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SE8301257L - 1-SUBSTITUTED N- (8ALFA-ERGOLINYL) -N ', N'-DIETHYL CARBAMIDS AND SET TO MAKE THEM - Google Patents

1-SUBSTITUTED N- (8ALFA-ERGOLINYL) -N ', N'-DIETHYL CARBAMIDS AND SET TO MAKE THEM

Info

Publication number
SE8301257L
SE8301257L SE8301257A SE8301257A SE8301257L SE 8301257 L SE8301257 L SE 8301257L SE 8301257 A SE8301257 A SE 8301257A SE 8301257 A SE8301257 A SE 8301257A SE 8301257 L SE8301257 L SE 8301257L
Authority
SE
Sweden
Prior art keywords
ergolinyl
substituted
group
carbon atoms
alkyl group
Prior art date
Application number
SE8301257A
Other languages
Swedish (sv)
Other versions
SE452321B (en
SE8301257D0 (en
Inventor
A Cerny
J Krepelka
M Seda
K Rezabek
Original Assignee
Spofa Vereinigte Pharma Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Vereinigte Pharma Werke filed Critical Spofa Vereinigte Pharma Werke
Publication of SE8301257D0 publication Critical patent/SE8301257D0/en
Publication of SE8301257L publication Critical patent/SE8301257L/en
Publication of SE452321B publication Critical patent/SE452321B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-Substituted N-(8 alpha -ergolinyl)- N',N'-diethylureas of general formula (I> <IMAGE> (wherein R<1> represents an alkyl group having from 1 to 4 carbon atoms and R<2> represents an alkyl group having from 1 to 4 carbon atoms, a benzyl group, an allyl group or a group of general formula -(CH2)nCOOR<3>, where R<3> represents a hydrogen atom or an alkyl group having 1 or 2 carbon atoms and n is integer from 1 to 4) and their salts exhibit dopaminergic action on the respective receptors, significant inhibiting effect on prolactin and growth hormone secretion and a stimulating effect on the secretion of gonadotrophins.
SE8301257A 1982-03-12 1983-03-08 1-SUBSTITUTED N- (8ALFA-ERGOLINYL) -N ', N'-DIETHYL CARBAMIDS AND SET TO MAKE THEM SE452321B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS821734A CS231214B1 (en) 1982-03-12 1982-03-12 Processing method of 1-substituted n+l8alpha-ergoline+p-n,diethyl urea

Publications (3)

Publication Number Publication Date
SE8301257D0 SE8301257D0 (en) 1983-03-08
SE8301257L true SE8301257L (en) 1983-09-13
SE452321B SE452321B (en) 1987-11-23

Family

ID=5352449

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8301257A SE452321B (en) 1982-03-12 1983-03-08 1-SUBSTITUTED N- (8ALFA-ERGOLINYL) -N ', N'-DIETHYL CARBAMIDS AND SET TO MAKE THEM

Country Status (15)

Country Link
JP (1) JPS58180484A (en)
AT (1) AT383349B (en)
AU (1) AU555961B2 (en)
BE (1) BE896122A (en)
CA (1) CA1203531A (en)
CH (1) CH652125A5 (en)
CS (1) CS231214B1 (en)
DE (1) DE3308719A1 (en)
DK (1) DK84683A (en)
FI (1) FI830754L (en)
FR (1) FR2523131B1 (en)
GB (1) GB2116548B (en)
IT (1) IT1161209B (en)
NL (1) NL8300829A (en)
SE (1) SE452321B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309493A1 (en) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen NEW ERGOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT
EP0208417A3 (en) * 1985-06-12 1989-09-06 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu Use of 1-(8-alpha-ergolinyl)-3,3-diethyl urea derivatives in the treatment of endometritis
DE3522894A1 (en) * 1985-06-24 1987-01-02 Schering Ag USE OF TERGURID AS GERIATRIC
FR2584720B1 (en) * 1985-07-11 1987-10-02 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF N-METHYL DERIVATIVES OF ERGOLINE
DE3620293A1 (en) * 1986-06-16 1987-12-17 Schering Ag 1 AND / OR 2 SUBSTITUTED ERGOL DERIVATIVES
DE3623503A1 (en) * 1986-07-09 1988-01-21 Schering Ag 1-ARYL-ERGOLINYL-UREA DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE USE OF THESE COMPOUNDS AS A MEDICINAL PRODUCT
DE10212564B4 (en) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl ergot alkaloid derivatives and their use for the prophylaxis and treatment of migraine
AU2011328299A1 (en) * 2010-11-11 2013-07-04 Sinoxa Pharma Gmbh Lisuride, terguride and derivatives thereof for use in the prophylaxis and/or treatment of fibrotic changes
BR112017015487A2 (en) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc COMPOUND; COMPOSITION; METHOD OF TREATMENT AND / OR PREVENTION OF MIGRAINE, ALS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, EXTRAPYRIMIDAL DISORDERS, DEPRESSION, NAUSEA, AEMESIS, SYNDROME OF THE WASTE LEGS, INSOMENESS, HYGERNESS, AGING , ANXIETY, DRUG DEPENDENCIES, DYSTONIA, PARASSONIA OR HYPERLACTINEMIA IN AN INDIVIDUAL; AGONIZATION METHODS OF D2, 5-HT1D, 5-HT1A AND 5-HT2C RECEPTORS, IN AN INDIVIDUAL; ANTAGONIZATION METHOD OF THE D3 RECEPTOR IN AN INDIVIDUAL; METHODS OF SELECTIVE AGONIZATION OF RECEPTORS 5 -HT1D, AND 5-HT2C, METHOD OF PROVIDING FUNCTIONAL ANTAGONIST ACTIVITY IN RECEPTOR 5 -HT2B OR IN RECEIVER 5-HT7, OR IN BOTH, IN AN INDIVIDUAL; METHOD OF PROVIDING FUNCTIONAL ANTAGONIST ACTIVITY IN ADRENERGIC RECEPTORS IN AN INDIVIDUAL
CA2974113A1 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH344731A (en) * 1956-05-18 1960-02-29 Sandoz Ag Process for the production of new derivatives of the lysergic acid series alkylated on the indole nitrogen
AT231082B (en) * 1960-10-12 1964-01-10 Sandoz Ag Process for the production of new urea derivatives
EP0021206B1 (en) * 1979-06-13 1983-06-22 Schering Aktiengesellschaft (ergolin-yl)-n', n'-diethyl urea derivatives, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPS58180484A (en) 1983-10-21
AT383349B (en) 1987-06-25
FR2523131A1 (en) 1983-09-16
ATA72783A (en) 1986-11-15
CH652125A5 (en) 1985-10-31
GB8305735D0 (en) 1983-04-07
DK84683A (en) 1983-09-13
DK84683D0 (en) 1983-02-24
AU555961B2 (en) 1986-10-16
IT1161209B (en) 1987-03-18
SE452321B (en) 1987-11-23
SE8301257D0 (en) 1983-03-08
FR2523131B1 (en) 1987-08-28
GB2116548A (en) 1983-09-28
AU1216783A (en) 1983-09-15
IT8319935A0 (en) 1983-03-07
GB2116548B (en) 1985-03-20
NL8300829A (en) 1983-10-03
FI830754A0 (en) 1983-03-07
DE3308719A1 (en) 1983-09-22
CA1203531A (en) 1986-04-22
FI830754A7 (en) 1983-09-13
FI830754L (en) 1983-09-13
CS231214B1 (en) 1984-10-15
BE896122A (en) 1983-07-01

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