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SG10201605664SA - New association between 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione and an egfr tyr kinase inhibitor - Google Patents

New association between 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione and an egfr tyr kinase inhibitor

Info

Publication number
SG10201605664SA
SG10201605664SA SG10201605664SA SG10201605664SA SG10201605664SA SG 10201605664S A SG10201605664S A SG 10201605664SA SG 10201605664S A SG10201605664S A SG 10201605664SA SG 10201605664S A SG10201605664S A SG 10201605664SA SG 10201605664S A SG10201605664S A SG 10201605664SA
Authority
SG
Singapore
Prior art keywords
morpholinylmethyl
thiazolidine
pyrrol
indol
dione
Prior art date
Application number
SG10201605664SA
Inventor
Burbridge Michael
Cattan Valérie
Jacquet-Bescond Anne
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55299545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201605664S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of SG10201605664SA publication Critical patent/SG10201605664SA/en

Links

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG10201605664SA 2015-07-31 2016-07-11 New association between 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione and an egfr tyr kinase inhibitor SG10201605664SA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1557412A FR3039401B1 (en) 2015-07-31 2015-07-31 NOVEL ASSOCIATION BETWEEN 3 - [(3 - {[4- (4-MORPHOLINYLMETHYL) -1H-PYRROL-2-YL] METHYLENE} -2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL) METHYL ] -1,3-THIAZOLIDINE-2,4-DIONE AND AN EGFR TYR KINASE INHIBITOR

Publications (1)

Publication Number Publication Date
SG10201605664SA true SG10201605664SA (en) 2017-02-27

Family

ID=55299545

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201605664SA SG10201605664SA (en) 2015-07-31 2016-07-11 New association between 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione and an egfr tyr kinase inhibitor

Country Status (40)

Country Link
US (1) US20170027952A1 (en)
EP (1) EP3124025B1 (en)
JP (2) JP2017061445A (en)
KR (1) KR101822492B1 (en)
CN (1) CN106397427A (en)
AR (1) AR105527A1 (en)
AU (1) AU2016206300A1 (en)
BR (1) BR102016017404A2 (en)
CA (1) CA2936904C (en)
CL (1) CL2018000256A1 (en)
CO (1) CO2018000953A2 (en)
CR (1) CR20180044A (en)
CU (1) CU20180013A7 (en)
CY (1) CY1120792T1 (en)
DK (1) DK3124025T3 (en)
EA (1) EA032217B1 (en)
EC (1) ECSP18003671A (en)
ES (1) ES2671133T3 (en)
FR (1) FR3039401B1 (en)
HR (1) HRP20180760T1 (en)
HU (1) HUE037632T2 (en)
IL (1) IL257232A (en)
LT (1) LT3124025T (en)
MA (1) MA39693B1 (en)
MD (1) MD3124025T2 (en)
ME (1) ME03052B (en)
MX (1) MX366748B (en)
NO (1) NO3124025T3 (en)
PE (1) PE20190350A1 (en)
PH (1) PH12016000248A1 (en)
PL (1) PL3124025T3 (en)
PT (1) PT3124025T (en)
RS (1) RS57057B1 (en)
RU (1) RU2695362C2 (en)
SG (1) SG10201605664SA (en)
SI (1) SI3124025T1 (en)
SV (1) SV2018005615A (en)
TN (1) TN2018000028A1 (en)
TW (1) TWI623315B (en)
WO (1) WO2017021634A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101956978B1 (en) * 2015-05-18 2019-03-12 주식회사 케이티 Methods for tranmitting ant receiving system information and apparatuses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2068880T1 (en) * 2006-09-18 2012-08-31 Boehringer Ingelheim Int Method for treating cancer harboring egfr mutations
JP2010520176A (en) * 2007-03-01 2010-06-10 ノバルティス アーゲー 5- (2,4-dihydroxy-5-isopropyl-phenyl) -4- (4-morpholin-4-ylmethyl-phenyl) -isoxazole-3-carboxylic acid ethylamide acid addition salts, hydrates and polymorphs, And preparations containing these forms
CN101641117B (en) * 2007-03-05 2012-06-13 协和发酵麒麟株式会社 pharmaceutical composition
UY31800A (en) * 2008-05-05 2009-11-10 Smithkline Beckman Corp CANCER TREATMENT METHOD USING A CMET AND AXL INHIBITOR AND AN ERBB INHIBITOR
FR2948940B1 (en) * 2009-08-04 2011-07-22 Servier Lab NOVEL DIHYDROINDOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP5945863B2 (en) * 2012-01-06 2016-07-05 国立大学法人高知大学 Renal cell cancer treatment
KR20150123250A (en) * 2013-03-06 2015-11-03 제넨테크, 인크. Methods of treating and preventing cancer drug resistance
FR3008411B1 (en) * 2013-07-12 2015-07-03 Servier Lab NOVEL 3 - [(3 - {[4- (4-MORPHOLINYLMETHYL) -1H-PYRROL-2-YL] METHYLENE} -2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL) METHYL SALT ] -1,3-THIAZOLIDINE-2,4-DIONE, ITS PREPARATION, AND THE FORMULATIONS CONTAINING IT
CA2935892C (en) * 2014-01-07 2022-08-02 Merck Patent Gmbh Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with gefitinib
WO2016055916A1 (en) * 2014-10-06 2016-04-14 Novartis Ag Therapeutic combination for the treatment of cancer

Also Published As

Publication number Publication date
TW201711686A (en) 2017-04-01
PE20190350A1 (en) 2019-03-07
CA2936904C (en) 2018-12-04
JP2019163306A (en) 2019-09-26
RU2016131395A3 (en) 2018-06-08
CY1120792T1 (en) 2019-12-11
IL257232A (en) 2018-03-29
EA032217B1 (en) 2019-04-30
CR20180044A (en) 2018-04-03
NO3124025T3 (en) 2018-07-28
MX366748B (en) 2019-07-23
LT3124025T (en) 2018-03-26
CL2018000256A1 (en) 2018-04-06
CA2936904A1 (en) 2017-01-31
JP2017061445A (en) 2017-03-30
MD3124025T2 (en) 2018-06-30
MA39693A (en) 2017-02-01
BR102016017404A2 (en) 2017-02-07
WO2017021634A1 (en) 2017-02-09
SV2018005615A (en) 2018-05-14
CN106397427A (en) 2017-02-15
EP3124025B1 (en) 2018-02-28
TN2018000028A1 (en) 2019-07-08
PT3124025T (en) 2018-04-09
US20170027952A1 (en) 2017-02-02
RU2695362C2 (en) 2019-07-23
PH12016000248A1 (en) 2018-01-22
RU2016131395A (en) 2018-02-02
HRP20180760T1 (en) 2018-06-15
DK3124025T3 (en) 2018-06-06
ES2671133T3 (en) 2018-06-05
MX2016009743A (en) 2017-03-03
ME03052B (en) 2018-10-20
HUE037632T2 (en) 2018-09-28
SI3124025T1 (en) 2018-04-30
EA201600507A2 (en) 2017-02-28
FR3039401B1 (en) 2018-07-13
CU20180013A7 (en) 2018-05-08
EA201600507A3 (en) 2017-03-31
FR3039401A1 (en) 2017-02-03
EP3124025A1 (en) 2017-02-01
AU2016206300A1 (en) 2017-02-16
KR101822492B1 (en) 2018-01-29
KR20170015218A (en) 2017-02-08
RS57057B1 (en) 2018-05-31
ECSP18003671A (en) 2018-03-31
TWI623315B (en) 2018-05-11
CO2018000953A2 (en) 2018-07-10
AR105527A1 (en) 2017-10-11
MA39693B1 (en) 2018-07-31
PL3124025T3 (en) 2018-06-29

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