[go: up one dir, main page]

SG10201400978PA - Oligonucleotide analogues incorporating 5-aza-cytosine therein - Google Patents

Oligonucleotide analogues incorporating 5-aza-cytosine therein

Info

Publication number
SG10201400978PA
SG10201400978PA SG10201400978PA SG10201400978PA SG10201400978PA SG 10201400978P A SG10201400978P A SG 10201400978PA SG 10201400978P A SG10201400978P A SG 10201400978PA SG 10201400978P A SG10201400978P A SG 10201400978PA SG 10201400978P A SG10201400978P A SG 10201400978PA
Authority
SG
Singapore
Prior art keywords
aza
cytosine
oligonucleotide analogues
analogues incorporating
incorporating
Prior art date
Application number
SG10201400978PA
Inventor
Pasit Phiasivongsa
Sanjeev Redkar
Original Assignee
Astex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37894870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201400978P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Pharmaceuticals Inc filed Critical Astex Pharmaceuticals Inc
Publication of SG10201400978PA publication Critical patent/SG10201400978PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
SG10201400978PA 2005-09-29 2006-09-25 Oligonucleotide analogues incorporating 5-aza-cytosine therein SG10201400978PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/241,799 US7700567B2 (en) 2005-09-29 2005-09-29 Oligonucleotide analogues incorporating 5-aza-cytosine therein

Publications (1)

Publication Number Publication Date
SG10201400978PA true SG10201400978PA (en) 2014-08-28

Family

ID=37894870

Family Applications (2)

Application Number Title Priority Date Filing Date
SG201007143-9A SG166112A1 (en) 2005-09-29 2006-09-25 Oligonucleotide analogues incorporating 5-aza-cytosine therein
SG10201400978PA SG10201400978PA (en) 2005-09-29 2006-09-25 Oligonucleotide analogues incorporating 5-aza-cytosine therein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG201007143-9A SG166112A1 (en) 2005-09-29 2006-09-25 Oligonucleotide analogues incorporating 5-aza-cytosine therein

Country Status (22)

Country Link
US (7) US7700567B2 (en)
EP (2) EP1943264B1 (en)
JP (1) JP5030958B2 (en)
KR (2) KR20130137725A (en)
CN (1) CN101282986B (en)
AU (1) AU2006297375C1 (en)
CA (2) CA2623090C (en)
CY (1) CY1116876T1 (en)
DK (2) DK2944646T3 (en)
ES (2) ES2550256T3 (en)
HU (1) HUE025782T2 (en)
IL (2) IL190248A (en)
MY (1) MY145619A (en)
NO (1) NO344764B1 (en)
NZ (2) NZ566617A (en)
PH (1) PH12012502290A1 (en)
PL (1) PL1943264T3 (en)
PT (1) PT1943264E (en)
SG (2) SG166112A1 (en)
SI (1) SI1943264T1 (en)
WO (1) WO2007041071A2 (en)
ZA (1) ZA200803522B (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US20060069060A1 (en) * 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US20070105792A1 (en) * 2005-11-04 2007-05-10 Dimartino Jorge F Administration Of DNA Methylation Inhibitors For Treating Epigenetic Diseases
US20110288042A1 (en) * 2007-08-02 2011-11-24 Chemagis Ltd. Stable highly pure azacitidine and preparation methods therefor
WO2009105258A1 (en) 2008-02-22 2009-08-27 Nektar Therapeutics Al, Corporation Oligomer conjugates of heteropentacyclic nucleosides
CN102282155B (en) 2008-12-02 2017-06-09 日本波涛生命科学公司 The synthetic method of the nucleic acid of phosphorus atoms modification
WO2011005761A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc Novel nucleic acid prodrugs and methods use thereof
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
WO2012039448A1 (en) 2010-09-24 2012-03-29 株式会社キラルジェン Asymmetric auxiliary group
WO2012142480A1 (en) * 2011-04-14 2012-10-18 Beth Israel Deaconess Medical Center, Inc. Chimeric rna oligonucleotides and uses thereof
EP2734208B1 (en) 2011-07-19 2017-03-01 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
PL2750768T3 (en) * 2011-08-30 2019-05-31 Astex Pharmaceuticals Inc Decitabine derivative formulations
EP2869852A4 (en) * 2012-07-09 2016-04-20 Metheor Therapeutics Corp Oligonucleotide inhibitors of dna methyltransferases and their use in treating diseases
AU2013288048A1 (en) 2012-07-13 2015-01-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
CN104661664B (en) 2012-07-13 2020-07-03 波涛生命科学有限公司 Chiral control
GB201215289D0 (en) 2012-08-28 2012-10-10 Medical Res Council Nanoparticle formulation
AR092982A1 (en) 2012-10-11 2015-05-13 Isis Pharmaceuticals Inc MODULATION OF THE EXPRESSION OF ANDROGEN RECEIVERS
CA2927565C (en) * 2012-10-30 2021-05-18 Mei Pharma, Inc. Combination therapies
RU2708246C2 (en) * 2013-03-01 2019-12-05 Астекс Фармасьютикалз, Инк. Drug combinations
CN103305604B (en) * 2013-05-09 2015-05-06 宁波大学 Kit for detecting CDKN2B gene promoter region methylation degree related to coronary disease and application thereof
WO2014204856A1 (en) * 2013-06-17 2014-12-24 Catabasis Pharmaceuticals, Inc. Fatty acid anticancer derivatives and their uses
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
CN113278617A (en) 2014-01-16 2021-08-20 波涛生命科学有限公司 Chiral design
HK1254645A1 (en) * 2015-07-02 2019-07-26 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions
EP3349749B1 (en) 2015-09-17 2022-12-14 University of Massachusetts Compositions and methods for modulating fmr1 expression
JP6162349B1 (en) * 2016-04-21 2017-07-12 大原薬品工業株式会社 Sacyl moiety silyl ether derivatives of 5-azacytidines
US10227374B2 (en) * 2016-04-21 2019-03-12 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
WO2017183215A1 (en) * 2016-04-21 2017-10-26 大原薬品工業株式会社 Sugar moiety silyl ether derivative of 5-azacytidine
MA46905A (en) 2016-11-23 2019-10-02 Wave Life Sciences Ltd COMPOSITIONS AND SYNTHESIS OF PHOSPHORAMIDITES AND OLIGONUCLEOTIDES
CN106929476A (en) * 2017-03-29 2017-07-07 大连理工大学 A kind of application of demethylation reagent in human leukemia cell
EP3634972A2 (en) 2017-07-11 2020-04-15 Teva Czech Industries s.r.o. Improved processes for the preparation of guadecitabine and intermediates thereof
EP3661522A2 (en) 2017-08-03 2020-06-10 Otsuka Pharmaceutical Co., Ltd. Drug compound and purification methods thereof
BR102018008324A2 (en) * 2018-04-25 2019-11-05 Laboratorios Ferring Ltda topical pharmaceutical composition and topical pharmaceutical composition manufacturing process
KR102785135B1 (en) 2018-06-11 2025-03-21 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Demethylation for treating eye diseases
CN109232692A (en) * 2018-09-14 2019-01-18 中国医学科学院放射医学研究所 A kind of deoxycytidine class organic synthesis intermediate and preparation method thereof
WO2020068657A1 (en) * 2018-09-25 2020-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
US12448624B2 (en) 2018-10-19 2025-10-21 Interoligo Corporation Modified nucleic acid having improved treatment efficacy, and anticancer pharmaceutical composition containing same
EP3868774A4 (en) * 2018-10-19 2023-05-10 Interoligo Corporation MODIFIED NUCLEIC ACID WITH IMPROVED TREATMENT EFFICIENCY AND ANTI-CANCER PHARMACEUTICAL COMPOSITION THEREOF
CN110215740B (en) * 2019-07-15 2021-05-04 大连医科大学 A kind of preparation method of zwitterion hydrophilic pretreatment silica gel material
WO2021060341A1 (en) * 2019-09-26 2021-04-01 大原薬品工業株式会社 Use of dnmt inhibitor
KR20220151210A (en) 2020-03-13 2022-11-14 샌트랄 글래스 컴퍼니 리미티드 Dry etching method, semiconductor device manufacturing method, and dry etching gas composition
CN113425293B (en) * 2021-06-29 2022-10-21 上海交通大学医学院附属新华医院 A system and method for assessing auditory agnosia disorders

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH527207A (en) 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Process for the preparation of 1-glycosyl-5-azacytosines
DE2105468A1 (en) 1970-04-23 1971-11-18 Czeskoslovenska akademie ved, Prag; VtnKarstedt, E., Dipl.-Ing. Dr., Pat-Anw., 4200 Oberhausen 1-glycosyl-5-aza-cytosines prepn
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4426330A (en) 1981-07-20 1984-01-17 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4534899A (en) 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4855304A (en) * 1985-01-10 1989-08-08 Repligen Corporation Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals
JPS61161204A (en) * 1985-01-10 1986-07-21 レプリゲン　コーポレーシヨン Anti-plant-viral
JPS61176523A (en) 1985-01-30 1986-08-08 Teruhiko Beppu Carcinostatic agent
US4740560A (en) * 1986-04-17 1988-04-26 The Dow Chemical Company ABS resins and process for making them
GB8612826D0 (en) 1986-05-27 1986-07-02 Boots Co Plc Insecticidal compositions
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
DE3712786A1 (en) 1987-04-15 1988-11-03 Merck Patent Gmbh METHOD AND MEANS FOR DETERMINING NUCLEIC ACIDS
CS269077B1 (en) 1987-10-01 1990-04-11 Piskala Alois Method of 5-azacytosines preparation
US5968914A (en) 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5736531A (en) 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US4904770A (en) 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US5324831A (en) * 1988-04-06 1994-06-28 The United States Of America As Represented By The Secretary Of Health And Human Services Phosphoramidite reagent for chemical synthesis of modified DNA
GB8824593D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
PT93772A (en) 1989-04-17 1991-01-08 Searle & Co PROCESS FOR THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF NEOPLASMS, CONTAINING AN ANTI-NEOPLASTIC AGENT, FOR EXAMPLE DOXORUBICIN AND A PROTEIN AGENT TO REDUCE THE SIDE EFFECTS, FOR EXAMPLE CARBETIMER
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5356633A (en) 1989-10-20 1994-10-18 Liposome Technology, Inc. Method of treatment of inflamed tissues
US5665710A (en) 1990-04-30 1997-09-09 Georgetown University Method of making liposomal oligodeoxynucleotide compositions
US5610289A (en) 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
JP3220180B2 (en) 1991-05-23 2001-10-22 三菱化学株式会社 Drug-containing protein-bound liposomes
WO1993001202A1 (en) 1991-07-05 1993-01-21 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
IL103311A0 (en) 1991-10-07 1993-03-15 Univ Johns Hopkins Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers
JPH05219974A (en) 1992-02-13 1993-08-31 Mitsui Petrochem Ind Ltd Production of tropane alkaloid
JPH05246891A (en) 1992-03-09 1993-09-24 Kobayashi Seiyaku Kogyo Kk Stable antipancreatitic parenteral solution
FR2692265B1 (en) 1992-05-25 1996-11-08 Centre Nat Rech Scient BIOLOGICALLY ACTIVE COMPOUNDS OF THE PHOSPHOTRIESTER TYPE.
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
JP3351476B2 (en) 1993-01-22 2002-11-25 三菱化学株式会社 Phospholipid derivatives and liposomes containing the same
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
FR2705099B1 (en) 1993-05-12 1995-08-04 Centre Nat Rech Scient Phosphorothioate triester oligonucleotides and process for their preparation.
AU6081294A (en) 1993-05-14 1994-12-12 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
GB9311252D0 (en) 1993-06-01 1993-07-21 Hafslund Nycomed As Cell growth regualtors
AU1061395A (en) 1993-11-30 1995-06-19 Mcgill University Inhibition of dna methyltransferase
US5540935A (en) 1993-12-06 1996-07-30 Nof Corporation Reactive vesicle and functional substance-fixed vesicle
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
US5543152A (en) 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5856090A (en) 1994-09-09 1999-01-05 The Scripps Research Institute DNA-methylase linking reaction
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US20030104576A1 (en) 1994-10-07 2003-06-05 Jonathan W. Nyce Dna construct, composition, formulations & methods for making the construct & for modulating expression
CA2221411A1 (en) 1995-05-19 1996-11-21 Phytera, Inc. Manipulation of plant cell and tissue cultures
EP0852463B1 (en) 1995-06-06 2008-09-03 Case Western Reserve University Myogenic differentiation of human mesenchymal stem cells
US5756122A (en) 1995-06-07 1998-05-26 Georgetown University Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
BR9609944A (en) 1995-08-01 1999-05-18 Novartis Ag Liposomal oligonucleotide compositions
US5858397A (en) 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
US6136791A (en) 1995-12-22 2000-10-24 East Carolina University Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression
CZ120699A3 (en) 1996-10-16 1999-09-15 Icn Pharmaceuticals, Inc. Monocyclic l-nucleoside analogs and their utilization
US6423692B2 (en) 1997-04-24 2002-07-23 Dana-Farber Cancer Institute, Inc. Method of enhancing the effectiveness of DCK phosphorylated molecules
DE69829984D1 (en) 1997-08-29 2005-06-02 Univ California MODULATORS OF CYTOSINE-5-METHYL-TRANSFERASE AND METHOD FOR THEIR USE
US6153383A (en) * 1997-12-09 2000-11-28 Verdine; Gregory L. Synthetic transcriptional modulators and uses thereof
JP4768121B2 (en) 1998-02-05 2011-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Tumor associated antigens from the MAGE family and the nucleic acid sequences encoding them, the use of fusion proteins and for the preparation of compositions for vaccination
WO2000023112A1 (en) 1998-10-19 2000-04-27 Methylgene, Inc. Modulation of gene expression by combination therapy
EP3553085A1 (en) 1998-12-23 2019-10-16 Pfizer Inc Human momoclonal antibodies to ctla-4
WO2000040269A2 (en) 1999-01-05 2000-07-13 Lee Clarence C Pharmaceutical compositions for treatment of diseased tissues
WO2000062075A1 (en) 1999-04-13 2000-10-19 Rutgers, The State University Of New Jersey Ubiquitin cross-reactive protein as a prognostic marker for tumor cell chemosensitivity
US6599912B1 (en) 1999-06-03 2003-07-29 Jessie L. -S. Au Methods and compositions for modulating cell proliferation and cell death
DE19935303A1 (en) * 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonucleotides to inhibit the expression of human eg5
DK1212422T3 (en) 1999-08-24 2007-07-02 Medarex Inc Human CTLA-4 antibodies and their uses
JP2001163776A (en) 1999-09-30 2001-06-19 Nisshin Oil Mills Ltd:The Stabilized liquid agent
WO2001029235A2 (en) 1999-10-18 2001-04-26 Emory University Tms1 compositions and methods of use
AU2001247444A1 (en) 2000-03-15 2001-09-24 University Of Massachusetts Erbeta-mediated gene expression
ATE461453T1 (en) 2000-09-08 2010-04-15 Seoul Nat Univ Ind Foundation NUCLEIC ACID SEQUENCE AND PROTEIN PLAYING A ROLE IN CELLULAR AGING
US6858935B1 (en) 2000-12-07 2005-02-22 Cadence Design Systems, Inc. Simulating euclidean wiring directions using manhattan and diagonal directional wires
WO2002053138A2 (en) 2001-01-02 2002-07-11 Elisabeth Shanahan-Prendergast Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens
DZ3487A1 (en) 2001-01-22 2002-07-25 Merck Sharp & Dohme NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT VIRAL RNA POLYMERASE
JP2002223753A (en) 2001-01-30 2002-08-13 Hitachi Ltd Oligonucleotide arrays for drug response analysis
CA2436340A1 (en) 2001-02-05 2002-10-03 Innoventus Project Ab Histidine-rich glycoprotein
US6613753B2 (en) 2001-02-21 2003-09-02 Supergen, Inc. Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation
AU2002252183A1 (en) 2001-03-06 2002-09-19 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
US20060194275A1 (en) 2001-04-13 2006-08-31 Incyte Corporation Transporter and ion channels
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
EP1383504A1 (en) 2001-04-26 2004-01-28 Control Delivery Systems, Inc. Sustained release drug delivery system containing codrugs
US20030148973A1 (en) 2001-05-23 2003-08-07 Peter Emtage MAGE-A1 peptides for treating or preventing cancer
JP2004536596A (en) 2001-06-08 2004-12-09 ユー．エス． ジェノミクス， インコーポレイテッド Methods and products for analyzing nucleic acids based on methylation status
JP2002370939A (en) 2001-06-12 2002-12-24 Taisho Pharmaceut Co Ltd Hair restorer
AU2002312487A1 (en) * 2001-06-15 2003-01-02 Ribapharm Nucleoside vaccine adjuvants
US20030045497A1 (en) 2001-07-27 2003-03-06 Geneinvent Bbl Ab Methylation resistant vectors
SE0102627L (en) 2001-07-27 2002-11-19 Geneinvent Bbl Ab Vectors resistant to methylation
WO2003012085A1 (en) 2001-07-30 2003-02-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Antigen presenting cells, method for their preparation and their use for cancer vaccines
PT2177223E (en) 2001-09-05 2012-05-23 Chemgenex Pharmaceuticals Ltd Homoharringtonine alone or combined with other agents for use in treating chronic myelogenous leukemia resistant or intolerant to protein kinase inhibitors other than sti 571
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
IN2014DN10834A (en) 2001-09-17 2015-09-04 Psivida Inc
CA2461227C (en) 2001-09-24 2012-05-15 Jessie L.-S Au Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy
AU2002342004A1 (en) 2001-10-05 2003-04-22 Case Western Reserve University Methods and compositions for detecting colon cancers
EP1452592A4 (en) 2001-11-08 2006-02-15 Japan Science & Tech Agency GENES OF A TRANSPOSON OF RICE
WO2003043631A2 (en) 2001-11-23 2003-05-30 Chugai Seiyaku Kabushiki Kaisha Method for identification of tumor targeting enzymes
DE60234115D1 (en) 2001-11-29 2009-12-03 Dandrit Biotech As PHARMACEUTICAL COMPOSITION FOR INDUCING AN IMMUNE RESPONSE TO A HUMAN OR ANIMAL
WO2003046190A1 (en) 2001-11-30 2003-06-05 Medigene Aktiengesellschaft Optimized production of viral vectors derived from paroviruses in packaging and production cells by hsv infection or treatment with dna methylation inhibitors
GB0201498D0 (en) 2002-01-23 2002-03-13 Biotech Res Ventures Pte Ltd Materials and methods for treating cancer
US6998391B2 (en) 2002-02-07 2006-02-14 Supergen.Inc. Method for treating diseases associated with abnormal kinase activity
US20030147813A1 (en) 2002-02-07 2003-08-07 John Lyons Method for treating chronic myelogenous leukemia
CA2373890C (en) * 2002-02-28 2006-11-28 Portes Patio Resiver Inc Stress distribution hole for window sash
WO2003076660A1 (en) 2002-03-13 2003-09-18 F.Hoffmann-La Roche Ag Method for selecting drug sensitivity-determining factors and method for predicting drug sensitivity using the selected factors
JP2003310293A (en) 2002-04-26 2003-11-05 Mitsui Chemicals Inc Method for producing nucleoside compound
BR122019027966B8 (en) 2002-05-02 2021-07-27 Wyeth Corp monomeric calicheamicin derivative/anti-cd22 antibody conjugate and their use
AU2003251483A1 (en) 2002-06-05 2003-12-22 Case Western Reserve University Methods and compositions for detecting cancers
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
EP1556010A4 (en) 2002-10-31 2007-12-05 Supergen Inc PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT
US20050037992A1 (en) 2003-07-22 2005-02-17 John Lyons Composition and method for treating neurological disorders
US20050059682A1 (en) 2003-09-12 2005-03-17 Supergen, Inc., A Delaware Corporation Compositions and methods for treatment of cancer
WO2005033278A2 (en) 2003-09-30 2005-04-14 Ludwig Institute For Cancer Research In vivo efficacy of ny-eso-1 plus iscom
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds
US20050266012A1 (en) 2004-05-26 2005-12-01 Jean-Marie Andrieu Compositions comprising demethylating agents as enhancers of immunotherapy for the treatment of chronic infections and neoplastic diseases and methods for treating the same
US20060014949A1 (en) 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
US20060063735A1 (en) 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
US20060069060A1 (en) 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
CA2586844A1 (en) 2004-11-04 2006-05-11 Pfizer Products Inc. Ctla-4 antibody and aromatase inhibitor or combination treatment for breast cancer
US20060128653A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of decitabine
US20060128654A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
US20060159694A1 (en) 2004-12-29 2006-07-20 Chih-Sheng Chiang Combinations of tumor-associated antigens in compositions for various types of cancers
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Substituted Amid derivatives & methods of use
KR101498834B1 (en) 2005-05-09 2015-03-05 오노 야꾸힝 고교 가부시키가이샤 Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
HRP20080053A2 (en) 2005-07-01 2009-08-31 Medarex HUMAN MONOCLONAL ANTIBODIES TO LIGAND 1 FOR PROGRAMMED DEATH OF THE STATION (PD-L1)
US7700567B2 (en) * 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US20070105792A1 (en) 2005-11-04 2007-05-10 Dimartino Jorge F Administration Of DNA Methylation Inhibitors For Treating Epigenetic Diseases
US20070117776A1 (en) 2005-11-04 2007-05-24 John Lyons Low Dose Therapy Of DNA Methylation Inhibitors
CN101361718B (en) 2008-09-26 2013-08-28 深圳万乐药业有限公司 Stable preparation method of decitabine freeze-dry preparation
GB201006096D0 (en) 2010-04-13 2010-05-26 Alligator Bioscience Ab Novel compositions and uses thereof
MX349622B (en) 2010-09-08 2017-08-07 Halozyme Inc Methods for assessing and identifying or evolving conditionally active therapeutic proteins.
KR20140029446A (en) 2011-04-15 2014-03-10 컴퓨젠 엘티디. Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
PL2750768T3 (en) 2011-08-30 2019-05-31 Astex Pharmaceuticals Inc Decitabine derivative formulations
US9872873B2 (en) 2012-02-06 2018-01-23 Fresenius Kabi Oncology Limited Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis
RU2708246C2 (en) 2013-03-01 2019-12-05 Астекс Фармасьютикалз, Инк. Drug combinations
HK1254645A1 (en) 2015-07-02 2019-07-26 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions

Also Published As

Publication number Publication date
US20220000900A1 (en) 2022-01-06
IL218618A (en) 2013-12-31
NZ566617A (en) 2012-02-24
NZ597432A (en) 2013-05-31
WO2007041071A3 (en) 2007-09-20
JP2009509531A (en) 2009-03-12
HK1120518A1 (en) 2009-04-03
US9480698B2 (en) 2016-11-01
DK2944646T3 (en) 2020-04-06
AU2006297375A1 (en) 2007-04-12
CY1116876T1 (en) 2017-04-05
ZA200803522B (en) 2009-07-29
ES2550256T3 (en) 2015-11-05
CA2623090C (en) 2015-11-10
PL1943264T3 (en) 2015-12-31
NO344764B1 (en) 2020-04-20
NO20082050L (en) 2008-06-27
IL190248A0 (en) 2008-11-03
PH12012502290A1 (en) 2015-02-25
US20130236536A1 (en) 2013-09-12
CA2623090A1 (en) 2007-04-12
US20200215092A1 (en) 2020-07-09
CN101282986A (en) 2008-10-08
CA2895866C (en) 2018-09-04
HUE025782T2 (en) 2016-05-30
US9358248B2 (en) 2016-06-07
US7700567B2 (en) 2010-04-20
SI1943264T1 (en) 2016-01-29
CN101282986B (en) 2012-06-27
US8461123B2 (en) 2013-06-11
JP5030958B2 (en) 2012-09-19
US10933079B2 (en) 2021-03-02
SG166112A1 (en) 2010-11-29
AU2006297375C1 (en) 2016-06-16
PT1943264E (en) 2015-11-02
WO2007041071A2 (en) 2007-04-12
ES2782998T3 (en) 2020-09-16
US20170035794A1 (en) 2017-02-09
IL218618A0 (en) 2012-04-30
EP1943264A4 (en) 2013-08-14
MY145619A (en) 2012-03-15
US20070072796A1 (en) 2007-03-29
EP2944646A1 (en) 2015-11-18
DK1943264T3 (en) 2015-10-26
EP2944646B1 (en) 2020-01-08
KR20080059612A (en) 2008-06-30
US20100215729A1 (en) 2010-08-26
EP1943264A2 (en) 2008-07-16
EP1943264B1 (en) 2015-07-29
IL190248A (en) 2012-08-30
CA2895866A1 (en) 2007-04-12
KR20130137725A (en) 2013-12-17
AU2006297375B2 (en) 2012-06-07
KR101478369B1 (en) 2015-01-02
US20160130296A1 (en) 2016-05-12
US10456415B2 (en) 2019-10-29

Similar Documents

Publication Publication Date Title
ZA200803522B (en) Oligonucleotide analogues incorporating 5-aza-cytosine therein
PT1957647E (en) Immunostimulatory oligoribonucleotides
PL2175273T3 (en) Kokumi-imparting agent
SI1962794T1 (en) Long acting injectable parasiticidal formulations
IL189064A0 (en) Insecticidal 3-acylaminobenzanilides
EP1841430A4 (en) Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine analogues
EP1852112A4 (en) Anti-tumor agent
GB0514889D0 (en) Oligonucleotides
EP1852499A4 (en) Neurotization promoting agent
GB0519245D0 (en) Purine compounds
EP1927347A4 (en) Bitterness-reducing agent
EP1889660A4 (en) Ozone-decomposing agent
EP1824490A4 (en) Piperazinyl-pyridine analogues
GB0523811D0 (en) Mass stectrometer
GB0503509D0 (en) An improved delivery agent
ZA200804303B (en) Immunostimulatory oligoribonucleotides
EP1854474A4 (en) Immunopotentiating agent
GB0613762D0 (en) Slabline structure
GB0500504D0 (en) Fluorescent nucleotide analogues
PL115561U1 (en) Spatula
GB0507255D0 (en) Low k8
GB0507201D0 (en) New antiviral indolilydene analogues
GB2453847B (en) Retaining member
ZAA200500720S (en) Retaining elements
GB0522257D0 (en) H-rtm-roha(c)