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SE9702001D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9702001D0
SE9702001D0 SE9702001A SE9702001A SE9702001D0 SE 9702001 D0 SE9702001 D0 SE 9702001D0 SE 9702001 A SE9702001 A SE 9702001A SE 9702001 A SE9702001 A SE 9702001A SE 9702001 D0 SE9702001 D0 SE 9702001D0
Authority
SE
Sweden
Prior art keywords
novel compounds
pyrimidinediones
thieno
processes
production
Prior art date
Application number
SE9702001A
Other languages
English (en)
Inventor
David Cheshire
Andrew Cooke
Martin Cooper
David Donald
Mark Furber
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9702001A priority Critical patent/SE9702001D0/sv
Publication of SE9702001D0 publication Critical patent/SE9702001D0/sv
Priority to IDW991450A priority patent/ID28432A/id
Priority to AT98924705T priority patent/ATE226205T1/de
Priority to PT98924705T priority patent/PT991653E/pt
Priority to HU0003355A priority patent/HU226627B1/hu
Priority to JP50056599A priority patent/JP2002500666A/ja
Priority to IL13276398A priority patent/IL132763A0/xx
Priority to NZ500853A priority patent/NZ500853A/en
Priority to BR9809481-5A priority patent/BR9809481A/pt
Priority to PL337126A priority patent/PL199567B1/pl
Priority to CA002289509A priority patent/CA2289509C/en
Priority to DE69808765T priority patent/DE69808765T2/de
Priority to RU99128111/04A priority patent/RU2225410C2/ru
Priority to UA99127140A priority patent/UA61111C2/uk
Priority to EEP199900539A priority patent/EE04018B1/xx
Priority to EP98924705A priority patent/EP0991653B1/en
Priority to CZ0420199A priority patent/CZ297536B6/cs
Priority to AU76808/98A priority patent/AU723708B2/en
Priority to ES98924705T priority patent/ES2184270T3/es
Priority to CN98807378A priority patent/CN1122037C/zh
Priority to PCT/SE1998/000935 priority patent/WO1998054190A1/en
Priority to KR1019997011086A priority patent/KR100561988B1/ko
Priority to US09/117,426 priority patent/US6180635B1/en
Priority to SK1513-99A priority patent/SK283589B6/sk
Priority to DK98924705T priority patent/DK0991653T3/da
Priority to TR1999/02904T priority patent/TR199902904T2/xx
Priority to IL132763A priority patent/IL132763A/en
Priority to IS5264A priority patent/IS1983B/is
Priority to NO19995810A priority patent/NO323752B1/no
Priority to US09/693,896 priority patent/US6342502B1/en
Priority to US09/977,944 priority patent/US6469014B1/en
Priority to US10/265,201 priority patent/US6984644B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Liquid Crystal (AREA)
SE9702001A 1997-05-28 1997-05-28 Novel compounds SE9702001D0 (sv)

Priority Applications (32)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds
TR1999/02904T TR199902904T2 (xx) 1997-05-28 1998-05-18 Yeni bile�imler.
EEP199900539A EE04018B1 (et) 1997-05-28 1998-05-18 Tieno[2,3-d]pürimidiindioonid, nende valmistamisemeetod ja neid sisaldavad ravimkoostised
EP98924705A EP0991653B1 (en) 1997-05-28 1998-05-18 Novel compounds
PT98924705T PT991653E (pt) 1997-05-28 1998-05-18 Novos compostos
HU0003355A HU226627B1 (en) 1997-05-28 1998-05-18 Thieno[2,3-d]pyrimidinedione derivatives and pharmaceutical compositions containing them, process for their preparation and use thereof
JP50056599A JP2002500666A (ja) 1997-05-28 1998-05-18 新規な化合物
IL13276398A IL132763A0 (en) 1997-05-28 1998-05-18 Novel compounds
NZ500853A NZ500853A (en) 1997-05-28 1998-05-18 Immunosuppressive thieno[2,3-d]pyrimidine derivatives
BR9809481-5A BR9809481A (pt) 1997-05-28 1998-05-18 Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente
PL337126A PL199567B1 (pl) 1997-05-28 1998-05-18 Związki tienopiryminodionu, zawierające je kompozycje farmaceutyczne, sposoby wytwarzania tych zwiazków i ich zastosowanie w terapii
CA002289509A CA2289509C (en) 1997-05-28 1998-05-18 Novel compounds
DE69808765T DE69808765T2 (de) 1997-05-28 1998-05-18 Verbindungen
RU99128111/04A RU2225410C2 (ru) 1997-05-28 1998-05-18 ПРОИЗВОДНЫЕ ТИЕНО[2,3-d]ПИРИМИДИН-2,4(1Н,3Н)-ДИОНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЕЕ ПОЛУЧЕНИЯ, СПОСОБ ИММУНОСУПРЕССИИ И СПОСОБ ЛЕЧЕНИЯ ИЛИ СНИЖЕНИЯ РИСКА ОБСТРУКЦИИ ДЫХАТЕЛЬНЫХ ПУТЕЙ
UA99127140A UA61111C2 (uk) 1997-05-28 1998-05-18 Тієно[2,3-d]піримідинова сполука, спосіб її одержання, фармацевтична композиція, що її містить, і спосіб її одержання, спосіб здійснення імуносупресії і спосіб лікування
IDW991450A ID28432A (id) 1997-05-28 1998-05-18 Senyawa-senyawa baru
CZ0420199A CZ297536B6 (cs) 1997-05-28 1998-05-18 Thienopyrimidindionový derivát, jeho použití a způsoby přípravy, a farmaceutický prostředek s jeho obsahem a způsob jeho výroby
CN98807378A CN1122037C (zh) 1997-05-28 1998-05-18 噻吩并[2,3－d]嘧啶二酮类化合物及其制法、用途和含其的药物组合物
AT98924705T ATE226205T1 (de) 1997-05-28 1998-05-18 Verbindungen
ES98924705T ES2184270T3 (es) 1997-05-28 1998-05-18 Nuevos compuestos.
AU76808/98A AU723708B2 (en) 1997-05-28 1998-05-18 Novel compounds
PCT/SE1998/000935 WO1998054190A1 (en) 1997-05-28 1998-05-18 Novel compounds
KR1019997011086A KR100561988B1 (ko) 1997-05-28 1998-05-18 신규 화합물
US09/117,426 US6180635B1 (en) 1997-05-28 1998-05-18 Compounds
SK1513-99A SK283589B6 (sk) 1997-05-28 1998-05-18 Tieno[2,3-d]pyrimidíndióny, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
DK98924705T DK0991653T3 (da) 1997-05-28 1998-05-18 Nye forbindelser
IL132763A IL132763A (en) 1997-05-28 1999-11-04 Theo [[2,3 – d] pyrimidine - 2, 4 (H1, H3) Diones - transformed at position 6, processes for their preparation, the compositions containing them and their use in healing
IS5264A IS1983B (is) 1997-05-28 1999-11-23 Ný þíeno[2,3-d]pýrimidíndíón, blöndur sem innihalda þau, aðferðir til framleiðslu þeirra og notkun þeirra í lækningalyf
NO19995810A NO323752B1 (no) 1997-05-28 1999-11-26 Nye tieno(2,3-d)pyrimidindioner, fremgangsmate for fremstilling derav, farmasoytisk preparat som inneholder slike, samt anvendelse derav i terapi.
US09/693,896 US6342502B1 (en) 1997-05-28 2000-10-23 Thieno[2,3-d]pyrimidine diones and their use in the treatment of reversible obstructive airways diseases
US09/977,944 US6469014B1 (en) 1997-05-28 2001-10-17 Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
US10/265,201 US6984644B2 (en) 1997-05-28 2002-10-07 Treatment of skin disorders using thieno[2,3-D]pyrimidinediones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds

Publications (1)

Publication Number Publication Date
SE9702001D0 true SE9702001D0 (sv) 1997-05-28

Family

ID=20407123

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds

Country Status (28)

Country Link
US (2) US6180635B1 (sv)
EP (1) EP0991653B1 (sv)
JP (1) JP2002500666A (sv)
KR (1) KR100561988B1 (sv)
CN (1) CN1122037C (sv)
AT (1) ATE226205T1 (sv)
AU (1) AU723708B2 (sv)
BR (1) BR9809481A (sv)
CA (1) CA2289509C (sv)
CZ (1) CZ297536B6 (sv)
DE (1) DE69808765T2 (sv)
DK (1) DK0991653T3 (sv)
EE (1) EE04018B1 (sv)
ES (1) ES2184270T3 (sv)
HU (1) HU226627B1 (sv)
ID (1) ID28432A (sv)
IL (2) IL132763A0 (sv)
IS (1) IS1983B (sv)
NO (1) NO323752B1 (sv)
NZ (1) NZ500853A (sv)
PL (1) PL199567B1 (sv)
PT (1) PT991653E (sv)
RU (1) RU2225410C2 (sv)
SE (1) SE9702001D0 (sv)
SK (1) SK283589B6 (sv)
TR (1) TR199902904T2 (sv)
UA (1) UA61111C2 (sv)
WO (1) WO1998054190A1 (sv)

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SE9801399D0 (sv) 1998-04-21 1998-04-21 Astra Pharma Prod Method and apparatus for filling containers
GB9819384D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds II
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
DE60104677T2 (de) * 2000-05-04 2005-07-28 Astrazeneca Ab THIENO[2,3-d]PYRIMIDINDIONE UND IHRE VERWENDUNG ALS PHARMAZEUTISCHE MITTEL
GB2361917A (en) * 2000-05-04 2001-11-07 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones
GB2363377B (en) * 2000-06-14 2004-06-09 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof
CA2433778A1 (en) * 2001-02-14 2002-08-22 William Glen Harter Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors
GB0117583D0 (en) 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
EP1458382A1 (en) * 2001-12-21 2004-09-22 Novo Nordisk A/S Amide derivatives as gk activators
CA2488642C (en) * 2002-06-27 2011-09-06 Dharma Rao Polisetti Aryl carbonyl derivatives as glucokinase activators
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
MXPA05007495A (es) * 2003-01-17 2005-09-21 Astrazeneca Ab Tienopiridazinonas y su uso en la modulacion de enfermedades autoinmunes.
SE0300120D0 (sv) 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
SE0300117D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel Compounds
PL1723128T3 (pl) 2004-01-06 2013-04-30 Novo Nordisk As Pochodne heteroarylowe mocznika oraz ich zastosowanie jako aktywatory glukokinazy
JO2629B1 (en) * 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
WO2007006760A1 (en) * 2005-07-08 2007-01-18 Novo Nordisk A/S Dicycloalkyl urea glucokinase activators
JP2009500378A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
MX2008000255A (es) 2005-07-14 2008-04-02 Novo Nordisk As Activadores de urea glucocinasa.
CA2624492C (en) * 2005-10-19 2014-02-18 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
WO2007103776A2 (en) * 2006-03-02 2007-09-13 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
WO2008070529A2 (en) * 2006-12-01 2008-06-12 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
EP2118083A1 (en) * 2007-01-09 2009-11-18 Novo Nordisk A/S Urea glucokinase activators
JP5226008B2 (ja) * 2007-01-11 2013-07-03 ノボ・ノルデイスク・エー／エス ウレアグルコキナーゼアクチベーター
EP2008656A1 (en) * 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions for the treatment of hyperphenylalaninemia
SI2411395T1 (sl) * 2009-03-23 2013-07-31 Glenmark Pharmaceuticals S.A. Furopirimidindionski derivati kot TRPA1 modulatorji
DK2776038T3 (en) 2011-11-11 2018-04-23 Gilead Apollo Llc ACC INHIBITORS AND APPLICATIONS THEREOF
WO2014042176A1 (ja) * 2012-09-14 2014-03-20 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
ES2659043T3 (es) 2013-10-07 2018-03-13 Bayer Pharma Aktiengesellschaft Tienouracil-carboxamidas cíclicas y su uso
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
US20170166585A1 (en) 2015-11-25 2017-06-15 Gilead Apollo, Llc Pesticidal compositions and uses thereof
PT3380479T (pt) 2015-11-25 2023-03-13 Gilead Apollo Llc Inhibidores de triazol acc e seus usos
US20170166582A1 (en) 2015-11-25 2017-06-15 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
US20170166583A1 (en) 2015-11-25 2017-06-15 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
CN112920200A (zh) 2016-03-02 2021-06-08 吉利德阿波罗公司 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法
WO2018041771A1 (de) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung
CN109963858A (zh) * 2016-09-23 2019-07-02 拜耳股份公司 N3－环状取代的噻吩并尿嘧啶及其用途
JP6906626B2 (ja) 2017-03-28 2021-07-21 ギリアード サイエンシーズ， インコーポレイテッド 肝疾患を処置するための治療的組み合わせ
JP2021526130A (ja) 2018-06-12 2021-09-30 ブイティーブイ・セラピューティクス・エルエルシー インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用
WO2021167840A1 (en) 2020-02-18 2021-08-26 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof

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Also Published As

Publication number Publication date
SK151399A3 (en) 2000-05-16
NO995810D0 (no) 1999-11-26
EP0991653B1 (en) 2002-10-16
RU2225410C2 (ru) 2004-03-10
NO323752B1 (no) 2007-07-02
PT991653E (pt) 2003-02-28
EE9900539A (et) 2000-06-15
ES2184270T3 (es) 2003-04-01
US6180635B1 (en) 2001-01-30
IS5264A (is) 1999-11-23
CN1264382A (zh) 2000-08-23
IL132763A (en) 2007-03-08
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ID28432A (id) 2001-05-24
CZ420199A3 (cs) 2000-07-12
CA2289509C (en) 2007-10-02
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UA61111C2 (uk) 2003-11-17
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PL337126A1 (en) 2000-07-31
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CA2289509A1 (en) 1998-12-03
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NO995810L (no) 2000-01-27
CZ297536B6 (cs) 2007-01-03
IS1983B (is) 2005-01-14
AU7680898A (en) 1998-12-30
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HU226627B1 (en) 2009-05-28
HUP0003355A3 (en) 2003-03-28
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PL199567B1 (pl) 2008-10-31
CN1122037C (zh) 2003-09-24
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US6342502B1 (en) 2002-01-29

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