SE0500054D0 - Therapeutic agents 2 - Google Patents
Therapeutic agents 2Info
- Publication number
- SE0500054D0 SE0500054D0 SE0500054A SE0500054A SE0500054D0 SE 0500054 D0 SE0500054 D0 SE 0500054D0 SE 0500054 A SE0500054 A SE 0500054A SE 0500054 A SE0500054 A SE 0500054A SE 0500054 D0 SE0500054 D0 SE 0500054D0
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- therapeutic agents
- nr1h2
- nr1h3
- dyslipidemias
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 102000004311 liver X receptors Human genes 0.000 abstract 4
- 108090000865 liver X receptors Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to certain novel compounds of formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) a (NR1H3) and/or ss (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0500054A SE0500054D0 (en) | 2005-01-10 | 2005-01-10 | Therapeutic agents 2 |
| US11/813,489 US20090029945A2 (en) | 2005-01-10 | 2006-01-09 | Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators |
| JP2007550337A JP2008526842A (en) | 2005-01-10 | 2006-01-09 | Aniline derivatives of isothiazole-3 (2H) -thione 1,1-dioxide as liver X receptor modulators |
| EP06700190A EP1838685A4 (en) | 2005-01-10 | 2006-01-09 | Derivatives of isothiazol-3 (2h)-thione 1,1-dioxides as liver x receptor modulators |
| CNA2006800018780A CN101098861A (en) | 2005-01-10 | 2006-01-09 | Aniline derivatives of isothiazole-3(2H)-thione 1,1-dioxide as liver X receptor modulators |
| PCT/SE2006/000027 WO2006073364A1 (en) | 2005-01-10 | 2006-01-09 | Derivatives of isothiazol-3 (2h)-thione 1,1-dioxides as liver x receptor modulators |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0500054A SE0500054D0 (en) | 2005-01-10 | 2005-01-10 | Therapeutic agents 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE0500054D0 true SE0500054D0 (en) | 2005-01-10 |
Family
ID=34132527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0500054A SE0500054D0 (en) | 2005-01-10 | 2005-01-10 | Therapeutic agents 2 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN101098861A (en) |
| SE (1) | SE0500054D0 (en) |
-
2005
- 2005-01-10 SE SE0500054A patent/SE0500054D0/en unknown
-
2006
- 2006-01-09 CN CNA2006800018780A patent/CN101098861A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101098861A (en) | 2008-01-02 |
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