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SE0001670D0 - Mass spectrometry-based biosensor - Google Patents

Mass spectrometry-based biosensor

Info

Publication number
SE0001670D0
SE0001670D0 SE0001670A SE0001670A SE0001670D0 SE 0001670 D0 SE0001670 D0 SE 0001670D0 SE 0001670 A SE0001670 A SE 0001670A SE 0001670 A SE0001670 A SE 0001670A SE 0001670 D0 SE0001670 D0 SE 0001670D0
Authority
SE
Sweden
Prior art keywords
mass spectrometry
detection
based biosensor
antibody
nucleic acid
Prior art date
Application number
SE0001670A
Other languages
Swedish (sv)
Inventor
Curt T Reimann
Original Assignee
Forskarpatent I Syd Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forskarpatent I Syd Ab filed Critical Forskarpatent I Syd Ab
Priority to SE0001670A priority Critical patent/SE0001670D0/en
Publication of SE0001670D0 publication Critical patent/SE0001670D0/en
Priority to AU2001258700A priority patent/AU2001258700A1/en
Priority to PCT/IB2001/000957 priority patent/WO2001084146A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

The invention provides a method for detection of substances. The method utilizes immunological detection of a substance, followed by amplification of a nucleic acid tag bound to the antibody, and identification of the amplified tag. The detection method utilizes mass spectrometry to detect specific binding of the antibody to an antigen by detecting the presence, and identifying the mass, of the nucleic acid tag.
SE0001670A 2000-05-04 2000-05-04 Mass spectrometry-based biosensor SE0001670D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE0001670A SE0001670D0 (en) 2000-05-04 2000-05-04 Mass spectrometry-based biosensor
AU2001258700A AU2001258700A1 (en) 2000-05-04 2001-05-04 A sensitive, multiplexed mass-spectrometry-based biosensor based on immuno-pcr
PCT/IB2001/000957 WO2001084146A2 (en) 2000-05-04 2001-05-04 A sensitive, multiplexed mass-spectrometry-based biosensor based on immuno-pcr

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0001670A SE0001670D0 (en) 2000-05-04 2000-05-04 Mass spectrometry-based biosensor

Publications (1)

Publication Number Publication Date
SE0001670D0 true SE0001670D0 (en) 2000-05-04

Family

ID=20279569

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0001670A SE0001670D0 (en) 2000-05-04 2000-05-04 Mass spectrometry-based biosensor

Country Status (3)

Country Link
AU (1) AU2001258700A1 (en)
SE (1) SE0001670D0 (en)
WO (1) WO2001084146A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001262943A1 (en) 2000-04-14 2001-10-30 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
DE10200374A1 (en) * 2002-01-08 2003-07-24 Friz Biochem Gmbh Method for the qualitative and quantitative comparative detection of chemical substances
WO2004094456A2 (en) 2003-04-18 2004-11-04 Becton, Dickinson And Company Immuno-amplification
WO2005086679A2 (en) 2004-03-05 2005-09-22 Medical College Of Ohio Methods and compositions for assessing nucleic acids and alleles
CA2568238C (en) 2004-04-12 2013-10-15 Medical College Of Ohio Methods and compositions for assaying analytes
WO2006128010A2 (en) * 2005-05-26 2006-11-30 The Trustees Of Boston University Quantification of nucleic acids and proteins using oligonucleotide mass tags
WO2008033575A2 (en) 2006-09-15 2008-03-20 Metabolon, Inc. Methods of identifying biochemical pathways
JP2009219388A (en) * 2008-03-14 2009-10-01 Jsr Corp Magnetic particle for immunopcr, method for detecting target substance and detection kit for target substance
HK1213019A1 (en) 2013-03-13 2016-06-24 Meso Scale Technologies, Llc Improved assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
US10408823B2 (en) 2014-05-15 2019-09-10 Meso Scale Technologies, Llc. Assay methods
AU2017370751B2 (en) 2016-12-09 2023-11-09 Ultivue, Inc. Improved methods for multiplex imaging using labeled nucleic acid imaging agents
EP3601339A4 (en) 2017-03-31 2020-11-04 Ultivue, Inc. Dna-antigen exchange and amplification
CN119224296A (en) * 2018-09-26 2024-12-31 北卡罗来纳-查佩尔山大学 Compounds, compositions and methods for improving assays

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5366296A (en) * 1995-03-22 1996-10-08 Trustees Of Boston University Methods for the detection of paracoccidioides
DE19802576B4 (en) * 1998-01-23 2004-10-28 Xerion Pharmaceuticals Ag Methods for the simultaneous identification of proteins and their binding partners
MXPA01009567A (en) * 1999-03-23 2003-08-19 Biovation Ltd Protein isolation and analysis.

Also Published As

Publication number Publication date
WO2001084146A3 (en) 2002-04-11
WO2001084146A2 (en) 2001-11-08
WO2001084146B1 (en) 2002-07-04
AU2001258700A1 (en) 2001-11-12

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