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SG10201703385YA - Discontinuous fed batch processing with the use of alternating bioreactors - Google Patents

Discontinuous fed batch processing with the use of alternating bioreactors

Info

Publication number
SG10201703385YA
SG10201703385YA SG10201703385YA SG10201703385YA SG10201703385YA SG 10201703385Y A SG10201703385Y A SG 10201703385YA SG 10201703385Y A SG10201703385Y A SG 10201703385YA SG 10201703385Y A SG10201703385Y A SG 10201703385YA SG 10201703385Y A SG10201703385Y A SG 10201703385YA
Authority
SG
Singapore
Prior art keywords
batch processing
fed batch
bioreactors
alternating
discontinuous fed
Prior art date
Application number
SG10201703385YA
Inventor
Jacob Arthur Tijsterman
Original Assignee
Biosana Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosana Pty Ltd filed Critical Biosana Pty Ltd
Publication of SG10201703385YA publication Critical patent/SG10201703385YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201703385YA 2012-11-09 2013-11-08 Discontinuous fed batch processing with the use of alternating bioreactors SG10201703385YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2012050798 2012-11-09

Publications (1)

Publication Number Publication Date
SG10201703385YA true SG10201703385YA (en) 2017-05-30

Family

ID=47278493

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201601362VA SG11201601362VA (en) 2012-11-09 2013-11-08 Discontinuous fed batch processing with the use of alternating bioreactors
SG10201703385YA SG10201703385YA (en) 2012-11-09 2013-11-08 Discontinuous fed batch processing with the use of alternating bioreactors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201601362VA SG11201601362VA (en) 2012-11-09 2013-11-08 Discontinuous fed batch processing with the use of alternating bioreactors

Country Status (11)

Country Link
US (1) US9982226B2 (en)
EP (1) EP2917323A1 (en)
AU (1) AU2013341858B2 (en)
BR (1) BR112015010544B1 (en)
CA (1) CA2890813C (en)
MX (1) MX364790B (en)
MY (1) MY181264A (en)
RU (1) RU2639556C2 (en)
SG (2) SG11201601362VA (en)
TW (1) TWI637057B (en)
WO (1) WO2014073967A1 (en)

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JP5746025B2 (en) * 2008-07-16 2015-07-08 ケーセップ・システムズ，リミテッド・ライアビリティ・カンパニー Method and system for manipulating particles using a fluidized bed
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
MX376623B (en) 2013-10-11 2025-03-07 Regeneron Pharma METABOLICLY OPTIMIZED CELL CULTURE.
JP6695814B2 (en) 2014-06-04 2020-05-20 アムジエン・インコーポレーテツド Methods for harvesting mammalian cell cultures
CN114058599A (en) * 2016-07-25 2022-02-18 瑞普利金公司 Alternating tangential flow for fast harvesting
US11371007B2 (en) * 2018-02-09 2022-06-28 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
US11414639B2 (en) 2018-02-09 2022-08-16 Global Life Sciences Solutions Usa Llc Bioprocessing vessel
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US20210163868A1 (en) * 2018-05-22 2021-06-03 Nantkwest, Inc. Methods and systems for cell bed formation during bioprocessing
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
US10792618B2 (en) 2018-06-19 2020-10-06 Sartorius Stedim Biotech Gmbh Particle separation and/or purification of a fluid
TWI662122B (en) * 2018-07-12 2019-06-11 聯發生物科技股份有限公司 Fermentation equipment
GB201904083D0 (en) * 2019-03-25 2019-05-08 Ge Healthcare Bio Sciences Ab A bioreactor system
JP2023537670A (en) * 2020-07-28 2023-09-05 シージェン インコーポレイテッド Methods and systems for producing polypeptides
EP4056671A1 (en) * 2021-03-10 2022-09-14 Sartorius Stedim Biotech GmbH Method for operating a bioprocess installation
EP4124653A1 (en) * 2021-07-27 2023-02-01 Sartorius Stedim Biotech GmbH Method for producing a bioproduct
US20250179417A1 (en) * 2022-03-01 2025-06-05 Biosanapharma B.V. Continuous Manufacturing of a Biological Substance with Process Traceability
WO2024256454A2 (en) 2023-06-14 2024-12-19 Stobbe Gmbh Bioprocess system extending a biological process

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK309184D0 (en) * 1984-06-25 1984-06-25 Nordisk Insulinlab PROCEDURE FOR INSULATING INSULIN OR INSULINARY MATERIALS FROM A FERMENTING FLUID
DE3833925A1 (en) * 1988-03-11 1989-09-21 Inst Angewandte Biotechnologie PROCESS AND MANUFACTURE OF VIRUS AND VIRAL ANTIGEN AND DEVICE THEREFOR
RU2058992C1 (en) * 1993-07-14 1996-04-27 Антипин Георгий Васильевич Method for production of feed protein and device for its embodiment
CA2529385A1 (en) 2003-06-17 2005-01-27 Centocor, Inc. Method and apparatus for filtration of bioreactor recombinant proteins
WO2005035748A1 (en) * 2003-10-10 2005-04-21 Novo Nordisk Health Care Ag Method for large-scale production of a polypeptide in eukaryote cells and a culture vessel suitable therefor
EP1720972B1 (en) 2004-03-05 2014-01-08 DSM IP Assets B.V. Process for cell culturing by continuous perfusion and alternating tangential flow
PT2634243T (en) 2006-07-14 2017-12-18 Patheon Holdings I B V METHOD FOR IMPROVING CELL CULTURE
EP2188371B1 (en) * 2007-08-09 2017-12-20 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2009131659A1 (en) * 2008-04-22 2009-10-29 Boston Technology Consultants Group, Inc. Single use centrifuge system
JP5746025B2 (en) 2008-07-16 2015-07-08 ケーセップ・システムズ，リミテッド・ライアビリティ・カンパニー Method and system for manipulating particles using a fluidized bed
EP3391970B1 (en) 2009-10-06 2020-01-22 Sartorius Stedim North America Inc. Method and apparatus for manipulating particles
HUE035508T2 (en) * 2009-11-17 2018-05-02 Squibb & Sons Llc Procedures for Increased Protein Production
WO2012081931A2 (en) * 2010-12-17 2012-06-21 Kim Sung-Chun Method and apparatus for producing cells and fat soluble materials by cell culture

Also Published As

Publication number Publication date
US9982226B2 (en) 2018-05-29
TW201418468A (en) 2014-05-16
BR112015010544A2 (en) 2017-07-11
MY181264A (en) 2020-12-21
RU2639556C2 (en) 2017-12-21
CA2890813A1 (en) 2014-05-15
CA2890813C (en) 2022-07-12
MX2015005822A (en) 2016-02-10
TWI637057B (en) 2018-10-01
MX364790B (en) 2019-05-03
AU2013341858A1 (en) 2015-06-11
BR112015010544B1 (en) 2021-01-05
EP2917323A1 (en) 2015-09-16
US20150299644A1 (en) 2015-10-22
WO2014073967A1 (en) 2014-05-15
AU2013341858B2 (en) 2017-11-02
RU2016105100A (en) 2017-08-21
SG11201601362VA (en) 2016-04-28

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