SE7903970L - PROCEDURE FOR THE PREPARATION OF O-ALKYLATED HYDROXYLAMINES - Google Patents
PROCEDURE FOR THE PREPARATION OF O-ALKYLATED HYDROXYLAMINESInfo
- Publication number
- SE7903970L SE7903970L SE7903970A SE7903970A SE7903970L SE 7903970 L SE7903970 L SE 7903970L SE 7903970 A SE7903970 A SE 7903970A SE 7903970 A SE7903970 A SE 7903970A SE 7903970 L SE7903970 L SE 7903970L
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen
- optionally substituted
- formula
- aryl
- atom
- Prior art date
Links
- 150000002443 hydroxylamines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxylamine compound Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A process for the preparation of 0-alkylated hydroxylamines of general formula (I) wherein X represents -OR', -SR' or ; R1 represents hydrogen or, if X is -OR1, an amino group, or alkyl or a mono- or binuclear optionally substituted aryl radical; R2 and R3 which may be the same or different each represents hydrogen, optionally substituted alkyl or cycloalkyl, aralkyl or diaralkyl or aryl, hydroxyl, if the other of R2 and R3 is hydrogen; or R2 and R3 together with the nitrogen atom to which they are attached represent an optionally substituted 5- to 7-membered saturated ring optionally interrupted by A further hetero atom or a 5-membered heteroaromatic ring optionally anellated with a benzene or uracil ring; together with their physiologically compatible acid addition salts with those organic or inorganic acids which permit the preparation of non-toxic salts, in which in a first state a hydroxylamine compound of formula (VII) (VII) is reacted with a compound of formula U-R6 (VIII) to form compounds of formula (IX) protecting groups are separated therefrom as by hydrolysis and the product of formula (I) is isolated in the form of a free base or is converted with a suitable acid into a physiologically compatible acid addition salt, wherein in the above formulae; R4 represents optionally substituted alkyl or aryl; R5' represents hydrogen, optionally substituted alkyl or aryl or halogen; R6 has the meanings specified above for y or additionally represents the radical ; T represents a hydrogen atom, if U has a different meaning from hydrogen, or the group or U represents a hydrogen atom, if T has a different meaning from hydrogen, or the group or and Z represents a halogen atom, or a reactive sulphonic acid ester group, whereby in each case T or U is hydrogen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782820013 DE2820013A1 (en) | 1978-05-08 | 1978-05-08 | PROCESS FOR THE PRODUCTION OF O-ALKYLATED HYDROXYLAMINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7903970L true SE7903970L (en) | 1979-11-09 |
Family
ID=6038858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7903970A SE7903970L (en) | 1978-05-08 | 1979-05-07 | PROCEDURE FOR THE PREPARATION OF O-ALKYLATED HYDROXYLAMINES |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT374448B (en) |
| CA (1) | CA1110642A (en) |
| CH (1) | CH647497A5 (en) |
| DE (1) | DE2820013A1 (en) |
| DK (1) | DK188379A (en) |
| ES (1) | ES480294A2 (en) |
| FI (1) | FI791453A7 (en) |
| HU (1) | HU179985B (en) |
| SE (1) | SE7903970L (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2651083A1 (en) * | 1976-11-09 | 1978-05-18 | Hoechst Ag | NEW O-ALKYLATED HYDROXYLAMINE, METHOD FOR THEIR PRODUCTION AND THEIR USE |
| EP0158159B1 (en) * | 1984-04-12 | 1988-10-05 | AlliedSignal Inc. | Process for the synthesis of o-substituted oxime compounds and the conversion thereof into the corresponding hydroxylamine o-substituted |
| US5393921A (en) * | 1993-07-07 | 1995-02-28 | The Gillette Company | Process for synthesizing O-substituted oxime compounds and conversion to the corresponding O-substituted hydroxylamine |
| DE102005044108A1 (en) | 2005-09-15 | 2007-03-29 | Bayer Cropscience Ag | Dioxazine- and oxdiazine-substituted arylamides |
-
1978
- 1978-05-08 DE DE19782820013 patent/DE2820013A1/en not_active Withdrawn
-
1979
- 1979-05-04 CA CA326,980A patent/CA1110642A/en not_active Expired
- 1979-05-07 ES ES480294A patent/ES480294A2/en not_active Expired
- 1979-05-07 SE SE7903970A patent/SE7903970L/en not_active Application Discontinuation
- 1979-05-07 CH CH4231/79A patent/CH647497A5/en not_active IP Right Cessation
- 1979-05-07 DK DK188379A patent/DK188379A/en not_active Application Discontinuation
- 1979-05-07 AT AT0340679A patent/AT374448B/en not_active IP Right Cessation
- 1979-05-07 FI FI791453A patent/FI791453A7/en not_active Application Discontinuation
- 1979-05-07 HU HU79HO2148A patent/HU179985B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1110642A (en) | 1981-10-13 |
| HU179985B (en) | 1983-01-28 |
| DE2820013A1 (en) | 1979-11-22 |
| FI791453A7 (en) | 1981-01-01 |
| ATA340679A (en) | 1983-09-15 |
| DK188379A (en) | 1979-11-09 |
| ES480294A2 (en) | 1979-12-01 |
| CH647497A5 (en) | 1985-01-31 |
| AT374448B (en) | 1984-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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