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SE9801617D0 - New compound - Google Patents

New compound

Info

Publication number
SE9801617D0
SE9801617D0 SE9801617A SE9801617A SE9801617D0 SE 9801617 D0 SE9801617 D0 SE 9801617D0 SE 9801617 A SE9801617 A SE 9801617A SE 9801617 A SE9801617 A SE 9801617A SE 9801617 D0 SE9801617 D0 SE 9801617D0
Authority
SE
Sweden
Prior art keywords
protein
testis
nucleic acid
acid sequence
fetal
Prior art date
Application number
SE9801617A
Other languages
Swedish (sv)
Inventor
Katarina Nordqvist
Virpi Toehoenen
Original Assignee
Karolinska Innovations Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab filed Critical Karolinska Innovations Ab
Priority to SE9801617A priority Critical patent/SE9801617D0/en
Publication of SE9801617D0 publication Critical patent/SE9801617D0/en
Priority to PCT/SE1999/000764 priority patent/WO1999058565A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A gene encoding a novel cystatin-related protein has been isolated from fetal male mouse gonad and adult male human testis. The novel protein has a potential role in inducing testis formation in fetal gonads. It is also highly probable that the protein inhibits testis tumor growth because of structural and functional similarities with tumor inhibiting cystatins. The corresponding nucleic acid sequence, as well as vectors and host cells containing the nucleic acid sequence, and pharmaceutical compositions containing the protein are also claimed.
SE9801617A 1998-05-08 1998-05-08 New compound SE9801617D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SE9801617A SE9801617D0 (en) 1998-05-08 1998-05-08 New compound
PCT/SE1999/000764 WO1999058565A1 (en) 1998-05-08 1999-05-06 Cystatin-related protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9801617A SE9801617D0 (en) 1998-05-08 1998-05-08 New compound

Publications (1)

Publication Number Publication Date
SE9801617D0 true SE9801617D0 (en) 1998-05-08

Family

ID=20411238

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9801617A SE9801617D0 (en) 1998-05-08 1998-05-08 New compound

Country Status (2)

Country Link
SE (1) SE9801617D0 (en)
WO (1) WO1999058565A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030190669A1 (en) * 1998-12-30 2003-10-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001046421A2 (en) * 1999-12-23 2001-06-28 Zymogenetics, Inc. Zcys5: a member of the cystatin superfamily
AU2001279182A1 (en) * 2000-08-07 2002-02-18 Zymogenetics Inc. Zcys9: a member of the cystatin superfamily
AU2001286871A1 (en) * 2000-09-01 2002-03-22 Zymogenetics Inc. Mammalian cystatin-8 and its use to inhibit cancer procoagulant protein
WO2002050105A1 (en) * 2000-12-19 2002-06-27 Smithkline Beecham Corporation Novel compounds
CN100368018C (en) * 2005-05-26 2008-02-13 福建医科大学 Antitumor Invasion and Metastasis Effect and Application of Snake Venom Cysteine Protease Inhibitor

Also Published As

Publication number Publication date
WO1999058565A1 (en) 1999-11-18
WO1999058565A8 (en) 2000-01-06

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