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SE2450459A1 - A microfluidic device with valves - Google Patents

A microfluidic device with valves

Info

Publication number
SE2450459A1
SE2450459A1 SE2450459A SE2450459A SE2450459A1 SE 2450459 A1 SE2450459 A1 SE 2450459A1 SE 2450459 A SE2450459 A SE 2450459A SE 2450459 A SE2450459 A SE 2450459A SE 2450459 A1 SE2450459 A1 SE 2450459A1
Authority
SE
Sweden
Prior art keywords
valves
microfluidic device
microfluidic
Prior art date
Application number
SE2450459A
Inventor
Elias Amselem
Jimmy Larsson
Johan Öhman
Johan Elf
Original Assignee
Ab Burill
Cjl Micro Ab
Elfscience AB
Imaginarypi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Burill, Cjl Micro Ab, Elfscience AB, Imaginarypi Ab filed Critical Ab Burill
Priority to SE2450459A priority Critical patent/SE2450459A1/en
Priority to PCT/EP2025/052618 priority patent/WO2025223693A1/en
Priority to PCT/EP2025/061264 priority patent/WO2025224264A1/en
Publication of SE2450459A1 publication Critical patent/SE2450459A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Fluid Mechanics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SE2450459A 2024-04-26 2024-04-26 A microfluidic device with valves SE2450459A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE2450459A SE2450459A1 (en) 2024-04-26 2024-04-26 A microfluidic device with valves
PCT/EP2025/052618 WO2025223693A1 (en) 2024-04-26 2025-01-31 Method for studying cells
PCT/EP2025/061264 WO2025224264A1 (en) 2024-04-26 2025-04-24 A microfluidic device with valves

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE2450459A SE2450459A1 (en) 2024-04-26 2024-04-26 A microfluidic device with valves

Publications (1)

Publication Number Publication Date
SE2450459A1 true SE2450459A1 (en) 2025-10-27

Family

ID=94478445

Family Applications (1)

Application Number Title Priority Date Filing Date
SE2450459A SE2450459A1 (en) 2024-04-26 2024-04-26 A microfluidic device with valves

Country Status (2)

Country Link
SE (1) SE2450459A1 (en)
WO (2) WO2025223693A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178582A1 (en) * 2004-02-17 2007-08-02 Hur Koser Microfabricated cellular traps based on three-dimensional micro-scale flow geometries
WO2008124781A1 (en) * 2007-04-09 2008-10-16 Auburn University A microfluidic array system for biological, chemical, and biochemical assessments
WO2013072790A1 (en) * 2011-11-16 2013-05-23 International Business Machines Corporation Microfluidic device with deformable valve
WO2020100659A1 (en) * 2018-11-12 2020-05-22 株式会社日立ハイテク Nucleic acid analysis device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7378280B2 (en) * 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
CA2954360C (en) 2014-07-07 2022-11-22 Johan ELF Phenotypic characterization and in situ genotyping of a library of genetically different cells
CN106497771B (en) * 2016-10-21 2018-08-31 辽宁中医药大学 A kind of multifunctional microflow control chip screened simultaneously for a variety of drugs and cell
DK3601588T3 (en) 2017-03-22 2023-08-28 Astrego Diagnostics Ab PHENOTYPICAL CHARACTERIZATION OF CELLS
US12319901B2 (en) * 2019-06-20 2025-06-03 President And Fellows Of Harvard College Isolating live cells after high-throughput, long-term, time-lapse microscopy
US11959057B2 (en) * 2019-10-17 2024-04-16 New Jersey Institute Of Technology Automated addressable microfluidic technology for minimally disruptive manipulation of cells and fluids within living cultures
GB201919190D0 (en) * 2019-12-23 2020-02-05 Celltool Gmbh Identification of microbial contaminations or infections in liquid samples by raman spectroscopy
CN116218654A (en) * 2023-03-21 2023-06-06 中国科学院深圳先进技术研究院 A microfluidic chip, preparation method and detection method of bacterial drug resistance

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178582A1 (en) * 2004-02-17 2007-08-02 Hur Koser Microfabricated cellular traps based on three-dimensional micro-scale flow geometries
WO2008124781A1 (en) * 2007-04-09 2008-10-16 Auburn University A microfluidic array system for biological, chemical, and biochemical assessments
WO2013072790A1 (en) * 2011-11-16 2013-05-23 International Business Machines Corporation Microfluidic device with deformable valve
WO2020100659A1 (en) * 2018-11-12 2020-05-22 株式会社日立ハイテク Nucleic acid analysis device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Liu G et al., "Design automation for continuous-flow microfluidic biochips: A comprehensive review", Integration, the VLSI journal, 2022, Vol. 82, pp. 48-66 *
Mustafa A et al., "Development of a single layer microfluidic device for dynamic stimulation, culture and imaging of mammalian cells", bioRxiv preprint doi: https://doi.org/10.1101/2022.03.14.484262, posted March 16, 2022 *
Qin N et al., "Microfluidic technology for antibacterial resistance study and antibiotic susceptibility testing: Review and perspective", ACS Sens., 2021, Vol. 6, pp. 3-21 *

Also Published As

Publication number Publication date
WO2025224264A1 (en) 2025-10-30
WO2025223693A1 (en) 2025-10-30

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