[go: up one dir, main page]

SE9501682D0 - Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits - Google Patents

Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits

Info

Publication number
SE9501682D0
SE9501682D0 SE9501682A SE9501682A SE9501682D0 SE 9501682 D0 SE9501682 D0 SE 9501682D0 SE 9501682 A SE9501682 A SE 9501682A SE 9501682 A SE9501682 A SE 9501682A SE 9501682 D0 SE9501682 D0 SE 9501682D0
Authority
SE
Sweden
Prior art keywords
amino
pct
ltb
disclosed
acid sequence
Prior art date
Application number
SE9501682A
Other languages
English (en)
Inventor
Jan Holmgren
Michael R Lebens
Original Assignee
Jan Holmgren
Michael R Lebens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jan Holmgren, Michael R Lebens filed Critical Jan Holmgren
Priority to SE9501682A priority Critical patent/SE9501682D0/sv
Publication of SE9501682D0 publication Critical patent/SE9501682D0/sv
Priority to KR1019970707816A priority patent/KR100492305B1/ko
Priority to DE69634003T priority patent/DE69634003T2/de
Priority to CA2219943A priority patent/CA2219943C/en
Priority to CNB961952237A priority patent/CN1154660C/zh
Priority to PT96915275T priority patent/PT824548E/pt
Priority to US08/952,337 priority patent/US6019973A/en
Priority to EP96915275A priority patent/EP0824548B1/en
Priority to PCT/SE1996/000570 priority patent/WO1996034893A1/en
Priority to AU57085/96A priority patent/AU702637B2/en
Priority to JP53323796A priority patent/JP4081140B2/ja
Priority to ES96915275T priority patent/ES2233968T3/es
Priority to DK96915275T priority patent/DK0824548T3/da
Priority to AT96915275T priority patent/ATE284416T1/de
Priority to IL118136A priority patent/IL118136A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE9501682A 1995-05-05 1995-05-05 Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits SE9501682D0 (sv)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE9501682A SE9501682D0 (sv) 1995-05-05 1995-05-05 Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits
AT96915275T ATE284416T1 (de) 1995-05-05 1996-05-02 Hybrid-moleküle aus hitzelabilem enterotoxin und choleratoxin-b-untereinheiten
US08/952,337 US6019973A (en) 1995-05-05 1996-05-02 Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits
PCT/SE1996/000570 WO1996034893A1 (en) 1995-05-05 1996-05-02 Hybrid molecules between heat-labile enterotoxin and cholera toxin b subunits
CA2219943A CA2219943C (en) 1995-05-05 1996-05-02 Hybrid molecules between heat-labile enterotoxin and cholera toxin b subunits
CNB961952237A CN1154660C (zh) 1995-05-05 1996-05-02 热易变肠毒素和霍乱毒素b亚基之间的杂合分子
PT96915275T PT824548E (pt) 1995-05-05 1996-05-02 Moleculas hibridas entre a enterotoxina labil ao calor e a subunidade b da toxina da colera
KR1019970707816A KR100492305B1 (ko) 1995-05-05 1996-05-02 열에 불안정한 엔테로톡신과 콜레라톡신 b 유니트간의 혼성분자 및 구조유전자, 플라즈미드, 면역원성단백질, 백신, 약학적 조성물
EP96915275A EP0824548B1 (en) 1995-05-05 1996-05-02 Hybrid molecules between heat-labile enterotoxin and cholera toxin b subunits
DE69634003T DE69634003T2 (de) 1995-05-05 1996-05-02 Hybrid-moleküle aus hitzelabilem enterotoxin und choleratoxin-b-untereinheiten
AU57085/96A AU702637B2 (en) 1995-05-05 1996-05-02 Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits
JP53323796A JP4081140B2 (ja) 1995-05-05 1996-05-02 非耐熱性エンテロトキシンとコレラトキシンｂサブユニットの雑種分子
ES96915275T ES2233968T3 (es) 1995-05-05 1996-05-02 Moleculas hibridas entre enterotoxina termolabil y subunidades b de toxina colerica.
DK96915275T DK0824548T3 (da) 1995-05-05 1996-05-02 Hybridmolekyler mellem varmelabil enterotoksin og choleratoksin B-underenheder
IL118136A IL118136A (en) 1995-05-05 1996-05-03 Hybrid molecules between the heat-sensitive entrotoxin B subunits and cholera toxin B

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9501682A SE9501682D0 (sv) 1995-05-05 1995-05-05 Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits

Publications (1)

Publication Number Publication Date
SE9501682D0 true SE9501682D0 (sv) 1995-05-05

Family

ID=20398217

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9501682A SE9501682D0 (sv) 1995-05-05 1995-05-05 Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits

Country Status (15)

Country Link
US (1) US6019973A (sv)
EP (1) EP0824548B1 (sv)
JP (1) JP4081140B2 (sv)
KR (1) KR100492305B1 (sv)
CN (1) CN1154660C (sv)
AT (1) ATE284416T1 (sv)
AU (1) AU702637B2 (sv)
CA (1) CA2219943C (sv)
DE (1) DE69634003T2 (sv)
DK (1) DK0824548T3 (sv)
ES (1) ES2233968T3 (sv)
IL (1) IL118136A (sv)
PT (1) PT824548E (sv)
SE (1) SE9501682D0 (sv)
WO (1) WO1996034893A1 (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2235845C (en) * 1995-10-31 2005-05-17 Maruha Corporation Prostaglandin d synthase-specific monoclonal antibody
KR20010043441A (ko) * 1998-05-08 2001-05-25 더 유니버시티 오브 브리스톨 백신용 면역조절제
AUPQ242899A0 (en) * 1999-08-25 1999-09-16 Aristocrat Leisure Industries Pty Ltd Gaming machine with buy feature games
US7041296B1 (en) * 1999-11-12 2006-05-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of treating inflammatory bowel disease using cholera toxin B subunit
US7063852B2 (en) 2000-05-19 2006-06-20 The Administrators Of The Tulane Educational Fund Hybrid LT-A/CT-B holotoxin for use as an adjuvant
ES2365035T3 (es) * 2003-07-21 2011-09-20 Intervet International Bv Toxinas híbridas que comprenden subunidades de la toxina similar a shiga condensadas con subunidades de la enterotoxina termolábil de escherichia coli y vacunas de las mismas.
WO2006011151A2 (en) * 2004-07-28 2006-02-02 Gavish - Galilee Bio Applications Ltd. Vaccine comprising recombinant ct or lt toxin
BR112014005601B1 (pt) * 2011-09-12 2020-09-29 Scandinavian Biopharma Holding Ab Vacina oral para a imunização contra a diarréia induzida pela etec
EP3385286A4 (en) * 2015-11-30 2019-05-01 Idemitsu Kosan Co., Ltd. VACCINE FANTASY WITH INCREASED IMMUNOGENITY
CN113813398B (zh) * 2021-04-23 2023-11-07 天津医科大学 一种向表面富含神经节苷脂的细胞递送重组蛋白质的方法
CN114409804B (zh) * 2022-01-07 2022-10-21 湖北神地生物科技有限公司 一种大肠杆菌肠毒素多表位融合蛋白及其制备方法和应用
CN114456240B (zh) * 2022-03-04 2023-08-15 青岛农业大学 一种非洲猪瘟病毒基因工程亚单位口服疫苗

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758655A (en) * 1983-01-03 1988-07-19 Scripps Clinic And Research Foundation Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods of therewith

Also Published As

Publication number Publication date
DE69634003D1 (de) 2005-01-13
DE69634003T2 (de) 2005-12-29
AU5708596A (en) 1996-11-21
JP4081140B2 (ja) 2008-04-23
PT824548E (pt) 2005-04-29
KR100492305B1 (ko) 2006-01-12
DK0824548T3 (da) 2005-04-11
CN1154660C (zh) 2004-06-23
AU702637B2 (en) 1999-02-25
ES2233968T3 (es) 2005-06-16
WO1996034893A1 (en) 1996-11-07
ATE284416T1 (de) 2004-12-15
CA2219943C (en) 2010-10-12
EP0824548B1 (en) 2004-12-08
KR19990008290A (ko) 1999-01-25
JPH11504811A (ja) 1999-05-11
CN1189840A (zh) 1998-08-05
US6019973A (en) 2000-02-01
CA2219943A1 (en) 1996-11-07
EP0824548A1 (en) 1998-02-25
IL118136A (en) 2006-04-10
IL118136A0 (en) 1996-09-12

Similar Documents

Publication Publication Date Title
De Haan et al. Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat‐labile enterotoxin and its B subunit
NO963508L (no) Urease-basert vaksine og behandling av Helicobacter-infeksjon
SE9501682D0 (sv) Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits
DE69814177T2 (de) Impfstoffe mit einem ltb adjuvans
CA2231603A1 (en) Chicken interleukin-15 and uses thereof
DK0835315T3 (da) Vaccine til porcint reproduktivt og respiratorisk syndrom virus
DE69829668D1 (de) Herstellung und verwendung von rekombinanten influenza a virus m2 konstruktionen und impstoffe
DK1724354T3 (da) Cirkulær DNA-molekyle med en afhængig replikationsoprindelse, fremgangsmåde til fremstilling heraf og anvendelse heraf i genterapi
EE200200709A (et) Liitvalku sisaldava kompositsiooni ning seda liitvalku ja liitpolüpeptiidi kodeeriva nukleiinhappe kasutamine
ES8306797A1 (es) Un metodo para producir un polipeptido.
NO975546D0 (no) Antigene gruppe B-streptokokk-type II- og type III-polysakkaridfragmenter med en 2,5-anhydro-D-mannose-terminal struktur samt en konjugatvaksine derav
AU3075995A (en) Process for modifying the stability of antibodies
Adan-Kubo et al. Morphology of isolated Gli349, a leg protein responsible for Mycoplasma mobile gliding via glass binding, revealed by rotary shadowing electron microscopy
NZ503039A (en) Recombinant porcine adenovirus vector
BR9712556A (pt) Plasmìdeo, composição farmacêutica, e, processo de imunizar um indivìduo contra um antìgeno
AU7617796A (en) Variants of human recombinant interferon-gamma (rhu-ifn-gamma) having increased heat-stability
ATE121754T1 (de) Vakzine gegen bordetella.
ATE346931T1 (de) Clostridium perfringens impfstoff
AU4149699A (en) Use of inactivated immunosuppressive and/or angiogenic immunogenic proteins, preparation method and pharmaceutical or vaccine uses
AU5573196A (en) A pluripotent vaccine against enveloped viruses
CA1263307C (en) PSEUDOMONAS NATIVE FLAGELLAR NATIVE FLAGELLAR ANTIGENS AND METHOD OF PRODUCING
CA2366462A1 (en) Two-step immunization procedure against chlamydia infection
DK0623170T3 (da) Vacciner baseret på streptokinase
BR0009746A (pt) Molécula de veìculo, composição imunogênica, polipeptìdeo, método para tratar um indivìduo, e, plasmìdeos pebl1-pv e pviii
EP0949333A4 (en) Mutant measles virus antigens and genes encoding the same