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SE9002384D0 - DERIVATIVE OF BACKGROUND HORMONES - Google Patents

DERIVATIVE OF BACKGROUND HORMONES

Info

Publication number
SE9002384D0
SE9002384D0 SE9002384A SE9002384A SE9002384D0 SE 9002384 D0 SE9002384 D0 SE 9002384D0 SE 9002384 A SE9002384 A SE 9002384A SE 9002384 A SE9002384 A SE 9002384A SE 9002384 D0 SE9002384 D0 SE 9002384D0
Authority
SE
Sweden
Prior art keywords
derivatives
new
cys
tyr
thr
Prior art date
Application number
SE9002384A
Other languages
Swedish (sv)
Inventor
P Melin
Original Assignee
Ferring Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Ab filed Critical Ferring Ab
Priority to SE9002384A priority Critical patent/SE9002384D0/en
Publication of SE9002384D0 publication Critical patent/SE9002384D0/en
Priority to CA002085603A priority patent/CA2085603A1/en
Priority to IL98737A priority patent/IL98737A0/en
Priority to MC91@@D priority patent/MC2291A1/en
Priority to PCT/SE1991/000477 priority patent/WO1992000996A1/en
Priority to PL29760091A priority patent/PL297600A1/xx
Priority to AU82251/91A priority patent/AU8225191A/en
Priority to EP91913318A priority patent/EP0538367A1/en
Priority to JP91512399A priority patent/JPH05508849A/en
Priority to IE237891A priority patent/IE912378A1/en
Priority to FI930013A priority patent/FI930013A0/en
Priority to CZ939A priority patent/CZ993A3/en
Priority to NO930016A priority patent/NO930016D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Derivatives of pituitary posterior lobe hormones, more precisely new vasotocin derivatives, are disclosed. The new vasotocin derivatives are comprised by formula (I), wherein A = Mpa or Hmp, B = D-Tyr, D-Tyr(Et), D-Phe, D-Phe(p-Et) or D-Trp, C = Thr, Val or Hgn, D = Cys or alpha -Abu, E = Pro or a peptide bond, F = (a), wherein m = 0-6, n = 0-6, L = H, C00H, CO-NH2 or CH2-OH, K = H, (b) or a D- or L-amino acid residue with the proviso that L is not H when A is Mpa, C is Thr or Val and D is Cys. Further, pharmaceutical compositions including the new vasotocin derivatives and being preferably in a form suitable for intravenous, intranasal or intraintestinal administration, are described. The compositions are especially intended for use in the therapeutic treatment of excessive uterus muscle contractions.
SE9002384A 1990-07-09 1990-07-09 DERIVATIVE OF BACKGROUND HORMONES SE9002384D0 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
SE9002384A SE9002384D0 (en) 1990-07-09 1990-07-09 DERIVATIVE OF BACKGROUND HORMONES
JP91512399A JPH05508849A (en) 1990-07-09 1991-07-04 Posterior pituitary hormone derivative
PCT/SE1991/000477 WO1992000996A1 (en) 1990-07-09 1991-07-04 Derivatives of pituitary posterior lobe hormones
IL98737A IL98737A0 (en) 1990-07-09 1991-07-04 Derivatives of pituitary posterior lobe hormones
MC91@@D MC2291A1 (en) 1990-07-09 1991-07-04 DERIVATIVES OF HORMONES OF THE POSTERIOR LOBE OF HYPOPHYSIS
CA002085603A CA2085603A1 (en) 1990-07-09 1991-07-04 Derivatives of pituitary posterior lobe hormones
PL29760091A PL297600A1 (en) 1990-07-09 1991-07-04
AU82251/91A AU8225191A (en) 1990-07-09 1991-07-04 Derivatives of pituitary posterior lobe hormones
EP91913318A EP0538367A1 (en) 1990-07-09 1991-07-04 Derivatives of pituitary posterior lobe hormones
IE237891A IE912378A1 (en) 1990-07-09 1991-07-08 Derivatives of pituitary posterior lobe hormones
FI930013A FI930013A0 (en) 1990-07-09 1993-01-04 HORMONDERIVAT AV BAKRE HYPOFYSLOBEN
CZ939A CZ993A3 (en) 1990-07-09 1993-01-05 derivatives of neurohypophysis lobe hormones
NO930016A NO930016D0 (en) 1990-07-09 1993-01-05 DERIVATIVES OF HYPOPHYSIS BACKGROUND HORMONS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002384A SE9002384D0 (en) 1990-07-09 1990-07-09 DERIVATIVE OF BACKGROUND HORMONES

Publications (1)

Publication Number Publication Date
SE9002384D0 true SE9002384D0 (en) 1990-07-09

Family

ID=20379963

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9002384A SE9002384D0 (en) 1990-07-09 1990-07-09 DERIVATIVE OF BACKGROUND HORMONES

Country Status (11)

Country Link
EP (1) EP0538367A1 (en)
JP (1) JPH05508849A (en)
AU (1) AU8225191A (en)
CA (1) CA2085603A1 (en)
FI (1) FI930013A0 (en)
IE (1) IE912378A1 (en)
IL (1) IL98737A0 (en)
MC (1) MC2291A1 (en)
PL (1) PL297600A1 (en)
SE (1) SE9002384D0 (en)
WO (1) WO1992000996A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0710243B1 (en) * 1993-06-29 2000-06-14 Ferring B.V. Synthesis of cyclic peptides
SE501678C2 (en) * 1993-07-13 1995-04-10 Ferring Bv Peptide with oxytocin antagonist activity and pharmaceutical composition containing said peptide
SE9604341D0 (en) * 1996-11-26 1996-11-26 Ferring Bv Hepta-peptide oxytocin analogue
WO2003072597A1 (en) 2002-02-27 2003-09-04 Ferring Bv Intermediates and methods for making heptapeptide oxytocin analogues

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10075020I2 (en) * 1982-12-21 2003-01-09 Ferring Ab Vasotocinderivate
US4483794A (en) * 1983-05-10 1984-11-20 Ceskoslovenska Akademie Ved Analogs of neurohypophysial hormones
US4604378A (en) * 1984-11-21 1986-08-05 Smithkline Beckman Corporation Basic V1 -vasopressin antagonists
US4599324A (en) * 1984-11-21 1986-07-08 Smithkline Beckman Corporation V1-vasopressin antagonists
WO1987002676A1 (en) * 1985-10-25 1987-05-07 Gibson-Stephens Neuropharmaceuticals, Inc. Conformationally constrained oxytocin antagonists with prolonged biological activities

Also Published As

Publication number Publication date
IE912378A1 (en) 1992-01-15
MC2291A1 (en) 1993-07-14
JPH05508849A (en) 1993-12-09
FI930013A7 (en) 1993-01-04
CA2085603A1 (en) 1992-01-10
IL98737A0 (en) 1992-07-15
PL297600A1 (en) 1992-07-13
EP0538367A1 (en) 1993-04-28
FI930013A0 (en) 1993-01-04
AU8225191A (en) 1992-02-04
WO1992000996A1 (en) 1992-01-23

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