SE7901262L - 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION - Google Patents
3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATIONInfo
- Publication number
- SE7901262L SE7901262L SE7901262A SE7901262A SE7901262L SE 7901262 L SE7901262 L SE 7901262L SE 7901262 A SE7901262 A SE 7901262A SE 7901262 A SE7901262 A SE 7901262A SE 7901262 L SE7901262 L SE 7901262L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- group
- salt
- compound
- cooh
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I: (R<1> is NH2 or protected NH2 group; R<2> is isobutyl, cycloalkyl, lower alkyl, lower alkyl group, etc., R<3> is COOH or protected COOH; R<4> is alkanoyloxy, H, carbamoylxy group, etc.) and its salt. EXAMPLE:7-[2-Isobutoxyimino-2-(2-aminothiazole-4-yl)-acetamido]cephalo sporanic acid (syn-isomer). USE:Antibacterials effective against Gram-positive and Gram-negative bacteria. PROCESS:A compound of formula II, its reactive derivative at the NH2 group, or its salt is reacted with a compound of formula III, its reactive derivative at the COOH group, or its salt in a solvent, e.g. water or acetone, to give the compound of formula I or its salt. Some of the compounds of formula II and III are novel compounds.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87784878A | 1978-02-15 | 1978-02-15 | |
| US05/887,999 US4279818A (en) | 1976-04-12 | 1978-03-20 | Syn-isomers of 7-[2-alkoxyimino-2-(2-amino-thiazol-4-yl)acetamido]-3-[nitrobenzoyl-, or benzoyl-oxymethyl]-3-cephem-4-carboxylic acid |
| GB7836563 | 1978-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7901262L true SE7901262L (en) | 1979-08-16 |
Family
ID=27260590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7901262A SE7901262L (en) | 1978-02-15 | 1979-02-13 | 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS54117493A (en) |
| CH (1) | CH643266A5 (en) |
| DE (1) | DE2905656A1 (en) |
| ES (1) | ES477693A1 (en) |
| FR (1) | FR2434170A1 (en) |
| NL (1) | NL7901220A (en) |
| SE (1) | SE7901262L (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE878514A (en) * | 1978-09-04 | 1980-02-29 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY |
| BE878433A (en) * | 1978-08-31 | 1980-02-25 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVES 3,7-DISUBSTITUTED, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY |
| US4341775A (en) * | 1978-09-11 | 1982-07-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| JPS56131591A (en) * | 1980-02-20 | 1981-10-15 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent |
| EP0241901B1 (en) * | 1986-04-14 | 1994-08-24 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, processes for their preparation and antibacterial agents |
-
1979
- 1979-02-13 SE SE7901262A patent/SE7901262L/en not_active Application Discontinuation
- 1979-02-14 CH CH143279A patent/CH643266A5/en not_active IP Right Cessation
- 1979-02-14 DE DE19792905656 patent/DE2905656A1/en not_active Withdrawn
- 1979-02-14 ES ES477693A patent/ES477693A1/en not_active Expired
- 1979-02-14 FR FR7903780A patent/FR2434170A1/en not_active Withdrawn
- 1979-02-15 JP JP1637779A patent/JPS54117493A/en active Pending
- 1979-02-15 NL NL7901220A patent/NL7901220A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES477693A1 (en) | 1980-03-01 |
| NL7901220A (en) | 1979-08-17 |
| DE2905656A1 (en) | 1979-08-23 |
| JPS54117493A (en) | 1979-09-12 |
| CH643266A5 (en) | 1984-05-30 |
| FR2434170A1 (en) | 1980-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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