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SE9600329D0 - New anesthetic compounds - Google Patents

New anesthetic compounds

Info

Publication number
SE9600329D0
SE9600329D0 SE9600329A SE9600329A SE9600329D0 SE 9600329 D0 SE9600329 D0 SE 9600329D0 SE 9600329 A SE9600329 A SE 9600329A SE 9600329 A SE9600329 A SE 9600329A SE 9600329 D0 SE9600329 D0 SE 9600329D0
Authority
SE
Sweden
Prior art keywords
formula
compound
pharmaceutically acceptable
acceptable salt
pain
Prior art date
Application number
SE9600329A
Other languages
Swedish (sv)
Inventor
Rune Sandberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9600329A priority Critical patent/SE9600329D0/en
Publication of SE9600329D0 publication Critical patent/SE9600329D0/en
Priority to ARP960104736A priority patent/AR004691A1/en
Priority to TW085112594A priority patent/TW448142B/en
Priority to DK96935752T priority patent/DK0858445T3/en
Priority to CN96197845A priority patent/CN1113856C/en
Priority to CZ981241A priority patent/CZ124198A3/en
Priority to HK98110334.7A priority patent/HK1009437B/en
Priority to IL12391696A priority patent/IL123916A/en
Priority to DE69620213T priority patent/DE69620213T2/en
Priority to US08/776,620 priority patent/US6310252B1/en
Priority to PT96935752T priority patent/PT858445E/en
Priority to EE9800088A priority patent/EE03963B1/en
Priority to JP51653997A priority patent/JP4101877B2/en
Priority to SK553-98A priority patent/SK282757B6/en
Priority to EP96935752A priority patent/EP0858445B1/en
Priority to AU73561/96A priority patent/AU704635B2/en
Priority to TR1998/00714T priority patent/TR199800714T2/en
Priority to AT96935752T priority patent/ATE215061T1/en
Priority to CA002233489A priority patent/CA2233489C/en
Priority to BR9611234A priority patent/BR9611234A/en
Priority to ES96935752T priority patent/ES2174113T3/en
Priority to KR10-1998-0703023A priority patent/KR100460652B1/en
Priority to HU9901212A priority patent/HUP9901212A3/en
Priority to PL96326425A priority patent/PL186783B1/en
Priority to PCT/SE1996/001361 priority patent/WO1997015548A1/en
Priority to SI9630469T priority patent/SI0858445T1/en
Priority to RU98109937/04A priority patent/RU2193555C2/en
Priority to UA98042083A priority patent/UA59347C2/en
Priority to NZ320757A priority patent/NZ320757A/en
Priority to MYPI96004455A priority patent/MY132329A/en
Priority to SE9702456A priority patent/SE9702456D0/en
Priority to IS4702A priority patent/IS1932B/en
Priority to NO19981825A priority patent/NO310614B1/en

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel methylisopropyl-[(3-n-propoxyphenoxy)-ethyl]amine of the formula (I) where R1 means n-propyl group; R2 means methyl group; R3 means isopropyl group, or its pharmaceutically acceptable salt that show properties of topical anesthetics and can be used for preparing medicinal agent used for topical anesthesia. Methods of synthesis compound of the formula (I) involve interaction of a) compound of the formula (II) with compound of the formula (III) HN(R2)R3 (III) or its acid-additive salt either of b) compound of the formula (IV) with compound of the formula (V) R2(R3)NCH2CH2Hal (V) or its acid-additive salt. In indicated compounds (II) (V) R1-R3 have the above indicated values; Hal means Cl, Br or J. Pharmaceutical composition comprises compound of the formula (I) or its pharmaceutically acceptable salt in mixture with pharmaceutically acceptable adjuvant, diluting agent or carrier. Method of topical anesthesia involves application of compound of the formula (I) or its pharmaceutically acceptable salt taken in therapeutically effective dose on skin of patient suffering with pain or sensitive to pain. EFFECT: improved method of synthesis, valuable analgetic properties. 9 cl, 2 tbl, 3 dwg, 16 ex
SE9600329A 1995-10-27 1996-01-30 New anesthetic compounds SE9600329D0 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
SE9600329A SE9600329D0 (en) 1996-01-30 1996-01-30 New anesthetic compounds
ARP960104736A AR004691A1 (en) 1995-10-27 1996-10-14 NEW DERIVATIVES OF [3-ALCOXI-PENOXI -) - ETIL] -DIALKYLAMINE, A PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, THEIR USE AS LOCAL ANESTHETICS AND A PROCEDURE FOR THEIR PREPARATION
TW085112594A TW448142B (en) 1995-10-27 1996-10-15 New [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
NZ320757A NZ320757A (en) 1995-10-27 1996-10-23 [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
EP96935752A EP0858445B1 (en) 1995-10-27 1996-10-23 New [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
CA002233489A CA2233489C (en) 1995-10-27 1996-10-23 New [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
CZ981241A CZ124198A3 (en) 1995-10-27 1996-10-23 New [(3-alkoxy-phenoxy) -ethyl] -dialkylamine derivatives and their use as local anesthetics
HK98110334.7A HK1009437B (en) 1995-10-27 1996-10-23 New [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
IL12391696A IL123916A (en) 1995-10-27 1996-10-23 [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
DE69620213T DE69620213T2 (en) 1995-10-27 1996-10-23 [(3-ALKOXY-PHENOXY) -ETHYL] -DIALKYLAMINE DERIVATIVES AND THE USE THEREOF AS A LOCALANAESTHETIC
US08/776,620 US6310252B1 (en) 1995-10-27 1996-10-23 [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
PT96935752T PT858445E (en) 1995-10-27 1996-10-23 NEW ¬ (3-ALCOXY-PHENOXY) -ETIL | -DIALQUILAMINE DERIVATIVES AND THEIR USE AS LOCAL ANTHRODESIS
EE9800088A EE03963B1 (en) 1995-10-27 1996-10-23 [(3-Alkoxyphenoxy) ethyl] dialkylamine derivatives and their use as local anesthetics
JP51653997A JP4101877B2 (en) 1995-10-27 1996-10-23 Novel [(3-alkoxy-phenoxy) -ethyl] -dialkylamine derivatives and their use as local anesthetics
SK553-98A SK282757B6 (en) 1995-10-27 1996-10-23 New [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
DK96935752T DK0858445T3 (en) 1995-10-27 1996-10-23 New [(3-alkoxy-phenoxy) ethyl] dialkylamine derivatives and their use as local anesthetics
AU73561/96A AU704635B2 (en) 1995-10-27 1996-10-23 New {(3-alkoxy-phenoxy)-ethyl}-dialkylamine derivatives and their use as local anaesthetics
TR1998/00714T TR199800714T2 (en) 1995-10-27 1996-10-23 New derivatives of $(3-Alkoxy-phenoxy)-ethyl]-dialkylamine.
AT96935752T ATE215061T1 (en) 1995-10-27 1996-10-23 ((3-ALKOXY-PHENOXY)-ETHYL)-DIALKYLAMINE DERIVATIVES AND THEIR USE AS LOCAL ANESTHETICS
CN96197845A CN1113856C (en) 1995-10-27 1996-10-23 New (3-alkoxy-phenoxy)-ethyl] dialkylamine derivatives and their use as local anaesthetics
BR9611234A BR9611234A (en) 1995-10-27 1996-10-23 Compound pharmaceutical formulation use of the compound and processes for treating a pain and for preparing compounds
ES96935752T ES2174113T3 (en) 1995-10-27 1996-10-23 NEW DERIVATIVES OF ((3-ALCOXI-FENOXI) -ETIL) -DIALQUILAMINE AND ITS USE AS LOCAL ANESTHETICS.
KR10-1998-0703023A KR100460652B1 (en) 1995-10-27 1996-10-23 New [(3-Alkoxy-Phenoxy)-Ethyl]-Dialkylamine Derivatives and Their Use as Local Anaesthetics
HU9901212A HUP9901212A3 (en) 1995-10-27 1996-10-23 N-[2-(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives, pharmaceutical compositions containing the same and their use as local anaesthetics
PL96326425A PL186783B1 (en) 1995-10-27 1996-10-23 Novel derivatives of [(3-alkoxyphenoxy)ethyl]-dialkyl amine and their application as locally acting analgesic agents
PCT/SE1996/001361 WO1997015548A1 (en) 1995-10-27 1996-10-23 New [(3-alkoxy-phenoxy)-ethyl]-dialkylamine derivatives and their use as local anaesthetics
SI9630469T SI0858445T1 (en) 1995-10-27 1996-10-23 New ((3-alkoxy-phenoxy)-ethyl)-dialkylamine derivatives and their use as local anaesthetics
RU98109937/04A RU2193555C2 (en) 1996-01-30 1996-10-23 Methylisopropyl-[(3-n-propoxyphenoxy)ethyl]amine or its pharmaceutically acceptable salt, methods of its synthesis (variants), pharmaceutical composition, method of topical anesthesia
UA98042083A UA59347C2 (en) 1995-10-27 1996-10-23 [2-(3-(alkoxy)phenoxy)ethyl]dialkylamine derivatives, a method for producing thereof (variants), a pharmaceutical composition, a medicinal form for external application and a method for relief of pain
MYPI96004455A MY132329A (en) 1995-10-27 1996-10-25 [(3-alkoxy-phenoxy)-ethyl] - dialkylamine derivatives and their use as local anaesthetics
SE9702456A SE9702456D0 (en) 1995-10-27 1997-06-26 New ((3-Alkoxy-phenoxy -) - dialkylamine derivatives and their use as local anesthetics
IS4702A IS1932B (en) 1995-10-27 1998-03-25 New [(3-alkoxy-phenoxy) -ethyl] -dialkylamine derivatives, pharmaceutical compositions, use of the derivatives for the preparation of existing anesthetics and a method of producing them
NO19981825A NO310614B1 (en) 1995-10-27 1998-04-23 New [(3-alkoxyphenoxy) ethyl] dialkylamine derivatives, pharmaceutical preparation, use of the derivatives for the preparation of local anesthetics, and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9600329A SE9600329D0 (en) 1996-01-30 1996-01-30 New anesthetic compounds

Publications (1)

Publication Number Publication Date
SE9600329D0 true SE9600329D0 (en) 1996-01-30

Family

ID=20401197

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9600329A SE9600329D0 (en) 1995-10-27 1996-01-30 New anesthetic compounds

Country Status (2)

Country Link
RU (1) RU2193555C2 (en)
SE (1) SE9600329D0 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US310854A (en) * 1885-01-13 Half to abneb woodwaed

Also Published As

Publication number Publication date
RU2193555C2 (en) 2002-11-27

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