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SG10201405022PA - Ketoreductase polypeptides for the preparation of phenylephrine - Google Patents

Ketoreductase polypeptides for the preparation of phenylephrine

Info

Publication number
SG10201405022PA
SG10201405022PA SG10201405022PA SG10201405022PA SG10201405022PA SG 10201405022P A SG10201405022P A SG 10201405022PA SG 10201405022P A SG10201405022P A SG 10201405022PA SG 10201405022P A SG10201405022P A SG 10201405022PA SG 10201405022P A SG10201405022P A SG 10201405022PA
Authority
SG
Singapore
Prior art keywords
phenylephrine
preparation
ketoreductase polypeptides
ketoreductase
polypeptides
Prior art date
Application number
SG10201405022PA
Inventor
Oscar Alvizo
Steven J Collier
Joerg Hennemann
Seong Ho Oh
Wenjuan Zha
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG10201405022PA publication Critical patent/SG10201405022PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG10201405022PA 2009-08-19 2010-08-19 Ketoreductase polypeptides for the preparation of phenylephrine SG10201405022PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23532409P 2009-08-19 2009-08-19

Publications (1)

Publication Number Publication Date
SG10201405022PA true SG10201405022PA (en) 2014-10-30

Family

ID=43607588

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012010864A SG178456A1 (en) 2009-08-19 2010-08-19 Ketoreductase polypeptides for the preparation of phenylephrine
SG10201405022PA SG10201405022PA (en) 2009-08-19 2010-08-19 Ketoreductase polypeptides for the preparation of phenylephrine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012010864A SG178456A1 (en) 2009-08-19 2010-08-19 Ketoreductase polypeptides for the preparation of phenylephrine

Country Status (5)

Country Link
US (8) US9102959B2 (en)
EP (1) EP2467473B1 (en)
ES (1) ES2575560T3 (en)
SG (2) SG178456A1 (en)
WO (1) WO2011022548A2 (en)

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EP2329014B1 (en) * 2008-08-29 2014-10-22 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
SG178456A1 (en) 2009-08-19 2012-04-27 Codexis Inc Ketoreductase polypeptides for the preparation of phenylephrine
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WO2017001907A1 (en) 2015-06-29 2017-01-05 Teva Pharmaceuticals International Gmbh Biocatalytic processes for the preparation of vilanterol
CN106636239B (en) * 2016-11-16 2019-12-31 苏州引航生物科技有限公司 Preparation method of chloramphenicol
CN106566851B (en) * 2016-11-11 2020-11-10 苏州引航生物科技有限公司 Preparation method of chloramphenicol compound
WO2019012095A1 (en) 2017-07-14 2019-01-17 C-Lecta Gmbh Ketoreductases
CN109576313B (en) * 2017-09-29 2022-02-22 尚科生物医药（上海）有限公司 Method for preparing (S) -2-chloro-1- (3-hydroxyphenyl) ethanol
CN109576312B (en) * 2017-09-29 2021-08-24 尚科生物医药（上海）有限公司 Method for preparing (R) -2-chloro-1- (3-hydroxyphenyl) ethanol
CN108410830B (en) * 2018-03-15 2021-06-25 尚科生物医药（上海）有限公司 Ketoreductase and method for preparing (S) -1- (2-chlorphenyl) ethanol by catalyzing ketoreductase
CN109456949A (en) * 2018-12-27 2019-03-12 尚科生物医药（上海）有限公司 A kind of Ketoreductase mutant being used to prepare R type neo-synephrine
CN115478059B (en) * 2021-05-31 2025-04-11 尚科生物医药（上海）有限公司 A ketoreductase mutant and its application
CN118667775A (en) * 2023-03-14 2024-09-20 宁波酶赛生物工程有限公司 A biocatalyst and method for synthesizing chiral alcohol compounds
CN119662576B (en) * 2024-12-31 2025-07-29 浙江博崤生物制药有限公司 Ketoreductase and application thereof in phenylephrine hydrochloride biosynthesis

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Also Published As

Publication number Publication date
WO2011022548A3 (en) 2011-07-21
US9834758B2 (en) 2017-12-05
US20180066239A1 (en) 2018-03-08
SG178456A1 (en) 2012-04-27
US9102959B2 (en) 2015-08-11
US10590396B2 (en) 2020-03-17
EP2467473A4 (en) 2013-03-20
US12480100B2 (en) 2025-11-25
EP2467473B1 (en) 2016-03-23
WO2011022548A2 (en) 2011-02-24
US12031159B2 (en) 2024-07-09
US11345898B2 (en) 2022-05-31
US20200157511A1 (en) 2020-05-21
US20190309267A1 (en) 2019-10-10
US10870835B2 (en) 2020-12-22
US10358631B2 (en) 2019-07-23
US20210062162A1 (en) 2021-03-04
ES2575560T3 (en) 2016-06-29
US20120149073A1 (en) 2012-06-14
EP2467473A2 (en) 2012-06-27
US20150299671A1 (en) 2015-10-22
US20240301366A1 (en) 2024-09-12
US20220267744A1 (en) 2022-08-25

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