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SE8803931D0 - NEW ALCOXY DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THE SAME - Google Patents

NEW ALCOXY DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THE SAME

Info

Publication number
SE8803931D0
SE8803931D0 SE8803931A SE8803931A SE8803931D0 SE 8803931 D0 SE8803931 D0 SE 8803931D0 SE 8803931 A SE8803931 A SE 8803931A SE 8803931 A SE8803931 A SE 8803931A SE 8803931 D0 SE8803931 D0 SE 8803931D0
Authority
SE
Sweden
Prior art keywords
same
ginkgolides
compositions containing
therapeutic compositions
preparation
Prior art date
Application number
SE8803931A
Other languages
Swedish (sv)
Other versions
SE8803931L (en
Inventor
P Braquet
Original Assignee
Scras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras filed Critical Scras
Publication of SE8803931D0 publication Critical patent/SE8803931D0/en
Publication of SE8803931L publication Critical patent/SE8803931L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

This invention relates to 1-alkoxy or 10-alkoxy substituted Ginkgolides or mixtures of the same, to a preparation process of these compounds consisting in reacting a dioxan solution of the selected Ginkgolide on a diethyl ether solution of diazoalkane in excess, at room temperature for 1 to 10 hours and to therapeutic compositions containing the same.
SE8803931A 1987-11-04 1988-10-31 NEW ALCOXIDE DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC CONTENTS SE8803931L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878725871A GB8725871D0 (en) 1987-11-04 1987-11-04 Ginkgolide derivatives

Publications (2)

Publication Number Publication Date
SE8803931D0 true SE8803931D0 (en) 1988-10-31
SE8803931L SE8803931L (en) 1989-05-05

Family

ID=10626449

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8803931A SE8803931L (en) 1987-11-04 1988-10-31 NEW ALCOXIDE DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC CONTENTS

Country Status (28)

Country Link
JP (1) JPH0686455B2 (en)
KR (1) KR970005536B1 (en)
AT (1) AT397097B (en)
AU (1) AU616367B2 (en)
BE (1) BE1003455A3 (en)
CA (1) CA1303619C (en)
CH (1) CH675583A5 (en)
DE (1) DE3837550A1 (en)
DK (1) DK612788A (en)
ES (1) ES2009364A6 (en)
FI (1) FI90081C (en)
FR (2) FR2622448B1 (en)
GB (2) GB8725871D0 (en)
GR (1) GR1000264B (en)
HK (1) HK53992A (en)
IE (1) IE61541B1 (en)
IN (1) IN173404B (en)
IT (1) IT1227456B (en)
MA (1) MA21423A1 (en)
MY (1) MY103446A (en)
NL (1) NL8802635A (en)
NO (1) NO167739C (en)
NZ (1) NZ226738A (en)
PT (1) PT88924B (en)
SE (1) SE8803931L (en)
SG (1) SG48292G (en)
TN (1) TNSN88118A1 (en)
ZA (1) ZA888184B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895785A (en) * 1987-10-20 1999-04-20 Ruth Korth Treatment and prevention of disorders mediated by LA-paf or endothelial cells
DE69132379T2 (en) * 1990-06-06 2001-03-01 Ruth-Maria Korth Treatment of diseases with Paf antagonists and method for determining their effectiveness
DE540767T1 (en) * 1991-11-04 2001-10-25 Ruth-Maria Korth Treatment and prevention of mental illnesses mediated by increased Lyso-PAF levels with PAF antagonists
GB9408044D0 (en) * 1994-04-22 1994-06-15 Sod Conseils Rech Applic Conversion of ginkgolide c to ginkgolide b
FR2763592B1 (en) * 1997-05-20 1999-07-16 Sod Conseils Rech Applic NOVEL GLYCOSYL DERIVATIVES OF GINKGOLIDES, THEIR APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2771639B1 (en) * 1997-12-03 2000-05-05 Sod Conseils Rech Applic USE OF GINKGO BILOBA EXTRACTS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR FACILITATING THE WITHDRAWAL OF DEPENDENT AND / OR ADDICTIVE SUBSTANCES
FR2777280B1 (en) * 1998-04-10 2001-04-20 Centre Nat Rech Scient GINKGOLIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP3381921B1 (en) * 2015-12-18 2021-02-03 Chengdu Baiyu Ginkgolide Pharmaceuticals Co., Ltd. Ginkgolide b derivative and preparation method and use thereof
CN108373474B (en) * 2017-12-25 2020-06-09 上海信谊百路达药业有限公司 A bilobalide compound extracted from folium Ginkgo and its preparation method
CN108383852B (en) * 2017-12-25 2019-11-22 上海信谊百路达药业有限公司 A kind of Ginkgolid extracted from ginkgo leaf and its preparation
CN117567480A (en) * 2019-04-24 2024-02-20 复旦大学 Ginkgolide B derivatives and salts thereof, and preparation methods and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418424D0 (en) * 1984-07-19 1984-08-22 Scras Inhibition of platelets aggregation
DE3710921C2 (en) * 1986-10-21 1996-09-26 Korth Ruth Use of Gingkolide BN 52020, BN 52021 and BN 52063 for the treatment of arteriosclerosis
DE3735525C2 (en) * 1987-10-20 1997-02-20 Korth Ruth Maria Method for determining the efficacy of paf-acether receptor antagonists

Also Published As

Publication number Publication date
DE3837550C2 (en) 1991-12-12
IE61541B1 (en) 1994-11-16
AT397097B (en) 1994-01-25
ZA888184B (en) 1989-07-26
NL8802635A (en) 1989-06-01
ATA269688A (en) 1993-06-15
FI885046A0 (en) 1988-11-02
GB8725871D0 (en) 1987-12-09
NZ226738A (en) 1990-05-28
PT88924A (en) 1988-12-01
FR2622448A1 (en) 1989-05-05
JPH0686455B2 (en) 1994-11-02
NO167739B (en) 1991-08-26
JPH01151583A (en) 1989-06-14
GB2211841B (en) 1991-01-16
MA21423A1 (en) 1989-07-01
AU2464488A (en) 1989-05-25
NO884900L (en) 1989-05-05
IT8822493A0 (en) 1988-11-04
HK53992A (en) 1992-07-30
IN173404B (en) 1994-04-30
DK612788A (en) 1989-05-05
ES2009364A6 (en) 1989-09-16
KR890008156A (en) 1989-07-10
SG48292G (en) 1992-06-12
CH675583A5 (en) 1990-10-15
KR970005536B1 (en) 1997-04-17
SE8803931L (en) 1989-05-05
MY103446A (en) 1993-06-30
NO884900D0 (en) 1988-11-03
FI90081C (en) 1993-12-27
NO167739C (en) 1991-12-04
IT1227456B (en) 1991-04-11
GR1000264B (en) 1992-05-12
AU616367B2 (en) 1991-10-24
DK612788D0 (en) 1988-11-03
GB2211841A (en) 1989-07-12
CA1303619C (en) 1992-06-16
GB8824859D0 (en) 1988-11-30
FI90081B (en) 1993-09-15
FR2622448B1 (en) 1992-01-10
FI885046L (en) 1989-05-05
FR2622584A1 (en) 1989-05-05
TNSN88118A1 (en) 1990-07-10
IE883315L (en) 1989-05-04
DE3837550A1 (en) 1989-05-18
FR2622584B1 (en) 1992-01-10
PT88924B (en) 1993-01-29
BE1003455A3 (en) 1992-03-31

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