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SE9901667D0 - Method and device for forming particles - Google Patents

Method and device for forming particles

Info

Publication number
SE9901667D0
SE9901667D0 SE9901667A SE9901667A SE9901667D0 SE 9901667 D0 SE9901667 D0 SE 9901667D0 SE 9901667 A SE9901667 A SE 9901667A SE 9901667 A SE9901667 A SE 9901667A SE 9901667 D0 SE9901667 D0 SE 9901667D0
Authority
SE
Sweden
Prior art keywords
fluid gas
vehicle system
mixing chamber
disorder
controlled
Prior art date
Application number
SE9901667A
Other languages
Swedish (sv)
Inventor
Catherine Boissier
Haakan Glad
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9901667A priority Critical patent/SE9901667D0/en
Publication of SE9901667D0 publication Critical patent/SE9901667D0/en
Priority to JP2000616911A priority patent/JP2002543961A/en
Priority to CN00807307A priority patent/CN1350475A/en
Priority to EP00930027A priority patent/EP1191998B1/en
Priority to PCT/SE2000/000877 priority patent/WO2000067892A1/en
Priority to KR1020017014121A priority patent/KR20020013871A/en
Priority to AU47923/00A priority patent/AU759786B2/en
Priority to MXPA01011099A priority patent/MXPA01011099A/en
Priority to CA002368087A priority patent/CA2368087A1/en
Priority to AT00930027T priority patent/ATE302647T1/en
Priority to US09/600,068 priority patent/US6551532B1/en
Priority to DE60022195T priority patent/DE60022195T2/en
Priority to NZ515146A priority patent/NZ515146A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0488—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/44—Mixers in which the components are pressed through slits
    • B01F25/441—Mixers in which the components are pressed through slits characterised by the configuration of the surfaces forming the slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00162—Controlling or regulating processes controlling the pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Accessories For Mixers (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Glanulating (AREA)

Abstract

The present invention relates to a method for forming particles of a substance, comprising the step of introducing into a mixing chamber (8), in which the temperature and pressure are controlled, a fluid gas (4) and at least one vehicle system (1) comprising at least one substance in solution or suspension such that droplet formation and extraction of the vehicle occur substantially simultaneously by the action of the fluid gas (4). Turbulence is induced in at least one of said fluid gas (4) and said vehicle system (1) so as to create a controlled disorder in the flow of the at least one of the fluid gas (4) or the vehicle system (1) in order to control the particle formation in said mixing chamber (8), said controlled disorder being created by at least one flow perturbation means (11). The invention also relates to a mixing chamber having at least one flow perturbation means (11) that is disposed for interacting with at least one of a fluid gas (4) or vehicle system (1) supplied by the at least one supply member (4, 5) so as to induce turbulence or limited disorder in the at least one of the fluid gas (4) or vehicle system (1).
SE9901667A 1999-05-07 1999-05-07 Method and device for forming particles SE9901667D0 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
SE9901667A SE9901667D0 (en) 1999-05-07 1999-05-07 Method and device for forming particles
NZ515146A NZ515146A (en) 1999-05-07 2000-05-04 Method and device for forming particles
PCT/SE2000/000877 WO2000067892A1 (en) 1999-05-07 2000-05-04 Method and device for forming particles
CN00807307A CN1350475A (en) 1999-05-07 2000-05-04 Method and device for forming particles
EP00930027A EP1191998B1 (en) 1999-05-07 2000-05-04 Method and device for forming particles
JP2000616911A JP2002543961A (en) 1999-05-07 2000-05-04 Particle generation method and particle generation device
KR1020017014121A KR20020013871A (en) 1999-05-07 2000-05-04 Method and device for forming particles
AU47923/00A AU759786B2 (en) 1999-05-07 2000-05-04 Method and device for forming particles
MXPA01011099A MXPA01011099A (en) 1999-05-07 2000-05-04 Method and device for forming particles.
CA002368087A CA2368087A1 (en) 1999-05-07 2000-05-04 Method and device for forming particles
AT00930027T ATE302647T1 (en) 1999-05-07 2000-05-04 METHOD AND DEVICE FOR PRODUCING PARTICLES
US09/600,068 US6551532B1 (en) 1999-05-07 2000-05-04 Method and device for forming particles
DE60022195T DE60022195T2 (en) 1999-05-07 2000-05-04 METHOD AND DEVICE FOR PRODUCING PARTICLES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901667A SE9901667D0 (en) 1999-05-07 1999-05-07 Method and device for forming particles

Publications (1)

Publication Number Publication Date
SE9901667D0 true SE9901667D0 (en) 1999-05-07

Family

ID=20415513

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9901667A SE9901667D0 (en) 1999-05-07 1999-05-07 Method and device for forming particles

Country Status (13)

Country Link
US (1) US6551532B1 (en)
EP (1) EP1191998B1 (en)
JP (1) JP2002543961A (en)
KR (1) KR20020013871A (en)
CN (1) CN1350475A (en)
AT (1) ATE302647T1 (en)
AU (1) AU759786B2 (en)
CA (1) CA2368087A1 (en)
DE (1) DE60022195T2 (en)
MX (1) MXPA01011099A (en)
NZ (1) NZ515146A (en)
SE (1) SE9901667D0 (en)
WO (1) WO2000067892A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
SI1363726T1 (en) 2001-02-26 2005-02-28 Dompe S.P.A. Apparatus and method for micron and submicron particle formation
FR2824754B1 (en) * 2001-05-15 2004-05-28 Separex Sa PROCESS FOR OBTAINING SOLID PARTICLES FROM AT LEAST ONE WATER-SOLUBLE PRODUCT
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
CA2482272C (en) * 2002-04-12 2011-08-16 Feyecon Development & Implementation B.V. Process for small particle formation
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
WO2004098561A2 (en) 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
US7098342B2 (en) * 2003-10-16 2006-08-29 Teva Pharmaceutical Industries Ltd. Preparation of candesartan cilexetil
US7692023B2 (en) * 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CA2562597A1 (en) * 2004-05-05 2005-11-24 Marina Yu Etinger Preparation of candesartan cilexetil in high purity
WO2005123720A1 (en) * 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof
WO2006122254A2 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Stable micronized candesartan cilexetil and methods for preparing thereof
EP2078052B1 (en) * 2006-10-31 2010-07-28 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
ES2691033T3 (en) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Therapeutic administration method of DHE to activate rapid migraine relief while minimizing the profile of side effects
ES2326402B1 (en) * 2008-04-07 2010-08-10 Activery Biotech, S.L. PROCEDURE FOR THE PREPARATION OF AMBASS COMBINATIONS OF ANTAGONISTS OF THE ANGIOTENSIN II RECEPTOR AND DIURETICS.
MX350838B (en) 2011-02-11 2017-09-18 Grain Proc Corporation * Salt composition.

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JPS5243163A (en) * 1975-10-02 1977-04-04 Matsushita Electric Ind Co Ltd Mixer for fluid
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ES481924A1 (en) * 1978-06-28 1980-09-01 Gen Foods Ltd Process for producing a spray-dried agglomerated soluble coffee product
NL8001874A (en) * 1980-03-29 1981-11-02 Stamicarbon DEVICE FOR SPRAYING A LIQUID USING A GAS.
US4606939A (en) * 1983-06-22 1986-08-19 The Ohio State University Research Foundation Small particle formation
JPS61138529A (en) * 1984-12-10 1986-06-26 Idemitsu Petrochem Co Ltd Production of emulsified solution for sizing
US4606940A (en) * 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
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Also Published As

Publication number Publication date
AU759786B2 (en) 2003-05-01
NZ515146A (en) 2003-07-25
EP1191998A1 (en) 2002-04-03
US6551532B1 (en) 2003-04-22
JP2002543961A (en) 2002-12-24
KR20020013871A (en) 2002-02-21
MXPA01011099A (en) 2002-06-04
CA2368087A1 (en) 2000-11-16
ATE302647T1 (en) 2005-09-15
DE60022195D1 (en) 2005-09-29
WO2000067892A1 (en) 2000-11-16
CN1350475A (en) 2002-05-22
EP1191998B1 (en) 2005-08-24
DE60022195T2 (en) 2006-06-29
AU4792300A (en) 2000-11-21

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