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SG10201806844SA - Uv associated mtdna fusion transcripts and methods and uses thereof - Google Patents

Uv associated mtdna fusion transcripts and methods and uses thereof

Info

Publication number
SG10201806844SA
SG10201806844SA SG10201806844SA SG10201806844SA SG10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA
Authority
SG
Singapore
Prior art keywords
methods
fusion transcripts
mtdna
associated mtdna
molecules
Prior art date
Application number
SG10201806844SA
Inventor
Andrew Harbottle
Gabriel Dakubo
Ryan L Parr
Jennifer Creed
Brian Reguly
Kerry Robinson
Original Assignee
Mdna Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mdna Life Sciences Inc filed Critical Mdna Life Sciences Inc
Publication of SG10201806844SA publication Critical patent/SG10201806844SA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/148—Screening for cosmetic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/99—Oxidoreductases acting on NADH or NADPH (1.6) with other acceptors (1.6.99)
    • C12Y106/99003—NADH dehydrogenase (1.6.99.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y109/00—Oxidoreductases acting on a heme group of donors (1.9)
    • C12Y109/03—Oxidoreductases acting on a heme group of donors (1.9) with oxygen as acceptor (1.9.3)
    • C12Y109/03001—Cytochrome-c oxidase (1.9.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01003—Adenosine triphosphatase (3.6.1.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

UV ASSOCIATED MTDNA FUSION TRANSCRIPTS AND METHODS AND USES THEREOF The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products. (Figure )
SG10201806844SA 2010-03-01 2011-03-01 Uv associated mtdna fusion transcripts and methods and uses thereof SG10201806844SA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30921610P 2010-03-01 2010-03-01

Publications (1)

Publication Number Publication Date
SG10201806844SA true SG10201806844SA (en) 2018-09-27

Family

ID=44541588

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201806844SA SG10201806844SA (en) 2010-03-01 2011-03-01 Uv associated mtdna fusion transcripts and methods and uses thereof
SG10201501541QA SG10201501541QA (en) 2010-03-01 2011-03-01 Uv associated mtdna fusion transcripts and methods and uses thereof
SG2012064937A SG183562A1 (en) 2010-03-01 2011-03-01 Uv associated mtdna fusion transcripts and methods and uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201501541QA SG10201501541QA (en) 2010-03-01 2011-03-01 Uv associated mtdna fusion transcripts and methods and uses thereof
SG2012064937A SG183562A1 (en) 2010-03-01 2011-03-01 Uv associated mtdna fusion transcripts and methods and uses thereof

Country Status (12)

Country Link
US (4) US20140024025A1 (en)
EP (2) EP2542680B1 (en)
JP (1) JP6008743B2 (en)
KR (2) KR20190136107A (en)
CN (2) CN104946676A (en)
AU (1) AU2011223463B2 (en)
CA (1) CA2791817A1 (en)
HK (1) HK1253690A1 (en)
NZ (1) NZ602137A (en)
RU (1) RU2012141575A (en)
SG (3) SG10201806844SA (en)
WO (1) WO2011106892A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107011428B (en) * 2008-03-28 2022-02-25 Mdna生命科学有限公司 Abnormal mitochondrial DNA, related fusion transcript and hybridization probe thereof
KR101705421B1 (en) * 2015-01-05 2017-02-09 건국대학교 산학협력단 Nucler Moelcules for detecting UV induced damage and Methods and Systems for evaluating UV induced damage and repairby using thereof
US10864153B2 (en) * 2016-11-14 2020-12-15 The Regents Of The University Of Michigan Compositions and methods for blocking ultraviolet radiation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020197633A1 (en) * 2001-05-09 2002-12-26 Jones Brian C. Evaluation of ultraviolet radiation damage to skin using new gene markers, methods and compositions related thereto
EP1291640A1 (en) * 2001-09-05 2003-03-12 Beiersdorf AG In vitro test method to assess the UVA protection performance of sun care products
CA2480184C (en) * 2004-10-14 2011-12-20 Mark Birch-Machin The use of a 3895 bp mitochondrial dna deletion as a marker for sunlight exposure in human skin
KR101363032B1 (en) * 2005-04-18 2014-02-13 미토믹스 인크. Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
WO2007016419A2 (en) * 2005-07-29 2007-02-08 The General Hospital Corporation Methods and compositions for reducing skin damage
TWI428143B (en) * 2006-01-18 2014-03-01 Gen Hospital Corp Methods of increasing lymphatic function
US20110082218A1 (en) * 2006-06-15 2011-04-07 Karin Wertz Treatment and modulation of gene expression and skin aging
CA2702212C (en) * 2007-10-11 2019-01-15 Genesis Genomics Inc. Methods for assaying mc1r variants and mitochondrial markers in skin samples
US20110201011A2 (en) * 2007-10-11 2011-08-18 Mitomics Inc. Methods for assaying mc1r variants and mitochondrial markers in skin samples
JP6309184B2 (en) * 2007-11-15 2018-04-11 ザ ジェネラル ホスピタル コーポレイション Methods and compositions for reduction of skin damage
CN107011428B (en) * 2008-03-28 2022-02-25 Mdna生命科学有限公司 Abnormal mitochondrial DNA, related fusion transcript and hybridization probe thereof

Also Published As

Publication number Publication date
SG183562A1 (en) 2012-10-30
US20180346985A1 (en) 2018-12-06
SG10201501541QA (en) 2015-04-29
CA2791817A1 (en) 2011-09-09
US20140024025A1 (en) 2014-01-23
CN104946676A (en) 2015-09-30
EP2542680A4 (en) 2013-08-21
EP2542680A1 (en) 2013-01-09
AU2011223463B2 (en) 2015-07-30
HK1253690A1 (en) 2019-06-28
JP6008743B2 (en) 2016-10-19
RU2012141575A (en) 2014-04-10
KR20190136107A (en) 2019-12-09
EP3305902A1 (en) 2018-04-11
KR20120128658A (en) 2012-11-27
WO2011106892A1 (en) 2011-09-09
US20150322516A1 (en) 2015-11-12
US20170175194A1 (en) 2017-06-22
CN102791864B (en) 2015-06-17
CN102791864A (en) 2012-11-21
NZ602137A (en) 2015-05-29
AU2011223463A1 (en) 2012-09-06
JP2013520965A (en) 2013-06-10
EP2542680B1 (en) 2017-09-27
KR102051010B1 (en) 2019-12-02

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SG10201806844SA (en) Uv associated mtdna fusion transcripts and methods and uses thereof