SE0001642D0 - Reagent for detection of biomolecules, and use thereof - Google Patents
Reagent for detection of biomolecules, and use thereofInfo
- Publication number
- SE0001642D0 SE0001642D0 SE0001642A SE0001642A SE0001642D0 SE 0001642 D0 SE0001642 D0 SE 0001642D0 SE 0001642 A SE0001642 A SE 0001642A SE 0001642 A SE0001642 A SE 0001642A SE 0001642 D0 SE0001642 D0 SE 0001642D0
- Authority
- SE
- Sweden
- Prior art keywords
- domain
- reagent
- molecule
- binding domain
- target molecule
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 5
- 238000001514 detection method Methods 0.000 title abstract 2
- 238000006471 dimerization reaction Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A cell-free reagent for detection of a target molecule is disclosed. Said reagent comprises a binding domain linked to a reporter domain. The binding domain has affinity to the target molecule and will bind to it when brought in contact therewith. The binding of the binding domain to the target molecule will induce dimerization of one reagent molecule with another reagent molecule with a similar binding domain, and as a result the reporter domain will induce a measurable signal. The binding domain may e.g. be the extracellular domain of a receptor, and the reporter molecule may be the intracellular domain of another receptor. Also the use of said receptor for the determination of the presence and/or the level of a target molecule present in a fluid sample and for the screening of potentially pharmaceutical active biomolecules is disclosed.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001642A SE0001642D0 (en) | 2000-05-04 | 2000-05-04 | Reagent for detection of biomolecules, and use thereof |
| AU2001256892A AU2001256892A1 (en) | 2000-05-04 | 2001-05-03 | Reagent for detection of biomolecules, and use thereof |
| PCT/SE2001/000941 WO2001083551A1 (en) | 2000-05-04 | 2001-05-03 | Reagent for detection of biomolecules, and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001642A SE0001642D0 (en) | 2000-05-04 | 2000-05-04 | Reagent for detection of biomolecules, and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE0001642D0 true SE0001642D0 (en) | 2000-05-04 |
Family
ID=20279543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0001642A SE0001642D0 (en) | 2000-05-04 | 2000-05-04 | Reagent for detection of biomolecules, and use thereof |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2001256892A1 (en) |
| SE (1) | SE0001642D0 (en) |
| WO (1) | WO2001083551A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2557164A1 (en) | 2003-02-18 | 2013-02-13 | Kevin M. Slawin | Induced activation in dendritic cells |
| WO2008049113A2 (en) | 2006-10-19 | 2008-04-24 | Baylor College Of Medicine | Generating an immune response by inducing cd40 and pattern recognition receptors |
| WO2010033949A1 (en) | 2008-09-22 | 2010-03-25 | Baylor College Of Medicine | Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| CN105209065B (en) | 2013-03-14 | 2020-07-31 | 贝里坤制药股份有限公司 | Method for controlling T cell proliferation |
| DK3004329T3 (en) | 2013-06-05 | 2020-05-18 | Bellicum Pharmaceuticals Inc | METHODS FOR INDUCTION OF PARTIAL APOPTOSIS USING CASPASE POLYPEPTIDES |
| US10934346B2 (en) | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| AU2015312117A1 (en) | 2014-09-02 | 2017-03-02 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by Myd88 and CD40 polypeptides |
| JP6718444B2 (en) | 2014-11-03 | 2020-07-08 | アカデミッシュ ザイケンホイス レイデン （エイチ．オー．ディー．エヌ． エルユーエムシー） | T cell receptors directed against Bob1 and uses thereof |
| GB201520021D0 (en) * | 2015-11-13 | 2015-12-30 | Asterion Ltd | Fusion polypeptide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0705341A1 (en) * | 1993-06-07 | 1996-04-10 | Amgen Inc. | Hybrid receptor molecules |
| US8349602B1 (en) * | 1996-04-19 | 2013-01-08 | Xenogen Corporation | Biodetectors targeted to specific ligands |
| JPH11285388A (en) * | 1998-04-03 | 1999-10-19 | Jcr Pharmaceuticals Co Ltd | Chimera receptor expression cell and use thereof |
-
2000
- 2000-05-04 SE SE0001642A patent/SE0001642D0/en unknown
-
2001
- 2001-05-03 AU AU2001256892A patent/AU2001256892A1/en not_active Abandoned
- 2001-05-03 WO PCT/SE2001/000941 patent/WO2001083551A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001256892A1 (en) | 2001-11-12 |
| WO2001083551A1 (en) | 2001-11-08 |
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