|
IL113010A0
(en)
*
|
1994-03-31 |
1995-10-31 |
Pharmacia Ab |
Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
|
|
SE9403915D0
(sv)
*
|
1994-11-14 |
1994-11-14 |
Annelie Almstedt |
Process A
|
|
US7253262B2
(en)
|
1995-01-19 |
2007-08-07 |
Quandrant Drug Delivery Limited |
Dried blood factor composition comprising trehalose
|
|
GB9501040D0
(en)
*
|
1995-01-19 |
1995-03-08 |
Quadrant Holdings Cambridge |
Dried composition
|
|
US7244824B2
(en)
|
1995-01-19 |
2007-07-17 |
Quadrant Drug Delivery Limited |
Dried blood factor composition comprising trehalose
|
|
SE9502285D0
(sv)
|
1995-06-22 |
1995-06-22 |
Pharmacia Ab |
Improvements related to injections
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
US7560107B2
(en)
*
|
1996-06-26 |
2009-07-14 |
Emory University |
Modified factor VIII
|
|
US5763401A
(en)
*
|
1996-07-12 |
1998-06-09 |
Bayer Corporation |
Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
|
|
US20030143662A1
(en)
*
|
1998-06-16 |
2003-07-31 |
Cummings Richard D. |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
|
|
JP2002518354A
(ja)
*
|
1998-06-16 |
2002-06-25 |
ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ |
糖硫酸ペプチド、その合成方法および使用方法
|
|
US7223845B2
(en)
|
1998-06-16 |
2007-05-29 |
The Board Of Regents Of The University Of Oklahoma |
Synthetic glycosulfopeptides and methods of synthesis thereof
|
|
DK1820516T3
(da)
|
1999-02-22 |
2013-10-28 |
Univ Connecticut |
Nye albuminfrie faktor VIII-præparater
|
|
GB0207092D0
(en)
|
2002-03-26 |
2002-05-08 |
Sod Conseils Rech Applic |
Stable pharmaceutical composition containing factor VIII
|
|
WO2004075923A2
(en)
*
|
2003-02-26 |
2004-09-10 |
Nektar Therapeutics Al, Corporation |
Polymer-factor viii moiety conjugates
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US7977460B2
(en)
*
|
2003-05-19 |
2011-07-12 |
National Institute For Biological Standards And Control |
Compositions comprising coagulation factors IXA and VIII for the treatment of haemophilia A or B
|
|
CN1266144C
(zh)
*
|
2003-09-01 |
2006-07-26 |
上海凯曼生物科技有限公司 |
黄芩甙和黄芩甙元的用途和剂型
|
|
ES2229931B1
(es)
*
|
2003-10-03 |
2006-01-16 |
Grifols, S.A. |
Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos.
|
|
DE102004005095A1
(de)
|
2004-01-27 |
2005-09-22 |
Coty B.V. |
Kosmetische Zusammensetzung mit wasserbeständiger Parfümkomponente
|
|
WO2005107776A1
(en)
|
2004-05-03 |
2005-11-17 |
Emory University |
METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII
|
|
ES2633916T3
(es)
|
2004-11-12 |
2017-09-26 |
Bayer Healthcare Llc |
Modificación de FVIII dirigida al sitio
|
|
TWI264608B
(en)
*
|
2005-04-08 |
2006-10-21 |
Delta Electronics Inc |
Light tunnel module
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
CN101557830B
(zh)
|
2006-12-15 |
2016-06-08 |
巴克斯特国际公司 |
具有延长的体内半衰期的因子VIIa-聚唾液酸结合物
|
|
EP2486936A1
(en)
|
2007-06-13 |
2012-08-15 |
CSL Behring GmbH |
A composition comprising VWF and FVIII preparations for use in treating of bleeding disorders
|
|
BRPI0921429B1
(pt)
|
2008-11-07 |
2022-07-12 |
Takeda Pharmaceutical Company Limited |
Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável
|
|
EA020843B1
(ru)
|
2009-02-03 |
2015-02-27 |
Амуникс Оперейтинг Инк. |
Удлиненные рекомбинантные полипептиды и содержащие их композиции
|
|
US10172949B2
(en)
|
2009-06-09 |
2019-01-08 |
Prolong Pharmaceuticals, LLC |
Hemoglobin compositions
|
|
US10172950B2
(en)
|
2009-06-09 |
2019-01-08 |
Prolong Pharmaceuticals, LLC |
Hemoglobin compositions
|
|
TWI626057B
(zh)
|
2009-06-09 |
2018-06-11 |
普龍製藥有限責任公司 |
血紅素組成物
|
|
CA2769244A1
(en)
|
2009-07-27 |
2011-02-03 |
Lipoxen Technologies Limited |
Glycopolysialylation of non-blood coagulation proteins
|
|
CN104530182A
(zh)
|
2009-07-27 |
2015-04-22 |
利普森技术有限公司 |
非凝血蛋白的糖基多唾液酸化
|
|
US8642737B2
(en)
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
RU2595442C2
(ru)
|
2009-07-27 |
2016-08-27 |
Баксалта Инкорпорейтед |
Конъюгаты белков свертывания крови
|
|
JP6250282B2
(ja)
*
|
2009-08-20 |
2017-12-20 |
ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー |
出血性障害の治療および予防的治療における非静脈内投与のためのアルブミン融合凝固因子
|
|
US20120263701A1
(en)
|
2009-08-24 |
2012-10-18 |
Volker Schellenberger |
Coagulation factor vii compositions and methods of making and using same
|
|
DK2506868T3
(da)
|
2009-12-06 |
2018-01-29 |
Bioverativ Therapeutics Inc |
Kimæriske og hybride faktor viii-fc-polypeptider og fremgangsmåder til anvendelse deraf
|
|
GB201007356D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIIa
|
|
DK2591006T3
(da)
|
2010-07-09 |
2019-07-29 |
Bioverativ Therapeutics Inc |
Processerbare enkeltkædede molekyler og polypeptider fremstillet ved anvendelse deraf
|
|
US9611310B2
(en)
|
2010-07-09 |
2017-04-04 |
Bioverativ Therapeutics Inc. |
Systems for factor VIII processing and methods thereof
|
|
CN103209992A
(zh)
*
|
2010-09-15 |
2013-07-17 |
诺沃—诺迪斯克有限公司 |
具有减少的细胞摄取的因子viii变体
|
|
MY165089A
(en)
|
2010-11-05 |
2018-02-28 |
Baxalta Inc |
A new variant of antihemophilic factor viii having increased specific activity
|
|
BR112013015898A2
(pt)
|
2010-12-22 |
2018-06-26 |
Baxter International Inc. |
derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada.
|
|
EP2709648A4
(en)
|
2011-05-19 |
2015-04-08 |
Geysen Hendrik M |
COMPOUNDS FOR BINDING TO THE ERYTHROPOIETIN RECEPTOR
|
|
DK3412305T3
(da)
*
|
2011-06-10 |
2021-03-01 |
Baxalta GmbH |
Behandling af koagulationssygdom ved administration af rekombinant vwf
|
|
HUE043894T2
(hu)
|
2011-06-10 |
2019-09-30 |
Bioverativ Therapeutics Inc |
Koagulációt elõsegítõ vegyületek és alkalmazásuk módszerei
|
|
PL3513804T3
(pl)
|
2011-07-08 |
2022-07-11 |
Bioverativ Therapeutics Inc. |
Chimeryczne i hybrydowe polipeptydy czynnika VIII i sposoby ich stosowania
|
|
EP2737311B1
(en)
|
2011-07-25 |
2020-12-02 |
Bioverativ Therapeutics Inc. |
Assays to monitor bleeding disorders
|
|
CN103889445A
(zh)
|
2011-10-18 |
2014-06-25 |
德国杰特贝林生物制品有限公司 |
硫酸化糖胺聚糖用于改善因子viii的生物利用度的用途
|
|
EP2768521B1
(en)
|
2011-10-18 |
2016-07-13 |
CSL Behring GmbH |
Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii
|
|
PL2802668T3
(pl)
|
2012-01-12 |
2019-03-29 |
Bioverativ Therapeutics Inc. |
Sposoby zmniejszania immunogenności wobec czynnika krzepnięcia viii u pacjentów poddawanych leczeniu czynnikiem krzepnięcia viii
|
|
CN104271150A
(zh)
|
2012-01-12 |
2015-01-07 |
比奥根艾迪克Ma公司 |
嵌合因子viii多肽及其用途
|
|
MX369862B
(es)
|
2012-02-15 |
2019-11-25 |
Bioverativ Therapeutics Inc |
Composiciones del factor viii y metodos para hacerlas y usarlas.
|
|
NZ628014A
(en)
|
2012-02-15 |
2016-09-30 |
Biogen Ma Inc |
Recombinant factor viii proteins
|
|
CA2875247A1
(en)
|
2012-06-08 |
2013-12-12 |
Biogen Idec Ma Inc. |
Chimeric clotting factors
|
|
AU2013270682A1
(en)
|
2012-06-08 |
2014-12-11 |
Biogen Ma Inc. |
Procoagulant compounds
|
|
US10023628B2
(en)
|
2012-07-06 |
2018-07-17 |
Bioverativ Therapeutics Inc. |
Cell line expressing single chain factor VIII polypeptides and uses thereof
|
|
RS59876B1
(sr)
|
2012-07-11 |
2020-03-31 |
Bioverativ Therapeutics Inc |
Kompleks faktora viii sa xten i proteinom fon vilebrandovog faktora, i njihova primena
|
|
EP3970738A1
(en)
|
2012-07-25 |
2022-03-23 |
Bioverativ Therapeutics Inc. |
Blood factor monitoring assay and uses thereof
|
|
EP2908847B1
(en)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Methods of using a fixed dose of a clotting factor
|
|
EP2914293A4
(en)
|
2012-10-30 |
2016-04-20 |
Biogen Ma Inc |
METHOD OF USE OF FVIII POLYPEPTIDE
|
|
ES2959747T3
(es)
|
2013-02-15 |
2024-02-28 |
Bioverativ Therapeutics Inc |
Gen del factor VIII optimizado
|
|
UY35463A
(es)
|
2013-03-15 |
2014-10-31 |
Biogen Idec Inc |
Formulaciones de polipéptido fc-factor ix.
|
|
PL3666283T3
(pl)
|
2013-03-15 |
2022-10-03 |
Bioverativ Therapeutics Inc. |
Formulacje polipeptydu czynnika viii
|
|
WO2014176125A1
(en)
*
|
2013-04-22 |
2014-10-30 |
The Scripps Research Institute |
Methods and compositions for treating bleeding disorders
|
|
ES2657291T3
(es)
|
2013-04-22 |
2018-03-02 |
Csl Ltd. |
Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro
|
|
KR102714760B1
(ko)
|
2013-06-28 |
2024-10-11 |
바이오버라티브 테라퓨틱스 인크. |
Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
|
|
WO2015021423A2
(en)
|
2013-08-08 |
2015-02-12 |
Biogen Idec Ma Inc. |
Purification of chimeric fviii molecules
|
|
EP3033097B1
(en)
|
2013-08-14 |
2021-03-10 |
Bioverativ Therapeutics Inc. |
Factor viii-xten fusions and uses thereof
|
|
EP3065769A4
(en)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Procoagulant fusion compound
|
|
US10325687B2
(en)
|
2013-12-06 |
2019-06-18 |
Bioverativ Therapeutics Inc. |
Population pharmacokinetics tools and uses thereof
|
|
PT4176894T
(pt)
|
2014-01-10 |
2024-05-21 |
Bioverativ Therapeutics Inc |
Proteínas quiméricas de fator viii e utilizações destas
|
|
WO2015120056A1
(en)
|
2014-02-04 |
2015-08-13 |
Biogen Ma Inc. |
Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
|
|
US10251940B2
(en)
|
2014-06-06 |
2019-04-09 |
Octapharma Ag |
Preparation comprising factor VIII and Von Willebrand factor peptides
|
|
WO2016004113A1
(en)
|
2014-06-30 |
2016-01-07 |
Biogen Ma Inc. |
Optimized factor ix gene
|
|
US9987241B2
(en)
|
2014-09-25 |
2018-06-05 |
The Board Of Regents Of The University Of Oklahoma |
Enzyme conjugate and prodrug cancer therapy
|
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
|
CA2994547A1
(en)
|
2015-08-03 |
2017-02-09 |
Bioverativ Therapeutics Inc. |
Factor ix fusion proteins and methods of making and using same
|
|
US10189888B2
(en)
|
2015-11-13 |
2019-01-29 |
Baxalta Incorporated |
Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
|
|
SG11201804064WA
(en)
|
2015-11-13 |
2018-06-28 |
Baxalta Inc |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
|
EP3411478B1
(en)
|
2016-02-01 |
2022-06-08 |
Bioverativ Therapeutics Inc. |
Optimized factor viii genes
|
|
WO2017222337A1
(ko)
|
2016-06-24 |
2017-12-28 |
재단법인 목암생명과학연구소 |
Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도
|
|
AU2017358865A1
(en)
|
2016-11-11 |
2019-05-09 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
|
|
US12257288B2
(en)
|
2016-12-02 |
2025-03-25 |
Bioverativ Therapeutics Inc. |
Methods of inducing immune tolerance to clotting factors
|
|
WO2018102743A1
(en)
|
2016-12-02 |
2018-06-07 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
|
MY203184A
(en)
|
2017-08-09 |
2024-06-13 |
Bioverativ Therapeutics Inc |
Nucleic acid molecules and uses thereof
|
|
US11446365B2
(en)
|
2017-08-09 |
2022-09-20 |
The Board Of Regents Of The University Of Oklahoma |
Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same
|
|
EP3746136A1
(en)
|
2018-02-01 |
2020-12-09 |
Bioverativ Therapeutics Inc. |
Use of lentiviral vectors expressing factor viii
|
|
UY38160A
(es)
|
2018-04-04 |
2019-11-29 |
Sigilon Therapeutics Inc |
Partículas implantables y métodos relacionados
|
|
SG11202010767SA
(en)
|
2018-05-18 |
2020-11-27 |
Bioverativ Therapeutics Inc |
Methods of treating hemophilia a
|
|
CA3106590A1
(en)
|
2018-07-16 |
2020-01-23 |
Baxalta Incorporated |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
|
MX2021001599A
(es)
|
2018-08-09 |
2021-07-02 |
Bioverativ Therapeutics Inc |
Moleculas de acido nucleico y sus usos para la terapia genica no viral.
|
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
|
TWI851647B
(zh)
|
2019-01-16 |
2024-08-11 |
日商武田藥品工業股份有限公司 |
用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
|
|
WO2020257462A1
(en)
|
2019-06-19 |
2020-12-24 |
Bioverativ Therapeutics Inc. |
Recombinant factor viii-fc for treating hemophilia and low bone mineral density
|
|
US12403164B2
(en)
|
2019-09-30 |
2025-09-02 |
Bioverativ Therapeutics Inc. |
Lentiviral vector formulations
|
|
EP4073106A2
(en)
|
2019-12-12 |
2022-10-19 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
|
CN114929261A
(zh)
|
2020-02-17 |
2022-08-19 |
生物测试股份公司 |
凝血因子viii的皮下施用
|
|
JP2023537565A
(ja)
|
2020-06-24 |
2023-09-04 |
バイオベラティブ セラピューティクス インコーポレイテッド |
タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第viii因子を除去する方法
|
|
WO2022159414A1
(en)
|
2021-01-22 |
2022-07-28 |
University Of Rochester |
Erythropoietin for gastroinfestinal dysfunction
|
|
WO2022264040A1
(en)
|
2021-06-14 |
2022-12-22 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
|
TW202323274A
(zh)
|
2021-08-23 |
2023-06-16 |
美商百歐維拉提夫治療公司 |
優化因子viii基因
|
|
IL311725A
(en)
|
2021-09-30 |
2024-05-01 |
Bioverativ Therapeutics Inc |
Nucleic acids encoding factor VIII polypeptides with reduced immunogenicity
|
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|
|
TW202517669A
(zh)
|
2023-07-05 |
2025-05-01 |
日商武田藥品工業股份有限公司 |
用於A型血友病之基因療法的編碼表現增加之重組FVlll變異體的病毒載體
|