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SE9201966D0 - INTERLEUKIN-1BETA DELETION MUTANT - Google Patents

INTERLEUKIN-1BETA DELETION MUTANT

Info

Publication number
SE9201966D0
SE9201966D0 SE9201966A SE9201966A SE9201966D0 SE 9201966 D0 SE9201966 D0 SE 9201966D0 SE 9201966 A SE9201966 A SE 9201966A SE 9201966 A SE9201966 A SE 9201966A SE 9201966 D0 SE9201966 D0 SE 9201966D0
Authority
SE
Sweden
Prior art keywords
interleukin
beta
deletion
deletion mutant
receptors
Prior art date
Application number
SE9201966A
Other languages
Swedish (sv)
Inventor
T Bartfai
Original Assignee
Trion Forskning & Utveckling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trion Forskning & Utveckling filed Critical Trion Forskning & Utveckling
Priority to SE9201966A priority Critical patent/SE9201966D0/en
Publication of SE9201966D0 publication Critical patent/SE9201966D0/en
Priority to JP6502266A priority patent/JPH07508408A/en
Priority to AU45191/93A priority patent/AU4519193A/en
Priority to EP93915072A priority patent/EP0647238A1/en
Priority to PCT/SE1993/000562 priority patent/WO1994000491A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Luminescent Compositions (AREA)
  • Conversion Of X-Rays Into Visible Images (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)

Abstract

An Interleukin-1(beta) deletion mutant, which has a quasi conserved sequence of three amino acids deleted from the amino acid sequence of an endogenous mammalian Interleukin-1(beta) is disclosed. The deletion is Ser Asn Asp (numbers 52-54 of mature human IL-1(beta)) in the case of human, mouse, rat and rabbit, and Arg Asp Asn in the case of bovine and sheep Interleukin-1(beta). The Interleukin-1(beta) deletion mutant is shown to be an Interleukin-1 receptor ligand which binds to both Interleukin-1 type I receptors and Interleukin-1 type II receptors with substantially different binding-affinities. The ligand may have additional amino acid deletion(s) and/or point mutation(s). The Interleukin-1(beta) deletion mutants may be used as carriers and adjuvants for biologically active molecules as well as in therapeutic and/or prophylactic agent.
SE9201966A 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT SE9201966D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SE9201966A SE9201966D0 (en) 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT
JP6502266A JPH07508408A (en) 1992-06-25 1993-06-23 Interleukin-1β deletion mutant
AU45191/93A AU4519193A (en) 1992-06-25 1993-06-23 Interleukin-1beta deletion mutant
EP93915072A EP0647238A1 (en) 1992-06-25 1993-06-23 INTERLEUKIN-1$g(b) DELETION MUTANT
PCT/SE1993/000562 WO1994000491A1 (en) 1992-06-25 1993-06-23 INTERLEUKIN-1β DELETION MUTANT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9201966A SE9201966D0 (en) 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT

Publications (1)

Publication Number Publication Date
SE9201966D0 true SE9201966D0 (en) 1992-06-25

Family

ID=20386611

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9201966A SE9201966D0 (en) 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT

Country Status (5)

Country Link
EP (1) EP0647238A1 (en)
JP (1) JPH07508408A (en)
AU (1) AU4519193A (en)
SE (1) SE9201966D0 (en)
WO (1) WO1994000491A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114163514A (en) * 2021-12-13 2022-03-11 青岛瑞斯凯尔生物科技有限公司 IL-10 mutants and their applications

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4408890A1 (en) * 1994-03-16 1995-09-21 Knoll Ag Use of Il-1 antagonists as a medicine for the treatment of diseases with an increased interleukin-6 serum level
US6335426B1 (en) 1996-06-14 2002-01-01 Bayer Corporation T-cell selective interleukin-4 agonists
US5986059A (en) * 1996-06-14 1999-11-16 Bayer Corporation T-cell selective interleukin-4 agonists
US6028176A (en) 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
US5978749A (en) * 1997-06-30 1999-11-02 Pile Dynamics, Inc. Pile installation recording system
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
WO2017077382A1 (en) 2015-11-06 2017-05-11 Orionis Biosciences Nv Bi-functional chimeric proteins and uses thereof
CN116769054A (en) 2016-02-05 2023-09-19 奥里尼斯生物科学私人有限公司 Bispecific signaling agents and uses thereof
US11248057B2 (en) 2016-03-07 2022-02-15 Vib Vzw CD20 binding single domain antibodies
EP3454887B1 (en) 2016-05-13 2021-01-20 Orionis Biosciences BV Targeted mutant interferon-beta and uses thereof
CN109563141A (en) 2016-05-13 2019-04-02 奥里尼斯生物科学公司 To the therapeutic targeting of cellular structures
CN110114368B (en) 2016-10-24 2024-08-02 奥睿尼斯生物科学私人有限公司 Targeted mutant interferon-gamma and uses thereof
WO2018144999A1 (en) 2017-02-06 2018-08-09 Orionis Biosciences, Inc. Targeted engineered interferon and uses thereof
EP3577133A1 (en) 2017-02-06 2019-12-11 Orionis Biosciences NV Targeted chimeric proteins and uses thereof
WO2019148089A1 (en) 2018-01-26 2019-08-01 Orionis Biosciences Inc. Xcr1 binding agents and uses thereof
US12410225B2 (en) 2018-11-08 2025-09-09 Orionis Biosciences, Inc Modulation of dendritic cell lineages

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2591615B2 (en) * 1986-03-14 1997-03-19 大塚製薬株式会社 Interleukin-1β derivative and pharmaceutical
FR2667601A1 (en) * 1990-10-05 1992-04-10 Rhone Poulenc Sante POLYPEPTIDES DERIVED FROM INTERLEUKIN-1 BETA, PROCESS FOR THE PREPARATION AND USE THEREOF, PARTICULARLY IN THE CONTEXT OF OSTEOARTICULAR PATHOLOGIES.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114163514A (en) * 2021-12-13 2022-03-11 青岛瑞斯凯尔生物科技有限公司 IL-10 mutants and their applications
CN114163514B (en) * 2021-12-13 2023-05-26 青岛瑞斯凯尔生物科技有限公司 IL-10 mutants and uses thereof

Also Published As

Publication number Publication date
WO1994000491A1 (en) 1994-01-06
AU4519193A (en) 1994-01-24
JPH07508408A (en) 1995-09-21
EP0647238A1 (en) 1995-04-12

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