 2021-08-31
EP3057987A2 (en) 2016-08-24
KR20160078994A (en) 2016-07-05
US20160272675A1 (en) 2016-09-22
SG11201603028SA (en) 2016-05-30

Similar Documents

Publication Publication Date Title
SG10201811186XA (en) Purification of proteins
MX381456B (en) Transduction buffer
EA202092987A3 (en) LIPID CONTAINING DOCOSAPENTAENIC ACID
EA201890204A1 (en) ANTIBACTERIAL CONNECTIONS
EA201590586A1 (en) THERAPEUTIC NANOPARTICLES, INCLUDING THE THERAPEUTIC AGENT, METHODS OF THEIR RECEIVING AND USE
EA201691216A1 (en) COMPOUNDS OF LINACLOTIDE WITH Slow Release
SG11201601363YA (en) Process for purifying an acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid
PH12014502010A1 (en) Bispecific antibodies against human tweak and human il17 and uses thereof
UA114901C2 (en) Acc inhibitors and uses thereof
MX2016008086A (en) Mixtures comprising a superabsorbent polymer (sap) and a biopesticide.
EA201590890A1 (en) DERIVATIVES 5-FLUOR-N- (PYRIDIN-2-IL) PYRIDIN-2-AMINE CONTAINING A SULPHOXIMINE GROUP
MX391216B (en) PHARMACEUTICAL COMPOSITION COMPRISING AN ADENOVIRAL VECTOR.
UA116999C2 (en) SELECTED HEMAGLUTIN ANTIBODY AND PHARMACEUTICAL COMPOSITION TO BE CONTAINED
EP2819978A4 (en) PROCESS FOR THE PREPARATION OF 2,3,3,3-TETRAFLUORPROPES
EA201591712A1 (en) ANTIBIOTIC COMPOSITIONS BASED ON CEFTOLOSAN
FR3001970B1 (en) PROCESS FOR THE PREPARATION OF DICARBOXYLIC 2,5-FURANE ACID
SG10201900541QA (en) Derivatives of xanthone compounds
UA115373C2 (en) AMG 416 (VELCALSETID) STABLE LIQUID COMPOSITION
PH12014501176A1 (en) Anticoagulant reversal agents
UA107836C2 (en) ALZHEIMER'S DISEASE METHOD
EP2987801A4 (en) METHOD FOR PURIFYING ANTIBODY PROTEIN
EP2565156A4 (en) LOW ACID HYPOCHLOROUS ACID, AND APPARATUS AND METHOD FOR PRODUCING THE SAME
EA201691563A1 (en) DRY ACID CONCENTRATE IN GRANULATED FORM
HUE040484T2 (en) Process for the preparation of (3S, 3S ') 4,4'-disulfanediylbis (3-aminobutane-1-sulfonic acid)
EA201401341A1 (en) SOLID FORMS N - ((S) -2,3-DIHYDROXIPROPYL) -3- (2-Fluoro-4-iodophenylamino) isonicotinamide