SE0401601D0 - Protofibril specific antibodies and uses thereof - Google Patents
Protofibril specific antibodies and uses thereofInfo
- Publication number
- SE0401601D0 SE0401601D0 SE0401601A SE0401601A SE0401601D0 SE 0401601 D0 SE0401601 D0 SE 0401601D0 SE 0401601 A SE0401601 A SE 0401601A SE 0401601 A SE0401601 A SE 0401601A SE 0401601 D0 SE0401601 D0 SE 0401601D0
- Authority
- SE
- Sweden
- Prior art keywords
- abeta
- protofibril
- specific antibodies
- forms
- terminal truncated
- Prior art date
Links
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 abstract 3
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000009260 cross reactivity Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401601A SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Protofibril specific antibodies and uses thereof |
| PT57536724T PT1781703E (pt) | 2004-06-21 | 2005-06-21 | Anticorpos específicos para protofibrilhas de péptido betaamiloide solúveis e utilizações destes |
| ES05753672.4T ES2537001T3 (es) | 2004-06-21 | 2005-06-21 | Anticuerpos específicos para protofibrillas solubles de péptido beta amiloide y usos de los mismos |
| DK05753672.4T DK1781703T3 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble beta-amyloid peptide protofibrils and uses thereof |
| CA2570130A CA2570130C (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| HUE05753672A HUE025628T2 (en) | 2004-06-21 | 2005-06-21 | Soluble amyloid beta peptide protofibrils are specific antibodies and applications |
| AU2005254928A AU2005254928B2 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| SI200531986T SI1781703T1 (sl) | 2004-06-21 | 2005-06-21 | Protitelesa, specifična za topne protofibrile amiloidnega beta peptida, in njihove uporabe |
| PCT/SE2005/000993 WO2005123775A1 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| EP05753672.4A EP1781703B1 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| PL05753672T PL1781703T3 (pl) | 2004-06-21 | 2005-06-21 | Przeciwciała swoiste wobec rozpuszczalnych protofibryli peptydu amyloidu beta i ich zastosowania |
| US11/570,995 US8106164B2 (en) | 2004-06-21 | 2005-06-21 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| US13/336,520 US8404459B2 (en) | 2004-06-21 | 2011-12-23 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| US13/780,643 US8999936B2 (en) | 2004-06-21 | 2013-02-28 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| US14/627,161 US20150307601A1 (en) | 2004-06-21 | 2015-02-20 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
| CY20151100678T CY1116776T1 (el) | 2004-06-21 | 2015-08-03 | Αντισωματα ειδικα για τα διαλυτα πρωτοϊνιδια των πεπτιδιων β-αμυλοειδους και χρησεις αυτων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401601A SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Protofibril specific antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE0401601D0 true SE0401601D0 (sv) | 2004-06-21 |
Family
ID=32906833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0401601A SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Protofibril specific antibodies and uses thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US8106164B2 (xx) |
| EP (1) | EP1781703B1 (xx) |
| AU (1) | AU2005254928B2 (xx) |
| CA (1) | CA2570130C (xx) |
| CY (1) | CY1116776T1 (xx) |
| DK (1) | DK1781703T3 (xx) |
| ES (1) | ES2537001T3 (xx) |
| HU (1) | HUE025628T2 (xx) |
| PL (1) | PL1781703T3 (xx) |
| PT (1) | PT1781703E (xx) |
| SE (1) | SE0401601D0 (xx) |
| SI (1) | SI1781703T1 (xx) |
| WO (1) | WO2005123775A1 (xx) |
Families Citing this family (70)
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| EP1309341A2 (en) | 2000-07-07 | 2003-05-14 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| WO2010011999A2 (en) | 2008-07-25 | 2010-01-28 | The Regents Of The University Of California | Methods and compositions for eliciting an amyloid-selective immune response |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| EP1660533A4 (en) * | 2003-09-12 | 2009-10-21 | Univ California | MONOCLONAL ANTIBODIES SPECIFIC TO HIGH MOLECULAR WEIGHT AGGREGATION INTERMEDIATES COMMON TO AMYLOIDS FORMED FROM PROTEINS OF DIFFERENT SEQUENCE |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
| CN101528770A (zh) | 2005-11-30 | 2009-09-09 | 艾博特公司 | 制备重组形式的人β-淀粉样蛋白的方法和这些蛋白质的应用 |
| CA2628703C (en) | 2005-11-30 | 2019-10-29 | Abbott Laboratories | Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| MX358175B (es) | 2005-12-12 | 2018-08-08 | Ac Immune Sa | Anticuerpos monoclonales especificos 1-42 beta con propiedades terapeuticas. |
| CN1329413C (zh) * | 2006-01-23 | 2007-08-01 | 南京医科大学 | 一种治疗或预防老年性痴呆的抗体及其表达载体和在制药中的应用 |
| RS51723B2 (sr) * | 2006-03-23 | 2018-03-30 | Bioarctic Neuroscience Ab | Poboljšana antitela selektivna za protofibrile i njihova primena |
| PL2468770T3 (pl) | 2006-07-14 | 2018-07-31 | Ac Immune S.A. | Humanizowane przeciwciało przeciw amyloidowi beta |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| DK2099826T3 (da) * | 2007-01-05 | 2014-01-20 | Univ Zuerich | Anti-beta-amyloid-antistof og anvendelser deraf |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| EP2104682B1 (en) | 2007-01-11 | 2016-09-21 | Michael Bacher | Diagnosis and treatment of alzheimer's and other neurodementing diseases |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| US20090175847A1 (en) * | 2007-05-30 | 2009-07-09 | Abbott Laboratories | Humanized antibodies to ab (20-42) globulomer and uses thereof |
| TWI557136B (zh) * | 2007-06-12 | 2016-11-11 | Ac免疫公司 | 特異性結合β-類澱粉蛋白之抗體及相關核酸分子、表現載體、細胞、組合物、套組、方法及用途 |
| US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| WO2009033309A1 (en) * | 2007-09-13 | 2009-03-19 | Esbatech Ag | HUMANIZED ANTIBODIES AGAINST THE ß-AMYLOYD PEPTIDE |
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| DK2238166T3 (da) * | 2007-10-05 | 2014-01-27 | Ac Immune Sa | Anvendelse af et anti-amyloid-beta-antistof ved øjensygdomme |
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| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
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| LT2282758T (lt) | 2008-04-29 | 2019-03-12 | Bioarctic Ab | Antikūnai ir vakcinos, skirti su alfa sinukleinu susijusių sutrikimų gydymo ir diagnostiniams metodams |
| CA2746778C (en) | 2008-12-19 | 2019-04-23 | University Of Zurich | Human anti-alpha-synuclein autoantibodies |
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| PL2448968T3 (pl) | 2009-06-29 | 2021-09-13 | Bioarctic Ab | Antybiotyki selektywne względem n-końcowych skróconych protofibryli/oligomerów amyloidu beta |
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| KR20130080795A (ko) * | 2010-06-04 | 2013-07-15 | 키에시 파르마슈티시 엣스. 피. 에이. | 프리온 질환의 치료를 위한 1-(2-플루오로비페닐-4-일)-시클로프로판카복실산 유도체 |
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-
2004
- 2004-06-21 SE SE0401601A patent/SE0401601D0/xx unknown
-
2005
- 2005-06-21 PT PT57536724T patent/PT1781703E/pt unknown
- 2005-06-21 HU HUE05753672A patent/HUE025628T2/en unknown
- 2005-06-21 PL PL05753672T patent/PL1781703T3/pl unknown
- 2005-06-21 WO PCT/SE2005/000993 patent/WO2005123775A1/en not_active Ceased
- 2005-06-21 US US11/570,995 patent/US8106164B2/en active Active
- 2005-06-21 ES ES05753672.4T patent/ES2537001T3/es not_active Expired - Lifetime
- 2005-06-21 EP EP05753672.4A patent/EP1781703B1/en not_active Revoked
- 2005-06-21 AU AU2005254928A patent/AU2005254928B2/en not_active Expired
- 2005-06-21 SI SI200531986T patent/SI1781703T1/sl unknown
- 2005-06-21 CA CA2570130A patent/CA2570130C/en not_active Expired - Lifetime
- 2005-06-21 DK DK05753672.4T patent/DK1781703T3/en active
-
2011
- 2011-12-23 US US13/336,520 patent/US8404459B2/en not_active Expired - Lifetime
-
2013
- 2013-02-28 US US13/780,643 patent/US8999936B2/en not_active Expired - Lifetime
-
2015
- 2015-02-20 US US14/627,161 patent/US20150307601A1/en not_active Abandoned
- 2015-08-03 CY CY20151100678T patent/CY1116776T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005254928A1 (en) | 2005-12-29 |
| CA2570130A1 (en) | 2005-12-29 |
| PL1781703T3 (pl) | 2015-10-30 |
| DK1781703T3 (en) | 2015-06-01 |
| CA2570130C (en) | 2016-02-23 |
| US20120230912A1 (en) | 2012-09-13 |
| US20150307601A1 (en) | 2015-10-29 |
| US8106164B2 (en) | 2012-01-31 |
| ES2537001T3 (es) | 2015-06-01 |
| EP1781703B1 (en) | 2015-05-06 |
| CY1116776T1 (el) | 2017-03-15 |
| US20130236452A1 (en) | 2013-09-12 |
| AU2005254928B2 (en) | 2011-11-10 |
| HUE025628T2 (en) | 2016-04-28 |
| US20090155246A1 (en) | 2009-06-18 |
| PT1781703E (pt) | 2015-08-24 |
| EP1781703A1 (en) | 2007-05-09 |
| US8999936B2 (en) | 2015-04-07 |
| SI1781703T1 (sl) | 2015-08-31 |
| US8404459B2 (en) | 2013-03-26 |
| WO2005123775A1 (en) | 2005-12-29 |
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