SG10201801188XA - Selective delivery of material to cells - Google Patents
Selective delivery of material to cellsInfo
- Publication number
- SG10201801188XA SG10201801188XA SG10201801188XA SG10201801188XA SG10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- selective delivery
- selective
- delivery
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1028—Sorting particles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Fluid Mechanics (AREA)
- Toxicology (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361866972P | 2013-08-16 | 2013-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201801188XA true SG10201801188XA (en) | 2018-03-28 |
Family
ID=52468732
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201801188XA SG10201801188XA (en) | 2013-08-16 | 2014-08-15 | Selective delivery of material to cells |
| SG11201601927SA SG11201601927SA (en) | 2013-08-16 | 2014-08-15 | Selective delivery of material to cells |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201601927SA SG11201601927SA (en) | 2013-08-16 | 2014-08-15 | Selective delivery of material to cells |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10124336B2 (en) |
| EP (2) | EP3848695A1 (en) |
| JP (1) | JP6502940B2 (en) |
| KR (4) | KR102386122B1 (en) |
| CN (1) | CN105848793B (en) |
| AU (2) | AU2014306423B2 (en) |
| CA (1) | CA2921579C (en) |
| ES (1) | ES2865107T3 (en) |
| IL (1) | IL244113B (en) |
| MX (2) | MX382654B (en) |
| PL (1) | PL3033184T3 (en) |
| SG (2) | SG10201801188XA (en) |
| WO (1) | WO2015023982A1 (en) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107058101B (en) | 2011-10-17 | 2021-06-01 | 麻省理工学院 | intracellular delivery |
| KR102386122B1 (en) | 2013-08-16 | 2022-04-14 | 메사추세츠 인스티튜트 오브 테크놀로지 | Selective delivery of material to cells |
| CA2964392A1 (en) * | 2014-10-31 | 2016-05-06 | Massachussetts Institute Of Technology | Delivery of biomolecules to immune cells |
| CA2964138C (en) | 2014-11-14 | 2023-11-14 | Massachusetts Institute Of Technology | Disruption and field enabled delivery of compounds and compositions into cells |
| AU2016206870B2 (en) | 2015-01-12 | 2022-02-17 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| CA2988996A1 (en) | 2015-07-09 | 2017-01-12 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| ES2930017T3 (en) | 2015-09-04 | 2022-12-05 | Sqz Biotechnologies Co | Intracellular delivery of biomolecules mediated by a pore surface |
| WO2017070169A1 (en) * | 2015-10-19 | 2017-04-27 | The Methodist Hospital | Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation |
| NZ783532A (en) | 2015-12-28 | 2025-09-26 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
| JP7033535B2 (en) | 2016-01-12 | 2022-03-10 | スクイーズ バイオテクノロジーズ カンパニー | Intracellular delivery of complex |
| WO2017173373A1 (en) | 2016-03-31 | 2017-10-05 | Massachusetts Institute Of Technology | Flow-through microfluidic methods and devices featuring membrane-perturbing surface interactions for intracellular delivery |
| IL262677B2 (en) | 2016-05-03 | 2025-08-01 | Sqz Biotechnologies Co | Intracellular administration of biomolecules to suppress an immune response or induce tolerance to a particular antigen |
| EP3452062A1 (en) | 2016-05-03 | 2019-03-13 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| CN106378213B (en) * | 2016-05-05 | 2018-08-17 | 海南大学 | Deformable microparticle separating chips based on dielectrophoresis |
| WO2018039084A1 (en) | 2016-08-20 | 2018-03-01 | The Regents Of The University Of California | High-throughput system and method for the temporary permeablization of cells |
| WO2018089497A1 (en) * | 2016-11-08 | 2018-05-17 | Georgia Tech Research Corporation | Methods for convectively-driven intracellular delivery |
| TW201839136A (en) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | Composition and method for treating hemochromatosis |
| US11383241B2 (en) * | 2017-10-11 | 2022-07-12 | The Regents Of The University Of California | Mechano-node pore sensing |
| WO2019089034A1 (en) * | 2017-11-02 | 2019-05-09 | The Methodist Hospital | Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation |
| EP3720878A1 (en) | 2017-12-05 | 2020-10-14 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to modulate antibody production |
| WO2019126146A1 (en) | 2017-12-19 | 2019-06-27 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| IL320767A (en) | 2017-12-20 | 2025-07-01 | Stemcell Technologies Canada Inc | Cargo transfer system into a compartment |
| JP2019154314A (en) * | 2018-03-13 | 2019-09-19 | 国立大学法人九州大学 | Capillary chip and device comprising the same and introduction method of foreign material to cell |
| EP3556845A1 (en) | 2018-04-20 | 2019-10-23 | Cellix Limited | A method and device for transfecting cells |
| CN109351370B (en) * | 2018-11-21 | 2020-05-05 | 晶准生物医学(深圳)有限公司 | Microfluidic chip and cell screening method |
| AU2020212601A1 (en) | 2019-01-25 | 2021-09-09 | Sqz Biotechnologies Company | Anucleate cell-derived vaccines |
| EP3931309A4 (en) | 2019-02-28 | 2022-12-21 | SQZ Biotechnologies Company | Delivery of biomolecules to pbmcs to modify an immune response |
| DE102019108155B3 (en) | 2019-03-29 | 2020-06-04 | Leibniz-Institut Für Photonische Technologien E.V. | Micro drop retention assembly |
| CN113840906B (en) | 2019-04-08 | 2024-09-06 | Sqz生物技术公司 | Kit for use in a system for delivering a payload into a cell |
| WO2020207456A1 (en) * | 2019-04-11 | 2020-10-15 | The Chinese University Of Hong Kong | Systems and methods for controlled membrane disruption |
| WO2020232418A1 (en) * | 2019-05-15 | 2020-11-19 | Cellfe, Inc. | Intracellular delivery |
| WO2020252215A1 (en) | 2019-06-12 | 2020-12-17 | Cellfe, Inc. | Methods and systems for cell labeling and imaging |
| EP4077676A1 (en) | 2019-12-18 | 2022-10-26 | Novartis AG | Compositions and methods for the treatment of hemoglobinopathies |
| CN111413257B (en) * | 2020-01-21 | 2021-05-14 | 中国科学院电子学研究所 | Cell nucleus electrical property detection device and method |
| CA3177288A1 (en) | 2020-05-11 | 2021-11-18 | F.Hoffmann-La Roche Ag | Combination therapy with modified pbmcs and an immunoconjugate |
| EP4158039A4 (en) * | 2020-05-26 | 2024-11-13 | Transcytos, LLC | TRANSFECTION DEVICES AND METHODS |
| KR20230058388A (en) | 2020-07-29 | 2023-05-03 | 에스큐지 바이오테크놀로지스 컴퍼니 | A method for stimulating an immune response against mutant RAS using nucleated cells |
| US20250255961A1 (en) | 2020-07-29 | 2025-08-14 | Stemcell Technologies Canada Inc. | Methods to stimulate immune responses to mutant ras using nucleated cells |
| EP4232554A1 (en) | 2020-11-18 | 2023-08-30 | Cellfe, Inc. | Methods and systems for mechanoporation-based payload delivery into biological cells |
| US12227729B2 (en) | 2020-12-24 | 2025-02-18 | Cellfe, Inc. | Methods and systems for high-throughput cell processing |
| CA3203356A1 (en) | 2020-12-29 | 2022-07-07 | Oliver Rosen | Methods for treating cancers with activating antigen carriers |
| WO2022147428A1 (en) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | Microfluidic chip having increased throughput for use in a system for delivery of a payload into a cell |
| JP2024503277A (en) | 2020-12-29 | 2024-01-25 | スクイーズ バイオテクノロジーズ カンパニー | Formulation of activated antigen carriers |
| US12150982B2 (en) | 2020-12-29 | 2024-11-26 | Stemcell Technologies Canada Inc. | Formulations of PBMCs |
| JP2024502791A (en) | 2020-12-29 | 2024-01-23 | スクイーズ バイオテクノロジーズ カンパニー | High-throughput microfluidic chip with parallelized constrictions for perturbing cell membranes |
| WO2022147026A1 (en) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | METHODS FOR TREATING CANCERS WITH MODIFIED PBMCs |
| EP4359527A2 (en) | 2021-06-23 | 2024-05-01 | Novartis AG | Compositions and methods for the treatment of hemoglobinopathies |
| EP4377447A1 (en) | 2021-07-29 | 2024-06-05 | SQZ Biotechnologies Company | Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery |
| JP2024545582A (en) | 2021-11-11 | 2024-12-10 | ステムセル テクノロジーズ カナダ インコーポレイテッド | Methods for creating enhanced tumor-infiltrating lymphocytes by microfluidic delivery |
| JP2025517524A (en) | 2022-05-27 | 2025-06-05 | ステムセル テクノロジーズ カナダ インコーポレイテッド | Cartridge and device for use in a system for intracellular payload delivery - Patents.com |
| CA3262748A1 (en) | 2022-07-28 | 2024-02-01 | Stemcell Technologies Canada Inc. | Enhanced antigen presenting cell formulations |
| WO2024026492A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Methods for treating cancer with enhanced antigen presenting cells |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2502621C3 (en) | 1975-01-23 | 1978-09-14 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Measurement of elastic and dielectric properties of the membrane of living cells |
| US4376634A (en) | 1980-05-30 | 1983-03-15 | Mallinckrodt, Inc. | Assay kit having syringe, dilution device and reagents within sealed container |
| US4478824A (en) | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
| FR2569477B1 (en) | 1984-08-24 | 1987-01-02 | Descartes Universite Rene | APPARATUS AND METHOD FOR DETERMINING THE DEFORMABILITY OF RED BLOOD CELLS |
| JP2720161B2 (en) | 1988-02-01 | 1998-02-25 | 株式会社アドバンス | Cell deformability measuring device |
| JP2685544B2 (en) | 1988-11-11 | 1997-12-03 | 株式会社日立製作所 | Blood filter, blood test method, and blood test apparatus |
| JP2532707B2 (en) | 1990-03-08 | 1996-09-11 | 佑二 菊池 | Blood circuit, blood measuring apparatus and blood measuring method using the same |
| DK0528859T3 (en) | 1990-04-24 | 1998-09-14 | Flustat Pty Ltd | Oral vaccine which includes antigen attached to the surface of red blood cells |
| US5658892A (en) | 1993-01-15 | 1997-08-19 | The General Hospital Corporation | Compound delivery using high-pressure impulse transients |
| US6218166B1 (en) | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
| DK0814838T3 (en) | 1995-03-08 | 2003-09-15 | Scripps Research Inst | Antigen presenting system and activation of T cells |
| US6051409A (en) | 1995-09-25 | 2000-04-18 | Novartis Finance Corporation | Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells |
| US6133503A (en) | 1995-10-31 | 2000-10-17 | The Regents Of The University Of California | Mammalian artificial chromosomes and methods of using same |
| DE69626853T2 (en) | 1995-12-04 | 2004-02-19 | Puget Sound Blood Center And Programm, Seattle | Preparations containing non-immunogenic platelets and red blood cells |
| JP2000516911A (en) | 1996-03-28 | 2000-12-19 | ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ | Opsonin-enhanced cells and methods of modulating the immune response to antigens |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| EP0882448B1 (en) | 1997-05-05 | 2005-01-12 | DIDECO S.r.l. | Method of encapsulating biologically active agents within erythrocytes and apparatus therefor |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| SE9704076D0 (en) | 1997-11-06 | 1997-11-06 | Holdingbolaget Vid Goeteborgs | Method for permeabilization of cell structures and use thereof |
| GB9816583D0 (en) | 1998-07-31 | 1998-09-30 | Univ Ulster | Nucleic acid carrier |
| WO2000078920A1 (en) | 1999-06-21 | 2000-12-28 | The General Hospital Corporation | Methods and devices for cell culturing and organ assist systems |
| JP2002325572A (en) | 2000-12-25 | 2002-11-12 | Univ Osaka | How to introduce foreign substances |
| AU2002252073A1 (en) | 2001-02-22 | 2002-09-12 | The Scepens Eye Research Institute, Inc. | Tolerogenic antigen presenting cells and in treating immune-inflammatory conditions |
| WO2003020039A1 (en) | 2001-08-28 | 2003-03-13 | Rush-Presbyterian-St. Luke's Medical Center | Immune tolerance to predetermined antigens |
| CA2468424A1 (en) | 2001-11-27 | 2003-06-05 | Cecilia Farre | A method for combined parallel agent delivery and electroporation for cell structures and use thereof |
| US20030133922A1 (en) | 2002-01-15 | 2003-07-17 | Kasha John R. | Oral tolerance using allogeneic platelets in ITP |
| EP2365325A1 (en) | 2002-06-05 | 2011-09-14 | Panasonic Corporation | Device for measuring extracellular potential and method of manufacturing the device |
| GB0214528D0 (en) | 2002-06-24 | 2002-08-07 | Univ Aberdeen | Materials and methods for induction of immune tolerance |
| EP1587908A4 (en) | 2003-01-09 | 2008-02-20 | Invitrogen Corp | Cellular delivery and activation polypeptide-nucleic acid complexes |
| US20060134067A1 (en) | 2003-02-18 | 2006-06-22 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
| EP1780266A4 (en) | 2004-06-17 | 2009-09-09 | Ken Nakata | Cell culturing method by biomechanical stimulus load and its device |
| CA2574128C (en) | 2004-07-27 | 2012-10-09 | Dsm Ip Assets B.V. | Process for making a carbon nanotubes / ultra-high molar mass polyethylene composite fibre |
| FR2873925B1 (en) | 2004-08-05 | 2006-10-13 | Erytech Pharma Soc Par Actions | METHOD AND DEVICE FOR LYSE-RESCALING FOR THE INCORPORATION OF ACTIVE PRINCIPLE, IN PARTICULAR ASPARAGINASE OR INOSITOL HEXAPHOSPHATE, IN ERYTHROCYTES |
| ES2350895T3 (en) | 2004-08-19 | 2011-01-28 | University College Cardiff Consultants Limited | PREPARATION OF T GAMMA DELTA HUMAN CELLS PRESENTING ANTIGENS AND ITS USE IN IMMUNOTHERAPY. |
| US20060134772A1 (en) | 2004-11-18 | 2006-06-22 | The Regents Of The University Of California | System for locating cells and for cellular analysis |
| WO2006095330A2 (en) | 2005-03-10 | 2006-09-14 | Yeda Research And Development Co. Ltd. | Methods and immunogenic cell preparations for treating antigen-associated diseases |
| US7704743B2 (en) | 2005-03-30 | 2010-04-27 | Georgia Tech Research Corporation | Electrosonic cell manipulation device and method of use thereof |
| KR100760309B1 (en) | 2005-07-06 | 2007-10-05 | 한국과학기술원 | Microparticle Deformation Analyzer using Micro Filter |
| US7993821B2 (en) | 2005-08-11 | 2011-08-09 | University Of Washington | Methods and apparatus for the isolation and enrichment of circulating tumor cells |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| WO2007097934A2 (en) | 2006-02-17 | 2007-08-30 | Elusys Therapeutics, Inc. | Methods and compositions for using erythrocytes as carriers for delivery of drugs |
| US8293524B2 (en) | 2006-03-31 | 2012-10-23 | Fluxion Biosciences Inc. | Methods and apparatus for the manipulation of particle suspensions and testing thereof |
| US20070249038A1 (en) | 2006-04-21 | 2007-10-25 | Andrea Adamo | Microfluidic device for single cell targeted operations |
| EP2054499A2 (en) | 2006-08-17 | 2009-05-06 | Massachusetts Institute of Technology | Method and apparatus for microfluidic injection |
| WO2008098094A1 (en) | 2007-02-06 | 2008-08-14 | Network Biosystems, Inc. | Devices and methods for the performance of miniaturized in vitro assays |
| US20080311140A1 (en) | 2007-05-29 | 2008-12-18 | Baylor College Of Medicine | Antigen specific immunosuppression by dendritic cell therapy |
| US8841135B2 (en) * | 2007-06-20 | 2014-09-23 | University Of Washington | Biochip for high-throughput screening of circulating tumor cells |
| US8420891B2 (en) | 2007-06-21 | 2013-04-16 | National University Corporation Nagoya University | Method for introducing foreign substance into cell having cell wall |
| FR2919804B1 (en) | 2007-08-08 | 2010-08-27 | Erytech Pharma | COMPOSITION AND ANTI-TUMOR THERAPEUTIC VACCINE |
| GB0718160D0 (en) | 2007-09-18 | 2007-10-24 | Medical Res Council | Methods |
| EP2057998A1 (en) | 2007-10-31 | 2009-05-13 | Universitätsklinikum Hamburg-Eppendorf | Use of modified cells for the treatment of multiple sclerosis |
| KR100891487B1 (en) | 2007-11-01 | 2009-04-01 | 한국과학기술원 | Nuclear elimination system of oocytes or eggs based on microfluidic control technology |
| CN101874201B (en) | 2007-11-28 | 2012-08-15 | 柯尼卡美能达精密光学株式会社 | Blood fluidity measurement apparatus and blood fluidity measurement method |
| US20090280518A1 (en) | 2008-05-12 | 2009-11-12 | Massachusetts Institute Of Technology | System for high throughput measurement of mechanical properties of cells |
| JP5137129B2 (en) | 2008-07-23 | 2013-02-06 | 国立大学法人山口大学 | Measuring device for mechanical properties of blood cells |
| EP2321405A4 (en) | 2008-08-08 | 2012-09-12 | Agency Science Tech & Res | MICROFLUIDIC CONTINUOUS FLOW DEVICE |
| US8211656B2 (en) | 2008-08-13 | 2012-07-03 | The Invention Science Fund I, Llc | Biological targeting compositions and methods of using the same |
| US20110091973A1 (en) | 2008-12-09 | 2011-04-21 | Glaser Larry F | Modified and fusion enhanced erythrocytes, cells and uses thereof |
| US9157550B2 (en) | 2009-01-05 | 2015-10-13 | The Board Of Trustees Of The University Of Illinois | Microfluidic systems and methods |
| EP2405959A4 (en) | 2009-03-13 | 2013-10-16 | Univ Tufts | METHODS, APPARATUSES AND KITS FOR INTRODUCING GENETIC MATERIAL INTO LIVING CELLS |
| US9017991B2 (en) | 2009-03-13 | 2015-04-28 | Tufts University | Methods tip assemblies and kits for introducing material into cells |
| WO2010107399A1 (en) | 2009-03-20 | 2010-09-23 | Agency For Science, Technology And Research | Devices for separating cells and methods of using them |
| JP4849278B2 (en) | 2009-03-27 | 2012-01-11 | セイコーエプソン株式会社 | Cell treatment device, cell treatment cartridge, and body fluid treatment system |
| WO2010129671A2 (en) | 2009-05-08 | 2010-11-11 | Chauncey Sayre | Method of and apparatus for changing one type of cell into another type of cell |
| GB0909754D0 (en) | 2009-06-05 | 2009-07-22 | Magnani Mauro | Drug delivery systems |
| EP2449135B1 (en) | 2009-06-30 | 2016-01-06 | Sangamo BioSciences, Inc. | Rapid screening of biologically active nucleases and isolation of nuclease-modified cells |
| US20110300205A1 (en) | 2009-07-06 | 2011-12-08 | Novartis Ag | Self replicating rna molecules and uses thereof |
| KR101125060B1 (en) * | 2009-07-22 | 2012-03-21 | 한국과학기술원 | Microfluidic device of capturing particles and method of capturing particles using it |
| US9364831B2 (en) | 2009-08-08 | 2016-06-14 | The Regents Of The University Of California | Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting |
| JP5944318B2 (en) | 2009-10-27 | 2016-07-05 | エリテック・ファルマ | Composition for inducing specific immune tolerance |
| CN102791865B (en) | 2009-12-21 | 2015-07-01 | 凯津公司 | Improved techniques for transfecting protoplasts |
| JP5624629B2 (en) | 2009-12-23 | 2014-11-12 | サイトベラ,インコーポレイテッド | System and method for filtering particles |
| WO2011084882A2 (en) | 2010-01-05 | 2011-07-14 | Contrafect Corporation | Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria |
| US8844570B2 (en) | 2010-02-01 | 2014-09-30 | California Institute Of Technology | Generating binary states using a microfluidic channel |
| JP5704590B2 (en) | 2010-02-05 | 2015-04-22 | 国立大学法人東京農工大学 | Detection of circulating tumor cells using size-selective microcavity array |
| US9458489B2 (en) | 2010-03-04 | 2016-10-04 | Massachusetts Institute Of Technology | Microfluidics sorter for cell detection and isolation |
| US20110287948A1 (en) | 2010-03-22 | 2011-11-24 | Massachusetts Institute Of Technology | Measurement of material properties and related methods and compositions based on cytoadherence |
| JP6343147B2 (en) | 2010-08-30 | 2018-06-13 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Controlled release by shear for stenotic lesions and thrombolytic therapy |
| WO2015061458A1 (en) | 2013-10-22 | 2015-04-30 | Cellanyx Diagnostics, Inc. | Systems, devices and methods for microfluidic culturing, manipulation and analysis of tissues and cells |
| CN103261218B (en) | 2010-11-25 | 2020-08-14 | Imnate责任有限公司 | Use of immunogenic peptides in the prevention and/or treatment of diseases |
| EP2665540A1 (en) * | 2011-01-19 | 2013-11-27 | The University of British Columbia | Apparatus and method for particle separation |
| CA2828239C (en) | 2011-02-25 | 2020-10-06 | Recombinetics, Inc. | Genetically modified animals and methods for making the same |
| CN103502426B (en) | 2011-02-28 | 2018-03-13 | 哈佛大学校长及研究员协会 | Cell culture system |
| CA2836608C (en) | 2011-05-27 | 2016-10-11 | The University Of British Columbia | Microfluidic cell trap and assay apparatus for high-throughput analysis |
| MX2013013243A (en) | 2011-07-05 | 2014-05-30 | Sotio As | Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells. |
| US20130065314A1 (en) | 2011-08-25 | 2013-03-14 | Phytocentric Biotech Inc. | Algal transformation systems, compositions and methods |
| CN107058101B (en) | 2011-10-17 | 2021-06-01 | 麻省理工学院 | intracellular delivery |
| JP2015520194A (en) | 2012-06-07 | 2015-07-16 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Nanotherapy for drug targeting |
| US9255245B2 (en) | 2012-07-03 | 2016-02-09 | Agilent Technologies, Inc. | Sample probes and methods for sampling intracellular material |
| SG11201503059XA (en) | 2012-10-23 | 2015-06-29 | Toolgen Inc | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| CN102925337B (en) | 2012-11-08 | 2014-06-18 | 武汉友芝友生物制药有限公司 | Microfluid cell capturing chip and manufacture method thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| GB201300052D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-suppressive dendritic cells |
| GB201300049D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-stimulatory dendritic cells |
| WO2014120956A1 (en) | 2013-01-30 | 2014-08-07 | Asta Fluidic Technologies, Inc. | Microfluidic-based fetal red blood cell detection |
| US9725709B2 (en) | 2013-03-12 | 2017-08-08 | OpenCell Technologies, Inc. | Intracellular delivery and transfection methods and devices |
| CN105452471A (en) | 2013-03-15 | 2016-03-30 | 加利福尼亚大学董事会 | High-throughput cargo delivery into live cells using photothermal platforms |
| KR20140115560A (en) | 2013-03-21 | 2014-10-01 | 인하대학교 산학협력단 | Method of modifying characteristics of cells by mechanical stress and device for the same |
| WO2014165707A2 (en) | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
| KR101508974B1 (en) * | 2013-05-14 | 2015-04-07 | 한국과학기술연구원 | Device for detection of tumor cells and detecting method thereof |
| KR102386122B1 (en) | 2013-08-16 | 2022-04-14 | 메사추세츠 인스티튜트 오브 테크놀로지 | Selective delivery of material to cells |
| WO2015103331A1 (en) | 2013-12-31 | 2015-07-09 | Canon U.S. Life Sciences, Inc. | Methods and systems for continuous flow cell lysis in a microfluidic device |
| RU2736495C2 (en) | 2014-04-01 | 2020-11-17 | Рубиус Терапьютикс, Инк. | Method and compositions for immunomodulation |
| EP3800248A3 (en) | 2014-04-18 | 2021-08-04 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| EP3164482B1 (en) | 2014-07-03 | 2024-05-22 | Massachusetts Institute of Technology | Apparatus and method for optimization of cell electroporation |
| CA2964392A1 (en) | 2014-10-31 | 2016-05-06 | Massachussetts Institute Of Technology | Delivery of biomolecules to immune cells |
| CA2964138C (en) | 2014-11-14 | 2023-11-14 | Massachusetts Institute Of Technology | Disruption and field enabled delivery of compounds and compositions into cells |
| US9744533B2 (en) | 2014-12-10 | 2017-08-29 | Berkeley Lights, Inc. | Movement and selection of micro-objects in a microfluidic apparatus |
| HK1247241A1 (en) | 2015-01-07 | 2018-09-21 | 英迪公司 | A method for mechanical and hydrodynamic microfluidic transfection and apparatus therefor |
| AU2016206870B2 (en) | 2015-01-12 | 2022-02-17 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| US20180135012A1 (en) | 2015-05-13 | 2018-05-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
| GB201513278D0 (en) | 2015-07-03 | 2015-09-09 | Transimmune Ag And Yale University | Device and method for obtaining immunostimulatory antigen-presenting cells |
| CA2988996A1 (en) | 2015-07-09 | 2017-01-12 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| ES2930017T3 (en) | 2015-09-04 | 2022-12-05 | Sqz Biotechnologies Co | Intracellular delivery of biomolecules mediated by a pore surface |
| EP3393482A4 (en) | 2015-12-22 | 2019-08-21 | Sangui Bio Pty. Ltd | Therapeutic methods using erythrocytes |
| RS62939B1 (en) | 2016-01-11 | 2022-03-31 | Rubius Therapeutics Inc | Compositions and methods related to multimodal therapeutic cell systems for cancer indications |
| JP7033535B2 (en) | 2016-01-12 | 2022-03-10 | スクイーズ バイオテクノロジーズ カンパニー | Intracellular delivery of complex |
| EP3452062A1 (en) | 2016-05-03 | 2019-03-13 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| IL262677B2 (en) | 2016-05-03 | 2025-08-01 | Sqz Biotechnologies Co | Intracellular administration of biomolecules to suppress an immune response or induce tolerance to a particular antigen |
| US20170326213A1 (en) | 2016-05-16 | 2017-11-16 | Augusta University Research Institute, Inc. | Protein-Coupled Red Blood Cell Compositions and Methods of Their Use |
| CN106244543A (en) | 2016-07-29 | 2016-12-21 | 北京时合生物科技有限公司 | A kind of method that PBMC Differentiation Induction in vitro becomes dendritic cell |
| WO2018089497A1 (en) | 2016-11-08 | 2018-05-17 | Georgia Tech Research Corporation | Methods for convectively-driven intracellular delivery |
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