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SG10201605397PA - Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides - Google Patents

Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides

Info

Publication number
SG10201605397PA
SG10201605397PA SG10201605397PA SG10201605397PA SG10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA
Authority
SG
Singapore
Prior art keywords
polypeptides
separation
aggregated
monomeric
monomeric polypeptides
Prior art date
Application number
SG10201605397PA
Inventor
Monika Baehner
Adelbert Grossmann
Stefan Hepbildikler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG10201605397PA publication Critical patent/SG10201605397PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
SG10201605397PA 2011-07-01 2012-06-28 Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides SG10201605397PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11172348 2011-07-01

Publications (1)

Publication Number Publication Date
SG10201605397PA true SG10201605397PA (en) 2016-08-30

Family

ID=46466477

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201605397PA SG10201605397PA (en) 2011-07-01 2012-06-28 Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides

Country Status (5)

Country Link
US (3) US9783570B2 (en)
EP (1) EP2726496B1 (en)
JP (1) JP6292718B2 (en)
SG (1) SG10201605397PA (en)
WO (1) WO2013004587A1 (en)

Families Citing this family (12)

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MX2009012786A (en) 2007-06-01 2009-12-10 Hoffmann La Roche Immunoglobulin purification.
ES2648264T3 (en) 2010-03-10 2017-12-29 F. Hoffmann-La Roche Ag Procedure for purification of immunoglobulin solutions
SG10201605397PA (en) * 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
BR112015005937A2 (en) 2012-09-17 2017-07-04 Grace W R & Co chromatographic media and devices
ES2887110T3 (en) 2014-01-16 2021-12-21 Grace W R & Co Affinity Chromatography Media and Chromatography Devices
DK3114455T3 (en) * 2014-03-04 2020-04-06 Merck Patent Gmbh ROBUST ANTIBODY CLEANING
KR20160134687A (en) 2014-03-21 2016-11-23 에프. 호프만-라 로슈 아게 In vitro prediction of in vivo half-life of antibodies
US11389783B2 (en) 2014-05-02 2022-07-19 W.R. Grace & Co.-Conn. Functionalized support material and methods of making and using functionalized support material
SI3215528T1 (en) 2014-11-06 2019-11-29 Hoffmann La Roche Fc-region variants with modified fcrn-binding and methods of use
PL3302784T3 (en) 2015-06-05 2022-01-17 W.R. Grace & Co.-Conn. Adsorbent bioprocessing clarification agents and methods of making and using the same
JP6621176B2 (en) * 2016-01-22 2019-12-18 旭化成メディカル株式会社 Protein purification method
BR112020019882A2 (en) 2018-04-02 2021-01-05 Amgen Inc. ERENUMAB COMPOSITIONS AND THEIR USES

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BRPI0812398A2 (en) 2007-06-06 2019-09-24 Domantis Ltd anti-vegf immunoglobulin single variable domain, anti-vegf antagonist, protease resistant immunoglobulin simple variable domain, use of vegf antagonist, method for oral or drug delivery to a patient's gi tract or lung or lung tissue or a patient's eye, pulmonary dispensing device, oral formulation, double specific ligand, isolated or recombinant nucleic acid, vector, host cell, method for producing polypeptide, pharmaceutical composition, polypeptide, and fusion protein.
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ES2648264T3 (en) 2010-03-10 2017-12-29 F. Hoffmann-La Roche Ag Procedure for purification of immunoglobulin solutions
JP5947802B2 (en) * 2010-11-05 2016-07-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Method for optimizing antibody capture by mixed-mode chromatography
SG10201605397PA (en) * 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
SI2814587T1 (en) 2012-02-15 2018-08-31 F. Hoffmann-La Roche Ag Fc-receptor based affinity chromatography

Also Published As

Publication number Publication date
US20140142283A1 (en) 2014-05-22
JP2014520775A (en) 2014-08-25
US20180094023A1 (en) 2018-04-05
US9783570B2 (en) 2017-10-10
JP6292718B2 (en) 2018-03-14
US20200291063A1 (en) 2020-09-17
WO2013004587A1 (en) 2013-01-10
EP2726496B1 (en) 2018-04-04
EP2726496A1 (en) 2014-05-07
US11168110B2 (en) 2021-11-09
US10654886B2 (en) 2020-05-19

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