SE8303913L - Heterocyclic Associations - Google Patents
Heterocyclic AssociationsInfo
- Publication number
- SE8303913L SE8303913L SE8303913A SE8303913A SE8303913L SE 8303913 L SE8303913 L SE 8303913L SE 8303913 A SE8303913 A SE 8303913A SE 8303913 A SE8303913 A SE 8303913A SE 8303913 L SE8303913 L SE 8303913L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- represents hydrogen
- cycloalkyl
- hydroxy
- substituted
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
The invention relates to compounds of the general formula (I> <IMAGE> and physiologically acceptable salts, solvates and hydrates thereof, in which R1 represents hydrogen, C1-14 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, trifluoroalkyl, heteroaralkyl or alkyl substituted by cycloalkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino; and R2 represents hydrogen or a C1-4 alkyl group; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom selected from oxygen or sulphur; Alk represents a straight or branched alkylene chain or 1 to 3 carbon atoms; Q represents a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4-positions; R5 represents hydrogen or acyl; n and m, which may be the same or different, are each 1 or 2; R3 represents hydrogen or alkyl; R4 represents hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, pyridyl, aralkyl, heteroaralkyl or alkyl substituted by hydroxy, C1-3 alkoxy, amino C1-3 alkylamino or C1-3 dialkylamino, or R3 and R4 together with the nitrogen atom to which they are attached form a 5-7 membered ring which may contain another heteroatom; and r represents an integer which is 1 or 2. The compounds of formula (I) show biological activity as selective histamine H2-antagonists.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8219746 | 1982-07-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8303913D0 SE8303913D0 (en) | 1983-07-08 |
| SE8303913L true SE8303913L (en) | 1984-01-09 |
Family
ID=10531541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8303913A SE8303913L (en) | 1982-07-08 | 1983-07-08 | Heterocyclic Associations |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5927880A (en) |
| AU (1) | AU1666583A (en) |
| BE (1) | BE897247A (en) |
| DE (1) | DE3324771A1 (en) |
| DK (1) | DK317283A (en) |
| FR (1) | FR2532937A1 (en) |
| GB (1) | GB2124622A (en) |
| IT (1) | IT8348653A0 (en) |
| NL (1) | NL8302450A (en) |
| SE (1) | SE8303913L (en) |
| ZA (1) | ZA835009B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4567191A (en) * | 1983-06-07 | 1986-01-28 | Merck & Co., Inc. | Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors |
| DE3326545A1 (en) * | 1983-07-22 | 1985-01-31 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | PROPAN-2-OL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3408327A1 (en) * | 1984-03-07 | 1985-09-12 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | DIAMOND DERIVATIVES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| JP4664074B2 (en) | 2002-10-09 | 2011-04-06 | シェーリング コーポレイション | Thiadiazole dioxide and thiadiazole oxide as CXC-chemokine receptor ligand and CC-chemokine receptor ligand |
| WO2005066147A1 (en) | 2003-12-19 | 2005-07-21 | Schering Corporation | Thiadiazoles as cxc- and cc- chemokine receptor ligands |
| CN1918156B (en) | 2003-12-22 | 2010-10-27 | 先灵公司 | Isothiazole dioxides as CXC-and CC-chemokine receptor ligands |
| DE602006017849D1 (en) | 2005-06-29 | 2010-12-09 | Schering Corp | 5,6-DISUBSTITUTED OXADIAZOLO PYRAZINES AND THIADIAZOLOPYRACINES AS LIGANDS OF THE CXC CHEMOKIN RECEPTOR |
| US7718678B2 (en) | 2005-06-29 | 2010-05-18 | Schering Corporation | Di-substituted oxadiazoles as CXC-chemokine receptor ligands |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0040696B1 (en) * | 1980-04-30 | 1986-08-27 | Merck & Co. Inc. | Aminothiadiazoles as gastric secretion inhibitors |
| US4411899A (en) * | 1981-12-21 | 1983-10-25 | Merck & Co., Inc. | Substituted derivatives of amino alkane diols as gastric secretion inhibitors |
-
1983
- 1983-07-08 ZA ZA835009A patent/ZA835009B/en unknown
- 1983-07-08 DK DK317283A patent/DK317283A/en not_active Application Discontinuation
- 1983-07-08 FR FR8311402A patent/FR2532937A1/en not_active Withdrawn
- 1983-07-08 JP JP58124554A patent/JPS5927880A/en active Pending
- 1983-07-08 GB GB08318525A patent/GB2124622A/en not_active Withdrawn
- 1983-07-08 DE DE19833324771 patent/DE3324771A1/en not_active Withdrawn
- 1983-07-08 AU AU16665/83A patent/AU1666583A/en not_active Abandoned
- 1983-07-08 SE SE8303913A patent/SE8303913L/en not_active Application Discontinuation
- 1983-07-08 IT IT8348653A patent/IT8348653A0/en unknown
- 1983-07-08 BE BE0/211139A patent/BE897247A/en not_active IP Right Cessation
- 1983-07-08 NL NL8302450A patent/NL8302450A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5927880A (en) | 1984-02-14 |
| BE897247A (en) | 1984-01-09 |
| DK317283A (en) | 1984-01-09 |
| IT8348653A0 (en) | 1983-07-08 |
| DE3324771A1 (en) | 1984-01-12 |
| GB8318525D0 (en) | 1983-08-10 |
| ZA835009B (en) | 1985-02-27 |
| DK317283D0 (en) | 1983-07-08 |
| GB2124622A (en) | 1984-02-22 |
| FR2532937A1 (en) | 1984-03-16 |
| AU1666583A (en) | 1984-01-12 |
| SE8303913D0 (en) | 1983-07-08 |
| NL8302450A (en) | 1984-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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