SE512047C2 - Measuring device, especially for blood sugar determination - Google Patents
Measuring device, especially for blood sugar determinationInfo
- Publication number
- SE512047C2 SE512047C2 SE9800629A SE9800629A SE512047C2 SE 512047 C2 SE512047 C2 SE 512047C2 SE 9800629 A SE9800629 A SE 9800629A SE 9800629 A SE9800629 A SE 9800629A SE 512047 C2 SE512047 C2 SE 512047C2
- Authority
- SE
- Sweden
- Prior art keywords
- contact surfaces
- electrical contact
- blood sugar
- measuring device
- measuring
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims abstract description 25
- 210000004369 blood Anatomy 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 6
- 230000008822 capillary blood flow Effects 0.000 claims abstract description 5
- 238000005259 measurement Methods 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 12
- 239000008103 glucose Substances 0.000 description 12
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 101001116872 Xenopus laevis Protein Pat Proteins 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Optics & Photonics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
lO 15 20 25 30 35 512 047 2 diabetikern vid varje tillfälle han eller hon så önskar kan kontrollera sitt blodsockervärde och agera därefter. The diabetic at any time he or she so wishes can check his or her blood sugar level and act accordingly.
Ytterligare ett ändamål med uppfinningen är att tillhandahålla ett förfarande för evasiv mätning av en biofysikalisk parameter, särskilt blodsockerhalten.A further object of the invention is to provide a method for evasive measurement of a biophysical parameter, in particular the blood sugar content.
Dessa ändamål uppnås medelst en mätanordning av det slag, som anges i ingressen till patentkravet 1, och som uppvisar de kännetecken, som framgår av den kännetecknan- de delen av patentkravet l, respektive ett förfarande för evasiv mätning av en biofysikalisk parameter i enlighet med patentkraven 2 och 3.These objects are achieved by means of a measuring device of the type stated in the preamble of claim 1, which has the features which appear from the characterizing part of claim 1, respectively a method for evasive measurement of a biophysical parameter in accordance with the claims. 2 and 3.
Blodets ledningsmotstånd i ett visst vävnadsparti, exempelvis fingertoppen, varierar i förhållande till glukoskoncentrationen i blodet, som genomströmmar väv- nadspartiet. Denna variation kan registreras, förstärkas och avläsas evasivt, utan direkt tillgång till blod, i en mätanordning bestående av en mätdel och en därmed elekt- riskt förbunden sensordel. Avläsningen sker spontant me- delst sensordelen och kan ske i de flesta vardagliga situationer. Diabetikern får på detta sätt möjlighet att kontinuerligt registrera sitt aktuella blodsockervärde.The conduction resistance of the blood in a certain part of the tissue, for example the fingertip, varies in relation to the concentration of glucose in the blood, which flows through the part of the tissue. This variation can be registered, amplified and read evasively, without direct access to blood, in a measuring device consisting of a measuring part and an electrically connected sensor part. The reading takes place spontaneously by means of the sensor part and can take place in most everyday situations. In this way, the diabetic is given the opportunity to continuously register his current blood sugar value.
Med denna kunskap kan diabetikern anpassa sin diabetes- terapi för att minimera svängningarna i blodsockervärdet.With this knowledge, the diabetic can adapt his diabetes therapy to minimize fluctuations in blood sugar levels.
Särskilt för s k IDDM-patienter (Insulin-Dependent-Dia- betes-Mellitus) har detta stor betydelse för samspelet mellan kost och insulintillförsel.Especially for so-called IDDM patients (Insulin-Dependent-Diabetes-Mellitus), this is of great importance for the interaction between diet and insulin supply.
Den till grund för uppfinningen liggande insikten består således i att i en mänsklig vävnad med hög kapil- lärblodgenomströmning, t ex en fingertopp, tå, öronsnibb, etc, glukoshalten i blodet förändrar motståndet av en konstant elektrisk ström. Med andra ord varierar spän- ningen över två fasta poler, eller omvänt strömstyrkan vid en given konstant spänning mellan två fasta poler, med koncentrationen av blodsockret i det genomströmmande blodet.The insight underlying the invention thus consists in that in a human tissue with high capillary blood flow, eg a fingertip, toe, earlobe, etc., the glucose content in the blood changes the resistance of a constant electric current. In other words, the voltage across two fixed poles, or vice versa, at a given constant voltage between two fixed poles, varies with the concentration of blood sugar in the flowing blood.
Vidare kan denna variation bestämmas integrerat med ett kalibreringsförfarande över två eller flera inpro- 10 15 20 25 30 35 512 047 3 grammerbara blodglukosvärden, som bestäms medelst konventionella mätmetoder.Furthermore, this variation can be determined integrally with a calibration method over two or more programmable blood glucose values, which are determined by conventional measurement methods.
Mätmetoden enligt uppfinningen utgår ifrån att kapillärblodet till sin molekylära sammansättning är konstant i alla andra avseenden än vad avser glukos- mängden, uttryckt mmol/l.The measurement method according to the invention is based on the fact that the capillary blood in its molecular composition is constant in all respects other than the amount of glucose, expressed in mmol / l.
Uppfinningen kommer nedan att ytterligare beskrivas med hänvisning till bifogade ritning, på vilken fig 1 är en schematisk vy av en mätanordning enligt uppfinningen, som visar en mätdel och en därmed förbunden sensordel, och fig 2 är en schematisk vy av den i anordningen enligt fig 1 ingående mätdelen.The invention will be further described below with reference to the accompanying drawing, in which Fig. 1 is a schematic view of a measuring device according to the invention, showing a measuring part and a sensor part connected thereto, and Fig. 2 is a schematic view of that in the device according to Fig. 1. constituent measuring part.
Den i fig 1 visade mätdelen 1 innefattar, såsom framgår av fig 2, strömförsörjningsorgan 11, en elektrisk krets 12, organ 15 dels för inmatning och avläsning av information ett minnesmedium 13, en mikrodator 14, samt i minnesmediet 13, dels för avläsning av mätdata. Mät- delen 1 är elektriskt förbunden med sensordelen 2, vilken omfattar motstående på avstånd från varandra placerade elektriska kontaktytor 21, 22. (polerna) genereras en elektrisk ström, exempelvis av Mellan kontaktytorna storleksordningen 10 mA, vars genomströmningsmotstànd är direkt proportionellt mot glukoshalten i det blod, som genomströmmar den mänskliga vävnaden, exempelvis en fingertopp (inte visad) som är införd i sensordelen så att kontaktytorna 21, 22 ligger an mot denna på ömse sidor därav. Med andra ord föreligger ett linjärt förhål- lande mellan genomströmningsmotstàndet och glukosvärdet i blodet. Därvid gäller formeln: vg=KixRxL där Vs Ki R = genomströmningsmotståndet glukosvärdet i mmol/l individens kalibreringskoefficient I = strömstyrkan. 10 15 20 25 30 512 047 4 Kalibreringskoefficienten för individen erhålles i mätanordningen genom minst två pà varandra följande mätningar vid kända glukosvärden för individen. Dessa inmatas som referensvärden i mätanordningen vid kalibre- ringens respektive mättillfällen. Glukosvärdena bör vid kalibreringen ha en minsta differens av 10 mmol/1.The measuring part 1 shown in Fig. 1 comprises, as can be seen from Fig. 2, power supply means 11, an electrical circuit 12, means 15 for input and reading of information a memory medium 13, a microcomputer 14, and in the memory medium 13, partly for reading measurement data . The measuring part 1 is electrically connected to the sensor part 2, which comprises opposite spaced apart electrical contact surfaces 21, 22. (the poles) an electric current is generated, for example of Between the contact surfaces of the order of 10 mA, the flow resistance is directly proportional to the glucose content in the blood flowing through the human tissue, for example a fingertip (not shown) inserted into the sensor part so that the contact surfaces 21, 22 abut thereon on either side thereof. In other words, there is a linear relationship between the flow resistance and the glucose value in the blood. The formula then applies: vg = KixRxL where Vs Ki R = the flow resistance glucose value in mmol / l the individual's calibration coefficient I = the current. 10 15 20 25 30 512 047 4 The calibration coefficient for the individual is obtained in the measuring device by at least two consecutive measurements at known glucose values for the individual. These are entered as reference values in the measuring device at the respective measuring times of the calibration. During calibration, the glucose values should have a minimum difference of 10 mmol / l.
Dessa värden, fràn en glukosbestämning av kapillär- blodet i en kemisk blodsockermätare, inprogrammeras i minnesmediet 13. Spänningsfallet över den bestämda väv- nadsmassan (fingertoppen) är linjärt proportionellt mot blodsockerhalten i det kapillärt genomströmmande blodet inom ett särskilt mätomràde, exempelvis 2-17 mmol/1. Det aktuella mätvärdet anges exempelvis med en decimal och uttrycks exempelvis mmol/1. De elektriska kontaktytorna 21, 22 befinner sig pá ett fast avstànd fràn varandra och detta avstånd bestäms av den individ, som skall använda mätanordningen. Som ett icke begränsande exempel pà en föredragen utföringsform av en mätanordning enligt upp- finningen anges nedan en teknisk specifikation: Mätomràde: blodglukos 2-17 mmol/1 Noggrannhet: 0,1 i 0,05 mmol/1 Mättid: l-2 Sek Kalibrersingsdifferens: minst 10 mmol/1 Kalibreringsvärden: två eller flera.These values, from a glucose determination of the capillary blood in a chemical blood glucose meter, are programmed into the memory medium 13. The voltage drop across the determined tissue mass (fingertip) is linearly proportional to the blood sugar level in the capillary flowing blood within a special measuring range, e.g. / 1. The current measured value is stated, for example, with a decimal and is expressed, for example, mmol / 1. The electrical contact surfaces 21, 22 are at a fixed distance from each other and this distance is determined by the individual who is to use the measuring device. As a non-limiting example of a preferred embodiment of a measuring device according to the invention, a technical specification is given below: Measuring range: blood glucose 2-17 mmol / l Accuracy: 0.1 in 0.05 mmol / l Measuring time: 1-2 Sec Calibration difference : at least 10 mmol / l Calibration values: two or more.
Komponenter Mätdel: mikrodator, tablå för kalibrering, strömkrets, avläsningsfönster, knapp- batterier och felindikator.Components Measuring unit: microcomputer, calibration table, circuit, reading window, button batteries and fault indicator.
Dimension: höjd 20 x bredd 8 x djup 4 (cm) Avläsningsfönster: LCD Arbetstemperatur: -5 - 40°C Sladdanslutning med mätdel: (för pekfinger) Kabellängd: 40 cm Sensordel: diameter 10-25 mm (20 olika dimensioner) konisk med plan botten.Dimension: height 20 x width 8 x depth 4 (cm) Reading window: LCD Working temperature: -5 - 40 ° C Cable connection with measuring part: (for index finger) Cable length: 40 cm Sensor part: diameter 10-25 mm (20 different dimensions) conical with plan bottom.
Djup: 20 mm, 10 15 20 25 30 35 5 512 047 att anbringa minst tvà elektriska kontaktytor mot motstàende sidor av en kroppsdel med hög kapillärblod- genomströmning; att applicera en konstant ström mellan de båda elektriska kontaktytorna: att avläsa spänningen mellan de båda elektriska kontaktytorna; och att under utnyttjande av referensvàrdena omvandla det avlàsta spänningsvärdet till ett värde pà den upp- mätta biofysikaliska parametern. 199%* v (lá - Ca' lïšà g; Xpat\il'\,ans\p298OS3B.docDepth: 20 mm, 10 15 20 25 30 35 5 512 047 to apply at least two electrical contact surfaces to opposite sides of a body part with high capillary blood flow; applying a constant current between the two electrical contact surfaces: reading the voltage between the two electrical contact surfaces; and using the reference values, converting the read voltage value to a value of the measured biophysical parameter. 199% * v (lá - Ca 'lïšà g; Xpat \ il' \, ans \ p298OS3B.doc
Claims (3)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9800629A SE512047C2 (en) | 1998-03-02 | 1998-03-02 | Measuring device, especially for blood sugar determination |
| AU27558/99A AU2755899A (en) | 1998-03-02 | 1999-03-02 | A device for the determination of blood sugar |
| PCT/SE1999/000294 WO1999044495A1 (en) | 1998-03-02 | 1999-03-02 | A device for the determination of blood sugar |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9800629A SE512047C2 (en) | 1998-03-02 | 1998-03-02 | Measuring device, especially for blood sugar determination |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9800629D0 SE9800629D0 (en) | 1998-03-02 |
| SE9800629L SE9800629L (en) | 1999-09-03 |
| SE512047C2 true SE512047C2 (en) | 2000-01-17 |
Family
ID=20410352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9800629A SE512047C2 (en) | 1998-03-02 | 1998-03-02 | Measuring device, especially for blood sugar determination |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2755899A (en) |
| SE (1) | SE512047C2 (en) |
| WO (1) | WO1999044495A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7315767B2 (en) | 2001-03-06 | 2008-01-01 | Solianis Holding Ag | Impedance spectroscopy based systems and methods |
| WO2002069791A1 (en) | 2001-03-06 | 2002-09-12 | Pendragon Medical Ltd. | Method and device for determining the concentration of a substance in body liquid |
| DE60234138D1 (en) | 2002-09-04 | 2009-12-03 | Solianis Holding Ag | METHOD AND APPARATUS FOR GLUCOSE MEASUREMENT |
| WO2004028358A1 (en) | 2002-09-24 | 2004-04-08 | Pendragon Medical Ltd. | Device for the measurement of glucose concentrations |
| CN100427025C (en) * | 2003-04-10 | 2008-10-22 | 宇东科技股份有限公司 | Method for measuring blood sugar concentration |
| US6954662B2 (en) * | 2003-08-19 | 2005-10-11 | A.D. Integrity Applications, Ltd. | Method of monitoring glucose level |
| US8197406B2 (en) | 2003-12-02 | 2012-06-12 | Biovotion Ag | Device and method for measuring a property of living tissue |
| US9713447B2 (en) | 2005-11-10 | 2017-07-25 | Biovotion Ag | Device for determining the glucose level in body tissue |
| WO2010118538A1 (en) | 2009-04-17 | 2010-10-21 | Solianis Holding Ag | Wide band field response measurement for glucose determination |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2033575B (en) * | 1978-05-24 | 1983-03-02 | Rolfe P | Investigating substances in a patient's bloodstream |
| US5119819A (en) * | 1990-05-02 | 1992-06-09 | Miles Inc. | Method and apparatus for non-invasive monitoring of blood glucose |
| US5741211A (en) * | 1995-10-26 | 1998-04-21 | Medtronic, Inc. | System and method for continuous monitoring of diabetes-related blood constituents |
| GB9526309D0 (en) * | 1995-12-22 | 1996-02-21 | Cme Telemetrix Inc A Company O | Integrating cavity for spectroscopic measurement in light scattering samples |
-
1998
- 1998-03-02 SE SE9800629A patent/SE512047C2/en not_active IP Right Cessation
-
1999
- 1999-03-02 WO PCT/SE1999/000294 patent/WO1999044495A1/en not_active Ceased
- 1999-03-02 AU AU27558/99A patent/AU2755899A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2755899A (en) | 1999-09-20 |
| SE9800629L (en) | 1999-09-03 |
| SE9800629D0 (en) | 1998-03-02 |
| WO1999044495A1 (en) | 1999-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0364216B1 (en) | Screening and monitoring instrument | |
| Schroeder et al. | Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer | |
| US6064896A (en) | Non-invasive measurement of blood glucose using instruments that have less precise detection capability | |
| CN100421617C (en) | A human body impedance measuring device and a fat meter using the device | |
| CN113433193B (en) | Noninvasive blood glucose detector and blood glucose detection method thereof | |
| CN102414560A (en) | Analyte sensor offset normalization | |
| JPS61125329A (en) | Heart pulse output measuring apparatus | |
| JPH11113873A5 (en) | ||
| EP0075277A1 (en) | A menstruation periodic counter | |
| SE512047C2 (en) | Measuring device, especially for blood sugar determination | |
| CN110249219B (en) | Risk factor monitoring | |
| Anas et al. | Non-invasive blood glucose measurement | |
| CA3060910A1 (en) | Analyte measurement system and method | |
| US3593704A (en) | Pulse sensor for body pulse rate measuring means | |
| KR20090118314A (en) | Bloodless blood glucose measurement apparatus and method using electrophoresis | |
| US9494555B2 (en) | System and method for measuring an analyte in a sample and calculating glucose results to account for physical characteristics of the sample | |
| JP2013128689A (en) | Ac constant current source and bioelectric impedance measurement device | |
| JP2004226273A (en) | Liquid volume measuring device and urine test instrument | |
| KR100437488B1 (en) | Bioelectrical impedance analyzer | |
| Tonello et al. | Multimodal sweat ion and sweat rate sensing with inkjet-printed flexible bracelet and paperfluidics | |
| Smit et al. | A comparison of three electrodes for the measurement of pH in small volumes | |
| TW202206024A (en) | Devices, systems, and methods for measuring analytes in interstitial fluid | |
| Sameera Fathimal et al. | A Novel Approach for the Measurement of pH of Body Fluids at Various Temperatures Using Compensation Technique | |
| RU54428U1 (en) | DEVICE FOR REGISTRATION OF RADIATIONS OF LIVING ORGANISMS, PLANTS, MINERALS, MEDICINES | |
| SU1039479A1 (en) | Device for investigating hemodynamics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |