SG10201710218RA - Sc-beta cells and compositions and methods for generating the same - Google Patents
Sc-beta cells and compositions and methods for generating the sameInfo
- Publication number
- SG10201710218RA SG10201710218RA SG10201710218RA SG10201710218RA SG10201710218RA SG 10201710218R A SG10201710218R A SG 10201710218RA SG 10201710218R A SG10201710218R A SG 10201710218RA SG 10201710218R A SG10201710218R A SG 10201710218RA SG 10201710218R A SG10201710218R A SG 10201710218RA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- generating
- methods
- same
- beta cells
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/38—Vitamins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/395—Thyroid hormones
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361833898P | 2013-06-11 | 2013-06-11 | |
| US201461972212P | 2014-03-28 | 2014-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201710218RA true SG10201710218RA (en) | 2018-01-30 |
Family
ID=52022750
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201710218RA SG10201710218RA (en) | 2013-06-11 | 2014-06-11 | Sc-beta cells and compositions and methods for generating the same |
| SG11201510176VA SG11201510176VA (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| SG11201510177WA SG11201510177WA (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201510176VA SG11201510176VA (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| SG11201510177WA SG11201510177WA (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
Country Status (17)
| Country | Link |
|---|---|
| US (16) | US20170029778A1 (en) |
| EP (4) | EP4461806A3 (en) |
| JP (8) | JP6677634B2 (en) |
| KR (12) | KR102773841B1 (en) |
| CN (5) | CN120796168A (en) |
| AU (6) | AU2014284677B2 (en) |
| BR (2) | BR112015030946A8 (en) |
| CA (2) | CA2915091A1 (en) |
| DE (2) | DE202014011287U1 (en) |
| DK (1) | DK3008168T3 (en) |
| GB (3) | GB2531952C (en) |
| HK (1) | HK1257187B (en) |
| MX (2) | MX2015017103A (en) |
| PH (1) | PH12015502767A1 (en) |
| RU (2) | RU2016100219A (en) |
| SG (3) | SG10201710218RA (en) |
| WO (2) | WO2014201167A1 (en) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2185693B1 (en) | 2007-07-31 | 2019-07-03 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| CN107574142B (en) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | Differentiation of human embryonic stem cells |
| SG11201403473QA (en) | 2011-12-22 | 2014-10-30 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| KR101942769B1 (en) | 2012-12-31 | 2019-01-28 | 얀센 바이오테크 인코포레이티드 | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| WO2014168973A2 (en) * | 2013-04-08 | 2014-10-16 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating skeletal muscle stem cells |
| CN120796168A (en) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-beta cells, compositions and methods for producing the same |
| CN117821369A (en) | 2014-05-16 | 2024-04-05 | 詹森生物科技公司 | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells |
| WO2016100930A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
| US20160175363A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived beta cells and uses thereof |
| US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100857A1 (en) * | 2014-12-19 | 2016-06-23 | Regeneron Pharmaceuticals, Inc. | Stem cells for modeling type 2 diabetes |
| EP3286563B1 (en) | 2015-04-23 | 2022-11-02 | The Regents of The University of California | Controlled induction of human pancreatic progenitors produces functional beta-like cells |
| EP3285572B1 (en) * | 2015-04-24 | 2020-12-02 | University of Copenhagen | Method for production of insulin-producing cells |
| EP3286300B1 (en) * | 2015-04-24 | 2020-10-21 | University of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| EP3328404A4 (en) * | 2015-07-27 | 2018-12-26 | The Regents of The University of California | Methods and compositions for producing pancreatic beta cells |
| US11499140B2 (en) * | 2015-10-29 | 2022-11-15 | Juntendo Educational Foundation | Method for producing pancreatic endocrine cells, and transdifferentiation agent |
| EP3386543B1 (en) | 2015-11-10 | 2021-07-21 | City of Hope | Conditioning regimens and methods for inducing mixed chimerism |
| US20190000889A1 (en) * | 2015-12-31 | 2019-01-03 | City Of Hope | Methods for treating diabetes |
| EP3949979A1 (en) * | 2016-01-06 | 2022-02-09 | President and Fellows of Harvard College | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
| US20190018000A1 (en) | 2016-01-12 | 2019-01-17 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| AU2017213795A1 (en) | 2016-02-01 | 2018-08-16 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
| WO2017144695A1 (en) * | 2016-02-24 | 2017-08-31 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| CA3014662A1 (en) * | 2016-03-02 | 2017-09-08 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgf-beta inhibition |
| MA45329A (en) * | 2016-04-08 | 2019-02-13 | Univ California | PRODUCTION OF FULLY FUNCTIONAL MATURE BETA CELLS FROM HUMAN PANCREATIC PROGENITORS |
| US20190151371A1 (en) * | 2016-06-09 | 2019-05-23 | Georgetown University | Process for continuous cell culture of islet cells |
| MA45502A (en) * | 2016-06-21 | 2019-04-24 | Janssen Biotech Inc | GENERATION OF FUNCTIONAL BETA CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS WITH GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE |
| WO2018094114A2 (en) * | 2016-11-16 | 2018-05-24 | Allele Biotechnology & Pharmaceuticals, Inc. | Induction of pancreatic beta cells by stem cell differentiation with rna |
| US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| KR101745297B1 (en) | 2017-02-02 | 2017-06-09 | 경북대학교 산학협력단 | Composition for diagnosis of obesity and uses thereof |
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| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| IL313825B2 (en) | 2017-06-14 | 2025-07-01 | Vertex Pharma | Devices and methods for delivering therapeutics |
| WO2019005871A1 (en) * | 2017-06-26 | 2019-01-03 | City Of Hope | Methods of islet cell culture |
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