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SG10201600303WA - Methods Of Synthesizing A Prostacyclin Analog - Google Patents

Methods Of Synthesizing A Prostacyclin Analog

Info

Publication number
SG10201600303WA
SG10201600303WA SG10201600303WA SG10201600303WA SG10201600303WA SG 10201600303W A SG10201600303W A SG 10201600303WA SG 10201600303W A SG10201600303W A SG 10201600303WA SG 10201600303W A SG10201600303W A SG 10201600303WA SG 10201600303W A SG10201600303W A SG 10201600303WA
Authority
SG
Singapore
Prior art keywords
synthesizing
methods
prostacyclin analog
prostacyclin
analog
Prior art date
Application number
SG10201600303WA
Inventor
Kirk William Hering
Gilles Chambournier
Gregory William Endres
Victor Fedij
Thomas James Ii Krell
Hussein Mahmoud Mahmoud
Original Assignee
Cayman Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cayman Chemical Co Inc filed Critical Cayman Chemical Co Inc
Publication of SG10201600303WA publication Critical patent/SG10201600303WA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/34Separation; Purification; Stabilisation; Use of additives
    • C07C41/44Separation; Purification; Stabilisation; Use of additives by treatments giving rise to a chemical modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41Preparation of salts of carboxylic acids
    • C07C51/412Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D301/00Preparation of oxiranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D301/00Preparation of oxiranes
    • C07D301/32Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14Benz[f]indenes; Hydrogenated benz[f]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SG10201600303WA 2012-12-07 2013-12-06 Methods Of Synthesizing A Prostacyclin Analog SG10201600303WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261734672P 2012-12-07 2012-12-07
US201361777882P 2013-03-12 2013-03-12

Publications (1)

Publication Number Publication Date
SG10201600303WA true SG10201600303WA (en) 2016-02-26

Family

ID=49881039

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201504430TA SG11201504430TA (en) 2012-12-07 2013-12-06 Methods of synthesizing a prostacyclin analog
SG10201600303WA SG10201600303WA (en) 2012-12-07 2013-12-06 Methods Of Synthesizing A Prostacyclin Analog

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201504430TA SG11201504430TA (en) 2012-12-07 2013-12-06 Methods of synthesizing a prostacyclin analog

Country Status (20)

Country Link
US (4) US20150315114A1 (en)
EP (2) EP2928858B1 (en)
JP (2) JP6342414B2 (en)
KR (1) KR20150091170A (en)
CN (3) CN104837806A (en)
AU (2) AU2013355130B2 (en)
BR (1) BR112015013085A2 (en)
CA (1) CA2893604A1 (en)
CL (1) CL2015001535A1 (en)
DK (1) DK2928858T3 (en)
EA (1) EA034309B1 (en)
ES (1) ES2664026T3 (en)
IL (1) IL239172B (en)
MX (2) MX369094B (en)
NZ (1) NZ708130A (en)
PE (1) PE20160090A1 (en)
PH (2) PH12015501258B1 (en)
SG (2) SG11201504430TA (en)
TW (1) TWI634104B (en)
WO (1) WO2014089385A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104837806A (en) * 2012-12-07 2015-08-12 开曼化学股份有限公司 Synthetic method of prostacyclin analog
EP3712142B1 (en) 2013-01-11 2022-07-06 Corsair Pharma, Inc. Prodrugs of treprostinil
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
EP3068752A1 (en) * 2013-11-13 2016-09-21 Cayman Chemical Company Incorporated Amine salts of a prostacyclin analog
HU231184B1 (en) * 2014-10-08 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Treprostinyl-sodium-monohydrate and process for its preparation
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
JP7220650B2 (en) 2016-09-26 2023-02-10 ユナイテッド セラピューティクス コーポレイション Treprostinil prodrug
EP3498283A1 (en) 2017-12-14 2019-06-19 Ipsol AG Glycosidic derivatives of treprostinil
HU231296B1 (en) 2018-03-09 2022-09-28 Chinoin Zrt Process for the preparation of the b polymorph form of treprostinil-diethanol-amine salt
JP6503508B2 (en) * 2018-08-03 2019-04-17 Jxtgエネルギー株式会社 Tetracarboxylic acid dianhydride, polyimide precursor resin, polyimide, polyimide precursor resin solution, polyimide solution and polyimide film
CN114616225A (en) 2019-08-23 2022-06-10 联合治疗公司 Treprostinil prodrugs
US11826327B2 (en) 2020-04-17 2023-11-28 United Therapeutics Corporation Treatment for interstitial lung disease
WO2021252446A1 (en) 2020-06-09 2021-12-16 United Therapeutics Corporation Fumaryl diketopiperidine prodrugs of treprostinil
KR20220030006A (en) 2020-09-02 2022-03-10 바이오플러스 주식회사 Mask comprising cosmetic composition and manufacturing method thereof
JP2023553989A (en) 2020-12-14 2023-12-26 ユナイテッド セラピューティクス コーポレイション How to treat diseases with treprostinil prodrugs
AU2022229367A1 (en) 2021-03-03 2023-09-14 United Therapeutics Corporation A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
US11884640B2 (en) * 2021-06-02 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom
US11884613B2 (en) * 2022-05-05 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparation of carbaprostacyclin analogues

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US4306075A (en) 1980-03-28 1981-12-15 The Upjohn Company Composition and process
CA2039857A1 (en) * 1990-04-26 1991-10-27 Wilfred Po-Sum Shum Process for producing epoxyalcohols of high optical purity
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
US6700025B2 (en) 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
CN101265226B (en) * 2003-05-22 2013-04-24 联合治疗公司 Compounds and methods for delivery of prostacyclin analogs
WO2009019868A1 (en) * 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. 10a-azalide compound crosslinked at position-10a and position-12
KR20160048222A (en) 2007-12-17 2016-05-03 유나이티드 세러퓨틱스 코오포레이션 An improved preparation of treprostinil, the active ingredient of remodulin,
US20110294815A1 (en) * 2008-06-27 2011-12-01 Harbeson Scott L Prostacyclin analogs
WO2010039531A1 (en) * 2008-09-23 2010-04-08 Resolvyx Pharmaceuticals, Inc. Therapeutic compounds
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CN104837806A (en) * 2012-12-07 2015-08-12 开曼化学股份有限公司 Synthetic method of prostacyclin analog
EP3068752A1 (en) * 2013-11-13 2016-09-21 Cayman Chemical Company Incorporated Amine salts of a prostacyclin analog

Also Published As

Publication number Publication date
CA2893604A1 (en) 2014-06-12
WO2014089385A3 (en) 2014-08-28
PE20160090A1 (en) 2016-02-20
CL2015001535A1 (en) 2016-01-15
MX2015006972A (en) 2016-02-11
EA201591093A1 (en) 2015-09-30
NZ708130A (en) 2020-01-31
BR112015013085A2 (en) 2017-07-11
US20150315114A1 (en) 2015-11-05
HK1212323A1 (en) 2016-06-10
US20200002261A1 (en) 2020-01-02
TW201422577A (en) 2014-06-16
JP2016504303A (en) 2016-02-12
MX369094B (en) 2019-10-29
ES2664026T3 (en) 2018-04-18
WO2014089385A2 (en) 2014-06-12
US20170297995A1 (en) 2017-10-19
EP2928858A2 (en) 2015-10-14
IL239172B (en) 2020-01-30
KR20150091170A (en) 2015-08-07
US9908834B2 (en) 2018-03-06
US10450257B2 (en) 2019-10-22
CN110590547A (en) 2019-12-20
CN104837806A (en) 2015-08-12
US20180141889A1 (en) 2018-05-24
PH12015501258A1 (en) 2015-08-17
PH12015501258B1 (en) 2015-08-17
AU2018233009B2 (en) 2020-01-23
EP3398931B1 (en) 2020-04-08
JP2018162250A (en) 2018-10-18
AU2013355130A1 (en) 2015-06-11
SG11201504430TA (en) 2015-07-30
DK2928858T3 (en) 2018-02-19
TWI634104B (en) 2018-09-01
IL239172A0 (en) 2015-07-30
CN107098925B (en) 2019-09-13
EP2928858B1 (en) 2018-01-31
JP6342414B2 (en) 2018-06-13
MX2019009102A (en) 2019-09-16
AU2018233009A1 (en) 2018-10-18
CN107098925A (en) 2017-08-29
AU2013355130B2 (en) 2018-06-21
PH12018500562A1 (en) 2019-03-04
EA034309B1 (en) 2020-01-27
EP3398931A1 (en) 2018-11-07

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