[go: up one dir, main page]

SG10201609982PA - Pharmaceutical formulations of tnf-alpha anitbodies - Google Patents

Pharmaceutical formulations of tnf-alpha anitbodies

Info

Publication number
SG10201609982PA
SG10201609982PA SG10201609982PA SG10201609982PA SG10201609982PA SG 10201609982P A SG10201609982P A SG 10201609982PA SG 10201609982P A SG10201609982P A SG 10201609982PA SG 10201609982P A SG10201609982P A SG 10201609982PA SG 10201609982P A SG10201609982P A SG 10201609982PA
Authority
SG
Singapore
Prior art keywords
anitbodies
tnf
alpha
pharmaceutical formulations
formulations
Prior art date
Application number
SG10201609982PA
Inventor
Sanjeev Kumar Mendiratta
Sanjay Bandyopadhyay
Chintan G Patel
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48901138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201609982P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of SG10201609982PA publication Critical patent/SG10201609982PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201609982PA 2012-03-07 2013-03-05 Pharmaceutical formulations of tnf-alpha anitbodies SG10201609982PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN610MU2012 2012-03-07
IN1606MU2012 2012-05-30
IN3031MU2012 2012-10-17

Publications (1)

Publication Number Publication Date
SG10201609982PA true SG10201609982PA (en) 2017-01-27

Family

ID=48901138

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201405475UA SG11201405475UA (en) 2012-03-07 2013-03-05 Pharmaceutical formulations of tnf-alpha antibodies
SG10201609982PA SG10201609982PA (en) 2012-03-07 2013-03-05 Pharmaceutical formulations of tnf-alpha anitbodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201405475UA SG11201405475UA (en) 2012-03-07 2013-03-05 Pharmaceutical formulations of tnf-alpha antibodies

Country Status (19)

Country Link
US (3) US10093728B2 (en)
EP (3) EP2822591B1 (en)
JP (3) JP2015509526A (en)
KR (2) KR101730694B1 (en)
CN (1) CN104159614A (en)
AP (1) AP2014007922A0 (en)
AU (1) AU2013255413C1 (en)
BR (1) BR112014021325A2 (en)
CA (1) CA2866692A1 (en)
CL (1) CL2014002316A1 (en)
EA (1) EA201491644A1 (en)
HK (1) HK1200709A1 (en)
MX (2) MX363700B (en)
NZ (1) NZ629261A (en)
PH (1) PH12014501988B1 (en)
SG (2) SG11201405475UA (en)
TR (1) TR201810815T4 (en)
WO (1) WO2013164837A1 (en)
ZA (1) ZA201406414B (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
SG11201405475UA (en) * 2012-03-07 2014-10-30 Cadila Healthcare Ltd Pharmaceutical formulations of tnf-alpha antibodies
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
EP2863951A1 (en) * 2012-06-12 2015-04-29 Boehringer Ingelheim International GmbH Pharmaceutical formulation for a therapeutic antibody
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
MX2015003007A (en) 2012-09-07 2015-06-05 Coherus Biosciences Inc Stable aqueous formulations of adalimumab.
UA117466C2 (en) * 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. STABLE COMPOSITION IN THE VIEW OF AN ANTIBODY ANTIBODY TO IL-23p19
CA2905010A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
CN104707146B (en) * 2013-12-16 2019-04-16 浙江海正药业股份有限公司 A kind of pharmaceutical composition containing adalimumab
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US10688187B2 (en) 2014-04-02 2020-06-23 Intas Pharmaceuticals Ltd. Liquid pharmaceutical composition of adalimumab
ES2600488T3 (en) * 2014-05-23 2017-02-09 Ares Trading S.A. Liquid pharmaceutical composition
EP2946766B1 (en) 2014-05-23 2016-03-02 Ares Trading S.A. Liquid pharmaceutical composition
ES2607489T3 (en) 2014-05-23 2017-03-31 Ares Trading S.A. Liquid pharmaceutical composition
US9821059B2 (en) * 2014-10-17 2017-11-21 Alteogen Inc. Composition for stabilizing protein and pharmaceutical formulation comprising the same
HUP1400510A1 (en) * 2014-10-28 2016-05-30 Richter Gedeon Nyrt Pharmaceutical anti-tnfalpha antibody formulation
WO2016089946A1 (en) * 2014-12-02 2016-06-09 Biogen Ma Inc. Methods and compositions for controlling antibody aggregation
EP3227338A4 (en) 2014-12-04 2018-05-16 Janssen Biotech, Inc. Anti-cd38 antibodies for treatment of acute myeloid leukemia
AR103173A1 (en) 2014-12-22 2017-04-19 Novarits Ag PHARMACEUTICAL PRODUCTS AND STABLE LIQUID COMPOSITIONS OF ANTIBODIES IL-17
EP3053572A1 (en) * 2015-02-06 2016-08-10 Ares Trading S.A. Liquid pharmaceutical composition
WO2016162819A1 (en) 2015-04-07 2016-10-13 Lupin Limited Stable aqueous pharmaceutical composition of anti-tnf alpha antibody
CR20170526A (en) 2015-05-20 2018-04-03 Janssen Biotech Inc ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF LIGHT CHAIN AMYLOIDOSIS and OTHER POSITIVE HEMATOLOGICAL MALIGNAL DISEASES FOR CD38
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
PL3827845T3 (en) 2015-11-03 2022-07-11 Janssen Biotech, Inc. Subcutaneous formulations of anti-cd38 antibodies and their uses
EP4606820A3 (en) * 2015-11-30 2025-10-29 Medimmune, LLC Optimized ratios of amino acids and sugars as amorphous stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents
US10525137B2 (en) * 2015-12-30 2020-01-07 Genentech, Inc. Formulations with reduced degradation of polysorbate
JP6738608B2 (en) * 2016-01-22 2020-08-12 田中貴金属工業株式会社 Chromatographic media
GB201604124D0 (en) * 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
WO2017184880A1 (en) 2016-04-20 2017-10-26 Coherus Biosciences, Inc. A method of filling a container with no headspace
EP3479819B1 (en) * 2016-06-30 2024-01-24 Celltrion Inc. Stable liquid pharmaceutical preparation
FR3054444A1 (en) * 2016-07-29 2018-02-02 Laboratoire Francais Du Fractionnement Et Des Biotechnologies ORAL COMPOSITION OF ANTI-TNF ALPHA ANTIBODY
WO2018063963A1 (en) * 2016-09-28 2018-04-05 Board Of Regents, The University Of Texas System Antibody and protein therapeutic formulations and uses thereof
WO2018080196A2 (en) * 2016-10-28 2018-05-03 (주)셀트리온 Stable pharmaceutical formulation
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
KR102471458B1 (en) 2016-12-28 2022-11-25 제이씨알 파마 가부시키가이샤 Freeze-dried formulation
RU2665966C2 (en) * 2016-12-30 2018-09-05 Закрытое Акционерное Общество "Биокад" Recombinant monoclonal antibody to tnf-alpha aqueous pharmaceutical composition
JOP20190162A1 (en) * 2016-12-30 2019-06-27 Biocad Joint Stock Co Aqueous Pharmaceutical Composition of a Recombinant Monoclonal Antibody to TNF?
AU2018207367B2 (en) 2017-01-11 2024-02-15 Celltrion Inc. Stable Liquid Formula
US11608357B2 (en) 2018-08-28 2023-03-21 Arecor Limited Stabilized antibody protein solutions
EP3372242A1 (en) 2017-03-06 2018-09-12 Ares Trading S.A. Liquid pharmaceutical composition
EP3372241A1 (en) * 2017-03-06 2018-09-12 Ares Trading S.A. Liquid pharmaceutical composition
MY197202A (en) * 2017-03-16 2023-05-31 Lg Chemical Ltd A liquid formulation of anti-tnf alpha antibody
CN108686205B (en) * 2017-04-07 2021-12-10 海正生物制药有限公司 Lyophilized preparation of infliximab
CN108686204A (en) 2017-04-07 2018-10-23 浙江海正药业股份有限公司 Include the infliximab composition of histidine buffer system
JOP20190260A1 (en) 2017-05-02 2019-10-31 Merck Sharp & Dohme Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof
SG11201909955XA (en) 2017-05-02 2019-11-28 Merck Sharp & Dohme Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
CA3071930A1 (en) 2017-08-08 2019-02-14 Csl Behring Ag Hemopexin formulations
CA3079242A1 (en) 2017-10-31 2019-05-09 Janssen Biotech, Inc. Methods of treating high risk multiple myeloma
CN110151988A (en) * 2018-02-11 2019-08-23 百奥泰生物制药股份有限公司 A kind of human antibody preparation of targeted therapy TNF-α related disease
CN110302377B (en) * 2018-02-11 2020-04-17 百奥泰生物制药股份有限公司 Human antibody preparation for targeted therapy of TNF- α related diseases
EP3876990A4 (en) 2018-11-07 2023-09-06 Merck Sharp & Dohme LLC Co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
MX2021009851A (en) 2019-02-18 2021-09-10 Lilly Co Eli Therapeutic antibody formulation.
JP2022546400A (en) * 2019-08-30 2022-11-04 カシーヴ バイオサイエンシズ，リミテッド・ライアビリティ・カンパニー Novel formulations of high concentrations of pharmacologically active antibodies
US20220042977A1 (en) * 2020-08-04 2022-02-10 ProStabilis, Inc. Protein Solubility Screening Kits and Their Use
MX2023002063A (en) * 2020-08-20 2023-03-16 Momenta Pharmaceuticals Inc Sialylated glycoproteins.
WO2022111547A1 (en) * 2020-11-24 2022-06-02 The University Of Hong Kong Inhaled powder formulations for respiratory delivery of antibodies
WO2023036193A1 (en) * 2021-09-08 2023-03-16 同宜医药（苏州）有限公司 Pharmaceutical preparation, preparation method therefor and use thereof
WO2023043232A1 (en) * 2021-09-16 2023-03-23 주식회사 에이프로젠 PHARMACEUTICAL COMPOSITION CONTAINING ANTI-TNFα ANTIBODY
WO2024259656A1 (en) * 2023-06-21 2024-12-26 Shanghai Mabgeek Biotech Co., Ltd. Formulation of an anti-il-4 receptor alpha mab or an antigen-binding fragment thereof comprising 2hpbetacd and leucine
WO2025188845A1 (en) * 2024-03-05 2025-09-12 Zenas Biopharma, Inc. STABLE FORMULATIONS FOR TNFα ANTIBODIES AND USES THEREOF
CN118225545B (en) * 2024-05-23 2024-08-13 江西赛基生物技术有限公司 Recombinant human TNF-alpha protein freeze-dried pellet and preparation method and application thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US609382A (en) 1898-08-16 Cotton-chopper
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
DE69721548T2 (en) 1996-02-09 2004-04-01 Abbott Laboratories(Bermuda)Ltd. HUMAN ANTIBODIES THAT BIND TO HUMAN TNFalpha
EP0852951A1 (en) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stable lyophilized monoclonal or polyclonal antibodies containing pharmaceuticals
ATE454137T1 (en) * 2001-07-25 2010-01-15 Facet Biotech Corp STABLE LYOPHILIZED PHARMACEUTICAL FORMULATION OF THE IGG ANTIBODY DACLIZUMAB
US20030180287A1 (en) * 2002-02-27 2003-09-25 Immunex Corporation Polypeptide formulation
US20040033228A1 (en) * 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
AU2003293543A1 (en) * 2002-12-13 2004-07-09 Abgenix, Inc. System and method for stabilizing antibodies with histidine
AU2007212147A1 (en) 2006-02-03 2007-08-16 Medimmune, Llc Protein formulations
KR101440795B1 (en) * 2006-06-30 2014-09-22 애브비 바이오테크놀로지 리미티드 Automatic injection device
US20080254029A1 (en) * 2007-04-11 2008-10-16 Alcon Research, Ltd. Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis
PE20091174A1 (en) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd LIQUID FORMULATION WITH HIGH CONCENTRATION OF ANTIBODY CONTENT
EP3011953A1 (en) * 2008-10-29 2016-04-27 Ablynx N.V. Stabilised formulations of single domain antigen binding molecules
KR20110086705A (en) * 2008-11-17 2011-07-29 제넨테크, 인크. Methods and agents for reducing the aggregation of macromolecules under physiological conditions
NZ613809A (en) 2009-05-04 2015-02-27 Abbvie Biotechnology Ltd Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
WO2011104381A2 (en) * 2010-02-26 2011-09-01 Novo Nordisk A/S Stable antibody containing compositions
CA2808577C (en) * 2010-08-19 2018-09-25 Abbott Laboratories Anti-ngf antibodies and their use
EP2471554A1 (en) 2010-12-28 2012-07-04 Hexal AG Pharmaceutical formulation comprising a biopharmaceutical drug
GB201112429D0 (en) 2011-07-19 2011-08-31 Glaxo Group Ltd Antigen-binding proteins with increased FcRn binding
SG11201405475UA (en) * 2012-03-07 2014-10-30 Cadila Healthcare Ltd Pharmaceutical formulations of tnf-alpha antibodies
EP2863951A1 (en) 2012-06-12 2015-04-29 Boehringer Ingelheim International GmbH Pharmaceutical formulation for a therapeutic antibody
MX2015003007A (en) 2012-09-07 2015-06-05 Coherus Biosciences Inc Stable aqueous formulations of adalimumab.

Also Published As

Publication number Publication date
EP3412310A1 (en) 2018-12-12
KR20140134689A (en) 2014-11-24
US20230047111A1 (en) 2023-02-16
PH12014501988B1 (en) 2018-01-17
SG11201405475UA (en) 2014-10-30
CN104159614A (en) 2014-11-19
MX2014010776A (en) 2014-10-14
EP2822591A1 (en) 2015-01-14
AU2013255413B2 (en) 2015-11-05
AU2013255413C1 (en) 2016-03-24
EP3412310B1 (en) 2022-09-07
KR101730694B1 (en) 2017-04-27
HK1200709A1 (en) 2015-08-14
MX363700B (en) 2019-03-29
TR201810815T4 (en) 2018-08-27
CL2014002316A1 (en) 2015-02-27
US10093728B2 (en) 2018-10-09
WO2013164837A1 (en) 2013-11-07
JP2015509526A (en) 2015-03-30
BR112014021325A2 (en) 2017-08-22
US20190071496A1 (en) 2019-03-07
US20150071936A1 (en) 2015-03-12
JP6416841B2 (en) 2018-10-31
ZA201406414B (en) 2016-08-31
EA201491644A1 (en) 2014-12-30
EP3912639A1 (en) 2021-11-24
PH12014501988A1 (en) 2014-11-24
EP2822591B1 (en) 2018-05-02
NZ629261A (en) 2017-08-25
JP2017019855A (en) 2017-01-26
AP2014007922A0 (en) 2014-09-30
MX2019003716A (en) 2019-09-04
JP2018162295A (en) 2018-10-18
KR20160105535A (en) 2016-09-06
CA2866692A1 (en) 2013-07-11
AU2013255413A1 (en) 2014-09-25

Similar Documents

Publication Publication Date Title
SG10201609982PA (en) Pharmaceutical formulations of tnf-alpha anitbodies
ZA201703992B (en) Inhalable pharmaceutical compositions
ZA201501847B (en) Formulations of enzalutamide
ZA201407373B (en) Novel pharmaceutical formulations
ZA201503594B (en) Pharmaceutical compositions
IL232305A0 (en) Pharmaceutical formulations
ZA201409020B (en) Pharmaceutical formulation
AP2015008208A0 (en) Pharmaceutical administration forms comprising
ZA201405925B (en) Pharmaceutical formulation having improved stability
GB201211153D0 (en) Pharmaceutical compositions
ZA201406407B (en) Pharmaceutical formulation containing flupirtin
GB201211406D0 (en) Pharmaceutical formulations
GB201211403D0 (en) Pharmaceutical formulations
IL238075A0 (en) Pharmaceutical compositions
GB201111577D0 (en) Pharmaceutical formulations
GB201219234D0 (en) Pharmaceutical compositions
GB201213303D0 (en) Pharmaceutical compositions
GB201204810D0 (en) Pharmaceutical compositions