SG10201705673QA - Polymorphs Of 2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4] Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide, Methods Of Production, And Pharmaceutical Uses Thereof - Google Patents

Polymorphs Of 2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4] Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide, Methods Of Production, And Pharmaceutical Uses Thereof

Info

Publication number: SG10201705673QA
Authority: SG; Singapore
Prior art keywords: oxazepin; methylpropanamide; dihydrobenzo; polymorphs; imidazo
Prior art date: 2013-12-16

Application number

SG10201705673QA

Inventor

Jeffrey Stults

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-16

Filing date

2014-12-15

Publication date

2017-08-30

2014-12-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2017-08-30 Publication of SG10201705673QA publication Critical patent/SG10201705673QA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

SG10201705673QA 2013-12-16 2014-12-15 Polymorphs Of 2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4] Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide, Methods Of Production, And Pharmaceutical Uses Thereof SG10201705673QA (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361916657P	2013-12-16	2013-12-16

Publications (1)

Publication Number	Publication Date
SG10201705673QA true SG10201705673QA (en)	2017-08-30

Family

ID=52023532

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SG11201604903VA SG11201604903VA (en)	2013-12-16	2014-12-15	Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
SG10201705669QA SG10201705669QA (en)	2013-12-16	2014-12-15	Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
SG10201705673QA SG10201705673QA (en)	2013-12-16	2014-12-15	Polymorphs Of 2-(4-(2-(1-Isopropyl-3-Methyl-1H-1,2,4-Triazol-5-Yl)-5,6-Dihydrobenzo[F]Imidazo[1,2-D][1,4] Oxazepin-9-Yl)-1H-Pyrazol-1-Yl)-2-Methylpropanamide, Methods Of Production, And Pharmaceutical Uses Thereof

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
SG11201604903VA SG11201604903VA (en)	2013-12-16	2014-12-15	Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
SG10201705669QA SG10201705669QA (en)	2013-12-16	2014-12-15	Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof

Country Status (16)

Country	Link
US (2)	US9266903B2 (en)
EP (1)	EP3083640A1 (en)
JP (2)	JP6302089B2 (en)
KR (2)	KR20180093138A (en)
CN (2)	CN109293674A (en)
AR (1)	AR098762A1 (en)
AU (3)	AU2014365079B2 (en)
BR (1)	BR112016009665A8 (en)
CA (1)	CA2927125A1 (en)
IL (2)	IL244915A0 (en)
MX (1)	MX356804B (en)
RU (2)	RU2018119749A (en)
SG (3)	SG11201604903VA (en)
TW (2)	TWI638818B (en)
WO (1)	WO2015091305A1 (en)
ZA (1)	ZA201602534B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3314265B1 (en) *	2015-06-29	2019-07-24	H. Hoffnabb-La Roche Ag	Methods of treatment with taselisib
MX377955B (en) *	2015-06-30	2025-03-10	Genentech Inc	IMMEDIATE-RELEASE TABLETS CONTAINING A DRUG AND PROCESSES FOR FORMING THE TABLETS
EP4534148A3 (en)	2017-04-28	2025-05-21	F. Hoffmann-La Roche AG	Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production
WO2019064071A1 (en) *	2017-09-27	2019-04-04	F. Hoffmann-La Roche Ag	Crystalline forms of diazabicyclooctane derivatives and production process thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20121025A1 (en) *	2009-09-28	2012-08-06	Hoffmann La Roche	BENZOXAZEPINE COMPOUNDS AS P13K INHIBITORS
NZ702244A (en) *	2012-06-08	2017-06-30	Hoffmann La Roche	Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
EP3404032B1 (en) *	2013-03-13	2025-07-02	F. Hoffmann-La Roche AG	Process for making benzoxazepin compounds

2014
- 2014-12-15 RU RU2018119749A patent/RU2018119749A/en unknown
- 2014-12-15 AU AU2014365079A patent/AU2014365079B2/en not_active Ceased
- 2014-12-15 SG SG11201604903VA patent/SG11201604903VA/en unknown
- 2014-12-15 EP EP14811921.7A patent/EP3083640A1/en not_active Withdrawn
- 2014-12-15 CA CA2927125A patent/CA2927125A1/en not_active Abandoned
- 2014-12-15 US US14/570,019 patent/US9266903B2/en active Active
- 2014-12-15 JP JP2016558275A patent/JP6302089B2/en active Active
- 2014-12-15 AR ARP140104667A patent/AR098762A1/en unknown
- 2014-12-15 BR BR112016009665A patent/BR112016009665A8/en not_active Application Discontinuation
- 2014-12-15 SG SG10201705669QA patent/SG10201705669QA/en unknown
- 2014-12-15 KR KR1020187023324A patent/KR20180093138A/en not_active Withdrawn
- 2014-12-15 MX MX2016007581A patent/MX356804B/en active IP Right Grant
- 2014-12-15 CN CN201811256901.1A patent/CN109293674A/en active Pending
- 2014-12-15 CN CN201480068672.4A patent/CN105829323B/en active Active
- 2014-12-15 TW TW103143724A patent/TWI638818B/en not_active IP Right Cessation
- 2014-12-15 WO PCT/EP2014/077666 patent/WO2015091305A1/en not_active Ceased
- 2014-12-15 KR KR1020167015862A patent/KR101902664B1/en not_active Expired - Fee Related
- 2014-12-15 TW TW105143616A patent/TW201731852A/en unknown
- 2014-12-15 SG SG10201705673QA patent/SG10201705673QA/en unknown
- 2014-12-15 RU RU2016127039A patent/RU2658009C2/en not_active IP Right Cessation
2016
- 2016-01-08 US US14/991,658 patent/US9481690B2/en active Active
- 2016-04-05 IL IL244915A patent/IL244915A0/en unknown
- 2016-04-14 ZA ZA201602534A patent/ZA201602534B/en unknown
- 2016-11-14 IL IL248965A patent/IL248965A0/en unknown
2017
- 2017-06-06 AU AU2017203819A patent/AU2017203819B2/en not_active Ceased
- 2017-06-06 AU AU2017203817A patent/AU2017203817B2/en not_active Ceased
- 2017-12-20 JP JP2017244553A patent/JP2018080179A/en active Pending

Also Published As

Publication number	Publication date
KR20160075824A (en)	2016-06-29
AU2014365079B2 (en)	2017-07-06
BR112016009665A8 (en)	2020-04-07
AR098762A1 (en)	2016-06-15
JP2016540834A (en)	2016-12-28
RU2658009C2 (en)	2018-06-19
SG11201604903VA (en)	2016-07-28
MX2016007581A (en)	2016-10-04
AU2017203817B2 (en)	2018-10-18
JP6302089B2 (en)	2018-03-28
KR20180093138A (en)	2018-08-20
US20160222027A1 (en)	2016-08-04
AU2017203819B2 (en)	2018-10-18
CN105829323A (en)	2016-08-03
US20150166570A1 (en)	2015-06-18
TW201534610A (en)	2015-09-16
WO2015091305A1 (en)	2015-06-25
CN109293674A (en)	2019-02-01
IL248965A0 (en)	2017-01-31
US9266903B2 (en)	2016-02-23
AU2014365079A1 (en)	2016-04-28
CN105829323B (en)	2019-04-12
TW201731852A (en)	2017-09-16
CA2927125A1 (en)	2015-06-25
SG10201705669QA (en)	2017-08-30
AU2017203819A1 (en)	2017-06-22
JP2018080179A (en)	2018-05-24
US9481690B2 (en)	2016-11-01
KR101902664B1 (en)	2018-09-28
TWI638818B (en)	2018-10-21
HK1223101A1 (en)	2017-07-21
MX356804B (en)	2018-06-13
RU2018119749A (en)	2018-11-09
EP3083640A1 (en)	2016-10-26
IL244915A0 (en)	2016-05-31
AU2017203817A1 (en)	2017-06-22
RU2016127039A (en)	2018-01-23
ZA201602534B (en)	2019-10-30

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