SG10201607768YA - Humanized il-15 animals - Google Patents

Humanized il-15 animals

Info

Publication number: SG10201607768YA
Authority: SG; Singapore
Prior art keywords: humanized; animals
Prior art date: 2013-10-15

Application number

SG10201607768YA

Inventor

Jose F Rojas

Ka-Man Venus Lai

Andrew J Murphy

Original Assignee

Regeneron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-10-15

Filing date

2014-10-15

Publication date

2016-11-29

2014-10-15 Application filed by Regeneron Pharma filed Critical Regeneron Pharma

2016-11-29 Publication of SG10201607768YA publication Critical patent/SG10201607768YA/en

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SG10201607768YA 2013-10-15 2014-10-15 Humanized il-15 animals SG10201607768YA (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361891013P	2013-10-15	2013-10-15

Publications (1)

Publication Number	Publication Date
SG10201607768YA true SG10201607768YA (en)	2016-11-29

Family

ID=51830649

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG10201607768YA SG10201607768YA (en)	2013-10-15	2014-10-15	Humanized il-15 animals
SG11201601828XA SG11201601828XA (en)	2013-10-15	2014-10-15	Humanized il-15 animals

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SG11201601828XA SG11201601828XA (en)	2013-10-15	2014-10-15	Humanized il-15 animals

Country Status (27)

Country	Link
US (5)	US9155290B2 (en)
EP (3)	EP3138397B1 (en)
JP (3)	JP6492095B2 (en)
KR (1)	KR102376041B1 (en)
CN (2)	CN105744829B (en)
AU (2)	AU2014337526B2 (en)
BR (1)	BR112016008175A2 (en)
CA (1)	CA2926090C (en)
CY (2)	CY1118675T1 (en)
DK (2)	DK3138397T3 (en)
ES (2)	ES2613379T3 (en)
HR (2)	HRP20170380T1 (en)
HU (2)	HUE033272T2 (en)
IL (2)	IL244525B (en)
LT (2)	LT2908626T (en)
MX (1)	MX2016004781A (en)
NZ (1)	NZ718655A (en)
PL (2)	PL2908626T3 (en)
PT (2)	PT3138397T (en)
RS (2)	RS58465B1 (en)
RU (1)	RU2674910C2 (en)
SG (2)	SG10201607768YA (en)
SI (2)	SI3138397T1 (en)
SM (3)	SMT201700024T1 (en)
TR (1)	TR201904342T4 (en)
WO (1)	WO2015057758A1 (en)
ZA (1)	ZA201601676B (en)

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ES3010323T3 (en)	2009-10-06	2025-04-02	Regeneron Pharma	Genetically modified mice and engraftment
KR102714361B1 (en)	2011-02-15	2024-10-11	리제너론 파마슈티칼스 인코포레이티드	Humanized m-csf mice
KR102473555B1 (en)	2012-09-07	2022-12-05	예일 유니버시티	Genetically modified non-human animals and methods of use thereof
IL311744B2 (en)	2012-11-05	2025-10-01	Regeneron Pharma	Genetically modified non-human animals and methods of use thereof
EP3138397B1 (en)	2013-10-15	2018-12-26	Regeneron Pharmaceuticals, Inc.	Humanized il-15 animals
EP3071025B1 (en)	2013-11-19	2018-10-10	Regeneron Pharmaceuticals, Inc.	Non-human animals having a humanized a proliferation-inducing ligand gene
MX2016014504A (en)	2014-05-05	2017-05-23	Regeneron Pharma	Humanized c5 and c3 animals.
NO2785538T3 (en)	2014-05-07	2018-08-04
KR20250096864A (en)	2014-05-19	2025-06-27	리제너론 파마슈티칼스 인코포레이티드	Genetically modified non-human animals expressing human epo
EP3086637B1 (en)	2014-12-05	2019-01-02	Regeneron Pharmaceuticals, Inc.	Non-human animals having a humanized cluster of differentiation 47 gene
CN107896479B (en)	2015-04-13	2021-07-13	再生元制药公司	Humanized SIRPα-IL15 knock-in mice and methods of use
KR102487839B1 (en)	2016-02-04	2023-01-12	리제너론 파마슈티칼스 인코포레이티드	Non-human animals with an engineered ANGPTL8 gene
SG10202001578RA (en)	2016-02-29	2020-04-29	Regeneron Pharma	Rodents having a humanized tmprss gene
EP3476865B1 (en)	2016-06-28	2023-09-13	Biocytogen Pharmaceuticals (Beijing) Co., Ltd.	Method for constructing pd-1 gene-modified humanized animal model and use thereof
US11279948B2 (en)	2016-08-31	2022-03-22	Biocytogen Pharmaceuticals (Beijing) Co., Ltd.	Genetically modified non-human animal with human or chimeric OX40
WO2018041120A1 (en)	2016-08-31	2018-03-08	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric tigit
CN107815468B (en)	2016-08-31	2021-03-16	百奥赛图(北京)医药科技股份有限公司	Preparation method and application of humanized genetically modified animal model
WO2018041121A1 (en)	2016-08-31	2018-03-08	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric ctla-4
CN107815467B (en)	2016-08-31	2021-03-16	百奥赛图(北京)医药科技股份有限公司	Preparation method and application of humanized gene modified animal model
US11317611B2 (en)	2016-08-31	2022-05-03	Biocytogen Pharmaceuticals (Beijing) Co., Ltd.	Genetically modified non-human animal with human or chimeric PD-L1
CN108070613B (en)	2016-11-11	2020-03-13	百奥赛图江苏基因生物技术有限公司	Preparation method and application of humanized gene modified animal model
WO2018086594A1 (en)	2016-11-11	2018-05-17	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric tim-3
WO2018102546A1 (en)	2016-11-30	2018-06-07	The Jackson Laboratory	Humanized mouse model with improved human innate immune cell development
CN108239659B (en)	2016-12-23	2020-03-03	百奥赛图江苏基因生物技术有限公司	Preparation method and application of humanized gene modified animal model
CN108424928B (en)	2016-12-30	2021-03-16	百奥赛图(北京)医药科技股份有限公司	Preparation method and application of humanized gene modified animal model
US11629340B2 (en)	2017-03-03	2023-04-18	Obsidian Therapeutics, Inc.	DHFR tunable protein regulation
CN108467873B (en)	2017-03-17	2020-03-13	百奥赛图江苏基因生物技术有限公司	Preparation method and application of CD132 gene-deleted immunodeficiency animal model
WO2018177441A1 (en)	2017-03-31	2018-10-04	Beijing Biocytogen Co., Ltd	GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
CN108588126B (en)	2017-03-31	2020-04-10	北京百奥赛图基因生物技术有限公司	Preparation method and application of humanized modified animal model of CD47 gene
CN109136275B (en)	2017-06-19	2021-03-16	百奥赛图(北京)医药科技股份有限公司	Preparation method and application of humanized GITR gene modified animal model
CN109136274B (en)	2017-06-19	2021-04-23	百奥赛图江苏基因生物技术有限公司	Preparation method and application of humanized CD40 gene modified animal model
CN109136261B (en)	2017-06-19	2021-03-16	百奥赛图(北京)医药科技股份有限公司	Preparation method and application of humanized CD28 gene modified animal model
CA3072331A1 (en) *	2017-08-09	2019-02-14	The Jackson Laboratory	Immunodeficient mice expressing human interleukin 15
EP3585162B1 (en)	2017-09-29	2023-08-30	Regeneron Pharmaceuticals, Inc.	Rodents comprising a humanized ttr locus and methods of use
WO2019072241A1 (en)	2017-10-13	2019-04-18	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric pd-1
CN109913493B (en)	2017-12-12	2021-03-16	百奥赛图江苏基因生物技术有限公司	Preparation method and application of humanized CD3 gene modified animal model
SMT202400300T1 (en)	2018-07-16	2024-09-16	Regeneron Pharma	Rodent models of ditra disease and uses thereof
WO2020074005A1 (en)	2018-10-12	2020-04-16	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric genes
WO2020125763A1 (en)	2018-12-20	2020-06-25	Biocytogen Jiangsu Co., Ltd.	Genetically modified non-human animal with human or chimeric lag3
WO2020135518A1 (en) *	2018-12-25	2020-07-02	Biocytogen Jiangsu Co., Ltd.	Genetically modified non-human animal with human or chimeric il15
CN111218425B (en) *	2019-01-17	2022-02-08	百奥赛图(北京)医药科技股份有限公司	Humanized transgenic animal
CN117178959A (en)	2019-04-04	2023-12-08	瑞泽恩制药公司	Non-human animals including the humanized coagulation factor 12 locus
AU2020286382A1 (en)	2019-06-04	2021-11-04	Regeneron Pharmaceuticals, Inc.	Non-human animals comprising a humanized TTR locus with a beta-slip mutation and methods of use
MX2021015122A (en)	2019-06-07	2022-04-06	Regeneron Pharma	NON-HUMAN ANIMALS COMPRISING A HUMANIZED ALBUMIN LOCUS.
CN114786479B (en) *	2019-12-25	2023-12-15	江苏集萃药康生物科技股份有限公司	IL-15 humanized mouse model and application thereof
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CN111485001A (en) *	2020-04-14	2020-08-04	澎立生物医药技术（上海）有限公司	Construction method of humanized immune system mouse with NK (Natural killer) cell and ADCC (advanced Charge coupled device) capabilities
CN112481303B (en) *	2021-02-09	2021-05-25	百奥赛图(北京)医药科技股份有限公司	IL15RA gene humanized non-human animal and construction method and application thereof
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2014
- 2014-10-15 EP EP16192440.2A patent/EP3138397B1/en active Active
- 2014-10-15 DK DK16192440.2T patent/DK3138397T3/en active
- 2014-10-15 CA CA2926090A patent/CA2926090C/en active Active
- 2014-10-15 ES ES14790452.8T patent/ES2613379T3/en active Active
- 2014-10-15 HR HRP20170380TT patent/HRP20170380T1/en unknown
- 2014-10-15 HU HUE14790452A patent/HUE033272T2/en unknown
- 2014-10-15 RU RU2016116847A patent/RU2674910C2/en active
- 2014-10-15 MX MX2016004781A patent/MX2016004781A/en unknown
- 2014-10-15 DK DK14790452.8T patent/DK2908626T3/en active
- 2014-10-15 EP EP14790452.8A patent/EP2908626B1/en active Active
- 2014-10-15 PT PT16192440T patent/PT3138397T/en unknown
- 2014-10-15 LT LTEP14790452.8T patent/LT2908626T/en unknown
- 2014-10-15 SG SG10201607768YA patent/SG10201607768YA/en unknown
- 2014-10-15 US US14/514,454 patent/US9155290B2/en active Active
- 2014-10-15 PT PT147904528T patent/PT2908626T/en unknown
- 2014-10-15 WO PCT/US2014/060568 patent/WO2015057758A1/en not_active Ceased
- 2014-10-15 RS RS20190349A patent/RS58465B1/en unknown
- 2014-10-15 LT LTEP16192440.2T patent/LT3138397T/en unknown
- 2014-10-15 SG SG11201601828XA patent/SG11201601828XA/en unknown
- 2014-10-15 SM SM20170024T patent/SMT201700024T1/en unknown
- 2014-10-15 TR TR2019/04342T patent/TR201904342T4/en unknown
- 2014-10-15 PL PL14790452T patent/PL2908626T3/en unknown
- 2014-10-15 AU AU2014337526A patent/AU2014337526B2/en active Active
- 2014-10-15 CN CN201480056455.3A patent/CN105744829B/en active Active
- 2014-10-15 EP EP18206034.3A patent/EP3461331A1/en not_active Withdrawn
- 2014-10-15 SM SM20190177T patent/SMT201900177T1/en unknown
- 2014-10-15 CN CN201810808707.3A patent/CN109090037B/en active Active
- 2014-10-15 SI SI201431130T patent/SI3138397T1/en unknown
- 2014-10-15 KR KR1020167009228A patent/KR102376041B1/en active Active
- 2014-10-15 PL PL16192440T patent/PL3138397T3/en unknown
- 2014-10-15 RS RS20161140A patent/RS55472B1/en unknown
- 2014-10-15 ES ES16192440T patent/ES2715949T3/en active Active
- 2014-10-15 BR BR112016008175A patent/BR112016008175A2/en not_active Application Discontinuation
- 2014-10-15 HU HUE16192440A patent/HUE043969T2/en unknown
- 2014-10-15 SI SI201430109T patent/SI2908626T1/en unknown
- 2014-10-15 NZ NZ718655A patent/NZ718655A/en unknown
- 2014-10-15 JP JP2016549191A patent/JP6492095B2/en active Active
2015
- 2015-09-01 US US14/842,342 patent/US20150366175A1/en not_active Abandoned
2016
- 2016-03-10 IL IL24452516A patent/IL244525B/en active IP Right Grant
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2017
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2018
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Publication	Publication Date	Title
IL269907B (en)	2020-09-30	Humanized il-15 animals
IL269528A (en)	2019-11-28	Anti-fcrh5 antibodies
GB201322583D0 (en)	2014-02-05	Antibodies
IL244043A0 (en)	2016-04-21	Antibodies
GB201305935D0 (en)	2013-05-15	Scheduling
IL243581A0 (en)	2016-03-31	Lincrna-deficient non-human animals
GB201308658D0 (en)	2013-06-26	Antibodies
GB201315486D0 (en)	2013-10-16	Antibodies
IL245488B (en)	2020-03-31	Anti-ccl17 antibodies
GB201312226D0 (en)	2013-08-21	Improved antibodies
GB201306076D0 (en)	2013-05-22	Animal trap
GB2516488B (en)	2015-12-23	Animal harness
AU356315S (en)	2014-07-08	Lure
AU356313S (en)	2014-07-08	Bibbed lure
GB201318283D0 (en)	2013-11-27	Antibodies