SE7513671L - DESACYL-PEPSIDIN AND WAY TO PREPARE THE SAME - Google Patents
DESACYL-PEPSIDIN AND WAY TO PREPARE THE SAMEInfo
- Publication number
- SE7513671L SE7513671L SE7513671A SE7513671A SE7513671L SE 7513671 L SE7513671 L SE 7513671L SE 7513671 A SE7513671 A SE 7513671A SE 7513671 A SE7513671 A SE 7513671A SE 7513671 L SE7513671 L SE 7513671L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- amino
- hydroxy
- methylheptanoylalanyl
- deacylpepsidin
- Prior art date
Links
- 241000194103 Bacillus pumilus Species 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 2
- 102000057297 Pepsin A Human genes 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 229940111202 pepsin Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The deacylpepsidin valylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-hydroxy -6-methylheptanoic acid of the formula <IMAGE> is obtained by microbiological means, starting from the acylpentapeptide N-acylvalylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-h ydroxy-6-methylheptanoic acid of the formula <IMAGE> in which R is an acyl group. The compound of the second formula is converted into the product of the first formula by contacting with bacteria of the species Bacillus pumilus or with their acellular culture preparations. The employed bacteria are specifically those of the strain Bacillus pumilus Kawaguchi EF 49-210 (ATCC No. 31132). The deacylpepsidin of the formula (I) is obtained in higher yields and greater purities than in known processes. It has high activity as a pepsin inhibitor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49138862A JPS5167791A (en) | 1974-12-05 | 1974-12-05 | Desuashiruu oyobi desuashirubariruupepushijinno seizoho narabini saiashirukaho |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7513671L true SE7513671L (en) | 1976-06-08 |
| SE423710B SE423710B (en) | 1982-05-24 |
Family
ID=15231860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7513671A SE423710B (en) | 1974-12-05 | 1975-12-04 | DESACYL-PEPSIDINE FOR USE AS INTERMEDIATE FOR THE PREPARATION OF N-ACYLPENTAPEPTIDES AND PROCEDURE TO PREPARE IT |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5167791A (en) |
| CA (1) | CA1053167A (en) |
| CH (1) | CH620244A5 (en) |
| DE (2) | DE2554636C2 (en) |
| FR (1) | FR2293215A1 (en) |
| GB (1) | GB1530921A (en) |
| NL (1) | NL7514241A (en) |
| SE (1) | SE423710B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2660964C2 (en) * | 1975-09-12 | 1987-07-16 | Sumitomo Chemical Co., Ltd., Osaka, Jp | |
| JPS56164152A (en) * | 1980-05-20 | 1981-12-17 | Eisai Co Ltd | Novel desacylpepsidin derivative and its preparation |
| JPS56164153A (en) * | 1980-05-20 | 1981-12-17 | Eisai Co Ltd | Novel desacylvalypepsidin derivative and its preparation |
| JPS57189651U (en) * | 1981-05-27 | 1982-12-01 | ||
| JPS5956948A (en) * | 1982-09-28 | 1984-04-02 | Nippon Kokan Kk <Nkk> | Mold for horizontal continuous casting machine |
| JPS60213347A (en) * | 1984-04-06 | 1985-10-25 | Kawasaki Heavy Ind Ltd | Billet drawing device for continuous casting |
-
1974
- 1974-12-05 JP JP49138862A patent/JPS5167791A/en active Granted
-
1975
- 1975-12-04 DE DE2554636A patent/DE2554636C2/en not_active Expired
- 1975-12-04 FR FR7537098A patent/FR2293215A1/en active Granted
- 1975-12-04 DE DE2560238A patent/DE2560238C2/en not_active Expired
- 1975-12-04 SE SE7513671A patent/SE423710B/en not_active IP Right Cessation
- 1975-12-04 CH CH1581875A patent/CH620244A5/en not_active IP Right Cessation
- 1975-12-05 GB GB49988/75A patent/GB1530921A/en not_active Expired
- 1975-12-05 CA CA241,153A patent/CA1053167A/en not_active Expired
- 1975-12-05 NL NL7514241A patent/NL7514241A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7514241A (en) | 1976-06-09 |
| GB1530921A (en) | 1978-11-01 |
| CH620244A5 (en) | 1980-11-14 |
| JPS5167791A (en) | 1976-06-11 |
| SE423710B (en) | 1982-05-24 |
| CA1053167A (en) | 1979-04-24 |
| JPS5339514B2 (en) | 1978-10-21 |
| FR2293215A1 (en) | 1976-07-02 |
| DE2554636C2 (en) | 1983-02-17 |
| DE2554636A1 (en) | 1976-06-10 |
| DE2560238C2 (en) | 1984-07-19 |
| FR2293215B1 (en) | 1978-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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