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SG10201500350PA - 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition - Google Patents

15-valent pneumococcal polysaccharide-protein conjugate vaccine composition

Info

Publication number
SG10201500350PA
SG10201500350PA SG10201500350PA SG10201500350PA SG10201500350PA SG 10201500350P A SG10201500350P A SG 10201500350PA SG 10201500350P A SG10201500350P A SG 10201500350PA SG 10201500350P A SG10201500350P A SG 10201500350PA SG 10201500350P A SG10201500350P A SG 10201500350PA
Authority
SG
Singapore
Prior art keywords
vaccine composition
protein conjugate
conjugate vaccine
pneumococcal polysaccharide
valent pneumococcal
Prior art date
Application number
SG10201500350PA
Inventor
Michael J Caulfield
Patrick L Ahl
Jeffrey T Blue
Jayme L Cannon
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SG10201500350PA publication Critical patent/SG10201500350PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201500350PA 2010-02-09 2011-02-03 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition SG10201500350PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30272610P 2010-02-09 2010-02-09

Publications (1)

Publication Number Publication Date
SG10201500350PA true SG10201500350PA (en) 2015-03-30

Family

ID=44353903

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012058236A SG183199A1 (en) 2010-02-09 2011-02-03 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
SG10201500350PA SG10201500350PA (en) 2010-02-09 2011-02-03 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012058236A SG183199A1 (en) 2010-02-09 2011-02-03 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition

Country Status (25)

Country Link
US (2) US20120301502A1 (en)
EP (1) EP2533805A4 (en)
JP (2) JP2013518891A (en)
KR (1) KR101538535B1 (en)
CN (1) CN102858365A (en)
AR (2) AR080122A1 (en)
AU (1) AU2011216095B2 (en)
BR (1) BR112012019757B8 (en)
CA (1) CA2788680C (en)
CL (1) CL2012002195A1 (en)
EC (1) ECSP12012100A (en)
IL (1) IL221283A0 (en)
MA (1) MA34051B1 (en)
MX (1) MX2012009206A (en)
MY (1) MY159984A (en)
NZ (1) NZ601711A (en)
PE (1) PE20121698A1 (en)
PH (1) PH12012501559A1 (en)
RU (1) RU2012138368A (en)
SG (2) SG183199A1 (en)
TN (1) TN2012000377A1 (en)
TW (1) TW201136603A (en)
UA (1) UA106115C2 (en)
WO (1) WO2011100151A1 (en)
ZA (1) ZA201205737B (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113198012B (en) 2005-04-08 2024-09-17 惠氏有限责任公司 Multivalent pneumococcal polysaccharide-protein conjugate composition
EP2201961B1 (en) 2005-06-27 2018-01-24 GlaxoSmithKline Biologicals S.A. Immunogenic composition
SI2097102T1 (en) 2006-09-07 2012-09-28 Glaxosmithkline Biolog Sa Combination vaccine having reduced polio virus antigen quantities
HUE047085T2 (en) 2011-04-22 2020-04-28 Wyeth Llc Preparations and methods related to the Clostridium difficile mutant toxin
US9573811B2 (en) * 2011-11-23 2017-02-21 Merck Sharp & Dohme Corp. Method for preparation of aluminum hydroxyphosphate adjuvant
KR102057217B1 (en) * 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
US20140193451A1 (en) * 2012-10-17 2014-07-10 Glaxosmithkline Biologicals Sa Immunogenic composition
BR122016023101B1 (en) 2012-10-21 2022-03-22 Pfizer Inc Polypeptide, immunogenic composition comprising it, as well as recombinant cell derived from Clostridium difficile
KR20140075196A (en) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
KR20140075201A (en) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
CN103495161B (en) * 2013-10-08 2019-06-18 江苏康泰生物医学技术有限公司 A kind of mixture and preparation method thereof of polynary pneumococcal capsular polysaccharide-protein conjugate
TWI586363B (en) * 2013-10-30 2017-06-11 Sk化學公司 Multivalent pneumococcal polysaccharide-protein conjugate composition
US11160855B2 (en) 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
SI3583947T1 (en) 2014-01-21 2024-01-31 Pfizer Inc. Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
KR102157200B1 (en) * 2014-01-21 2020-09-21 화이자 인코포레이티드 Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
EP3096783B1 (en) * 2014-01-21 2021-07-07 Pfizer Inc. Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
ES2930318T3 (en) * 2014-02-14 2022-12-09 Pfizer Immunogenic glycoprotein conjugates
CN103893751B (en) * 2014-03-26 2016-04-20 天津康希诺生物技术有限公司 A kind of pneumococal polysaccharide Protein Conjugation vaccine and preparation method thereof
EP3302542A4 (en) 2015-06-08 2019-04-10 Serum Institute Of India Private Limited METHOD FOR ENHANCING ADSORPTION OF POLYSACCHARIDE-PROTEIN CONJUGATES AND MULTIVALENT VACCINE FORMULATION OBTAINED THEREBY
MX389480B (en) 2015-06-23 2025-03-20 Biological E Ltd Multivalent pneumococcal conjugate vaccine
IL303998A (en) * 2015-07-21 2023-08-01 Pfizer Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof
US10159728B2 (en) * 2015-09-10 2018-12-25 Inventprise, Llc Multivalent VLP conjugates
WO2017173415A2 (en) 2016-03-31 2017-10-05 Liffey Biotech Limited Saccharide-polypeptide conjugate compositions and methods of use thereof
WO2018009850A1 (en) * 2016-07-08 2018-01-11 Hawaii Biotech Inc. West nile virus vaccine and method of use thereof
IL264552B2 (en) * 2016-08-05 2023-04-01 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition
BR112019001995A2 (en) 2016-08-05 2019-05-07 Sanofi Pasteur, Inc. multivalent pneumococcal polysaccharide conjugate composition? protein
EP3518965A1 (en) * 2016-09-30 2019-08-07 Biological E Limited Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates
KR102083973B1 (en) * 2016-10-28 2020-04-23 주식회사 엘지화학 A multivalent immunogenic composition with improved IgG titer and use thereof
US11998599B2 (en) 2016-12-30 2024-06-04 Vaxcyte, Inc. Polypeptide-antigen conjugates with non-natural amino acids
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
CN110225764A (en) * 2017-01-31 2019-09-10 默沙东公司 The method for preparing polysaccharide-protein conjugate
CN110225757A (en) 2017-01-31 2019-09-10 默沙东公司 By the method for S. pneumoniae serotypes 19F production capsular polysaccharide protein conjugate
US11246918B2 (en) 2017-02-03 2022-02-15 Eva Barbara Schadeck Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof
EP3585803B1 (en) * 2017-02-24 2025-09-24 Merck Sharp & Dohme LLC Pneumococcal conjugate vaccine formulations
US11219680B2 (en) * 2017-02-24 2022-01-11 Merck Sharp & Dohme Corp. Polysaccharide-protein conjugates utilizing diphtheria toxin fragment B as a carrier
CA3050120A1 (en) 2017-02-24 2018-08-30 Merck Sharp & Dohme Corp. Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates
US11400162B2 (en) 2017-02-24 2022-08-02 Merck Sharp & Dohme Llc Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
KR20240018697A (en) 2017-06-10 2024-02-13 인벤트프라이즈 인크. Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity
CN110996992A (en) * 2017-08-16 2020-04-10 默沙东公司 Pneumococcal conjugate vaccine formulations
RS65893B1 (en) 2017-09-07 2024-09-30 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
KR102734995B1 (en) * 2017-09-07 2024-11-26 머크 샤프 앤드 돔 엘엘씨 Pneumococcal polysaccharide and its use in immunogenic polysaccharide-carrier protein conjugates
KR102736151B1 (en) 2017-09-07 2024-11-28 머크 샤프 앤드 돔 엘엘씨 Pneumococcal polysaccharide and its use in immunogenic polysaccharide-carrier protein conjugates
US11524076B2 (en) 2017-09-07 2022-12-13 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
AU2018328036B2 (en) 2017-09-07 2024-03-07 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
BR112020004410A8 (en) 2017-09-07 2023-01-31 Merck Sharp & Dohme PROCESSES FOR THE FORMULATION OF PNEUMOCOCCAL POLYSACCHARIDES FOR CONJUGATION TO A CARRIER PROTEIN
WO2019070994A1 (en) 2017-10-04 2019-04-11 Liffey Biotech Limited Saccharide-polypeptide conjugate compositions and methods of use thereof
UA128603C2 (en) 2017-12-06 2024-08-28 Мерк Шарп Енд Доум Елелсі Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
KR102812816B1 (en) 2018-02-05 2025-05-27 사노피 파스퇴르 인코포레이티드 Polyvalent pneumococcal polysaccharide-protein conjugate composition
KR20230008923A (en) * 2018-02-05 2023-01-16 사노피 파스퇴르 인코포레이티드 Multivalent pneumococcal polysaccharide-protein conjugate composition
JP2021522213A (en) 2018-04-18 2021-08-30 エスケー バイオサイエンス カンパニー リミテッド Streptococcus pneumoniae capsular polysaccharide and its immunogenic zygotes
CN120661645A (en) 2018-04-30 2025-09-19 默沙东有限责任公司 Method for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
JP7397000B2 (en) 2018-04-30 2023-12-12 メルク・シャープ・アンド・ドーム・エルエルシー Method for providing a homogeneous solution of lyophilized mutant diphtheria toxin in dimethyl sulfoxide
CN112074294B (en) 2018-04-30 2025-07-11 默沙东有限责任公司 Method for producing Streptococcus pneumoniae capsular polysaccharide carrier protein conjugate from freeze-dried pellets
WO2019220304A1 (en) * 2018-05-14 2019-11-21 Tergene Biotech Pvt. Ltd. 15 valent pneumococcal polysaccharide conjugate vaccine
US11389519B2 (en) 2018-06-11 2022-07-19 Inventprise, Llc Virus-like particle conjugates
WO2020009462A1 (en) * 2018-07-06 2020-01-09 주식회사 유바이오로직스 Multivalent immunogenic composition comprising polysaccharide-protein conjugates, and vaccine comprising same for preventing disease caused by streptococcus pneumoniae
CN112673054A (en) * 2018-07-19 2021-04-16 葛兰素史密丝克莱恩生物有限公司 Process for preparing dried polysaccharides
WO2020056202A1 (en) * 2018-09-12 2020-03-19 Affinivax, Inc. Multivalent pneumococcal vaccines
US20220143166A1 (en) * 2018-10-12 2022-05-12 Biological E Limited Multivalent pneumococcal polysaccharide-protein conjugate vaccine
SG11202106541WA (en) 2018-12-19 2021-07-29 Merck Sharp & Dohme Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
MX2021014948A (en) * 2019-06-05 2022-01-24 Merck Sharp & Dohme Llc METHODS OF TREATING PATIENTS WITH AN IMMUNOGENIC COMPOSITION THAT PROTECTS AGAINST <i>S. PNEUMONIAE</i> SEROTYPE 29.
JP2022535063A (en) * 2019-06-05 2022-08-04 メルク・シャープ・アンド・ドーム・コーポレーション Immunogenic serotype 35B pneumococcal polysaccharide-protein conjugates and conjugation processes for making them
WO2021010798A1 (en) * 2019-07-18 2021-01-21 (주)셀트리온 Immunogenic composition comprising multivalent streptococcus pneumoniae polysaccharide-protein conjugates
AU2020323498A1 (en) 2019-07-31 2022-03-03 Sk Bioscience Co., Ltd. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
JP7630603B2 (en) 2020-08-10 2025-02-17 インベントプライズ・インコーポレイテッド Multivalent pneumococcal glycoconjugate vaccine containing the emerging serotype 24F
KR20220102871A (en) * 2021-01-14 2022-07-21 (주)셀트리온 The immunogenic composition comprising multivalent pneumococcal polysaccharide-protein conjugate
TW202245835A (en) 2021-02-04 2022-12-01 美商默沙東有限責任公司 Nanoemulsion adjuvant composition for pneumococcal conjugate vaccines
WO2024238731A1 (en) 2023-05-18 2024-11-21 Merck Sharp & Dohme Llc Compounds and adjuvant formulations useful in pneumococcal vaccines
TW202532099A (en) 2024-02-14 2025-08-16 美商默沙東有限責任公司 Pneumococcal conjugate vaccines and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
SI1296715T2 (en) * 2000-06-29 2016-03-31 Smithkline Beecham Biologicals S.A. Multivalent vaccine composition
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
WO2005120563A2 (en) * 2004-06-04 2005-12-22 Pharmexa Inc. Induction of an immune response against streptococcus pneumoniae polysaccharides
CN1660881A (en) * 2005-01-12 2005-08-31 北京万赛生物医药技术发展有限公司 New type molecules of immunization stimulus and preparation method
CN113198012B (en) * 2005-04-08 2024-09-17 惠氏有限责任公司 Multivalent pneumococcal polysaccharide-protein conjugate composition
EP2201961B1 (en) * 2005-06-27 2018-01-24 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US20090035326A1 (en) * 2005-11-01 2009-02-05 Novartis Ag Compositions with antigens adsorbed to calcium phosphate
CA2808919C (en) * 2005-12-22 2016-04-19 Glaxosmithkline Biologicals S.A. Streptococcus pneumoniae capsular saccharide vaccine
AU2006327023A1 (en) * 2005-12-23 2007-06-28 Glaxosmithkline Biologicals Sa Conjugate vaccines
WO2007127668A2 (en) * 2006-04-26 2007-11-08 Wyeth Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations
SI2436700T1 (en) * 2007-03-23 2018-09-28 Wyeth Llc Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides
KR101579947B1 (en) * 2007-06-26 2015-12-28 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
CN101590224A (en) * 2009-06-30 2009-12-02 广州精达医学科技有限公司 High-efficiency 14-valent pneumococcal conjugate vaccine

Also Published As

Publication number Publication date
US20120301502A1 (en) 2012-11-29
TW201136603A (en) 2011-11-01
CL2012002195A1 (en) 2012-11-30
BR112012019757B8 (en) 2023-04-25
UA106115C2 (en) 2014-07-25
ECSP12012100A (en) 2013-03-28
ZA201205737B (en) 2013-04-24
CN102858365A (en) 2013-01-02
BR112012019757B1 (en) 2020-11-17
PH12012501559A1 (en) 2012-10-22
AU2011216095A1 (en) 2012-08-09
MX2012009206A (en) 2012-08-23
MA34051B1 (en) 2013-03-05
IL221283A0 (en) 2012-10-31
CA2788680C (en) 2014-12-16
TN2012000377A1 (en) 2014-01-30
WO2011100151A1 (en) 2011-08-18
KR101538535B1 (en) 2015-07-22
EP2533805A1 (en) 2012-12-19
SG183199A1 (en) 2012-09-27
CA2788680A1 (en) 2011-08-18
BR112012019757A2 (en) 2016-05-10
RU2012138368A (en) 2014-03-20
AR080122A1 (en) 2012-03-14
EP2533805A4 (en) 2013-08-28
AR116043A2 (en) 2021-03-25
US8192746B2 (en) 2012-06-05
MY159984A (en) 2017-02-15
PE20121698A1 (en) 2012-12-11
US20110195086A1 (en) 2011-08-11
JP2013518891A (en) 2013-05-23
KR20120114345A (en) 2012-10-16
AU2011216095B2 (en) 2013-07-18
NZ601711A (en) 2014-03-28
JP2014012720A (en) 2014-01-23

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