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SE8304361D0 - Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives - Google Patents

Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives

Info

Publication number
SE8304361D0
SE8304361D0 SE8304361A SE8304361A SE8304361D0 SE 8304361 D0 SE8304361 D0 SE 8304361D0 SE 8304361 A SE8304361 A SE 8304361A SE 8304361 A SE8304361 A SE 8304361A SE 8304361 D0 SE8304361 D0 SE 8304361D0
Authority
SE
Sweden
Prior art keywords
hydrogen
derivatives
different
lower alkyl
novel
Prior art date
Application number
SE8304361A
Other languages
English (en)
Inventor
A L Abramo
A K K Bjork
E G Christensson
B K R Gustafsson
K G Olsson
Original Assignee
Ferrosan Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of SE8304361D0 publication Critical patent/SE8304361D0/sv
Priority to SE8304361A priority Critical patent/SE8304361D0/sv
Application filed by Ferrosan Ab filed Critical Ferrosan Ab
Priority to IL72563A priority patent/IL72563A/xx
Priority to JP59503010A priority patent/JPH0723364B2/ja
Priority to HU843341A priority patent/HU196977B/hu
Priority to AT84850237T priority patent/ATE47850T1/de
Priority to AU32111/84A priority patent/AU569537B2/en
Priority to PCT/SE1984/000269 priority patent/WO1985000811A1/en
Priority to EP84850237A priority patent/EP0136274B1/en
Priority to DE8484850237T priority patent/DE3480395D1/de
Priority to ES535027A priority patent/ES8705411A1/es
Priority to NZ209166A priority patent/NZ209166A/en
Priority to IE205084A priority patent/IE58065B1/en
Priority to CA000460595A priority patent/CA1253148A/en
Priority to FI851350A priority patent/FI80449C/sv
Priority to DK157485A priority patent/DK157864C/da
Priority to NO851409A priority patent/NO166410C/no
Priority to ES552001A priority patent/ES8704917A1/es
Priority to ES556989A priority patent/ES8802039A1/es
Priority to US07/227,420 priority patent/US4935419A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/21—Radicals derived from sulfur analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE8304361A 1983-08-10 1983-08-10 Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives SE8304361D0 (sv)

Priority Applications (19)

Application Number Priority Date Filing Date Title
SE8304361A SE8304361D0 (sv) 1983-08-10 1983-08-10 Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives
IL72563A IL72563A (en) 1983-08-10 1984-08-01 1-piperazinecarboxamide derivatives,their preparation and pharmaceutical compositions containing them
JP59503010A JPH0723364B2 (ja) 1983-08-10 1984-08-02 新規な１−ピペラジンカルボキサミド誘導体
HU843341A HU196977B (en) 1983-08-10 1984-08-02 Process for producing new 1-piperazin-carboxamide derivatives
AT84850237T ATE47850T1 (de) 1983-08-10 1984-08-02 1-piperazinkarboxamid-derivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen praeparaten.
AU32111/84A AU569537B2 (en) 1983-08-10 1984-08-02 Novel 1-piperazinecarboxamide derivatives
PCT/SE1984/000269 WO1985000811A1 (en) 1983-08-10 1984-08-02 Novel 1-piperazinecarboxamide derivatives
EP84850237A EP0136274B1 (en) 1983-08-10 1984-08-02 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions
DE8484850237T DE3480395D1 (en) 1983-08-10 1984-08-02 1-piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions
ES535027A ES8705411A1 (es) 1983-08-10 1984-08-09 Procedimiento para preparar derivados de 1-piperazinacarboxamida
CA000460595A CA1253148A (en) 1983-08-10 1984-08-09 1-piperazinecarboxamide derivatives
NZ209166A NZ209166A (en) 1983-08-10 1984-08-09 1-piperazinecarboxamides and pharmaceutical compositions
IE205084A IE58065B1 (en) 1983-08-10 1984-08-09 1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions
FI851350A FI80449C (sv) 1983-08-10 1985-04-03 Förfarande för framställning av nya terapeutiskt användbara 1-piperazi nkarboxamidderivat
DK157485A DK157864C (da) 1983-08-10 1985-04-09 Hidtil ukendte 1-piperazincarboxamidderivater substitueret paa det basiske nitrogenatom samt farmaceutiske praeparater og sammensaetninger indeholdende disse
NO851409A NO166410C (no) 1983-08-10 1985-04-09 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1-piperazinkarboksamidderivater.
ES552001A ES8704917A1 (es) 1983-08-10 1986-02-14 Procedimiento para prepararar derivados de 1-piperazinacarboximida.
ES556989A ES8802039A1 (es) 1983-08-10 1986-08-01 Procedimiento par preparar derivados de 1-piperazinacarboxamida
US07/227,420 US4935419A (en) 1983-08-10 1988-07-29 Novel 1-piperazinecarboxamide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8304361A SE8304361D0 (sv) 1983-08-10 1983-08-10 Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives

Publications (1)

Publication Number Publication Date
SE8304361D0 true SE8304361D0 (sv) 1983-08-10

Family

ID=20352166

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8304361A SE8304361D0 (sv) 1983-08-10 1983-08-10 Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives

Country Status (16)

Country Link
US (1) US4935419A (sv)
EP (1) EP0136274B1 (sv)
JP (1) JPH0723364B2 (sv)
AT (1) ATE47850T1 (sv)
AU (1) AU569537B2 (sv)
CA (1) CA1253148A (sv)
DE (1) DE3480395D1 (sv)
DK (1) DK157864C (sv)
ES (3) ES8705411A1 (sv)
FI (1) FI80449C (sv)
HU (1) HU196977B (sv)
IE (1) IE58065B1 (sv)
IL (1) IL72563A (sv)
NZ (1) NZ209166A (sv)
SE (1) SE8304361D0 (sv)
WO (1) WO1985000811A1 (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
GB8713240D0 (en) * 1987-06-05 1987-07-08 Proteus Biotech Ltd Hormones
US5070089A (en) * 1988-01-26 1991-12-03 Nippon Chemiphar Co., Ltd. Therapeutic agent for liver disease and piperazine derivatives
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5795894A (en) * 1995-05-02 1998-08-18 Schering Corporation Piperazino derivatives as neurokinn antagonists
US5892039A (en) * 1995-08-31 1999-04-06 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5869488A (en) * 1996-05-01 1999-02-09 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
CA2362494A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US20100093935A1 (en) * 2008-10-15 2010-04-15 Nitto Denko Corporation Method of preparing polyglutamate conjugates
US20110144315A1 (en) * 2009-12-16 2011-06-16 Nitto Denko Corporation Controlled synthesis of polyglutamic acid
JP2015514135A (ja) * 2012-04-14 2015-05-18 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規組成物および方法
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
US10906906B2 (en) 2016-12-29 2021-02-02 Intra-Cellular Therapies, Inc. Organic compounds
CN119613404A (zh) 2018-03-23 2025-03-14 细胞内治疗公司 有机化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3000892A (en) * 1959-11-16 1961-09-19 Paul A J Janssen 1-aroylalkyl-4-aroylpiperazines
DE1670431A1 (de) * 1966-03-04 1971-02-11 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung neuer Piperazin-Derivate
GB1143882A (sv) * 1966-06-21
GB1186495A (en) * 1968-02-20 1970-04-02 Delalande Sa 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation
FR2262521A1 (en) * 1973-08-08 1975-09-26 Delalande Sa 3-(3,4,5-Trimethoxyphenyl)piperazines - with coronary vasodilator, hypotensive, antiinflammatory, analgesic, and antiulcer activity
JPS5143772A (en) * 1974-09-26 1976-04-14 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 furoirupiperajinjudotaino seizoho
AR207031A1 (es) * 1974-03-06 1976-09-09 Kyorin Seiyaku Kk Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina
JPS50131974A (sv) * 1974-03-06 1975-10-18
JPS518283A (en) * 1974-07-09 1976-01-23 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho
JPS5346988A (en) * 1976-10-07 1978-04-27 Kyorin Seiyaku Kk Piperadine derivative
NO154582C (no) * 1978-10-20 1986-11-05 Ferrosan Ab Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider.
DE3167049D1 (de) * 1980-06-16 1984-12-13 Ferrosan Ab Diphenylbutyl-1-acylpiperazines
EP0080992B1 (en) * 1981-12-02 1987-07-15 AB Ferrosan 1-piperazinocarboxylates, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL72563A0 (en) 1984-11-30
JPH0723364B2 (ja) 1995-03-15
DK157485A (da) 1985-04-09
ES8802039A1 (es) 1988-03-16
CA1253148A (en) 1989-04-25
ES8705411A1 (es) 1987-05-01
US4935419A (en) 1990-06-19
AU3211184A (en) 1985-03-12
IE842050L (en) 1985-02-10
ES556989A0 (es) 1988-03-16
FI851350L (fi) 1985-04-03
IE58065B1 (en) 1993-06-30
AU569537B2 (en) 1988-02-04
ATE47850T1 (de) 1989-11-15
ES535027A0 (es) 1987-05-01
FI851350A0 (fi) 1985-04-03
HUT37415A (en) 1985-12-28
DE3480395D1 (en) 1989-12-14
IL72563A (en) 1988-10-31
DK157485D0 (da) 1985-04-09
HU196977B (en) 1989-02-28
EP0136274B1 (en) 1989-11-08
EP0136274A1 (en) 1985-04-03
NZ209166A (en) 1987-07-31
DK157864C (da) 1990-07-23
JPS60501956A (ja) 1985-11-14
FI80449B (fi) 1990-02-28
FI80449C (sv) 1990-06-11
DK157864B (da) 1990-02-26
ES552001A0 (es) 1987-04-16
ES8704917A1 (es) 1987-04-16
WO1985000811A1 (en) 1985-02-28

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