[go: up one dir, main page]

SG10201705514WA - Targeted conjugates encapsulated in particles and formulations thereof - Google Patents

Targeted conjugates encapsulated in particles and formulations thereof

Info

Publication number
SG10201705514WA
SG10201705514WA SG10201705514WA SG10201705514WA SG10201705514WA SG 10201705514W A SG10201705514W A SG 10201705514WA SG 10201705514W A SG10201705514W A SG 10201705514WA SG 10201705514W A SG10201705514W A SG 10201705514WA SG 10201705514W A SG10201705514W A SG 10201705514WA
Authority
SG
Singapore
Prior art keywords
formulations
particles
targeted conjugates
encapsulated
conjugates encapsulated
Prior art date
Application number
SG10201705514WA
Inventor
Mark T Bilodeau
Sudhakar Kadiyala
Rajesh Shinde
Brian White
Richard Wooster
Timothy Edward Barder
Benoît Moreau
Original Assignee
Tarveda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tarveda Therapeutics Inc filed Critical Tarveda Therapeutics Inc
Publication of SG10201705514WA publication Critical patent/SG10201705514WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
SG10201705514WA 2012-12-28 2013-12-30 Targeted conjugates encapsulated in particles and formulations thereof SG10201705514WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261746866P 2012-12-28 2012-12-28

Publications (1)

Publication Number Publication Date
SG10201705514WA true SG10201705514WA (en) 2017-08-30

Family

ID=49998713

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201705514WA SG10201705514WA (en) 2012-12-28 2013-12-30 Targeted conjugates encapsulated in particles and formulations thereof
SG11201504235UA SG11201504235UA (en) 2012-12-28 2013-12-30 Targeted conjugates encapsulated in particles and formulations thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201504235UA SG11201504235UA (en) 2012-12-28 2013-12-30 Targeted conjugates encapsulated in particles and formulations thereof

Country Status (14)

Country Link
US (5) US20140187501A1 (en)
EP (1) EP2938364A1 (en)
JP (2) JP6118914B2 (en)
KR (1) KR20150100706A (en)
CN (2) CN110179995A (en)
AU (2) AU2013369982B2 (en)
CA (1) CA2896571C (en)
HK (1) HK1217085A1 (en)
IL (1) IL238994B (en)
MX (1) MX360098B (en)
MY (1) MY172519A (en)
SG (2) SG10201705514WA (en)
WO (1) WO2014106208A1 (en)
ZA (1) ZA201504109B (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ583931A (en) 2007-08-17 2012-06-29 Purdue Research Foundation Psma binding ligand-linker conjugates and methods for using
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
KR102575825B1 (en) 2012-11-15 2023-09-06 엔도사이트, 인코포레이티드 Conjugates for treating diseases caused by psma expressing cells
MY172519A (en) * 2012-12-28 2019-11-28 Tarveda Therapeutics Inc Solid polymeric controlled release nanoparticle
SG11201602249RA (en) 2013-10-18 2016-05-30 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
EA035171B1 (en) 2013-11-14 2020-05-08 Эндосайт, Инк. Conjugates based on psma binding ligands or psma inhibitors for positron emission tomography
WO2015102922A1 (en) * 2013-12-31 2015-07-09 Blend Therapeutics, Inc. Compounds, compositions, and methods for the treatment of cancers
KR102533331B1 (en) * 2014-12-01 2023-05-17 이노우프 파르마, 에스.엘. Nanoparticles for encapsulating compounds, the preparation and uses thereof
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
EP3265063A4 (en) 2015-03-03 2018-11-07 Cureport, Inc. Dual loaded liposomal pharmaceutical formulations
WO2016141167A1 (en) 2015-03-03 2016-09-09 Cureport, Inc. Combination liposomal pharmaceutical formulations
CN107708676A (en) * 2015-06-30 2018-02-16 塔弗达治疗有限公司 Targeted conjugates and particles and formulations thereof
EP3328377A4 (en) * 2015-07-31 2019-03-13 Tarveda Therapeutics, Inc. COMPOSITIONS AND METHODS FOR IMMUNO-ONCOLOGICAL THERAPIES
EP3353309A4 (en) * 2015-09-25 2019-04-10 Tarveda Therapeutics, Inc. COMPOSITIONS AND METHODS FOR GENOMIC EDITION
HRP20210183T1 (en) 2015-09-30 2021-04-30 Deutsches Krebsforschungszentrum 18f-tagged inhibitors of prostate specific membrane antigen (psma) and their use as imaging agents for prostate cancer
WO2017062657A1 (en) 2015-10-06 2017-04-13 University Of Wahsington Oxygen reactive polymers for treatment of traumatic brain injury
AU2016343817B2 (en) * 2015-10-28 2021-05-27 Tva (Abc), Llc SSTR-targeted conjugates and particles and formulations thereof
CN106957422B (en) * 2015-12-31 2020-07-07 南京绿叶制药有限公司 Phospholipid-polyethylene glycol-PSMA ligand compound and preparation method thereof
WO2017147240A1 (en) 2016-02-23 2017-08-31 Tarveda Therapeutics, Inc. Hsp90 targeted conjugates and particles and formulations thereof
US10744212B2 (en) 2016-03-14 2020-08-18 General Electric Company Topical application of nerve labeling dyes for image-guided surgery
EP3491374B1 (en) * 2016-07-28 2024-10-09 Waters Technologies Corporation Encapsulated pre-analytic workflow reagents for flow-through devices, liquid chromatography and mass spectrometric analysis
WO2018022957A1 (en) * 2016-07-29 2018-02-01 Tarveda Therapeutics, Inc. T cell binding conjugates and methods of use
WO2018112176A1 (en) * 2016-12-14 2018-06-21 Tarveda Therapeutics, Inc. Hsp90-targeting conjugates and formulations thereof
JP7112409B2 (en) * 2017-01-24 2022-08-03 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Compositions Comprising Anti-Fel D1 Antibodies and Methods of Reducing At Least One Symptom of Cat Allergy in Humans
US11358994B2 (en) 2017-07-27 2022-06-14 Saint Louis University Fatty acid modified human epidermal growth factor
EP3706801A4 (en) * 2017-11-08 2022-04-06 L.E.A.F Holdings Group LLC PLATINUM COMPLEXES AND THEIR USES
CN111712468A (en) 2017-12-22 2020-09-25 北卡罗莱纳州立大学 Polymeric fluorophores, compositions containing the same, and methods of making and using the same
BR112020020961A2 (en) 2018-04-17 2021-01-19 Endocyte, Inc. CANCER TREATMENT METHODS
CN112272519B (en) * 2018-05-27 2023-01-06 以色列国家农业部、农村发展农业研究组织 Single unit body encapsulation via pickering emulsions for biopesticides
US12357580B2 (en) 2018-06-19 2025-07-15 The Board Of Regents Of The University Of Texas System Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
US12194014B2 (en) 2018-06-21 2025-01-14 NanoMed Holdings Pty Ltd Platinum-based amphiphile prodrugs
WO2020005767A1 (en) * 2018-06-25 2020-01-02 The Board Of Regents Of The University Of Oklahoma Conjugates with internal and terminal-end heparosan linkages
AU2019336679B2 (en) 2018-09-04 2025-05-29 The Board Of Regents Of The University Of Texas System Compositions and methods for organ specific delivery of nucleic acids
GB2600800B (en) * 2018-09-04 2023-08-16 Univ Texas Compositions and methods for organ specific delivery of nucleic acids
CN109289053B (en) * 2018-09-30 2020-10-13 浙江大学 Cabazitaxel-oligo/polylactic acid coupled prodrug, preparation method and application thereof
US11541007B2 (en) * 2019-05-16 2023-01-03 Megapro Biomedical Co., Ltd. Pharmaceutical compositions containing mixed polymeric micelles
CN120097929A (en) 2019-05-20 2025-06-06 因多塞特股份有限公司 Method for preparing PSMA conjugates
US20220257766A1 (en) * 2019-06-25 2022-08-18 Tva (Abc), Llc Sstr-targeted conjugates and formulations thereof
CN110974972B (en) * 2019-12-03 2023-01-20 沈阳药科大学 Weakly acidic derivatives of poorly soluble drugs and liposome preparations thereof
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
KR20210116339A (en) * 2020-03-16 2021-09-27 주식회사 바이오이즈 Particles encapsulated in a targeted aptamer conjugate and its use
CN111888332B (en) * 2020-06-19 2023-07-25 杭州师范大学 A kind of cabazitaxel flexible emulsion and preparation method thereof
WO2022006269A1 (en) * 2020-06-30 2022-01-06 The Johns Hopkins University Non-intuitive combination of drug delivery carriers of the same drug for synergistic growth delay of solid tumors
US11896713B2 (en) * 2020-10-22 2024-02-13 Rutgers, The State University Of New Jersey Strategies to enhance lung cancer treatment
CN113087787B (en) * 2021-05-19 2023-03-21 广西医科大学第二附属医院(广西医科大学第二临床医学院) Earthworm hemoglobin separation and purification method
EP4282435A1 (en) * 2022-05-23 2023-11-29 Danmarks Tekniske Universitet Formulations of active pharmaceutical ingredients and excipients in icells via hydrophobic ion pairing
CN116440267A (en) * 2023-04-10 2023-07-18 浙江大学 Ultrasound-excited nano-droplet antimicrobial peptide loaded with antimicrobial peptide on its surface
WO2025029623A2 (en) * 2023-07-28 2025-02-06 The Children's Medical Center Corporation Light-triggered polymer-naloxone conjugate for opioid reversal

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030049203A1 (en) * 2001-08-31 2003-03-13 Elmaleh David R. Targeted nucleic acid constructs and uses related thereto
US20030109682A1 (en) * 2001-09-07 2003-06-12 Daniel Santi Maytansines and maytansine conjugates
US20040220081A1 (en) * 2002-10-30 2004-11-04 Spherics, Inc. Nanoparticulate bioactive agents
US7232805B2 (en) * 2003-09-10 2007-06-19 Inflabloc Pharmaceuticals, Inc. Cobalamin conjugates for anti-tumor therapy
WO2005118612A1 (en) * 2004-06-04 2005-12-15 Sonus Pharmaceuticals, Inc. Cholesterol/bile acid/bile acid derivative-modified therapeutic anti-cancer drugs
JP2008508291A (en) * 2004-07-27 2008-03-21 ギリアード サイエンシーズ， インコーポレイテッド Nucleoside phosphonate conjugates as anti-HIV agents
EP1700608A1 (en) * 2005-03-10 2006-09-13 Schering AG Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
EP1745802A1 (en) * 2005-07-20 2007-01-24 Kreatech Biotechnology B.V. Method of conjugating therapeutic compounds to cell targeting moieties via metal complexes
EP2019691B1 (en) * 2006-05-15 2020-08-12 Massachusetts Institute of Technology Polymers for functional particles
ES2647538T3 (en) * 2007-09-28 2017-12-22 Pfizer Inc. Addressing to cancer cells using nanoparticles
CN101835803B (en) * 2007-10-19 2016-05-25 健泰科生物技术公司 Cysteine engineered anti-tenb 2 antibodies and antibody drug conjugates
EP2303337A4 (en) * 2008-06-13 2014-09-03 Cedars Sinai Medical Center MEDICAMENT-LIGAND SMALL MOLECULE CONJUGATES FOR TARGETED CANCER TREATMENT
US20110105417A1 (en) * 2008-06-26 2011-05-05 The Curators Of The University Of Missouri Drug Conjugates
US8603532B2 (en) * 2008-10-20 2013-12-10 Massachusetts Institute Of Technology Nanostructures for drug delivery
US8470980B2 (en) * 2009-09-09 2013-06-25 Centrose, Llc Extracellular targeted drug conjugates
KR20130097636A (en) * 2010-04-15 2013-09-03 올리가시스 High molecular weight zwitterion-containing polymers
WO2012030745A1 (en) * 2010-08-30 2012-03-08 Access Pharmaecuticals, Inc MULTIVITAMIN TARGETING OF RNAi THERAPEUTICS
FR2967581B1 (en) * 2010-11-19 2012-12-28 Sanofi Aventis POLYMERIC CONJUGATES OF ACTIVE INGREDIENTS, PROCESS FOR THEIR PREPARATION AND POLYMERIC INTERMEDIATES
AU2012239943B2 (en) * 2011-04-07 2016-09-22 The Scripps Research Institute High-throughput screening for compounds modulating expression of cellular macromolecules
US20140308363A1 (en) * 2011-05-31 2014-10-16 Bind Therapeutics, Inc. Drug loaded polymeric nanoparticles and methods of making and using same
MY172519A (en) * 2012-12-28 2019-11-28 Tarveda Therapeutics Inc Solid polymeric controlled release nanoparticle

Also Published As

Publication number Publication date
AU2013369982A1 (en) 2015-06-18
CN104936622B (en) 2019-05-28
CN104936622A (en) 2015-09-23
KR20150100706A (en) 2015-09-02
WO2014106208A1 (en) 2014-07-03
CA2896571C (en) 2017-11-21
US20140187501A1 (en) 2014-07-03
IL238994B (en) 2019-07-31
MY172519A (en) 2019-11-28
US20180021454A1 (en) 2018-01-25
IL238994A0 (en) 2015-07-30
JP2017105855A (en) 2017-06-15
CA2896571A1 (en) 2014-07-03
AU2017200510A1 (en) 2017-02-16
EP2938364A1 (en) 2015-11-04
US20200121808A1 (en) 2020-04-23
US20160074526A1 (en) 2016-03-17
ZA201504109B (en) 2019-10-30
MX2015008503A (en) 2016-01-22
AU2013369982B2 (en) 2016-11-17
US20220288229A1 (en) 2022-09-15
JP2016505609A (en) 2016-02-25
SG11201504235UA (en) 2015-07-30
CN110179995A (en) 2019-08-30
HK1217085A1 (en) 2016-12-23
MX360098B (en) 2018-10-22
JP6118914B2 (en) 2017-04-19

Similar Documents

Publication Publication Date Title
ZA201504109B (en) Targeted conjugates encapsulated in particles and formulations thereof
IL245268A0 (en) Pyrrolobenzodiazepines and conjugates thereof
ZA201501781B (en) Pyrrolobenzodiazepines and conjugates thereof
IL238567A0 (en) Anti-notch3 antibodies and antibody-drug conjugates
IL237522A0 (en) Bioconjugates comprising modified antigens and uses thereof
IL237287A0 (en) Antibody formulations and uses thereof
IL236527A0 (en) Etanercept formulations exhibiting marked reduction in sub-visible particles
EP2811980A4 (en) Polymer-agent conjugates, particles, compositions, and related methods of use
ZA201501124B (en) Trans-clomiphene formulations and uses thereof
HUE13837694T1 (en) Daptomycin formulations and uses thereof
EP2901038A4 (en) Suspension device in agricultural implement and agricultural implement comprising such suspension device
IL235167A0 (en) Bis-polymer lipid-peptide conjugates and nanoparticles thereof