SE9901901D0 - Compounds - Google Patents
CompoundsInfo
- Publication number
- SE9901901D0 SE9901901D0 SE9901901A SE9901901A SE9901901D0 SE 9901901 D0 SE9901901 D0 SE 9901901D0 SE 9901901 A SE9901901 A SE 9901901A SE 9901901 A SE9901901 A SE 9901901A SE 9901901 D0 SE9901901 D0 SE 9901901D0
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- racemates
- tautomers
- inhibitors
- therapy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
There are provided novel compounds of formula (I), wherein R<1>, R<2>, A and X are as defined in the specification, and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9901901A SE9901901D0 (en) | 1999-05-26 | 1999-05-26 | Compounds |
| PCT/SE2000/001034 WO2000073313A1 (en) | 1999-05-26 | 2000-05-23 | New tricyclic amidine derivatives as inhibitors of nitric oxide synthase |
| AU51195/00A AU5119500A (en) | 1999-05-26 | 2000-05-23 | New tricyclic amidine derivatives as inhibitors of nitric oxide synthase |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9901901A SE9901901D0 (en) | 1999-05-26 | 1999-05-26 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9901901D0 true SE9901901D0 (en) | 1999-05-26 |
Family
ID=20415733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9901901A SE9901901D0 (en) | 1999-05-26 | 1999-05-26 | Compounds |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU5119500A (en) |
| SE (1) | SE9901901D0 (en) |
| WO (1) | WO2000073313A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA005409B1 (en) * | 2000-04-10 | 2005-02-24 | Пфайзер Продактс Инк. | Benzoamide piperidine containing derivatives as substance p receptor antagonists |
| US7119207B2 (en) | 2000-04-10 | 2006-10-10 | Pfizer Inc | Benzoamide piperidine containing compounds and related compounds |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| TW200808810A (en) | 2006-02-23 | 2008-02-16 | Novartis Ag | Organic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH476743A (en) * | 1962-06-08 | 1969-08-15 | Wander Ag Dr A | Process for the preparation of amidines of the dibenzo (b, e) (1,4) -diazepine series |
| US5605897A (en) * | 1991-04-23 | 1997-02-25 | Eli Lilly And Company | 2-methyl-thieno-benzodiazepine |
| TW458978B (en) * | 1995-11-07 | 2001-10-11 | Astra Ab | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
-
1999
- 1999-05-26 SE SE9901901A patent/SE9901901D0/en unknown
-
2000
- 2000-05-23 AU AU51195/00A patent/AU5119500A/en not_active Abandoned
- 2000-05-23 WO PCT/SE2000/001034 patent/WO2000073313A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU5119500A (en) | 2000-12-18 |
| WO2000073313A1 (en) | 2000-12-07 |
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