SG10201600836PA - Synthetic mimics of mir-34 - Google Patents
Synthetic mimics of mir-34Info
- Publication number
- SG10201600836PA SG10201600836PA SG10201600836PA SG10201600836PA SG10201600836PA SG 10201600836P A SG10201600836P A SG 10201600836PA SG 10201600836P A SG10201600836P A SG 10201600836PA SG 10201600836P A SG10201600836P A SG 10201600836PA SG 10201600836P A SG10201600836P A SG 10201600836PA
- Authority
- SG
- Singapore
- Prior art keywords
- mir
- synthetic mimics
- mimics
- synthetic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161439280P | 2011-02-03 | 2011-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201600836PA true SG10201600836PA (en) | 2016-03-30 |
Family
ID=45592829
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013058466A SG192252A1 (en) | 2011-02-03 | 2012-02-03 | Synthetic mimics of mir-34 |
| SG10201600836PA SG10201600836PA (en) | 2011-02-03 | 2012-02-03 | Synthetic mimics of mir-34 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013058466A SG192252A1 (en) | 2011-02-03 | 2012-02-03 | Synthetic mimics of mir-34 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8586727B2 (en) |
| EP (2) | EP3178932A1 (en) |
| JP (2) | JP2014506791A (en) |
| KR (1) | KR20140020900A (en) |
| CN (1) | CN103476931A (en) |
| AU (1) | AU2012212023B9 (en) |
| BR (1) | BR112013019853A2 (en) |
| CA (1) | CA2825981A1 (en) |
| CL (1) | CL2013002195A1 (en) |
| IL (1) | IL227697A0 (en) |
| MX (1) | MX342927B (en) |
| MY (1) | MY165507A (en) |
| RU (1) | RU2615117C2 (en) |
| SG (2) | SG192252A1 (en) |
| WO (1) | WO2012106591A1 (en) |
| ZA (1) | ZA201306518B (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2857881A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| EP2990487A1 (en) | 2008-05-08 | 2016-03-02 | Asuragen, INC. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
| US8846631B2 (en) | 2010-01-14 | 2014-09-30 | Regulus Therapeutics Inc. | MicroRNA compositions and methods |
| WO2012041959A1 (en) | 2010-09-30 | 2012-04-05 | University Of Zurich | Treatment of b-cell lymphoma with microrna |
| CN105969773A (en) | 2011-02-03 | 2016-09-28 | 米尔纳医疗股份有限公司 | Synthetic mimics of MIR-124 |
| JP2014506791A (en) | 2011-02-03 | 2014-03-20 | マーナ セラピューティクス インコーポレイテッド | miR-34 synthetic mimics |
| FI3366775T4 (en) | 2011-11-18 | 2025-11-14 | Alnylam Pharmaceuticals Inc | Modified RNAI agents |
| US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| US20140309278A1 (en) * | 2013-03-15 | 2014-10-16 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing micrornas and egfr-tki inhibitors |
| US20140308274A1 (en) * | 2013-03-15 | 2014-10-16 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors |
| CN105473742A (en) | 2013-06-24 | 2016-04-06 | 米尔纳疗法公司 | Biomarkers of miR-34 activity |
| CN105899663B (en) | 2013-12-26 | 2019-07-26 | 学校法人东京医科大学 | Manual simulation miRNA and application thereof for gene expression control |
| WO2015099188A1 (en) * | 2013-12-27 | 2015-07-02 | 株式会社ボナック | Artificial match-type mirna for controlling gene expression and use therefor |
| CN106068324B (en) | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | Artificially matched miRNA for controlling gene expression and its use |
| GB201400598D0 (en) | 2014-01-14 | 2014-03-05 | Univ Glasgow | Materials and methods for modulation of tendon healing |
| US20160136181A1 (en) | 2014-04-01 | 2016-05-19 | Mirna Therapeutics, Inc | Microrna dosing regimens |
| EP3800270B1 (en) * | 2014-07-29 | 2021-10-27 | Wellmarker Bio Co., Ltd. | Inhibitors of met and igsf1 for treating gastric and lung cancer |
| US9950194B2 (en) | 2014-09-09 | 2018-04-24 | Mevion Medical Systems, Inc. | Patient positioning system |
| WO2016081773A2 (en) * | 2014-11-19 | 2016-05-26 | Mirna Therapeutics, Inc. | Combination cancer therapy with c-met inhibitors and synthetic oligonucleotides |
| WO2016104775A1 (en) * | 2014-12-27 | 2016-06-30 | 株式会社ボナック | NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME |
| JP6602847B2 (en) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | Single-stranded nucleic acid molecule with delivery function and gene expression control ability |
| WO2017152182A1 (en) * | 2016-03-04 | 2017-09-08 | Rhode Island Hospital | Targeting microrna for cancer treatment |
| EP3426781B1 (en) | 2016-03-07 | 2024-06-26 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Micrornas and methods of their use |
| EP3216869B1 (en) | 2016-03-09 | 2019-09-18 | Colizzi, Vittorio | Nutraceutical plant derived microrna elements for treatment of leukemia |
| CN105779452A (en) * | 2016-03-10 | 2016-07-20 | 上海吉玛制药技术有限公司 | Oligonucleotide capable of inhibiting tumor growth and application of oligonucleotide |
| US11584932B2 (en) * | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| CN107699565B (en) * | 2017-11-24 | 2020-05-22 | 苏州大学 | Micro RNA and application thereof in preparation of antitumor drugs |
| EP3626820A1 (en) * | 2018-09-20 | 2020-03-25 | Fundación Imdea Nanociencia | Anticancer compositions containing mirna mimics and uses thereof |
| KR20230023612A (en) | 2020-04-02 | 2023-02-17 | 마이레큘, 인크. | Targeted inhibition using engineered oligonucleotides |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
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| WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
| JP2010268690A (en) * | 2009-05-19 | 2010-12-02 | Nippon Kayaku Co Ltd | Method for determining sensitivity of compound having anti-tumor activity |
| JP2014506791A (en) | 2011-02-03 | 2014-03-20 | マーナ セラピューティクス インコーポレイテッド | miR-34 synthetic mimics |
| CN105969773A (en) | 2011-02-03 | 2016-09-28 | 米尔纳医疗股份有限公司 | Synthetic mimics of MIR-124 |
| CN103186763B (en) | 2011-12-28 | 2017-07-21 | 富泰华工业（深圳）有限公司 | Face identification system and method |
-
2012
- 2012-02-03 JP JP2013552671A patent/JP2014506791A/en active Pending
- 2012-02-03 CN CN2012800162518A patent/CN103476931A/en active Pending
- 2012-02-03 SG SG2013058466A patent/SG192252A1/en unknown
- 2012-02-03 BR BR112013019853A patent/BR112013019853A2/en not_active IP Right Cessation
- 2012-02-03 RU RU2013140634A patent/RU2615117C2/en not_active IP Right Cessation
- 2012-02-03 MY MYPI2013002871A patent/MY165507A/en unknown
- 2012-02-03 SG SG10201600836PA patent/SG10201600836PA/en unknown
- 2012-02-03 KR KR1020137023160A patent/KR20140020900A/en not_active Abandoned
- 2012-02-03 AU AU2012212023A patent/AU2012212023B9/en not_active Ceased
- 2012-02-03 CA CA2825981A patent/CA2825981A1/en not_active Abandoned
- 2012-02-03 WO PCT/US2012/023755 patent/WO2012106591A1/en not_active Ceased
- 2012-02-03 MX MX2013008945A patent/MX342927B/en active IP Right Grant
- 2012-02-03 US US13/365,676 patent/US8586727B2/en not_active Expired - Fee Related
- 2012-02-03 EP EP16195581.0A patent/EP3178932A1/en not_active Withdrawn
- 2012-02-03 EP EP12703943.6A patent/EP2670850B1/en not_active Not-in-force
-
2013
- 2013-07-29 IL IL227697A patent/IL227697A0/en unknown
- 2013-07-31 CL CL2013002195A patent/CL2013002195A1/en unknown
- 2013-08-29 ZA ZA2013/06518A patent/ZA201306518B/en unknown
- 2013-11-15 US US14/081,295 patent/US9371526B2/en not_active Expired - Fee Related
-
2015
- 2015-11-05 US US14/933,118 patent/US20160053264A1/en not_active Abandoned
-
2016
- 2016-02-19 JP JP2016029508A patent/JP2016152804A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013008945A (en) | 2014-01-08 |
| RU2615117C2 (en) | 2017-04-04 |
| WO2012106591A1 (en) | 2012-08-09 |
| CN103476931A (en) | 2013-12-25 |
| JP2016152804A (en) | 2016-08-25 |
| EP3178932A1 (en) | 2017-06-14 |
| CL2013002195A1 (en) | 2014-05-30 |
| ZA201306518B (en) | 2014-05-28 |
| BR112013019853A2 (en) | 2017-03-21 |
| CA2825981A1 (en) | 2012-08-09 |
| MY165507A (en) | 2018-03-28 |
| AU2012212023B2 (en) | 2017-01-05 |
| JP2014506791A (en) | 2014-03-20 |
| SG192252A1 (en) | 2013-09-30 |
| US20140107182A1 (en) | 2014-04-17 |
| EP2670850B1 (en) | 2016-10-26 |
| AU2012212023A1 (en) | 2013-09-12 |
| EP2670850A1 (en) | 2013-12-11 |
| AU2012212023B9 (en) | 2017-01-12 |
| KR20140020900A (en) | 2014-02-19 |
| US20160053264A1 (en) | 2016-02-25 |
| MX342927B (en) | 2016-10-19 |
| RU2013140634A (en) | 2015-03-10 |
| IL227697A0 (en) | 2013-09-30 |
| US8586727B2 (en) | 2013-11-19 |
| US9371526B2 (en) | 2016-06-21 |
| US20120288933A1 (en) | 2012-11-15 |
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