[go: up one dir, main page]

SE9803238L - Biosensor cell device and its use - Google Patents

Biosensor cell device and its use

Info

Publication number
SE9803238L
SE9803238L SE9803238A SE9803238A SE9803238L SE 9803238 L SE9803238 L SE 9803238L SE 9803238 A SE9803238 A SE 9803238A SE 9803238 A SE9803238 A SE 9803238A SE 9803238 L SE9803238 L SE 9803238L
Authority
SE
Sweden
Prior art keywords
analyte
interaction partner
pna
inlet
cell device
Prior art date
Application number
SE9803238A
Other languages
Swedish (sv)
Other versions
SE9803238D0 (en
SE512994C3 (en
SE512994C2 (en
Inventor
Uelo Langel
Magnus Samuelsson
Klas Edstam
Pater Gaardhagen
Original Assignee
Biosensor Applic Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosensor Applic Sweden Ab filed Critical Biosensor Applic Sweden Ab
Priority to SE9803238A priority Critical patent/SE512994C2/en
Publication of SE9803238D0 publication Critical patent/SE9803238D0/en
Priority to AU64916/99A priority patent/AU6491699A/en
Priority to PCT/SE1999/001658 priority patent/WO2000016903A1/en
Publication of SE9803238L publication Critical patent/SE9803238L/en
Publication of SE512994C3 publication Critical patent/SE512994C3/en
Publication of SE512994C2 publication Critical patent/SE512994C2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/222—Constructional or flow details for analysing fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0255—(Bio)chemical reactions, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0426—Bulk waves, e.g. quartz crystal microbalance, torsional waves

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A biosensor cell device comprising a test chamber cavity (42) and a piezoelectric crystal (41) coated on the surface facing the test chamber cavity (42) with an interaction partner to an analyte, the crystal (41) being connected to an oscillation unit and signal processing electronics, is disclosed. The device further comprises an inlet needle (49) for the introduction of the analyte that ends at a small distance from the end of, and inside, an inlet sleeve (50) for the introduction of buffer solution that ends in the vicinity of the active surface of the crystal (41), the inlet sleeve being connected to an inlet (47) for buffer solution, and an outlet (48) for excessive fluid. The interaction partner may be an antibody which specifically binds to the analyte (antigen) e.g. a narcotic or an explosive such as 2,4,6-trinitrotoluene (TNT). The interaction partner may be a peptide nucleic acid (PNA) oligomer and the analyte may be a polynucleotide, such as RNA, DNA and PNA polymers complementary to the PNA oligomer, or vice versa. The biosensor cell device may be used for qualitative and quantitative analysis of at least one analyte and/or its interaction partner.
SE9803238A 1998-09-24 1998-09-24 Biosensor cell device and its use SE512994C2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9803238A SE512994C2 (en) 1998-09-24 1998-09-24 Biosensor cell device and its use
AU64916/99A AU6491699A (en) 1998-09-24 1999-09-22 Biosensor cell device and its use
PCT/SE1999/001658 WO2000016903A1 (en) 1998-09-24 1999-09-22 Biosensor cell device and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9803238A SE512994C2 (en) 1998-09-24 1998-09-24 Biosensor cell device and its use

Publications (4)

Publication Number Publication Date
SE9803238D0 SE9803238D0 (en) 1998-09-24
SE9803238L true SE9803238L (en) 2000-03-25
SE512994C3 SE512994C3 (en) 2000-03-25
SE512994C2 SE512994C2 (en) 2000-06-12

Family

ID=20412700

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9803238A SE512994C2 (en) 1998-09-24 1998-09-24 Biosensor cell device and its use

Country Status (3)

Country Link
AU (1) AU6491699A (en)
SE (1) SE512994C2 (en)
WO (1) WO2000016903A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2220227B1 (en) 2003-05-30 2006-02-16 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" METHOD AND APPARATUS FOR THE DETECTION OF SUBSTANCES OR ANALYTICS FROM THE ANALYSIS OF ONE OR SEVERAL SAMPLES.
US7943388B2 (en) 2003-11-14 2011-05-17 3M Innovative Properties Company Acoustic sensors and methods
US7402678B2 (en) 2004-12-17 2008-07-22 3M Innovative Properties Company Multifunctional amine capture agents
US7342082B2 (en) 2004-12-17 2008-03-11 3M Innovative Properties Company Soluble polymers as amine capture agents and methods
CA2552363A1 (en) * 2003-12-30 2005-07-21 3M Innovative Properties Company Acoustic sensors and methods
US7544756B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544754B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544755B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
FR2948767A1 (en) * 2009-07-28 2011-02-04 Commissariat Energie Atomique Electrochemical cell for measurement assembly, has support comprising window and mounted opposite to side opening, so that liquid is in contact with element through side opening and window
CN104407150B (en) * 2014-11-12 2016-03-30 浙江大学 Preparation method of bionano sensor for 2,4,6-TNT detection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468605A (en) * 1993-10-15 1995-11-21 Molecular Devices Corp. Transverse flow plungers for microphysiometers
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
IL114692A (en) * 1995-07-21 1999-10-28 Yissum Res Dev Co Determination of an analyte in a liquid medium
DE19548376A1 (en) * 1995-12-27 1997-07-03 Behringwerke Ag Mass sensitive biosensors

Also Published As

Publication number Publication date
SE9803238D0 (en) 1998-09-24
WO2000016903A1 (en) 2000-03-30
SE512994C2 (en) 2000-06-12
AU6491699A (en) 2000-04-10

Similar Documents

Publication Publication Date Title
Minunni et al. Biosensors as new analytical tool for detection of Genetically Modified Organisms (GMOs)
FR2422956A1 (en) METHOD OF DETECTION AND CHARACTERIZATION OF A NUCLEIC ACID OR OF A SEQUENCE OF THE SAME, AND ENZYMATIC REAGENT FOR THE IMPLEMENTATION OF THIS PROCESS
US8224582B2 (en) Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)-based methods for drug and diagnostic development
ATE539816T1 (en) DIAGNOSTIC TESTING METHOD
DE59401964D1 (en) ELECTROCHEMICAL SENSOR
RU94019336A (en) Method of identification, sets for analysis, wave guide, biosensor
DE60219207D1 (en) DIAGNOSTIC TEST PROCEDURE
SE9803238L (en) Biosensor cell device and its use
EP0969083A4 (en) Dna capillary
WO2002090572A3 (en) Nucleic acid detection in pooled samples
FR2558172B1 (en) PROBE CONTAINING MODIFIED NUCLEIC ACID AND RECOGNITION BY SPECIFIC ANTIBODIES AND USE OF SUCH PROBE AND THESE SPECIFIC ANTIBODIES TO DETECT AND CHARACTERIZE A HOMOLOGATED DNA SEQUENCE
ATE242054T1 (en) DIAGNOSTIC DEVICE FOR THE CONTROLLED MOVEMENT OF REAGENTS WITHOUT MEMBRANES
DK0656955T3 (en) Elimination of false negative test results in nucleic acid detection
Palchetti et al. Biosensor technology: a brief history
Ying et al. Light-up RNA aptamer enabled label-free protein detection via a proximity induced transcription assay
ATE269161T1 (en) CONTACTING DEVICE
SE8700821L (en) SET AND REAGENTS KIT FOR QUANTIFICATION OF NUCLEIC ACID MOLECULES
DE60037864D1 (en) Enzyme Inhibition IMMUNE PROCESS
AU1259801A (en) Detection method by pcr
ATE229571T1 (en) DETECTION AND IDENTIFICATION OF NON-POLIO ENTEROVIRUSES
Zhao et al. A sensitive tobramycin electrochemical aptasensor based on multiple signal amplification cascades
WO2000043774A3 (en) Detection of small molecules by use of a piezoelectric sensor
CN110907358B (en) Device and method for realizing light microflow microbubble cavity lead ion sensor
Yan et al. A one-step fluorescent biosensing strategy for highly sensitive detection of HIV-related DNA based on strand displacement amplification and DNAzymes
WO2003011768A3 (en) Microfluidic device for molecular analysis

Legal Events

Date Code Title Description
NUG Patent has lapsed